Liaquat National Medical College and Hospital

Karachi, Pakistan

Liaquat National Medical College and Hospital

Karachi, Pakistan

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Qamar S.,Liaquat National Medical College and Hospital | Shamim S.,Liaquat National Medical College and Hospital | Khan G.,Baqai Medical University
Journal of the College of Physicians and Surgeons Pakistan | Year: 2011

Objective: To estimate the serum levels of vitamin D in children with growing pains and determine the relationship between serum vitamin D levels, parathormone and routine biochemical markers. Study Design: Cross-sectional study. Place and Duration of Study: Department of Paediatrics, Liaquat National Hospital, Karachi, from October 2008 to September 2009. Methodology: Hundred children, aged 5-12 years presenting in Paediatric Outpatient Department of Liaquat National Hospital, Karachi, with limb pains, fulfilling the diagnostic criteria of growing pains, were included. Children with any systemic illness, organic cause of pain, rheumatologic disorders and signs of rickets were excluded from the study. Children were investigated for serum total calcium, inorganic phosphorus, alkaline phosphatase, vitamin D3 (25-hydroxecholecalciferol) and parathormone levels. On the basis of serum vitamin D3 level, patients were divided into 3 groups; group 1 with normal level of vitamin D3 (> 75 nmol/L), group 2 with vitamin D insufficiency (level between 50-75 nmol/L), and group 3 with vitamin D deficiency (level < 50 nmol/L). Significance of group proportions was determined using chi-square test with significance at p < 0.05. Results: The mean age of the participants was 8.05 years with the majority (59%) being females. Only 6% had normal vitamin D levels. Over 95% of the children with vitamin D insufficiency had normal alkaline phosphatase and parathormone levels. Conclusion: Hypovitaminosis D may have a role in pathogenesis of growing pains. All children with unexplained limb pains without identifiable organic pathology should be tested for vitamin D status, and treated, if necessary. Routine biochemical markers alone are not sufficient to detect all cases of hypovitaminosis D. © 2011. College of Physicians & Surgeons Pakistan.


Solangi N.A.,Liaquat National Medical College and Hospital | Ahmed S.P.,University of Karachi | Soomro K.,Dow University of Health Sciences
Medical Channel | Year: 2012

Lipids have an important role virtually in all aspects of life-serving as hormone or hormone precursors, aiding in digestion, providing energy storage and metabolic fuels, acting as functional and structural components in cell membranes and forming insulations to allow nerve conduction or to prevent heat loss. Increased cholesterol is a causative factor in the etiology of atherosclerotic diseases. About 60% of plasma cholesterol is normally found in LDL fraction; 25% in the HDL fraction; while the rest of Cholesterol is present in VLDL variety. High density lipoproteins are also mainly Cholesterol esters. They are scavengers of Cholesterol and their function is to transport Cholesterol from the tissues to the Liver. HMG-co A reductase inhibitors are widely used in the treatment of hypercholesterolemia due to their efficacy in reducing blood LDL-Cholesterol. Here we report the Cholesterol lowering effect of generic Simvastatin products in comparison with the Original brand Zocor. Method: The generic drugs used in the present study were Atcol & Limitrol of Atco & Pharmevo laboratories respectively. The serial blood samples were collected after drug administration every 4 weeks for 12 weeks. Results: After the administration of drugs for 12 weeks; there was no significant difference statistically between the Original brand Zocor and the Atcol & Limitrol treated groups. All the drugs were well tolerated and only minor side effects nausea & dizziness were observed in some patients. Conclusion: It can be concluded from this study that no significant difference can be observed as regards the efficacy & safety of these drugs. The efficacy & safety of the generic & brand drugs is almost the same & there is no statistical difference between them.


Bhurgri Y.,Karachi Cancer Registry | Bhurgri Y.,Aga Khan University | Bhurgri Y.,Liaquat National Medical College and Hospital | Bhurgri Y.,Panjwani Center for Molecular Medicine and Research | And 11 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2011

Introduction: Cancer ovary is the third most common malignancy diagnosed in women in Karachi, a moderate to high risk region for the disease. Materials and Methods: Three hundred and thirty seven cases of ovarian cancer registered at the Karachi Cancer Registry for the years 1995-2002 were reviewed. Results: The age-standardized incidence rate (ASR) world per 100,000, crude incidence rate per 100,000 (CIR) and frequency of ovarian malignancies in 1995-1997 were 10.9, 5.9 and 6.2% respectively. Corresponding figures for 1998-2002 were 8.1, 5.1 and 4.8%. The mean age at presentation in 1995-1997 was 45.7 years (95%CI 42.9, 48.4; SD±15.9), range 95 (3 to 98) years and in 1998-2002 it was 45.0 years (95%CI 42.8, 47.3; SD±16.1), range 79 (3 to 82) years. Eleven (3.3%) cases of childhood cancers, 13 (3.9%) adolescent cases, 126 (37.4%) reproductive age (20-44 years) and 187 (55.5%) cases in the 45+ age group were registered. Epithelial malignancies were the most common cancers above the age of 20 years (78.4%), the commonest amongst these was serous adenocarcinoma (33.3%). Germ cell tumors were more common (5.6%) in children and adolescents. Microscopic confirmation was 99.0%. Presentation was of a moderately differentiated (grade 2) malignancy with a regional or distant spread of disease in three fourths of the cases. Conclusions: The incidence of cancer ovary, though stable in Karachi, involves a relatively younger age group with a strong family history in a fourth of the cases. The disease presents at an advanced stage. An ageing population over time may translate into a higher incidence of ovarian cancer. The current incidence of cancer ovary in Karachi is an enigma and belies reproductive protective factors. Studies focused on the genetic risk factors in this population are recommended.


Khan A.,Aga Khan Hospital for Women and Children | Sultana K.,Liaquat National Medical College and Hospital
Journal of the Pakistan Medical Association | Year: 2010

Objective: To identify early warning signs and symptoms of ovarian cancer to create awareness for early diagnosis and management of the disease. Methods: This study was conducted at the department of Gynaecology and Obstetrics, Liaquat National Hospital, Karachi from 2003 to 2007, having 75 patients. The information collected included age, education, and self perceived state of socio-economic class, presenting clinical signs and symptoms, basic and specific laboratory investigations. The disease was staged from I to IV upon surgical staging and the type of cancer was determined by histopathological examination. Results: Mean age of the patients was 51 ± 12.3 years. Twenty (52%) patients were uneducated, 17 (22.6%) were below and remaining 19 (25.3%) were above higher secondary level. Most of the patients belonged to the middle socioeconomic class. Abdominal pain (57.3%) was the most common presenting symptom followed by abdominal distension (22.6%), urinary complaints (5.3%), vaginal discharge (2.6%) and postmenopausal bleeding (12%). More than half (56%) of the patients had stage III-IV disease. On histology, papillary serous cystic adenocarcinoma was the most common (54%) type followed by mucinious (22%), endometroid (10.6%), yolk sac (2.6%), dysgerminoma (4%), and adult granulose cell tumour (5.3%). Conclusion: There are no specific ovarian carcinoma symptoms either in early or late stages to ensure early diagnosis, but in the age group above 40 years persistent clinical symptoms should always be further investigated.


Ishtiaq O.,Shifa International Hospital | Qadri A.M.,Itefaq Hospital | Mehar S.,Liaquat National Medical College and Hospital | Gondal G.M.,Fauji Foundation Hospital | And 3 more authors.
Journal of Infection and Public Health | Year: 2012

Objective: To assess the use, handling and disposal of insulin injection equipment by diabetic patients in Pakistan. Methods: We conducted a cross-sectional study at diabetic clinics in five tertiary centers in Pakistan. All diabetic patients (type 1/type 2) who were on insulin for more than 1 month, were included. An Urdu (local language)-translated questionnaire was used to collect information on insulin administration equipment, the site and frequency of needle use, insulin syringe/pen/lancet disposal, sharing of needles and knowledge about diseases that are spread by sharing contaminated needles. Results: Of 375 patients, 58% were female. The mean (SD) duration of diabetes was 12.3 (7.3) years, and the duration of insulin use was 4.4 (4.3) years. The majority of the patients used syringes (88.3%) for insulin administration. Additionally, the majority of the patients disposed of used devices (syringes, 92%; pens, 75%; and lancets, 91%) in the household garbage collection bin. About half of the patients (n= 185) reported being educated by their physicians about the disposal of sharps. Those who were educated by a physician (adjusted odds ratio (adjOR): 0.36; 95%CI: 0.16-0.81) or could read/write English (adjOR: 0.32; 95%CI: 0.11-0.92) were less likely to dispose of syringes and needles in the household garbage. Conclusion: The common disposal of sharps in the household garbage has implications for disease transmission. Education on the safe disposal of sharps may improve the disposal practices. © 2012 King Saud Bin Abdulaziz University for Health Sciences.


Aziz M.U.,Liaquat National Medical College and Hospital | Shahzad S.,Liaquat National Medical College and Hospital | Mansoor M.A.,Liaquat National Medical College and Hospital
Chinese Journal of Traumatology - English Edition | Year: 2014

Objective: To determine the frequency of adrenal injuries in patients presenting with blunt abdominal trauma by computed tomography (CT). ethods: During a 6 month period from January 1, 2011 to June 30,2011,82 emergency CT examinations were performed in the setting of major abdominal trauma and retrospectively reviewed for adrenal gland injuries. Results: A total of 7 patients were identified as having adrenal gland injuries (6 males and 1 female). Two patients had isolated adrenal gland injuries. In the other 5 patients with nonisolated injuries, injuries to the liver (1 case), spleen (1 case), retroperitoneum (2 cases) and mesentery (4 cases) were identified. Overall 24 cases with liver injuries (29%), 11 cases with splenic injuries (13%), 54 cases with mesenteric injuries (65%), 14 cases (17%) with retroperitoneal injuries and 9 cases with renal injuries were identified. Conclusion: Adrenal gland injury is identified in 7 patients (11.7%) out of a total of 82 patients who underwent CT after major abdominal trauma. Most of these cases were nonisolated injuries. Our experience indicates that adrenal injury resulting from trauma is more common than suggested by other reports. The rise in incidence of adrenal injuries could be attributed to the mode of injury.


PubMed | Liaquat National Medical College and Hospital
Type: Journal Article | Journal: Chinese journal of traumatology = Zhonghua chuang shang za zhi | Year: 2014

To determine the frequency of adrenal injuries in patients presenting with blunt abdominal trauma by computed tomography (CT).During a 6 month period from January 1, 2011 to June 30, 2011, 82 emergency CT examinations were performed in the setting of major abdominal trauma and retrospectively reviewed for adrenal gland injuries.A total of 7 patients were identified as having adrenal gland injuries (6 males and 1 female). Two patients had isolated adrenal gland injuries. In the other 5 patients with nonisolated injuries, injuries to the liver (1 case), spleen (1 case), retroperitoneum (2 cases) and mesentery (4 cases) were identified. Overall 24 cases with liver injuries (29%), 11 cases with splenic injuries (13%), 54 cases with mesenteric injuries (65%), 14 cases (17%) with retroperitoneal injuries and 9 cases with renal injuries were identified.Adrenal gland injury is identified in 7 patients (11.7%) out of a total of 82 patients who underwent CT after major abdominal trauma. Most of these cases were nonisolated injuries. Our experience indicates that adrenal injury resulting from trauma is more common than suggested by other reports. The rise in incidence of adrenal injuries could be attributed to the mode of injury.


PubMed | Liaquat National Medical College and Hospital
Type: Journal Article | Journal: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP | Year: 2011

To estimate the serum levels of vitamin D in children with growing pains and determine the relationship between serum vitamin D levels, parathormone and routine biochemical markers.Cross-sectional study.Department of Paediatrics, Liaquat National Hospital, Karachi, from October 2008 to September 2009.Hundred children, aged 5-12 years presenting in Paediatric Outpatient Department of Liaquat National Hospital, Karachi, with limb pains, fulfilling the diagnostic criteria of growing pains, were included. Children with any systemic illness, organic cause of pain, rheumatologic disorders and signs of rickets were excluded from the study. Children were investigated for serum total calcium, inorganic phosphorus, alkaline phosphatase, vitamin D3 (25-hydroxecholecalciferol) and parathormone levels. On the basis of serum vitamin D3 level, patients were divided into 3 groups; group 1 with normal level of vitamin D3 (> 75 nmol/L), group 2 with vitamin D insufficiency (level between 50-75 nmol/L), and group 3 with vitamin D deficiency (level < 50 nmol/L). Significance of group proportions was determined using chi-square test with significance at p < 0.05.The mean age of the participants was 8.05 years with the majority (59%) being females. Only 6% had normal vitamin D levels. Over 95% of the children with vitamin D insufficiency had normal alkaline phosphatase and parathormone levels.Hypovitaminosis D may have a role in pathogenesis of growing pains. All children with unexplained limb pains without identifiable organic pathology should be tested for vitamin D status, and treated, if necessary. Routine biochemical markers alone are not sufficient to detect all cases of hypovitaminosis D.

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