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Wu X.,China Medical University at Heping | Zou S.,Dalian Municipal Central Hospital | Zhu B.,Liaoning Academy of Safety science | Zhu B.,Shenyang University | Shi J.,China Medical University at Heping
Journal of Stroke and Cerebrovascular Diseases | Year: 2015

Background The impact of stroke is devastating the life of patients, families, and even the communities. The cost of treatment; however, has the tendency of increasing nowadays, which has brought a heavy burden to patients and their families. Our study aims to collect the data of the hospital cost among stroke patients in Chinese island populations over the past decade and provide the scientific improvement for stroke. Methods We retrospectively collected the basic information and hospital costs of the stroke patients in Dalian Changhai Hospital from 2003 to 2013 using the Information Registration System of Inpatient. Results The total cumulative hospital admissions for stroke in Dalian Changhai Hospital were 1367 and showed a rising tendency from 2003 to 2013. Our results illustrated that the annual cumulative hospital costs of stroke inpatients increased rapidly in the past 11 years (the average rise was 37.71% per year), and the mean hospital cost per admission was 1.66% higher than that before, when the mean length of hospital days showed a downward tendency. Medication cost was found to be the largest part in the overall hospital cost (as a high percentage of 73.94%); however, traditional Chinese medicine only occupied quite a small proportion in the medicines. Conclusions The hospital cost for stroke in Dalian Changhai County has brought an increasingly heavy economic burden to the local government and residents. © 2015 National Stroke Association.


Zhu B.,China Medical University at Heping | Zhu B.,Liaoning Academy of Safety science | Wu X.,Shenyang University | Wang X.,Liaoning Academy of Safety science | And 2 more authors.
Asia-Pacific Journal of Public Health | Year: 2014

The number of people with diabetes has been exponentially increasing. A number of reports in the literature have suggested that exposure to passive smoke may play a key role in the development of diabetes; however, the association has not been jointly summarized yet. In this meta-analysis, 2 databases were searched to identify studies, and the references of these studies were scanned for further studies. Fourteen studies on the relationship between passive smoking and diabetes were included. After all the studies were pooled, the results showed that passive smoking was significantly associated with an increased risk of type 2 diabetes in a random model. The subgroup analysis results were consistent with overall results regardless of type of study design, age, gender, adjustment of dependent variables, area, or study quality. Sensitivity analysis indicated that the overall results were reliable. There was no publication bias observed in the selected studies. © 2014 APJPH.


Wu X.,Chinese Institute of Clinical Medicine | Zhu B.,Liaoning Academy of Safety science | Zhu B.,China Medical University at Taichung | Fu L.,Chinese Institute of Clinical Medicine | And 4 more authors.
PLoS ONE | Year: 2013

Background: In China, there are 2.5 million new stroke cases each year and 7.5 million stroke survivors. However, stroke incidence in some island populations is obviously lower compared with inland regions, perhaps due to differences in diet and lifestyle. As the lifestyle in China has changed significantly, along with dramatic transformations in social, economic and environmental conditions, such changes have also been seen in island regions. Thus, we analyzed stroke in the Chinese island regions over the past 30 years. Methods: We conducted a systematic review to identify reliable and comparable epidemiologic evidence about stroke in the Chinese island regions between 1980 and 2013. Two authors independently assessed the eligibility and the quality of the articles and disagreement was resolved by discussion. Owing to the great heterogeneity among individual study estimates, a random-effects or fixed-effects model was used to incorporate the heterogeneity among records into a pooled estimate for age-standardized rates. Age-standardized rates were calculated by the direct method with the 2000 world population if included records provided the necessary information. Results: During the past three decades, the overall pooled age-standardized prevalence of stroke is 6.17 per 1000 (95% CI 4.56-7.78), an increase from 5.54 per 1000 (95% CI 3.88-7.20) prior to 2000 to 8.34 per 1000 (95% CI 5.98-10.69) after 2000. However, this difference was not found to be statistically significant. The overall pooled age-standardized incidence of stroke is 120.42 per 100,000 person years (95% CI 26.17-214.67). Between 1982 and 2008, the incidence of stroke increased and mortality declined over time. Conclusions: Effective intervention and specific policy recommendations on stroke prevention should be required, and formulated in a timely fashion to effectively curb the increased trend of stroke in Chinese island regions. © 2013 Wu et al.


Zhu B.,Shenyang University | Zhu B.,Liaoning Academy of Safety science | Wu X.,Shenyang University | Zhi X.,Shenyang University | And 3 more authors.
PLoS ONE | Year: 2014

Background: Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, had significant effects on the homocysteine levels. The common functional MTHFR C677T polymorphism had been extensively researched. Several studies had evaluated the relationship between MTHFR C677T polymorphism and type 2 diabetes mellitus (T2DM), but the results were still controversial in the Chinese Han population. This meta-analysis was conducted to evaluate the relationship between MTHFR C677T polymorphism and T2DM in the Chinese Han population. Methods: We searched the relevant studies in multiple electronic databases, which published up to December 2013. We reviewed and extracted data from all the included studies on the relationship between MTHFR C677T polymorphism and T2DM in the Chinese Han population. The odds ratios (ORs) and their 95% confidence intervals (95%CIs) were used to evaluate the relationship. Fixed-effects and random-effects meta-analysis were used to pool ORs by the heterogeneity. Publication bias and sensitivity analysis were also examined. Results: 29 studies were finally included in our meta-analysis, which contained 4656 individuals with T2DM and 2127 healthy controls. There was a significant relationship between MTHFR C677T polymorphism and T2DM under dominant (OR: 1.70, 95% CI: 1.42-2.02), recessive (OR: 1.48, 95% CI: 1.21-1.80), homozygous (OR: 1.89, 95% CI: 1.47-2.42), heterozygous (OR: 1.58, 95% CI: 1.33-1.87), and additive (OR: 1.46, 95% CI: 1.28-1.68) genetic model in a random-effects model. Subgroup analysis also reached similar results. Sensitivity analysis indicated that the overall result were dependable. Conclusions: There was a significant relationship between MTHFR C677T polymorphism and T2DM in the Chinese Han population. The results of our meta-analysis suggested that MTHFR 677T allele might be a risk genetic factor of T2DM in the Chinese Han population. © 2014 Zhu et al.


Zou S.,Dalian Medical University | Wu X.,China Medical University at Heping | Zhu B.,Liaoning Academy of Safety science | Zhu B.,Shenyang University | And 3 more authors.
Topics in Stroke Rehabilitation | Year: 2015

Background: Post-stroke seizures and epilepsy may worsen the recovery and increase the disability of stroke patients during their daily lives. However, few meta-analysis studies have been conducted on post-stroke seizures incidence. We carried on a meta-analysis on the incidence rate of post-stroke seizures and associated factors. Methods: We searched the Medline, Embase, Web of Science, Science Citation Index, and Cochrane Library electronic databases (1990-2013) to identify observational studies of post-stroke seizures. Two authors independently extracted the related information from all included studies. We calculated the pooled incidence by meta-analysis using the software R version 12.3. Results: A total of 34 longitudinal cohort studies involving 102 008 patients were included in our meta-analysis. The pooled incidence rate of post-stroke seizures was found to be 0.07 [95% confidence interval (CI), 0.05-0.09] while the rate of post-stroke epilepsy (PSE) was 0.05 (95% CI, 0.04-0.06). The incidence of post-stroke seizures in hemorrhagic stroke (0.10, 0.08-0.13) was much higher than in ischemic stroke (0.06, 0.04-0.08) and when the cortical region was involved (0.15, 0.10-0.21). Conclusions: Our meta-analysis showed that seizures occurred in about 6.93% of people with stroke. Seizures occurred more commonly after hemorrhagic stroke and when stroke occurred in the cortical region. © 2006 W. S. Maney & Son Ltd.

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