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Matsueda K.,Life Clinic | Hongo M.,Tohoku University | Tack J.,Catholic University of Leuven | Saito Y.,Zeria Pharmaceutical Co. | Kato H.,Zeria Pharmaceutical Co.
Gut | Year: 2012

Objective: To determine the efficacy of acotiamide, an acetylcholinesterase inhibitor, in patients with functional dyspepsia (FD) in a 4-week trial Methods: A multicentre, randomised, placebocontrolled, parallel-group, phase III trial was carried out, in which patients with FD received 100 mg of acotiamide or placebo three times a day for 4 weeks, with 4 weeks post-treatment follow-up. The primary efficacy end points were global assessment of overall treatment efficacy (OTE) and elimination rate of all three mealrelated symptoms (postprandial fullness, upper abdominal bloating and early satiation), as derived from daily diaries. Secondary efficacy end points were individual symptom scores and quality of life. Adverse events were monitored. Results: 52.2% of those receiving acotiamide and 34.8% in the placebo group (p<0.001) were classified as responders according to a global assessment of OTE. Over 4 weeks, the elimination rate for all three mealrelated symptoms was 15.3% among patients receiving acotiamide compared with 9.0% in the placebo group (p=0.004). The significant benefit of acotiamide over placebo in OTE and elimination rate was maintained during the 4 week post-treatment follow-up. All other secondary efficacy end points, including quality of life, were significantly improved with 100 mg of acotiamide as compared with placebo. The number needed to treat was 6 for OTE and 16 for symptom elimination rate. The incidence of adverse events was similar between the acotiamide group and placebo group and no significant cardiovascular effects due to treatment were seen. Conclusions: Over 4 weeks, acotiamide significantly improved symptom severity and eliminated meal-related symptoms in patients with FD. Trial registration number: http://ClinicalTrials. gov number, NCT00761358.


Tofilski A.,Agricultural University of Krakow | Chuda-Mickiewicz B.,West Pomeranian University of Technology | Czekonska K.,Agricultural University of Krakow | Chorbinski P.,Life Clinic
Apidologie | Year: 2012

We tested whether flow cytometry can be used for assessment of viability of honey bee (Apis mellifera) sperm. The method was used to detect possible competition between the sperm of different drones. The flow cytometry analysis of semen stained with SYBR-14/propidium iodide revealed significant differences between fresh and freeze-thawed samples. The identification of populations corresponding to viable and nonviable sperm allowed us to assess the sperm viability. The comparison of single-drone semen with mixed semen of two unrelated drones showed that sperm viability was not affected by mixing, but there were differences between mixed and unmixed semen in side scatter, which correlates with shape and optical homogeneity of particles. The proportion of particles in different populations also was affected by mixing of the semen. The results suggest that there are interactions between ejaculates of different drones, possibly related to sperm competition. © 2011 INRA, DIB and Springer-Verlag, France.


Fukudo S.,Tohoku University | Ida M.,Astellas Pharma Inc. | Akiho H.,Astellas Pharma Inc. | Nakashima Y.,Astellas Pharma Inc. | Matsueda K.,Life Clinic
Clinical Gastroenterology and Hepatology | Year: 2014

Background & Aims: Ramosetron, a serotonin (5-hydroxytryptamine)-3 receptor antagonist with high selectivity, reduced stress-induced diarrhea and defecation caused by corticotropin-releasing hormone in rats. However, there have been no clinical trials of its effect in patients with diarrhea and irritable bowel syndrome (IBS-D). We performed a randomized, double-blind, placebo-controlled trial to determine whether ramosetron reduces diarrhea in these patients. Methods: Our study included 296 male outpatients with IBS-D treated at 52 centers in Japan. Patients were given 5 μg oral ramosetron (n= 147) or placebo (n= 149) once daily for 12 weeks after a 1-week baseline period. The primary end point was increased stool consistency in the first month. Secondary end points included relief of overall IBS symptoms and increased IBS-related quality of life. Results: More patients given ramosetron (74, 50.3%) than those given placebo (29, 19.6%) reported improved stool consistency in the first month (P <.001). The relative risk and number needed to treat were 2.57 (95% confidence interval, 1.79-3.70) and 3.25 (95% confidence interval, 2.44-4.89), respectively. The ramosetron group had significantly higher monthly rates of relief of overall IBS symptoms and IBS-related quality of life than the placebo group. Conclusions: Ramosetron (5 μg oral, once daily for 12 weeks) improved stool consistency in male patients with IBS-D, compared with placebo. These study results, along with the pharmacologic profile of ramosetron, indicate that increased stool consistency is the best end point for studies of ramosetron in patients with IBS-D. © 2014 AGA Institute.


Mlosek R.K.,Medical University of Warsaw | WoZniak W.,Medical University of Warsaw | Gruszecki L.,Life Clinic | Stapa R.Z.,Medical University of Warsaw
Phlebology | Year: 2014

Objective: Endovascular procedures are gaining more and more popularity as treatment of great saphenous vein (GSV) incompetence. The purpose of the present study was to assess the efficacy of steam GSV ablation. Methods: Steam ablation using the steam vein sclerosis system (CERMA, France) was performed in 20 patients with GSV incompetence. The efficacy of the procedure was evaluated using ultrasound and the following parameters were assessed: changes in lumen diameter, GSV wall thickness, reflux and presence/absence of blood flow. Results: The GSV steam ablation resulted in the obliteration of the vein lumen in all patients - reflux or blood flow were not observed in any subject. A significant decrease of GSV lumen diameter and an increase of GSV wall thickness were also observed in all subjects following the procedure. No postoperative complications were noted. The steam ablation technique was also positively assessed by the patients. Conclusions: Steam ablation is an endovascular surgical technique, which can become popular and widely used due to its efficacy and safety. It is also easy to use and patientfriendly. The research on its use should be continued.


Chompoo J.,Kagoshima University | Upadhyay A.,Kagoshima University | Kishimoto W.,University of Ryukyus | Makise T.,Life Clinic | Tawata S.,University of Ryukyus
Food Chemistry | Year: 2011

Advanced glycation end products (AGEs) are major factors responsible for the complication of diabetes. The present study was carried out to investigate the inhibitory activities on fructosamine adduct and α-dicarbonyl formations by hexane extracts of various parts of Alpinia zerumbet. Furthermore, we isolated two previously known compounds, namely 5,6-dehydrokawain (DK) and dihydro-5,6-dehydrokawain (DDK). 8(17),12-Labdadiene-15,16-dial (labdadiene) was isolated for the first time from the rhizome of A. zerumbet. The results showed that labdadiene (IC50 = 51.06 μg/mL) had similar activity to rutin and quercetin against fructosamine adduct. The inhibition of α-dicarbonyl compounds formation by labdadiene was significantly higher than that of DK and DDK. Our results indicate that labdadiene is a potent antiglycation agent which was found to inhibit AGEs formation in three different steps in the pathway. These data indicate that labdadiene could be used to prevent glycation-associated complications in diabetes. © 2011 Elsevier Ltd. All rights reserved.


Genuis S.K.,University of Alberta | Willows N.,Life Clinic | Jardine C.,University of Alberta | Alexander First Nation,Morinville
Child: Care, Health and Development | Year: 2015

Background: The related issues of food security and obesity among North American Indigenous children are serious public health concerns. This community-based participatory study sought to gain deeper understanding of young First Nation children's lived experience with food and to learn, from their perspective, about food security issues in their community. Methods: In this Photovoice investigation 26 young children attending a rural reserve school in Canada were asked to take photographs of the food they ate. Nine high school students from the same school were trained as co-researchers: they interviewed the younger students, helped identify emerging themes and contributed to knowledge translation. Data analysis incorporated conventional content analysis, grounded theory's constant-comparative method, and examination of photos and texts. Results: Five primary findings emerged from photographs and interviews: (1) children had a dualistic understanding of healthy vs. unhealthy foods; (2) packaged, quick-preparation foods played a dominant role in children's everyday food experiences; (3) families were critical to children's food-related experiences; (4) although traditional foods are viewed as central to Aboriginal health, few were depicted in the photographs; and (5) photos do not tell the whole story - despite the smaller numbers of fruits and vegetables in photos, children like to eat these foods when they are available at home. Conclusions: The study improved understanding of children's everyday food-related experiences, provided insight into community food security, and demonstrated the contribution of children and youth as experts on their lives and matters affecting them. A photobook representing findings provided a rich, visual tool for communicating the food-related experiences of children and messages about healthy eating within the school and to community members and leaders. Intervention efforts can build on participants' understanding of healthy versus unhealthy foods and on the critical role of family for healthy eating. © 2014 The Authors. Child: Care, Health and Development published by John Wiley & Sons Ltd.


King J.,Life Clinic
Journal of Psychoactive Drugs | Year: 2011

Best practices for Native Americans are rooted in culture. However, reclaiming best practices is a challenge given the genocidal policies that outlawed Native culture. Despite this challenge Native people have proven resilient in restoring culture. The Native American Health Center in Oakland, California, has made cultural interventions an option for an urban, intertribal and sometimes multiracial Native American population to create and maintain their health on a spiritual, emotional, mental and physical level. Nevertheless, sustaining these cultural options to maintain health continues to be a challenge. While the passage of the Mental Health Services Act (MHSA) in 2004 in California to transform treatment of mental and behavioral health "as we know it" would seem to create a gateway for cultural options, mainstream mental health has a hard time perceiving cultural interventions as a viable means to treat mental illness and maintain wellness. Frequently, the author has attended meetings of decisionmaking bodies that oversee how MHSA money is spent and someone will blurt out after someone has described an innovative cultural intervention "What does that have to do with mental illness?" The following article discusses how the clash of the two cultures, Native and mainstream, continues to be a challenge for sustained funding to implement culturally competent programs. © Taylor & Francis Group, LLC.


Lake D.F.,Life Clinic | Faigel D.O.,Mayo Medical School
Antioxidants and Redox Signaling | Year: 2014

Significance: Quiescin sulfhydryl oxidase 1 (QSOX1) is an enzyme that oxidizes thiols during protein folding, reducing molecular oxygen to hydrogen peroxide. Tumor cells may take advantage of oxidative environments at different stages of tumorigenesis, but QSOX1 may also serve additional functions in tumors. Recent Advances: Several groups have reported the over-expression of QSOX1 in breast, pancreas, and prostate cancers. A consensus is building that QSOX1 over-expression is important during tumor cell invasion, facilitating tumor cell migration at the tumor-stroma interface. As such, QSOX1 may be considered a prognostic indicator of metastatic potential or even indicate that cancer is present in a host. Critical Issues: However, some controversy exists between QSOX1 as a marker of poor or favorable outcome in breast cancer. More studies are required to reveal what advantage QSOX1 provides to breast and other types of cancer. More specifically, it is critical to learn which tumor types over-express QSOX1 and use its enzymatic activity to their advantage. Future Directions: As interest increases in understanding the mechanisms of tumorigenesis within the extracellular matrix and how tumor cells influence fibroblasts and other stromal cells, QSOX1 may be revealed as an important player in cancer detection and prognosis. Defining the mechanism(s) of QSOX1 activity in tumors and in in vivo models will provide important insights into how to target QSOX1 with anti-neoplastic agents. Antioxid. Redox Signal. 21, 485-496. © Mary Ann Liebert, Inc.


Trademark
Life Clinic | Date: 2016-08-24

Scholarly books on various topics, namely, medicine; Books in the field of medicine; Printed matter, namely, paper signs, books, manuals, curricula, newsletters, informational cards and brochures in the field of medicine.

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