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Sultan S.,Liaquat national hospital and medical college | Irfan S.M.,Liaquat National Medical College
Asian Pacific Journal of Cancer Prevention | Year: 2016

Background: Primary myelodysplastic syndrome (MDS) is an acquired clonal disorder of myeloid progenitor cells, characterized by peripheral cytopenias in the presence of hypercellular marrow with dysplastic features. Our aim was to study the demographical and clinicopathological features of adult Pakistani patients with MDS at disease presentation. Materials and Methods: This single centre study was conducted at Liaquat National Hospital and Medical College, extending from January 2010 to December 2014. Data were retrieved from the patient archives. Results: Overall 45 patients were diagnosed at our institution with de novo MDS during the study period. There were 28 males and 17 females. Age ranged between 18 and 95 years with a mean age of 57.6±17.4 years and median of 64 years. The male to female ratio was 1.7:1. The main presenting complaints were generalized fatigue (60%), fever (33.3%), dyspnea (15.5%), bleeding (13.3%) and weight loss (11.1%). Examination was unremarkable in 42.2% of patients. Physical examination revealed pallor in 37.7%, followed by petechial and purpuric rashes in 20%. The commonest laboratory finding was anemia (hemoglobin < 10 g/dl in 41 (91.1%) patients. Out of these, 27 (60%) patients had normocytic anemia, followed by macrocytic (22.2%) and microcytic (8.8%). Conclusions: Primary MDS in Pakistani patients demonstrates a male preponderance. The proportion of anemic patients was high in our series with predominance of normocytic anemia. However, other clinico-hematological features appear comparable to published data.

Imam K.,Liaquat national hospital and medical college
Advances in experimental medicine and biology | Year: 2012

Gestational diabetes mellitus is one of the most common medical problems that results from an increase in the insulin resistance as well as an impairment of the compensatory increase in insulin secretion from the beta cells of the pancreas. It serves as a metabolic stress test that uncovers underlying insulin resistance and beta-cell dysfunction. Gestational diabetes is associated with a variety of maternal and fetal complications, most notably macrosomia. Controversy surrounds the ideal approach for detecting gestational diabetes, andthe approaches recommended for screening and diagnosis are largely based on expert opinion. Controlling maternal glycemia with Medical Nutrition Therapy, close monitoring of blood glucose levels and treatment with insulin if blood glucose levels are not at goal has been shown to decrease fetal and maternal morbidities. Other treatment modalities, such as oral agents, need further study to validate their safety and efficacy. Finally, postpartum management of women with Gestational diabetes is critical because of their markedly increased risk of Type 2 diabetes in the future. Efforts should be made to prevent gestational diabetes in subsequent pregnancies. Because body fat and diet contribute to the risk of gestational diabetes mellitus, patients who lose weight before pregnancy and follow an appropriate diet may lower their risk of gestational diabetes mellitus.

Shinwari Z.K.,Quaid-i-Azam University | Salima M.,Quaid-i-Azam University | Faisal R.,Rehman Medical Institute | Huda S.,Liaquat national hospital and medical college | Asrar A.,Pakistan Council for Science and Technology
Pakistan Journal of Botany | Year: 2013

A survey was conducted in Kohat district of Khyber Pakhtoonkhwa of Pakistan to document the plants which are used to treat diarrhea. Based on the survey, 11 medicinal plants were selected (Acacia nilotica, Artemisia absinthim, Carumcopticum, Cinnamomumzeylanicum, Curcuma longa, Fumariaindica, Menthalongifolia, Phyllanthsemblica, Punicagranatum, Withaniasomnifera, Woodfordiafruticosa). Their antibacterial activity against 7 pathogenic bacterial strains (Escherichia coli, Staphylococcus aureus, Shigellasonnei, Klebsiellapneumoniae, Salmonella enteritidis, Yersinia enterocolitica, Listeria monocytogenes) causing diarrhea was checked. Forty four crude extracts at concentration of 50 mg/ml were used for in vitro antibacterial activity by agar well diffusion method. All of the crude extracts were found to inhibit one or the other bacterial strain examined. Minimum inhibitory concentration (MIC) was determined against susceptible bacterial strains. The (MIC) of the extracts against all tested bacterial strains ranged from 3.12 to 25 mg/ml. Minimum bactericidal concentration (MBC) was then determined for extracts with positive results for MIC that ranged between 6.25 to 50 mg/ml. Woodfordiafruticosa, Punicagranatumand Carumcopticum were found to be potential candidates for development of drugs for diarrhea.

Shaheen S.,Ziauddin University | Noor S.S.,Liaquat national hospital and medical college | Barakzai Q.,Ziauddin University
Journal of the College of Physicians and Surgeons Pakistan | Year: 2012

Objective: To determine whether serum vitamin D levels are correlated with serum levels of alkaline phosphatase or not. Study Design: Cross-sectional, observational study. Place and Duration of Study: Multi-centre study, conducted at Liaquat National Hospital and Medical College, National Medical Centre and Medicare Hospital, Karachi, from January to October 2009. Methodology: Patients attending the Orthopaedic OPDs with complaints of pain in different body regions and serum vitamin D3 levels of ≥ 30 ng/ml were included in the study. Patients with vitamin D deficiency were further categorized into mild deficiency or insufficiency (vit. D3 = 20-29 ng/ml), moderate deficiency (vit. D3 = 5 - 19 ng/ml) and severe deficiency forms (vit. D3 < 5 ng/ml). Pearson correlation was applied to test the correlation of serum alkaline phosphatase levels with serum vitamin D3 levels. P-value < 0.05 was considered to be significant. Results: Out of 110 samples, 26 had mild (23%), 61 had moderate (55%) and 21 had severe (19.1%) vitamin D deficiencies. All of the patients in the three groups had alkaline phosphatase with in normal limits and the total mean value of the enzyme was 135.97 ± 68.14I U/L. The inter group comparison showed highest values of alkaline phosphatase in the moderate vitamin D deficiency group. The correlation coefficient of alkaline phosphatase and serum vitamin D3 levels was r =0.05 (p =0.593). Conclusion: Serum vitamin D3 levels may not be correlated with increased serum alkaline phosphatase levels. Therefore, alkaline phosphatase may not be used as a screening test to rule out vitamin D deficiency.

Ali S.D.,Liaquat national hospital and medical college | Sheeraz-ur-Rahman S.,Liaquat national hospital and medical college
Journal of the Pakistan Medical Association | Year: 2013

Primary omental torsion is a rare cause of acute abdomen and mimics common acute abdominal condition like appendicitis. Torsion of the greater omentum may be primary or secondary. Here we present 2 cases admitted through emergency with the pain in right iliac fossa with this unusual diagnosis.

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