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Yang H.-Y.,Shenyang Pharmaceutical University | Zhang W.-M.,Shenyang Pharmaceutical University | Yang W.-W.,Shenyang Pharmaceutical University | Zhao T.,Liaoning Institute of Pharmaceutical Industry | Sun L.-X.,Shenyang Pharmaceutical University
Journal of Pharmaceutical Analysis | Year: 2011

The pharmacokinetics of 16-dehydropregnenolone (16-DHP), a sterols compound isolated from Solanum lyratum Thunb., was investigated in rats following a single intramuscular administration (40 mg/kg). The concentration of 16-DHP in rat plasma was determined by a high performance liquid chromatography (HPLC) method with UV detection. Levonorgestrel was used as the internal standard (IS). The pharmacokinetic parameters of 16-DHP were derived by non-compartmental method. After a single intramuscular administration, the maximum plasma concentration (Cmax) was (289±25)ng/mL, time to reach C max(tmax) was (0.38±0.14) h, the elimination half-life (t1/2) was (2.5±1.1) h, the area under the plasma concentration-time curve from time zero to the time of the last measurable concentration (AUC(0-1)) was (544±73)ng·h/mL. The results indicated that 16-DHP was absorbed quickly and eliminated rapidly in rats after the intramuscular injection. Source

Qi W.,Shenyang Pharmaceutical University | Zhao T.,Liaoning Institute of Pharmaceutical Industry | Yang W.-W.,Shenyang Pharmaceutical University | Wang G.-H.,Shenyang Pharmaceutical University | And 4 more authors.
Journal of Pharmaceutical Analysis | Year: 2011

The present study was aimed at the comparison of the pharmacokinetics of pure chlorogenic acid and extract of Solanum lyratum Thunb. The animals were allocated to two groups, and were administered chlorogenic acid or extract of S. lyratum Thunb. at a dose of 50.0 mg/kg orally. Blood samples were collected up to 8 h post-dosing. Plasma chlorogenic acid analyses were performed using an HPLC method with UV detector. The pharmacokinetic parameters were evaluated using non-compartmental assessment. Significant differences existed in the two groups for AUC0-t, AUC0-∞ and CLz/F. The reliable HPLC method was successfully applied to the determination of chlorogenic acid in rat plasma at dosage of 50.0 mg/kg. © 2011 Xi'an Jiaotong University. Production and hosting by Elsevier B.V. All rights reserved. Source

Ma S.,Shenyang Pharmaceutical University | Chen F.,Shenyang Pharmaceutical University | Ye X.,Liaoning Institute of Pharmaceutical Industry | Dong Y.,Liaoning Institute of Pharmaceutical Industry | And 7 more authors.
International Journal of Nanomedicine | Year: 2013

The purpose of this study was to develop a docetaxel microemulsion containing an anti-tumor synergistic ingredient (Brucea javanica oil) and to investigate the characteristics of the microemulsion. Brucea javanica oil contains oleic acid and linoleic acids that have been shown by animal and human studies to inhibit tumor formation. The microemulsion containing Brucea javanica oil, medium-chain triglyceride, soybean lecithin, Solutol®HS 15, PEG 400, and water was developed for docetaxel intravenous administration. A formulation with higher drug content, lower viscosity, and smaller particle size was developed. The droplet size distribution of the dispersed phase of the optimized microemulsion was 13.5 nm, determined using a dynamic light scattering technique. The small droplet size enabled the microemulsion droplets to escape from uptake and phagocytosis by the reticuloendothelial system and increased the circulation time of the drug. The zeta potential was -41.3 mV. The optimized microemulsion was pale yellow, transparent, and non-opalescent in appearance. The value of the combination index was 0.58, showing that there was a synergistic effect when docetaxel was combined with Brucea javanica oil. After a single intravenous infusion dose (10 mg/kg) in male Sprague Dawley rats, the area under the curve of the microemulsion was higher and the half-time was longer compared with that of docetaxel solution alone, and showed superior pharmacokinetic characteristics. These results indicate that this preparation of docetaxel in emulsion is likely to provide an excellent prospect for clinical tumor treatment. © 2013 Ma et al. Source

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