Liaoning Research Institute of Family Planning

Shenyang, China

Liaoning Research Institute of Family Planning

Shenyang, China
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Xu X.,Eastern Liaoning University | Yu Y.,Eastern Liaoning University | Yang L.,Liaoning Research Institute of Family Planning
Advanced Materials Research | Year: 2011

Silk fibroin film, which has good biological compatibility, is suitable for use as biomaterials and medical materials. However, silk fibroin film in dry state is too brittle to be used by itself. Blending with other natural or synthetic polymers could improve the poor mechanical properties of silk fibroin film. In this paper, recent researches in blend film of silk fibroin and their application were summarized. © (2011) Trans Tech Publications, Switzerland.


Zhang C.,Liaoning Research Institute of Family Planning | Zhang X.,Liaoning Research Institute of Family Planning | Yang D.,Liaoning Research Institute of Family Planning | Wang P.,Liaoning Research Institute of Family Planning
Journal of Applied Polymer Science | Year: 2013

Poly(dl-lactide-co-caprolactone) was dissolved in N-methyl-2-pyrolidone (NMP) for preparing blank group formulation, and drug group was prepared by dissolving testosterone undecanoate (TU) as model drug in blank group. These formulations rapidly gelled by solvent diffusion effect after subcutaneous injection. The in vivo degradation of copolymer gel in rabbits was investigated after injection. The GPC and 1H NMR results showed that no matter the gel contained drug or not, it had no effect on degradation rate for the P(DLLA-co-CL) carrier. Degradation products of copolymer were absorbed or excreted based on metabolism. Copolymer molar composition changed slightly in 3 months. The structures and characteristic of copolymers were characterized via DSC, TGA, and SEM, respectively. Experimental results showed that the copolymer had excellent heat resistance. Crystallinity increased gradually during degradation process. A dense cross-sectional structure formed after 90 days. In addition, it can be obviously found that the degradation process of the copolymer proceeded in two steps. Mechanism of copolymer biodegradation in vivo was bulk degradation. The gel could well administrate the release of TU in a sustained way without significant burst features. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 3800-3808, 2013 Copyright © 2013 Wiley Periodicals, Inc.


Xie Y.,Northeastern University China | Hu J.,Northeastern University China | Dou Q.,Northeastern University China | Xiao L.,Northeastern University China | Yang L.,Liaoning Research Institute of Family Planning
Liquid Crystals | Year: 2016

New cholesterol side-functionalised polycarbonate polymers were synthesised by the ring-opening homo- and copolymerisation reaction of the cyclic monomer cholesteryl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate and d,l-lactide using Sn(Oct)2 as a catalyst. The chemical structures and average molecular weights of the cyclic monomer, homopolymer and block copolymers obtained in this study were characterised using FT-IR, 1H NMR and gel permeation chromatographic measurement. The mesomorphism and mesophase structure were investigated with polarising optical microscopy, differential scanning calorimetry and X-ray diffraction measurement. As a result, the homopolymer and block copolymers showed an enantiotropic smectic A (SmA) phase. With the concentration of the lactide segment increasing, the glass transition temperature and isotropic temperature of the corresponding block copolymer all decreased. In addition, XRD suggested that the homopolymer and two block copolymers showed the SmA double-layer packing of side chains. © 2016 Informa UK Limited, trading as Taylor & Francis Group


Yang L.-Q.,Liaoning Research Institute of Family Planning | Meng S.,Liaoning Research Institute of Family Planning | Liu D.-H.,Liaoning Research Institute of Family Planning | Li M.,Liaoning Research Institute of Family Planning | And 3 more authors.
International Journal of Polymer Analysis and Characterization | Year: 2014

Random copolymers of ε{lunate}-caprolactone (CL) and D, L-lactide (DLLA) were synthesized by ring-opening polymerization using stannous octoate as catalyst. The effect of polymerization conditions, such as feeding dose, reaction temperature, polymerization time, and catalyst content on the properties of the copolymers was evaluated to prepare suitable copolymers with controlled properties for biodegradable implant applications. The results showed that the polymerization conditions influenced the thermal and mechanical properties of the copolymers strongly and controllable and tunable properties of random copolymers could be obtained by adjusting the copolymer compositions. The optimum reaction conditions to prepare the CL-DLLA copolymers for implant applications are 30-87 mol.% DLLA content in feeding dose, 110°C reaction temperature, and 24 h polymerization time. The results of in vivo implantation revealed the excellent degradability of CL-DLLA copolymers. Copolymers of CL and DLLA with different compositions and properties would be suitable for the application of biodegradable implants. © 2014 Copyright Taylor & Francis Group, LLC.


Guo Z.,Northeastern University China | Li Q.,Northeastern University China | Liu X.,Northeastern University China | Hu J.,Northeastern University China | Yang L.,Liaoning Research Institute of Family Planning
Liquid Crystals | Year: 2015

A new cholesterol side-functionalised polycarbonate was synthesised through a coupling reaction between the terminal carboxyl group of the monomer 6-cholesteroxy-6-oxocaproic acid (COHA) and side hydroxyl group of the polycarbonate (PHTMC). The chemical structures of the intermediate compounds, monomers and polymers obtained in this study were characterised with FT-IR and 1H NMR spectrum. Their phase behaviour and thermal stability were investigated using polarising optical microscopy, differential scanning calorimetry, X-ray diffraction and thermogravimetric analysis. The monomer COHA showed a cholesteric phase, while the corresponding cholesterol side-functionalised polycarbonate P(TMC-g-COHA) revealed a smectic A phase. This behaviour was attributed to an increased density of the mesogenic units in side chain and hence an ordered organisation into the mesophase. Furthermore, P(TMC-g-COHA) could exhibit a liquid crystalline state below body temperature (≈37°C). This fact indicated it could be used clinically as a self-assemble material with orientational-order mesophase. In addition, P(TMC-g-COHA) had a good thermal stability, the corresponding thermal decomposition temperature was 241°C. © 2015 Taylor & Francis


Yang L.-Q.,Liaoning Research Institute of Family Planning | Yang D.,Liaoning Research Institute of Family Planning | Guan Y.-M.,Liaoning Research Institute of Family Planning | Li J.-X.,Liaoning Research Institute of Family Planning | Li M.,Liaoning Research Institute of Family Planning
Journal of Applied Polymer Science | Year: 2012

Random copolymers of trimethylene carbonate (TMC) and ε-caprolactone (CL) have been synthesized by ring-opening polymerization of TMC and CL in the presence of stannous octoate. The effects of feeding dose, reaction temperature and polymerization time, and effect of catalyst content on the copolymerization were investigated. The results showed that the composition of the copolymers was in good agreement with the feeding dose, and the molecular weight of the copolymers decreased firstly with increasing CL content and then increased. The decrease in the reaction temperature, polymerization time and catalyst content would increase the molecular weight of the copolymers. Furthermore, the feeding dose affected the thermal and mechanical properties of the copolymer largely, and the possessing different properties of random copolymers could be obtained by adjusting the copolymer compositions. This work could optimize the polymerization conditions to achieve the copolymers with controlled properties for implant applications. © 2011 Wiley Periodicals, Inc.


Meng S.,Liaoning Research Institute of Family Planning | Chen Z.,Liaoning Medical University | Yang L.,Liaoning Research Institute of Family Planning | Zhang W.,Liaoning Research Institute of Family Planning | And 4 more authors.
International Journal of Nanomedicine | Year: 2013

The current investigation aimed to evaluate the transdermal potential of novel testosterone propionate (TP) ethosomes and liposomes prepared by surfactant modification. The effect of hexadecyl trimethyl ammonium bromide and cremophor EL-35 on the particle size and zeta potential of the prepared vesicles was investigated. The entrapment efficiency and stability, as well as in vitro and in vivo skin permeation, were studied with the various techniques, such as differential scanning calorimetry, confocal laser scanning microscopy, transmission electron microscopy, dynamic light scattering, and so on. The results indicated that the ethosomes were defined as spherical, unilamellar structures with low polydispersity (0.100 ± 0.015) and nanometric size (156.5 ± 3.5 nm). The entrapment efficiency of TP in ethosomal and liposomal carriers was 92.7% ± 3.7% and 64.7% ± 2.1%, respectively. The stability profile of the prepared TP ethosomal system assessed for 120 days revealed very low aggregation and very low growth in vesicular size. TP ethosomes also provided an enhanced transdermal flux of 37.85 ± 2.8 μg/cm2/ hour and a decreased lag time of 0.18 hours across mouse skin. The skin permeation efficiency of the TP ethosomes as further assessed by confocal laser scanning microscopy revealed enhanced permeation of rhodamine red-loaded formulations to the deeper layers of the skin (260 μm) than that of the liposomal formation (120 μm). © 2013 Meng et al.


PubMed | Liaoning Research Institute of Family Planning
Type: Journal Article | Journal: Asian journal of andrology | Year: 2016

We have investigated the feasibility of administration of testosterone undecanoate (TU)-loaded injectable in situ-forming implant (ISFI) for contraception in adult male Sprague-Dawley rats. Male rats were treated with vehicle, TU-loaded ISFIs (540, 270 and 135 mg TU kg-1 ) or TU injections (45 mg TU kg-1 every 30 days) for 120 days. Fertility tests served for determining infertility or restoration of fertility in treated rats. Serum testosterone concentration, epididymal sperm count, motility, morphology, and histology of the testis were monitored. The TU-loaded ISFIs increased serum testosterone levels in rats steadily without fluctuation over 3 months. One month after TU administration, the epididymal sperm count decreased significantly in all experimental groups. After 3 months, the animals treated with 270 and 135 mg kg-1 TU-loaded ISFIs were 100% infertile, and no implantation sites were produced in the mated females. However, some of males treated with 540 mg kg-1 ISFI or TU injections were still fertile but numbers of implantation sites were also significantly lower than control values. TU-loaded ISFI at an appropriate dose has potential as a long-acting male contraceptive drug that suppresses spermatogenesis consistently over a period of 3 months.


PubMed | Liaoning Research Institute of Family Planning
Type: Journal Article | Journal: Drug development and industrial pharmacy | Year: 2015

The purpose of this study was to evaluate the technical feasibility of poly (-caprolactone-co-DL-lactide), P (CL/DL-LA), for injectable in situ forming implants (ISFI). The ISFI was prepared by dissolving P (CL/DL-LA) in N-methyl-2-pyrrolidone (NMP), and Testosterone undecanoate (TU) was used as model drug. The effect of various polymer concentrations, molecular weights (Mws) and drug loads on the drug release from the TU-loaded ISFI systems was investigated in vitro. The release of TU-loaded ISFI was also evaluated in rats. In addition, a subcutaneous rabbit model was used to evaluate the degradation and foreign-body reaction of P (CL/DL-LA) ISFI. The use of higher concentration of P (CL/DL-LA) with higher molecule weight and larger CL:DL-LA monomer ratio for the TU-loaded ISFI gave a slower drug release. The ISFI of 80/20 P (CL/DL-LA) (Mw 61753):NMP 20:80 with 16% TU formulation increased serum testosterone levels in rats over a period of three months. The in vivo degradation and biocompatibility study of ISFI shows that P (CL/DL-LA) degrades by a process of bulk degradation and that the foreign-body reaction of this biomaterial is relatively mild. In summary, our investigations demonstrate that in situ parenteral drug delivery systems can be obtained from P (CL/DL-LA) solutions.


PubMed | Liaoning Research Institute of Family Planning
Type: Journal Article | Journal: Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society | Year: 2016

Biodegradable poly(d,l-lactide) (PDLLA), Poly(trimethylene carbonate) (PTMC), polycaprolactone (PCL), poly(caprolactone-co-d,l-lactide) (PCDLLA) and poly(trimethylene carbonate-co-caprolactone) (PTCL) are recently used for clinical drug delivery system such as subcutaneous contraceptive implant capsule due to their biodegradable properties that they could possess long-term stable performance in vivo without removal, however their permeation rate is unknown. In the work, biodegradable material membranes were prepared by solvent evaporation using chloroform, and commercial silicone rubber membrane served as a control. Gestodene was used as a model drug. Gestodene has high biologic progestational activity which allows for high contraceptive reliability at very low-dose levels. The permeation rate of gestodene for several biodegradable materials was evaluated. In vitro diffusion studies were done using Franz diffusion cells with a diffusion area of 1.33cm(2). Phosphate buffer solution (PBS, pH 7.4), 10% methanol solution and distilled water were taken in donor and receiver chambers at temperature of 37C respectively. The in vitro experiments were conducted over a period of 24h during which samples were collected at regular intervals. The withdrawn samples were appropriately diluted and measured on UV-vis spectrophotometer at 247nm. Conclusion data from our study showed that permeation rate of PCDLLA with CL ratio more than 70% could be more excellent than commercial silicone rubber membrane. They may be suitable as a candidate carrier for gestodene subcutaneous contraceptive implants in contraceptive fields.

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