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He G.-H.,Kunming General Hospital of Chengdu Military Region | Lu J.,Xian Jiaotong University | Shi P.-P.,Kunming General Hospital of Chengdu Military Region | Xia W.,Kunming General Hospital of Chengdu Military Region | And 4 more authors.
Gene | Year: 2013

Previous investigations indicated that histamine receptor H4 (HRH4) played important roles in many aspects of breast cancer pathogenesis, and that the polymorphisms of HRH4 gene may result in expression and functional changes of HRH4 proteins. However, the relationship between polymorphisms of HRH4 and breast cancer risk and malignant degree is unclear. In the present study, we conducted a case-control investigation among 185 Chinese Han breast cancer patients and 199 ethnicity-matched health controls. Four tag-SNPs (i.e. rs623590, rs16940762, rs11662595 and rs1421125) of HRH4 were genotyped and association analysis was performed. Odds ratios (ORs) with 95% confidence intervals (CI) were used to assess the association. We found that the T allele of rs623590 had a decreased risk of breast cancer (adjusted OR, 0.667; 95% CI, 0.486-0.913; P= 0.012) while the A allele of rs1421125 had an increased risk (adjusted OR, 1.653; 95% CI, 1.139-2.397; P= 0.008). Further haplotype analysis showed that the CAA haplotype of rs623590-rs11662595-rs1421125 was more frequent among patients with breast cancer (adjusted OR, 1.856; 95% CI, 1.236-2.787; P= 0.003). Additionally, polymorphisms of rs623590 and rs11662595 were also correlated with clinical stages, lymph node involvement, and HER2 status. These findings indicated that the variants of rs623590, rs11662595 and rs1421125 genotypes of HRH4 gene were significantly associated with the risk and malignant degree of breast cancer in Chinese Han populations, which may provide us novel insight into the pathogenesis of breast cancer although further studies with larger participants worldwide are still needed for conclusion validation. © 2013 Elsevier B.V. Source

Gao W.,Life Detection Systems
Chinese Journal of Organic Chemistry | Year: 2010

Naturally occurring terpenes constitute the largest group of natural products with complicated and variable structures and a great number of important biological activities. 2-Methyl-7D-erythreitol 4-phosphate (MEP) pathway is a newly found and established biosynthetic route for terpenoids and all the enzymes involved in this pathway can be used as targets for the screening of new antibiotics. Progress in chemical and enzymatic preparation of the key intermediates in MEP pathway, namely 1-deoxy-D-xylulose 5-phosphate and 2-methyk-D-erythreitol 4-phosphate is reviewed with the emphasis on the synthesis of these two compounds with isotope labels. Source

Wang S.,Chengdu Medical College | Chen Y.,PLA Fourth Military Medical University | Qu F.,PLA Fourth Military Medical University | He S.,PLA Fourth Military Medical University | And 5 more authors.
Neuro-Oncology | Year: 2014

Background. Compelling epidemiological evidence indicates that alterations of telomere length are associated with risks of many malignancies in a tumor-specific manner, such as lung cancer, breast cancer, and non-Hodgkin's lymphoma. However, the association between leukocyte telomere length and glioma risk has not been investigated. Methods. Relative telomere length (RTL) of peripheral blood leukocytes from 467 glioma patients and 467 healthy controls, matched by age and sex, was measured using the real-time PCR-based method in a case-control study. An unconditional multivariate logistic regression model was applied to estimate the association between RTL and glioma risk. Results. Glioma patients showed notably longer RTL than controls (median, 0.555 vs 0.444; P >. 04). RTL was negatively correlated with age in both cases (ρ = -0.430; P <. 001) and controls (ρ = -0.388; P <. 001). After adjusting for age, sex, smoking status and family history of cancer, multivariate logistic regression analysis showed that there was a U-shaped association between RTL and glioma risk (P for nonlinearity <.001). Compared with individuals in the second tertile of RTL, the odds ratios (95% CI) for participants in the first and third tertiles were 2.16 (range, 1.52-3.09) and 3.51 (range, 2.45-5.00), respectively. Stratified analysis showed that the association between RTL and glioma risk was not modulated by major host characteristics. Conclusions. Our study demonstrates for the first time that either shorter or longer RTL in peripheral blood leukocytes is associated with increased glioma risk, which warrants further investigation in the future. © 2013 © The Author(s) 2013. Source

Life Technologies and Life Detection Systems | Date: 2014-06-29

Integrated circuits and software for use in monitoring, reporting and sending alerts regarding a person, animal or objects physical conditions, for use in detecting, recording, measuring, receiving, transmitting and displaying distances, location, activity and movement and biological function data about a person, animal or object and for use in monitoring and sending alerts regarding the activity of persons, animals and objects.

Li G.,PLA Fourth Military Medical University | Zhang Z.,PLA Fourth Military Medical University | Tu Y.,PLA Fourth Military Medical University | Jin T.,Life Detection Systems | And 4 more authors.
Diagnostic Pathology | Year: 2013

MicroRNA-372 (miR-372) acts as either an oncogenic miRNA or an anti-oncomiR in various human malignancies. However, its roles in gliomas have not been elucidated. To address this problem, we here detected miR-372 expression in human gliomas and non-neoplastic brain tissues by real-time quantitative RT-PCR assay. The association of miR-372 expression with clinicopathological factors or prognosis of glioma patients was also statistically analyzed. As the results, miR-372 expression levels were significantly upregulated in glioma tissues compared to the corresponding non-neoplastic brain tissues (P<0.001). In addition, the high miR-372 expression was significantly associated with the advanced pathological grade (P=0.008) and the low Karnofsky performance score (KPS) of glioma patients (P=0.01). Moreover, the overall survival of patients with high miR-372 expression was dramatically shorter than those with low miR-372 expression (P<0.001). Furthermore, multivariate Cox regression analysis indicated that miR-372 expression was an independent prognostic factor for glioma patients (P=0.008). More importantly, subgroup analyses according to tumor pathological grade revealed that the cumulative overall survival of glioma patients with advanced pathological grades was significantly worse for high miR-372 expression group than for low miR-372 expression group (P<0.001), but no significant difference was found for patients with low pathological grades (P=0.08). Taken together, these data offer the convincing evidence for the first time that miR-372 may act as an oncogenic miRNA in gliomas and represent a potential regulator of aggressive development and a candidate prognostic marker for this malignancy, especially for advanced tumors with high pathological grades.Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1707761328850011. © 2013 Li et al.; licensee BioMed Central Ltd. Source

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