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Social Circle, GA, United States

Life University is a private university in the Atlanta suburb of Marietta, Georgia that offers a number of undergraduate programs. Life University is best known for its doctoral degree program in chiropractic. Wikipedia.

Ohnishi S.T.,University of Pennsylvania | Salerno J.C.,Life University at Georgia | Ohnishi T.,University of Pennsylvania
Biochimica et Biophysica Acta - Bioenergetics | Year: 2010

In many energy transducing systems which couple electron and proton transport, for example, bacterial photosynthetic reaction center, cytochrome bc1-complex (complex III) and E. coli quinol oxidase (cytochrome bo3 complex), two protein-associated quinone molecules are known to work together. T. Ohnishi and her collaborators reported that two distinct semiquinone species also play important roles in NADH-ubiquinone oxidoreductase (complex I). They were called SQNf (fast relaxing semiquinone) and SQNs (slow relaxing semiquinone). It was proposed that QNf serves as a "direct" proton carrier in the semiquinone-gated proton pump (Ohnishi and Salerno, FEBS Letters 579 (2005) 4555), while QNs works as a converter between one-electron and two-electron transport processes. This communication presents a revised hypothesis in which QNf plays a role in a "direct" redox-driven proton pump, while QNs triggers an "indirect" conformation-driven proton pump. QNf and QNs together serve as (1e-/2e-) converter, for the transfer of reducing equivalent to the Q-pool. © 2010 Elsevier B.V. Source

Dutra H.P.,Life University at Georgia | Barnett K.,University of Missouri-St. Louis | Reinhardt J.R.,University of Missouri-St. Louis | Marquis R.J.,University of Missouri-St. Louis | Orrock J.L.,University of Wisconsin - Madison
Oecologia | Year: 2011

Understanding the effects of invasive plants on native consumers is important because consumer-mediated indirect effects have the potential to alter the dynamics of coexistence in native communities. Invasive plants may promote changes in consumer pressure due to changes in protective cover (i. e., the architectural complexity of the invaded habitat) and in food availability (i. e., subsidies of fruits and seeds). No experimental studies have evaluated the relative interplay of these two effects. In a factorial experiment, we manipulated cover and food provided by the invasive shrub Amur honeysuckle (Loniceramaackii) to evaluate whether this plant alters the foraging activity of native mammals. Using tracking plates to quantify mammalian foraging activity, we found that removal of honeysuckle cover, rather than changes in the fruit resources it provides, reduced the activity of important seed consumers, mice in the genus Peromyscus. Two mesopredators, Procyonlotor and Didelphisvirginiana, were also affected. Moreover, we found rodents used L. maackii for cover only on cloudless nights, indicating that the effect of honeysuckle was weather-dependent. Our work provides experimental evidence that this invasive plant species changes habitat characteristics, and in so doing alters the behavior of small-and medium-sized mammals. Changes in seed predator behavior may lead to cascading effects on the seeds that mice consume. © 2011 Springer-Verlag. Source

McCoy M.,Life University at Georgia | Wijayawardana S.,Emory University | Easley K.,Emory University
PLoS ONE | Year: 2011

Objective: The objective of this study was to evaluate the intra-examiner and inter-examiner reproducibility of paraspinal thermography using an infrared scanner. Materials and Methods: The thermal functions of a commercially available infrared scanner (Insight Subluxation Station®) were evaluated for clinical reliability. Two practicing clinicians conducted the measures on 100 subjects. Intra class correlation coefficients (ICCs) and concordance correlation coefficients (CCCs) were calculated from the collected data. Results: Mean bilateral paraspinal skin temperature was 89.78° F and ranged from 88.77° F to 91.43° F. Intra class correlation coefficients (ICCs) for agreement and consistency ranged from 0.959 to 0.976. Concordance correlation coefficients (CCCs) ranged from 0.783 to 0.859 with tight confidence intervals indicating robust estimates of these quantities. Conclusion: This study revealed excellent intra-examiner and inter-examiner reproducibility of paraspinal thermography using a commercially available unit. © 2011 McCoy et al. Source

Orrock J.L.,University of Wisconsin - Madison | Dutra H.P.,Life University at Georgia | Marquis R.J.,University of Missouri-St. Louis | Barber N.,Northern Illinois University
Ecology | Year: 2015

Direct and indirect effects can play a key role in invasions, but experiments evaluating both are rare. We examined the roles of direct competition and apparent competition by exotic Amur honeysuckle (Lonicera maackii) by manipulating (1) L. maackii vegetation, (2) presence of L. maackii fruits, and (3) access to plants by small mammals and deer. Direct competition with L. maackii reduced the abundance and richness of native and exotic species, and native consumers significantly reduced the abundance and richness of native species. Although effects of direct competition and consumption were more pervasive, richness of native plants was also reduced through apparent competition, as small-mammal consumers reduced richness only when L. maackii fruits were present. Our experiment reveals the multiple, interactive pathways that affect the success and impact of an invasive exotic plant: exotic plants may directly benefit from reduced attack by native consumers, may directly exert strong competitive effects on native plants, and may also benefit from apparent competition. © 2015 by the Ecological Society of America. Source

Ingram K.H.,University of Alabama at Birmingham | Hill H.,Novo Nordisk AS | Moellering D.R.,University of Alabama at Birmingham | Hill B.G.,University of Louisville | And 8 more authors.
Journal of Clinical Endocrinology and Metabolism | Year: 2012

Objective: The relationships among skeletal muscle lipid peroxidation, intramyocellular lipid content (IMCL), and insulin sensitivity were evaluated in nine insulin-sensitive (IS), 13 insulin-resistant (IR), and 10 adults with type 2 diabetes (T2DM). Design: Insulin sensitivity was assessed by hyperinsulinemic-euglycemic clamp [glucose disposal rate (GDR)]. Lipid peroxidation was assessed by 4-hydroxynonenal (HNE)-protein adducts and general oxidative stress by protein carbonyl content. All patients were sedentary. Results: Protein-HNE adducts were elevated 1.6-fold in T2DM compared with IS adults, whereas IR showed intermediate levels of HNE-modified proteins. Protein-HNE adducts correlated with GDR, waist circumference, and body mass index. IMCL was increased by 4.0- and 1.9-fold in T2DM and IR patients, respectively, compared with IS, and was correlated with GDR and waist circumference but not BMI. Protein carbonyls were not different among groups and did not correlate with any of the measured variables. Correlations were detected between IMCL and protein-HNE. Conclusion: Our data show for the first time that skeletal muscle protein-HNE adducts are related to the severity of insulin resistance in sedentary adults. These results suggest that muscle lipid peroxidation couldbeinvolvedinthedevelopmentofinsulin resistance. Copyright © 2012 by The Endocrine Society. Source

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