Liaoning Medical University
Jinzhou, China

Liaoning Medical University is in Jinzhou, Liaoning, China. It was founded in 1946. Liaoning Medical University is located in the coastal city of Jinzhou in Liaoning Province, east of Beijing. The University is represented officially in India by Medico Abroad located at Hyderabad. The first batch of foreign students for English Medium Under Graduate Course in Medicine from India completed their Degree in 2010.The campus covers 1,140,000 square meters and has floor-space 279,000 square meters. It lies in the north of the city. The LMU offers six kinds of education: general high education, state-owned privately run education, adult education, vocational education, online education and international students` education. It enrolls undergraduate and postgraduate students. The University is recognised by World Health Organization WHO and listed in the world medical directory.There are 16 teaching departments, 98 teaching offices, 56 teaching laboratories, 4 affiliated comprehensive hospitals and 169 bases for teaching and practice. The university's curriculum comprises 21 specialized undergraduate subjects, 32 master degree programs and 1 doctor degree program. Among the faculty members there are 823 full-time teachers, 74 of whom have been granted a doctoral degree, 533 associate professors and 219 professors and chief doctors.The university’s library has an advanced electronic reading room and has access to the retrieval system for medical documents from the American MEDLINE and the Chinese Medical Institute.The total number of students has amounted to 13,806 of which 190 are international students, all of whom are currently studying in the undergraduate program taught in English. Furthermore, the university is actively involved in international academic exchange activities with universities abroad, such as the University of Glasgow and regularly exchanges scholars and specialists to give lectures. About 120 teachers have been sent to more than 20 countries to study and involve in research. Wikipedia.

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Sun L.,Liaoning Medical University
American Journal of Gastroenterology | Year: 2017

Objectives:We aimed to assess a serological biopsy using five stomach-specific circulating biomarkers—pepsinogen I (PGI), PGII, PGI/II ratio, anti-Helicobacter pylori (H. pylori) antibody, and gastrin-17 (G-17)—for identifying high-risk individuals and predicting risk of developing gastric cancer (GC).Methods:Among 12,112 participants with prospective follow-up from an ongoing population-based screening program using both serology and gastroscopy in China, we conducted a multi-phase study involving a cross-sectional analysis, a follow-up analysis, and an integrative risk prediction modeling analysis.Results:In the cross-sectional analysis, the five biomarkers (especially PGII, the PGI/II ratio, and H. pylori sero-positivity) were associated with the presence of precancerous gastric lesions or GC at enrollment. In the follow-up analysis, low PGI levels and PGI/II ratios were associated with higher risk of developing GC, and both low (<0.5 pmol/l) and high (>4.7 pmol/l) G-17 levels were associated with higher risk of developing GC, suggesting a J-shaped association. In the risk prediction modeling analysis, the five biomarkers combined yielded a C statistic of 0.803 (95% confidence interval (CI)=0.789–0.816) and improved prediction beyond traditional risk factors (C statistic from 0.580 to 0.811, P<0.001) for identifying precancerous lesions at enrollment, and higher serological biopsy scores based on the five biomarkers at enrollment were associated with higher risk of developing GC during follow-up (P for trend <0.001).Conclusions:A serological biopsy composed of the five stomach-specific circulating biomarkers could be used to identify high-risk individuals for further diagnostic gastroscopy, and to stratify individuals’ risk of developing GC and thus to guide targeted screening and precision prevention.Am J Gastroenterol advance online publication, 21 March 2017; doi:10.1038/ajg.2017.55. © 2017 American College of Gastroenterology

Cui L.,Liaoning Medical University
Restorative neurology and neuroscience | Year: 2013

Stromal cell-derived factor-1 was originally found as a chemoattractant for immune cells. Later it was shown that stromal cell-derived factor-1 and its specific receptor CXCR4 were widely expressed in the developing and mature brains. They participate in a variety of physiological and pathological processes including brain development, angiogenesis, neurodegeneration and neurogenesis. Stromal cell-derived factor-1/CXCR4 plays a particularly important role in adult neurogenesis through mediating the proliferation of neurogenitors, regulating the migration, differentiation, as well as functional integration of newborn neurons into existing networks. After stroke, adult neurogenesis in both the subventricular zone and subgranular zone is robustly increased and stromal cell-derived factor-1 and matrix metalloproteinases are released by damaged tissue. Stromal cell-derived factor-1 promotes the proliferation of neuroblasts and their migration to injured areas. However, the majority of the neuroblasts produced after stroke undergo apoptosis and only a few differentiate and survive in the long-term. The interaction of stromal cell-derived factor-1 and matrix' metalloproteinases may contribute to the unfavorable local microenvironment diminishing the survival of newborn neurons. Stromal cell-derived factor-1/matrix metalloproteinases and their downstream pathways may provide a new target for the treatment of stroke.

Guo B.,Liaoning Medical University
Molecular and cellular biochemistry | Year: 2012

Deficiency of zinc plays an important role in the pathogenesis of osteoporosis; however, the underlying mechanism is not well understood. Apoptosis of osteoblast causing the loss of bone mass is an important event in the osteoporosis. In this article, we investigated whether zinc deficiency would induce cell apoptosis in MC3T3-E1 cells and ask if it is involved in mitochondrial-mediated pathway. Significant increased apoptosis were observed in zinc deficiency group (ZnD: 5 μM TPEN and 1 μM zinc) compared with untreated control or zinc adequacy group (ZnA: 5 μM TPEN and 15 μM zinc). The mitochondrial membrane potential was strikingly reduced in ZnD group. Furthermore, we observed that the levels of Bax in mitochondria fraction and cyto c, AIF, and cleaved caspase-3/-9 in cytosol fraction were increased in ZnD group. We proposed that zinc deficiency would induce the translocation of Bax into mitochondria, which could lead to the reduction in mitochondrial membrane potential as well as the increase in mitochondrial membrane permeability. In addition, cyto c and AIF were released from mitochondria into the cytosol, which finally activated caspase-dependent and caspase-independent apoptosis processes in MC3T3-E1 cells. Our findings suggested that zinc deficiency is capable of inducing apoptosis through a mitochondria-mediated pathway in osteoblastic cells.

Zhang Z.,Liaoning Medical University
Molecular and cellular biochemistry | Year: 2012

Mammalian target of rapamycin (mTOR) controls cell growth and proliferation via the raptor-mTOR (TORC1) and rictor-mTOR (TORC2) protein complexes. The mTORC2 containing mTOR and rictor is thought to be rapamycin insensitive and it is recently shown that both rictor and mTORC2 are essential for the development of both embryonic and extra embryonic tissues. To explore rictor function in the early development of mouse embryos, we disrupted the expression of rictor, a specific component of mTORC2, in mouse fertilized eggs by using rictor shRNA. Our results showed that one-cell stage eggs that were lack of rictor could not enter into the two-cell stage normally. Recent biochemical studies suggests that TORC2 is the elusive PDK2 (3'-phosphoinositide-dependent kinase 2) for AKT/PKB Ser473 phosphorylation, which is deemed necessary for AKT function, so we microinjected AKT-S473A into mouse fertilized eggs to investigate whether AKT-S473A is downstream effector of mTOR.rictor to regulate the mitotic division. Our findings revealed that the rictor induced phosphorylation of AKT in Ser473 is required for TORC2 function in early development of mouse embryos.

BACKGROUND: The translocations of the anaplastic lymphoma kinase (ALK) gene with the echinoderm microtubule-associated protein-like 4 (EML4) gene on chromosome 2p have been identified in non-small-cell lung cancers (NSCLCs) as oncogenic driver mutations. It has been suggested that EML4-ALK fusion is associated with the resistance in NSCLCs to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs), such as gefitinib and erlotinib. In contrast, ALK tyrosine kinase inhibitor (ALK TKI) crizotinib has shown superior effects in combating NSCLCs with EML4-ALK. Thus, characterization of EML4-ALK fusion genes and clinical features of resulting carcinomas would be a great benefit to disease diagnosis and designing customized treatment plans. Studies have suggested that EML4-ALK translocation occurs more frequently in never-smokers with NSCLC, especially in female patients. However, it is not clear whether this is the case in male patients, too. In this study, we have determined the frequency of EML4-ALK translocation in male never-smokers with NSCLC in a cohort of Chinese patients. The clinical features associated with EML4-ALK translocation were also investigated.METHODS: A cohort of 95 Chinese male never-smokers with NSCLC was enrolled in this study. EML4-ALK fusion genes were detected using one-step real time RT-PCR and DNA sequencing. We further determined the expression levels of ALK mRNA by RT-PCR and ALK protein by immunohistochemistry in these specimens. The clinical features of EML4-ALK-positive carcinomas were also determined.RESULTS: We have identified EML4-ALK fusion genes in 8 out of 95 carcinoma cases, accounting for 8.42% in Chinese male never-smokers with NSCLC. It is significantly higher than that in all Chinese male patients (3.44%) regardless smoking habit. It is also significantly higher than that in all Chinese smokers (8/356 or 2.25%) or in smokers worldwide (2.9%) by comparing to published data. Interestingly, EML4-ALK fusion genes are more frequently found in younger patients and associated with less-differentiated carcinomas.CONCLUSIONS: The frequency of EML4-ALK translocation is strongly associated with smoking habits in Chinese male patients with higher frequency in male never-smokers. EML4-ALK translocation is associated with early-onset and less-differentiated carcinomas.

Wang F.,Liaoning Medical University
Frontiers in bioscience : a journal and virtual library | Year: 2012

Obesity has become a global health issue because of its increased morbidity and mortality, and a close association with at least 20 different cancers. Clinical and epidemiological studies have suggested that obesity and overweight are positively related with the risk of GBC. Gallbladder cancer (GBC) is a relatively infrequent but highly lethal neoplasm. Obesity may disturb lipid and endogenous hormones metabolism, affect gallbladder motility, increase the risk of gallstones, and thus plays a role in GBC. Control of obesity through measures such as lifestyle modification, healthy diet, and regular exercise may prove useful in the prevention of GBC.

Citation counts for peer-reviewed articles and the impact factor of journals have long been indicators of article importance or quality. In the Web 2.0 era, growing numbers of scholars are using scholarly social network tools to communicate scientific ideas with colleagues, thereby making traditional indicators less sufficient, immediate, and comprehensive. In these new situations, the altmetric indicators offer alternative measures that reflect the multidimensional nature of scholarly impact in an immediate, open, and individualized way. In this direction of research, some studies have demonstrated the correlation between altmetrics and traditional metrics with different samples. However, up to now, there has been relatively little research done on the dimension and interaction structure of altmetrics. Our goal was to reveal the number of dimensions that altmetric indicators should be divided into and the structure in which altmetric indicators interact with each other. Because an article-level metrics dataset is collected from scholarly social media and open access platforms, it is one of the most robust samples available to study altmetric indicators. Therefore, we downloaded a large dataset containing activity data in 20 types of metrics present in 33,128 academic articles from the application programming interface website. First, we analyzed the correlation among altmetric indicators using Spearman rank correlation. Second, we visualized the multiple correlation coefficient matrixes with graduated colors. Third, inputting the correlation matrix, we drew an MDS diagram to demonstrate the dimension for altmetric indicators. For correlation structure, we used a social network map to represent the social relationships and the strength of relations. We found that the distribution of altmetric indicators is significantly non-normal and positively skewed. The distribution of downloads and page views follows the Pareto law. Moreover, we found that the Spearman coefficients from 91.58% of the pairs of variables indicate statistical significance at the .01 level. The non-metric MDS map divided the 20 altmetric indicators into three clusters: traditional metrics, active altmetrics, and inactive altmetrics. The social network diagram showed two subgroups that are tied to each other but not to other groups, thus indicating an intersection between altmetrics and traditional metric indicators. Altmetrics complement, and most correlate significantly with, traditional measures. Therefore, in future evaluations of the social impact of articles, we should consider not only traditional metrics but also active altmetrics. There may also be a transfer phenomenon for the social impact of academic articles. The impact transfer path has transfer, or intermediate, stations that transport and accelerate article social impact from active altmetrics to traditional metrics and vice versa. This discovery will be helpful to explain the impact transfer mechanism of articles in the Web 2.0 era. Hence, altmetrics are in fact superior to traditional filters for assessing scholarly impact in multiple dimensions and in terms of social structure.

Yuan Y.,Liaoning Medical University
Cancer Biology and Medicine | Year: 2013

Screening and early diagnosis of gastric cancer play important roles in reducing the mortality of gastric cancer. A vast amount of study data on gastric cancer screening and early diagnosis has been accumulated in and out of China in the past decades. The practice of gastric cancer screening has also been efficiently carried out in different countries and regions. However, no widely accepted principle of population screening for gastric cancer has been developed yet. Screening for gastric cancer requires extensive exploration both theoretically and practically. This article focuses on the method and program of gastric cancer screening based on population. Moreover, the current situation of gastric cancer screening and its evaluation are evaluated. Copyright © 2013 by Cancer Biology & Medicine.

MicroRNAs are currently considered as an active and rapidly evolving area for the treatment of tumors. In this study, we elucidated the biological significance of miR-330 in glioblastoma stem cells (GSCs) as well as the possible molecular mechanisms. SH3GL2 is mainly distributed in the central nervous system and considered to be a tumor suppressor in many tumors. In the present study, we identified miR-330 as a potential regulator of SH3GL2 and we found that it was to be inversely correlated with SH3GL2 expression in GSCs which were isolated from U87 cell lines. The expression of miR-330 enhanced cellular proliferation, promoted cell migration and invasion, and dampened cell apoptosis. When the GSCs were co-transfected with the plasmid containing short hairpin RNA directed against human SH3GL2 gene and miR-330 mimic, we found that miR-330 promoted the malignant behavior of GSCs by down-regulating the expression of SH3GL2. Meanwhile, the ERK and PI3K/AKT signaling pathways were significantly activated, leading to the decreased expression of apoptotic protein and increased expression of anti-apoptotic protein. Furthermore, in orthotopic mouse xenografts, the mice given stable over-expressed SH3GL2 cells co-transfected with miR-330 knockdown plasmid had the smallest tumor sizes and longest survival. In conclusion, these results suggested that miR-330 negatively regulated the expression of SH3GL2 in GSCs, which promoted the oncogenic progression of GSCs through activating ERK and PI3K/AKT signaling pathways. The elucidation of these mechanisms will provide potential therapeutic approaches for human glioblastoma.

Xia P.,Liaoning Medical University
Current Stem Cell Research and Therapy | Year: 2014

Cancer stem cells (CSCs) are a small subpopulation of cells within tumors with capabilities of self-renewal, differentiation, and tumorigenicity. Successful cancer treatment would need to eliminate CSCs. The CSCs can be identified and isolated by both CSC-specific cell surface marker expression and functional assay, such as floating spheres, and aldehyde dehydrogenase (ALDH) activity assay. However, lack of universal expression of surface markers limits their usage to identify CSCs. Here, we give a brief overview of the current known surface markers of CSCs and associated tumor types. Finally, the possible reasons for contradiction are discussed in these surface markers. In this review, I not only provide an overview of the current known surface markers but also highlight the importance of achieving maximal accuracy of a new marker. © 2014 Bentham Science Publishers.

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