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Song M.,General Hospital of Shenyang Military Command | Bao J.,Liaoning Jinqiu Hospital | Wang X.,General Hospital of Shenyang Military Command | Li S.,General Hospital of Shenyang Military Command
European Archives of Oto-Rhino-Laryngology | Year: 2015

The polysomnography after nasopharyngeal tube insertion (NPT-PSG) was used to assess glossopharyngeal airway obstruction in patients with moderate-to-severe obstructive sleep apnea-hypopnea syndrome (OSAHS), and was compared with that obtained using spiral computed tomography (CT). A total of 125 patients diagnosed with moderate-to-severe OSAHS using PSG were subjected to PSG after NPT insertion, and spiral CT was used for continuous scan of the upper respiratory tract. The NPT-PSG and CT scan results were subjected to correlation analysis. In addition, the two sets of data were used separately to determine whether there was glossopharyngeal airway stenosis or obstruction, and the results were compared. Neither apnea hypopnea index (AHI) nor lowest oxygen saturation (LSaO2) obtained from the first PSG was significantly correlated with the cross-sectional area or the inner diameter of the glossopharyngeal airway. NPT-PSG AHI was significantly correlated with the cross-sectional area and anteroposterior diameter of the glossopharyngeal airway, with correlation coefficients of 0.264 and 0.185, and P values of 0.003 and 0.039, respectively. NPT-PSG AHI was not significantly correlated with the left–right diameter of the airway, and NPT-PSG LSaO2 was not significantly correlated with the cross-sectional area or the inner diameter of the glossopharyngeal airway. With NPT-PSG, 52 patients showed obvious glossopharyngeal airway stenosis while 73 patients did not, and with CT scan 41 patients showed obvious glossopharyngeal airway stenosis while 84 patients did not. The two methods reached the same diagnosis in 86 cases, with a consistency rate of 68.8 %. Spiral CT and NPT-PSG show certain degrees of consistency by assessing the presence of glossopharyngeal airway stenosis or obstruction, and there are also notable differences. Clinical assessment on glossopharyngeal airway obstruction should be based on a combination of multiple methods. © 2015, Springer-Verlag Berlin Heidelberg.


Li S.-H.,General Hospital of Shenyang Military Command | Wu D.-H.,General Hospital of Shenyang Military Command | Bao J.-M.,Liaoning Jinqiu Hospital | Shi H.-J.,General Hospital of Shenyang Military Command
Chinese Medical Journal | Year: 2013

Background The most common obstruction sites for obstructive sleep apnea hypopnea syndrome (OSAHS) are the oropharynx and the glossopharyx. The diagnosis of glossopharyngeal airway obstruction is difficult. The study aimed to assess the effect of upper airway reconstructive surgery for OSAHS based on polysomnography (PSG) after nasopharyngeal tube insertion (NPT-PSG), and to evaluate the clinical value of NPT-PSG in localizing the obstructive sites. Methods Seventy-nine OSAHS patients diagnosed with PSG were included in the study. PSG was repeated with a nasopharyngeal tube in place (NPT-PSG). Results of the two PSGs were compared. A NPT-PSG apnea hypopnea index (AHI) greater than 15 times per hour was used as a threshold for glossopharyngeal surgery. The cause of glossopharyngeal airway obstruction was taken into consideration in planning glossopharyngeal surgery. Assessment of efficacy was followed-up. Results After NPT-PSG, patients' AHI significantly decreased and lowest oxygen saturation (LaSO2) significantly increased. Of the 79 patients, 47 were treated with uvulopalatopharyngoplasty (UPPP) alone and 32 with UPPP + glossopharyngeal surgery. Thirty-two patients were considered cured, 33 markedly improved, and 14 failed. The overall surgery success rate was 82.3%. Conclusions NPT-PSG can be used as a diagnosis tool for localizing airway obstruction in OSAHS patients. Surgical treatment based on NPT-PSG results in good treatment efficacy.


Li S.,General Hospital of Shenyang Military Command | Wu D.,General Hospital of Shenyang Military Command | Bao J.,Liaoning Jinqiu Hospital | Shi H.,General Hospital of Shenyang Military Command
Laryngoscope | Year: 2014

Objectives/Hypothesis To compare polysomnography (PSG) data after nasopharyngeal tube (NPT) insertion and uvulopalatopharyngoplasty (UPPP), and explore the possibility of predicting UPPP outcomes with NPT-PSG. Study Design Prospective nonrandomized study. Methods PSG was performed after NPT insertion in 73 inpatients with obstructive sleep apnea-hypopnea syndrome (OSAHS). All patients accepted UPPP surgery. PSG was repeated after 12 months of UPPP to assess curative effects. Data were then compared to correlate NPT-PSG with the efficacy of UPPP. Results NPT insertion decreased the overall apnea-hypopnea index (AHI) and increased the lowest oxygen saturation (LaSO2). NPT-PSG results correlated well with surgical outcomes 12 months post-UPPP. The correlation coefficient for AHI and LaSO2 were 0.571 (P <.001) and 0.268 (P =.033), respectively. Next, enrolled patients were divided into two groups based on NPT-PSG results: group A, AHI <15 times/hr, 50 cases; group B, AHI ≥15 times/hr, 23 cases. The UPPP surgery success rates of the two groups were 86.0% and 39.1%, respectively. Conclusions NPT-PSG data are closely correlated with UPPP efficacy and may assist in the selection of appropriate OSAHS patients for UPPP. An AHI ≥15 times/hr after NPT insertion indicates glossopharyngeal obstruction and suggests the need for appropriate intervention. Level of Evidence 4. Laryngoscope, 124:1023-1028, 2014 © 2013 The American Laryngological, Rhinological and Otological Society, Inc.


Li S.,General Hospital of Shenyang Military Command | Wu D.,General Hospital of Shenyang Military Command | Bao J.,Liaoning Jinqiu Hospital | Qin J.,General Hospital of Shenyang Military Command
Journal of Clinical Sleep Medicine | Year: 2014

Study Objectives: The aim of this prospective controlled study was to explore the diagnostic value of repeated polysomnography (PSG) post-nasopharyngeal tube insertion in the setting of glossopharyngeal obstruction in obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: Patients were eligible for this study if they were diagnosed as OSAHS by the first PSG and presented with moderate to severe OSAHS by repeated PSG scanning post-nasopharyngeal tube insertion (NPT-PSG). Fifty-nine patients were enrolled into this study and assigned to received either modified uvulopalatopharyngoplasty (H-UPPP; n = 25) or H-UPPP in combination with glossopharyngeal surgery (n = 34). Results: General data and PSG data were collected prior to and following nasopharyngeal tube insertion and were found not to be significantly different. However, both the PSG and Epworth sleepiness scale (ESS) were significantly superior in the combination group compared to the UPPP alone group post-surgery. The success rates of surgery were 82.3% and 40.0%, respectively. Conclusion: Patients with moderate to severe OSAHS post-nasopharyngeal tube insertion generally have glossopharyngeal obstruction. Glossopharyngeal surgery can significantly improve surgical outcome in the setting of OSAHS.


PubMed | Liaoning Jinqiu Hospital and General Hospital of Shenyang Military Command
Type: Journal Article | Journal: Chinese medical journal | Year: 2013

The most common obstruction sites for obstructive sleep apnea hypopnea syndrome (OSAHS) are the oropharynx and the glossopharyx. The diagnosis of glossopharyngeal airway obstruction is difficult. The study aimed to assess the effect of upper airway reconstructive surgery for OSAHS based on polysomnography (PSG) after nasopharyngeal tube insertion (NPT-PSG), and to evaluate the clinical value of NPT-PSG in localizing the obstructive sites.Seventy-nine OSAHS patients diagnosed with PSG were included in the study. PSG was repeated with a nasopharyngeal tube in place (NPT-PSG).of the two PSGs were compared. A NPT-PSG apnea hypopnea index (AHI) greater than 15 times per hour was used as a threshold for glossopharyngeal surgery. The cause of glossopharyngeal airway obstruction was taken into consideration in planning glossopharyngeal surgery. Assessment of efficacy was followed-up.After NPT-PSG, patients AHI significantly decreased and lowest oxygen saturation (LaSO2) significantly increased. Of the 79 patients, 47 were treated with uvulopalatopharyngoplasty (UPPP) alone and 32 with UPPP + glossopharyngeal surgery. Thirty-two patients were considered cured, 33 markedly improved, and 14 failed. The overall surgery success rate was 82.3%.NPT-PSG can be used as a diagnosis tool for localizing airway obstruction in OSAHS patients. Surgical treatment based on NPT-PSG results in good treatment efficacy.


PubMed | Shenyang University and Liaoning Jinqiu Hospital
Type: | Journal: International immunopharmacology | Year: 2016

Connective tissue disease related pulmonary arterial hypertension (CTD-PAH) is characterized by vascular remodeling, endothelial dysfunction and inflammation. Endocan is a novel endothelial dysfunction marker. The aim of the present study was to investigate the role of endocan in CTD-PAH. Monocrotaline (MCT)-induced PAH rats were used as the CTD-PAH model. Short hairpin RNA packed in a lentiviral vector used to inhibit endocan expression was intratracheally instilled in rats prior to the MCT injection. Endocan was found to be increased in the serum and lung of MCT-induced PAH rats. Short hairpin RNA mediated knockdown of endocan significantly decreased right ventricular systolic pressure, attenuated pulmonary remodeling and inflammatory responses in the lung. In the in vitro study, tumor necrosis factor- (TNF-) exposure caused increased endocan expression in the primary cultured rat pulmonary microvascular endothelial cells (RPMECs). Endocan knockdown inhibited the permeability increase and adhesion molecules secretion in RPMECs induced by TNF-. In addition, TNF- induced MAPK activation was blocked when endocan gene was knocked down. These data demonstrate that endocan may play an important role in the development of CTD-PAH. This study provides novel evidence to better understand the pathogenesis of CTD-PAH, which may be beneficial for the treatment of this disease.


Chen H.,Liaoning Jinqiu Hospital | Ma F.,Zhejiang University | Hu X.,Liaoning Medical University | Jin T.,Liaoning Medical University | And 2 more authors.
Biochemical and Biophysical Research Communications | Year: 2013

Increased systemic level of inflammatory cytokines leads to numerous age-related diseases. In senescent macrophages, elevated prostaglandin E2 (PGE2) production contributes to the suppression of T cell function with aging, which increases the susceptibility to infections. However, the regulation of these inflammatory cytokines and PGE2 with aging still remains unclear. We have verified that cyclooxygenase (COX)-2 expression and PGE2 production are higher in LPS-stimulated macrophages from old mice than that from young mice. Downregulation of RXRα, a nuclear receptor that can suppress NF-κB activity, mediates the elevation of COX2 expression and PGE2 production in senescent macrophages. We also have found less induction of ABCA1 and ABCG1 by RXRα agonist in senescent macrophages, which partially accounts for high risk of atherosclerosis in aged population. Systemic treatment with RXRα antagonist HX531 in young mice increases COX2, TNF-α, and IL-6 expression in splenocytes. Our study not only has outlined a mechanism of elevated NF-κB activity and PGE2 production in senescent macrophages, but also provides RXRα as a potential therapeutic target for treating the age-related diseases. © 2013.


Yu L.,Liaoning University of Traditional Chinese Medicine | Zhang M.,Liaoning Jinqiu Hospital
Chinese Journal of Tissue Engineering Research | Year: 2014

Background: Myocardial infarction patients commonly appear to have left ventricular remodeling and heart failure. Because of physical characteristics, these two complications are more likely to occur in elderly patients with myocardial infarction. In recent years, stem cell transplantation in the treatment of acute myocardial infarction and heart failure has become a hot topic, and the feasibility and safety has been confirmed, but its long-term outcomes in elderly patients are still unclear. Objective:To assess the long-term effect of transplantation of autologous peripheral blood stem cells on the left ventricular remodeling and heart function in the old patients with myocardial infarction. Methods: Thirty old patients (age ≥ 60 years) with myocardial infarction were randomly assigned to receive intracoronary transplantation of peripheral blood stem cells following bone marrow cells mobilization by granulocyte colony-stimulating factor (300-600 μg per day) subcutaneously for 5 days in addition to conventional therapy (standard drug therapy and percutaneous coronary intervention; transplantation group, n= 15) or standard therapy (standard drug therapy and percutaneous coronary intervention; control group, n=15). Complications during intervention, left ventricular function and left ventricular remodeling at baseline and 6, 12, 24, 60 months after treatment were monitored. Results and Conclusion: Left ventricular function, left ventricular end diastolic volume, and left ventricular end-systolic volume were significantly improved 6,12, 24,60 months after autologous peripheral blood stem cell transplantation compared to baseline, while these parameters remained unchanged in the control group. These parameters had statistical difference between the two groups after treatment. During the follow-up, no severe side effects were observed. These findings indicate that autologous peripheral blood stem cell transplantation leads to significant and longstanding improvements in left ventricular performance of old patients with myocardial infarction, and shows good safety.


Yu L.,Liaoning University of Traditional Chinese Medicine | Zhang M.,Liaoning Jinqiu Hospital
Chinese Journal of Tissue Engineering Research | Year: 2014

BACKGROUND: Increasing basic researches have confirmed that human umbilical cord blood stem cells is safe and effective to treat acute myocardial infarction complicated by heart failure, but this method is not yet available for clinical use. OBJECTIVE: To observe the long-term effect of human umbilical cord blood mononuclear cell transplantation in the treatment of myocardial infarction combined with heart failure. METHODS: Twenty-five patients with myocardial infarction and heart failure admitted in the Department of Cardiology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, from January 2009 to June 2011 were randomly assigned to receive intracoronary transplantation of human umbilical cord blood mononuclear cells in addition to conventional therapy (transplantation group, n=12) or standard therapy (control group, n=13). All patients underwent standardized drug therapy, and coronary angiography and percutaneous coronary intervention were performed at acute phase. Improvement in heart function, left ventricular ejection fraction, left ventricular end-systolic volume and left ventricular end-diastolic volume at baseline and 12, 24 months after treatment were monitored. RESULTS AND CONCLUSION: The left ventricular ejection fraction, left ventricular end-systolic volume and left ventricular end-diastolic volume were significantly improved 12, 24 months after human umbilical cord blood stem cell transplantation compared to baseline (P < 0.05), while these parameters remained unchanged in the control group (P > 0.05). Compared with the control group, the left ventricular ejection fraction was increased significantly, and the left ventricular end-systolic volume and left ventricular end-diastolic volume were reduced significantly in the transplantation group. During the follow-up, no side effects were observed. These findings indicate that human umbilical cord blood mononuclear cell transplantation leads to significant and longstanding improvements in left ventricular performance of patients with myocardial infarction and heart failure. © 2014, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.


PubMed | Liaoning Jinqiu Hospital
Type: Journal Article | Journal: Biochemical and biophysical research communications | Year: 2013

Increased systemic level of inflammatory cytokines leads to numerous age-related diseases. In senescent macrophages, elevated prostaglandin E2 (PGE2) production contributes to the suppression of T cell function with aging, which increases the susceptibility to infections. However, the regulation of these inflammatory cytokines and PGE2 with aging still remains unclear. We have verified that cyclooxygenase (COX)-2 expression and PGE2 production are higher in LPS-stimulated macrophages from old mice than that from young mice. Downregulation of RXR, a nuclear receptor that can suppress NF-B activity, mediates the elevation of COX2 expression and PGE2 production in senescent macrophages. We also have found less induction of ABCA1 and ABCG1 by RXR agonist in senescent macrophages, which partially accounts for high risk of atherosclerosis in aged population. Systemic treatment with RXR antagonist HX531 in young mice increases COX2, TNF-, and IL-6 expression in splenocytes. Our study not only has outlined a mechanism of elevated NF-B activity and PGE2 production in senescent macrophages, but also provides RXR as a potential therapeutic target for treating the age-related diseases.

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