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Wang C.-Y.,Fujian Medical University | Zhang Y.-X.,Shanghai JiaoTong University | Wang D.-R.,Shanghai JiaoTong University | Pu Z.-M.,Shanghai JiaoTong University | And 4 more authors.
Journal of Shanghai Jiaotong University (Medical Science) | Year: 2012

Objective: To introduce a new incision method for latissimus dorsi flap in reconstruction of large deep tissue defects. Methods: Six patients with large deep tissue defects were selected, including 4 patients with wound defects in parietal region and 2 patients with wound defects in lower extremity, and the width of wound was more than 8 cm for each patient. The bilobed latissimus dorsi flap was designed, and two smaller skin paddles were lined up on one side of the back. The smaller skin paddles allowed primary closure of donor site, and were used to resurface a large defect when combined. Results: The transplanted skin flaps survived in all the 6 patients, and the maximum area of skin flap was 18 cm×16 cm. The donor sites were closed primarily in all patients, with linear scar left only. Patients were followed up for 3 to 6 months, and all were satisfied with the aesthetic and functional outcomes of the donor sites. Conclusion: The design of bilobed latissimus dorsi flap allows reconstruction of a large defect and primary closure of the donor site, with less invasion and favorable appearance.

Dong L.,Dalian Medical University | Yu H.-Q.,Liaohe Oil Field Central Hospital | Wang H.-J.,Dalian Medical University | Li K.-J.,Dalian Medical University | And 2 more authors.
Journal of Dalian Medical University | Year: 2012

[Objective] To evaluate experience with laparoscopic cholecystectomy in patients with cirrhosis and to provide recommendations for management. [Methods] Retrospective review of laparoscopic cholecystectomy in 212 cases patients with cirrhosis from Feb, 1994 to Feb, 2008 in our team was performed. Peri-operative characteristics and subgroup analysis were performed in patients with Child Pugh's classes A, B cirrhosis. [Results] Of the nine patients (4.24%) that were converted to an open cholecystectomy in this study. Postoperative main complications are ascites, biliary duct injury and pneumonia. No mortality and no liver function failure occur in the study. Compared with patients with Child's class B, laparoscopic cholecystectomy in patients with Child's class A was associated with significantly decreased operative time, short of hospital stay, less blood loss, lower conversion to open cholecystectomy and complications (P < 0.05). [Conclusions] Laparoscopic cholecystectomy in patients with Child's class A and B is feasible with no mortality and low morbidity. and appropriate preoperative preparations and careful intraoperative techniques are required for better outcomes.

Zou B.-J.,Liaohe Oil Field Central Hospital | Wang Z.-T.,Liaohe Oil Field Central Hospital | Zhang Y.-L.,Liaohe Oil Field Central Hospital | Yang H.,Liaohe Oil Field Central Hospital | And 3 more authors.
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2010

OBJECTIVE: To explore effects and safety of immunosuppressive agent on acute rejection following renal transplantation. METHODS: We retrieved Vip and Tsinghua Tongfang Databases for relevant articles published from January 2000 to October 2009. The key words were "renal transplantation, immunosuppressive agent, mycophenolate, tacrolimus, cyclosporine, rapamycin, anti-CD25 monoclonal antibody, anti-CD3 monoclonal antibody". The contents should be associated with the study concerning prevention and treatment of immunosuppressive agent on acute rejection following renal transplantation. RESULTS: The use of immunosuppressive agent for renal transplantation can decrease the incidence rate of acute rejection, which can significantly improve the survival of transplanted kidney in a short period. However, the renal toxicity of immunosuppressive agent remains a key factor for restricting long-term survival of the transplanted kidney. Recently, novel immunosuppressive agents enable the long-term survival of transplanted kidney such as rapamycin and FFY720. Novel immunosuppressive agents should pay great attention on reducing adverse reactions, rather than the reduction in incidence rate of rejection alone. CONCLUSION: With the deep understanding of transplantation immunity, we have made great progresses in immunosuppressive agents, which provide more and more choices for clinical physicians. However, satisfactory immunosuppressive agents and schemes deserve further investigations.

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