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Liaoyang, China

Li P.,Liaoning Medical University | Jiang R.,Liaoyang Diabetes Hospital | Li L.,Liaoning Medical University | Li L.,Liaoning Provincial Key Laboratory of Endocrine Diseases | And 3 more authors.
Journal of Pediatric Endocrinology and Metabolism | Year: 2014

Background: Identifying adolescents with metabolic syndrome (MetS) is important in China, where diabetes and MetS is highly prevalent among adults. We aimed to estimate MetS prevalence and to determine risk factors for MetS in adolescents of northeast China. Methods: This cross-sectional study was conducted from December 2010 to March 2011. We recruited 1312 healthy students from 30 high school classes and 910 who met the inclusion criteria (13.80 ± 1.44 years, 53.3% boys) were enrolled. All subjects underwent anthropometric and biochemical examinations. MetS was defined using the definition specific for children and adolescents proposed by the International Diabetes Federation in 2007. Results: Total prevalence of MetS was 7.6% and was higher in boys than in girls (10.9% vs. 3.8%, p < 0.0001). The most frequent component of MetS was low high-density lipoprotein-cholesterol (46.8%), followed by central obesity (22.5%). More than one third of adolescents were overweight or obese. Insulin resistance, hyperuricemia, abnormal lipid profiles, increased aminotransferase, overweight, and obesity were all associated with MetS. Only overweight [odds ratio (OR) = 9.29, 95% confidence interval (CI) 5.36-16.00] and obesity (OR = 61.85, 95% CI 32.73-116.86) evaluated with body mass index (BMI) were independent predictors for MetS. Receiver operating characteristic curve analysis revealed that BMI had high diagnostic accuracy (area under curve value 0.914, 95% CI 0.882-0.947) and the cutoff point of 23.8 kg/m2 had maximum accuracy for determining the presence of MetS (sensitivity 92.8%, specificity 80.1%). Conclusions: MetS is highly prevalent among adolescents in northeast China and obesity is the major indicator for this disorder. Early identification and lifestyle modifications are strongly recommended. Source


Li P.,Liaoning Medical University | Jiang R.,Liaoyang Diabetes Hospital | Li L.,Liaoning Medical University | Li L.,Liaoning Provincial Key Laboratory of Endocrine Diseases | And 4 more authors.
Journal of Investigative Medicine | Year: 2013

Aims: To examine whether hemoglobin A1c (HbA1c) can be used instead of fasting plasma glucose (FPG) to identify nondiabetic Chinese adolescents with metabolic syndrome (MS). Methods: This was a cross-sectional study involving 910 adolescents (11-16 years; 46.8% girls) with an Hb A1c less than or equal to 6.4% and an FPG less than or equal to 6.9 mmol/L. All participants underwent anthropometric and biochemical examinations. Metabolic syndrome was defined using the definition proposed by the International Diabetes Federation (IDF) and the American Heart Association (AHA). Replacement of an FPG greater than or equal to 5.6 mmol/L with an Hb A1c greater than or equal to 5.7% yielded 2 HbA1c definitions (IDF-HbA1c and AHA-HbA1c). The use of an HbA1c greater than or equal to 5.7% or an FPG greater than or equal to 5.6 mmol/L in the definition of the glycemic component of the MS was compared. Results: The HbA1c definition resulted in an increase in the population prevalence of MS by 2.4% (IDF-HbA1c) and 2.5% (AHA-HbA1c), respectively (P ≥ 0.05). The degree of concordance (κ index) was as high as 0.900 for the concordance between the IDF and IDF-HbA1c definition, and 0.811 between the AHA and AHA-Hb A1c definition. Subjects who were diagnosed as normal based on the FPG definition and met the HbA1c definition for MS had more cardiometabolic risk factors (waist circumference, blood pressure, lipid profiles, uric acid, and homeostasis assessment model of insulin resistance; all P < 0.05), indicating that the HbA1c definition identified more subjects with cardiovascular diseaseY related risk factors. HbA1c greater than or equal to 5.7% was significantly associated with the presence of MS [adjusted odds ratio, 2.61 (1.13-6.01)]. Conclusions: An HbA1c greater than or equal to 5.7% was associated with the presence of MS and can be considered a surrogate for FPG in the diagnosis of MS in nondiabetic Chinese adolescents. Copyright © 2013 by The American Federation for Medical Research. Source


Wang Z.-N.,Liaoning Medical University | Li P.,Liaoning Medical University | Jiang R.-H.,Liaoyang Diabetes Hospital | Li L.,Liaoning Medical University | And 4 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015

Purpose: Data about the association between serum uric acid and metabolic syndrome in healthy adolescents are sparse. This study examined this association and determined the optimal cutoffs for serum uric acid to predict metabolic syndrome among healthy adolescents. Methods: During 2010-2011, we conducted a crosssectional study of 927 adolescents (53.0% boys) aged 11-16 years from junior and senior high schools in northeast China. All participants received a physical examination and gave venous blood samples. Results: Serum uric acid was positively associated with abdominal obesity, dyslipidemia and hypertension in boys and with abdominal obesity and dyslipidemia in girls. For those with hyperurecemia, the odds ratios (95% CI) for metabolic syndrome were 7.67 (95% CI, 2.58~22.78) for boys and 4.77 (95% CI, 1.01~22.60) for girls. SUA was a better predictor of metabolic syndrome than fasting glucose, though not as good as waist circumference. Conclusions: Among adolescents in China, serum uric acid level may be a useful predictor of metabolic syndrome. © 2015 E-Century Publishing Corporation. All rights reserved. Source


Zhang J.,Liaoning Medical University | Jiang R.,Liaoyang Diabetes Hospital | Li L.,Liaoning Medical University | Li L.,Liaoning Province Key Laboratory of Endocrine Diseases | And 5 more authors.
International Journal of Endocrinology | Year: 2014

Metabolic syndrome is a medical disorder characterized by obesity, hyperglycemia, dyslipidemia, and hypertension. Thyroid hormone has been shown to affect many metabolic processes. This study was undertaken to explore the relationship between serum thyrotropin and components of metabolic syndrome in Chinese adolescents. Waist circumference (76.4 ± 10.7 versus 70.0 ± 10.6 cm, P = 0.006) and bodymass index (23.90 ± 4.20 versus 21.51 ± 4.16 kg/m2, P = 0.011) were significantly greater among adolescents with subclinical hypothyroidism compared with euthyroid subjects. The risk of obesity in the subclinical hypothyroid group was 3.444 times that in the euthyroid group (odds ratio = 3.444, 95% confidence interval (CI): 1.570-7.553). Serum TSH was significantly positively correlated with waist circumference (β = 1.512, P = 0.019), TC (β = 0.160, P = 0.003), LDL-C (β = 0.032, P = 0.008), and TG (β = 0.095, P = 0.001). The TSH level in the metabolic syndrome group was significantly higher than that in nonmetabolic syndrome group (2.65 [2.28-3.80] versus 2.53 [1.92-3.45] mIU/L, P = 0.032). Serum TSH within the reference range was positively associated with TC (β = 0.173, P = 0.013), LDL-C (β = 0.031, P = 0.043), and TG (β = 0.132, P = 0.021). Increased serum TSH in adolescents may be a potential risk factor for metabolic syndrome. Copyright © 2014 Jingfan Zhang et al. Source


Li P.,Liaoning Medical University | Jiang R.,Liaoyang Diabetes Hospital | Li L.,Liaoning Medical University | Li L.,Liaoning Provincial Key Laboratory of Endocrine Diseases | And 3 more authors.
European Journal of Clinical Nutrition | Year: 2015

Background/objectives: To investigate the association of adiponectin and its gene polymorphisms with metabolic syndrome (MetS) and cardiovascular disease (CVD) risk factors in Chinese adolescents. Subjects/methods: This cross-sectional study enrolled 919 healthy middle school students (aged 11-16 years; 46.7% females). All participants underwent anthropometric and biochemical examinations, and MetS was diagnosed using 2007 International Diabetes Federation criteria. The presence of adiponectin and its genotypes of single nucleotide polymorphisms (SNPs) rs266729 (-11377C/G), rs2241766 (+45T/G) and rs1501299 (+276G/T) was detected. Results: (1) Serum adiponectin levels were negatively correlated with numerous CVD risk factors (all P<0.05), and following adjustments for confounding factors, a lower adiponectin level was an independent risk factor for MetS (odds ratio=5.59; 95% confidence interval: 1.90, 16.41). Central obesity and low levels of high-density lipoprotein cholesterol were positively associated with MetS and reduced serum adiponectin levels. (2) The genotype and frequencies of SNP-11377 and SNP+276 in a MetS group and non-MetS group were not significantly different. Subjects with genotype SNP+45 GG were at higher risk for MetS compared with subjects with genotypes SNP+45 TT (P=0.033) or TT+TG (P=0.021). Subjects with genotype SNP+276 TT or TT+TG had higher levels of serum adiponectin compared with subjects with SNP+276 GG (P=0.012 and 0.014, respectively). Conclusions: Adiponectin may be used as a predictive biomarker of MetS, and shows a significant association with CVD risk factors in Chinese adolescents. Adiponectin gene polymorphisms are associated with serum adiponectin concentrations and the presence of MetS. © 2015 Macmillan Publishers Limited. Source

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