Liaocheng City Hospital

Liaocheng, China

Liaocheng City Hospital

Liaocheng, China

Time filter

Source Type

Gu H.,Peking University | Ma C.,Capital Medical University | Yang Q.,Liaocheng City Hospital | Hua W.,Capital Medical University | And 6 more authors.
Pediatric Infectious Disease Journal | Year: 2014

Specimens and clinical data were collected from 243 hand, foot and mouth disease patients in Beijing in 2013. In total, 130 stool specimens were genotyped for enterovirus. Hand, foot and mouth disease was mainly detected in suburban areas and at the edges of urban areas between May and August. Coxsackievirus (CV) A6 replaced enterovirus (EV) 71 and CVA16, becoming the main causative agent of hand, foot and mouth disease. CVA6 infection led to significantly reduced fever duration and glucose levels compared with EV71 infection. Copyright © 2014 by Lippincott Williams and Wilkins.


Wu X.-L.,Chinese PLA General Hospital | Yang D.-Y.,Chinese PLA General Hospital | Tan D.-J.,Roswell Park Cancer Institute | Yao H.-C.,Liaocheng City Hospital | And 2 more authors.
Oncology Reports | Year: 2013

Insulin-like growth factor 1 (IGF-1) is a molecule with strong proliferative effects, and statins have been reported to exhibit antitumor effects based on clinical and experimental studies. However, their effects on cardiac myxoma (CM) cells and the underlying signaling mechanism(s) are largely unknown. Therefore, we investigated whether the protein/lipid phosphatases and tensin homolog deleted on chromosome ten (PTEN) and pleckstrin homology domain leucine-rich repeat phosphatase 1 and 2 (PHLPP1 and 2) are involved in the proliferative effect of IGF-1 on CM cells and the pharmacological impact of atorvastatin. The activity of PTEN and PHLPPs was determined using specific substrate diC16PIP3 and pNPP. We found that IGF-1 enhanced CM cell proliferation and inhibited both PTEN and PHLPP2 activity in a concentration- and time-dependent manner. Atorvastatin acted counter to IGF-1 and reversed the above effects mediated by IGF-1. Both IGF-1 and atorvastatin did not affect the activity of PHLPP1 and the protein expression of the three phosphatases. The results suggest that IGF-1 may exert its proliferative effects by negatively regulating the PTEN/ PHLPP2 signaling pathway in CM cells, and atorvastatin may be a potential drug for the treatment of CM by enhancing the activity of PTEN and PHLPP2.


shao F.,Liaocheng City Hospital | Xin F.-Z.,Liaocheng City Hospital | Yang C.-G.,Liaocheng City Hospital | Yang D.-G.,Liaocheng City Hospital | And 3 more authors.
Cell Biochemistry and Biophysics | Year: 2014

The aim of the study was to investigate the effect of microbial immune enteral nutrition by microecopharmaceutics and deep sea fish oil and glutamine and Peptisorb on the patients with acute radiation enteritis in bowel function and immune status. From June 2010 to January 2013, 46 acute radiation enteritis patients in Liaocheng People's Hospital were randomized into the microbial immune enteral nutrition group and the control group: 24 patients in treatment group and 22 patients in control group. The immune microbial nutrition was given to the study group, but not to the control group. The concentration of serum albumin and prealbumin and the number of CD3 + T cell, CD4 + T cell, CD8 + T cell, CD4 +/CD8 + and natural killer cell of the two groups were detected on the 1, 7 and 14 days after treatment. The arm muscle circumference and triceps skinfold thickness (TSF) were recorded, and the tolerance of the two groups for enteral nutrition and intestinal symptoms was collected and then comparing the two indicators and get results. The tolerance of microbial immune enteral nutrition group about abdominal pain, bloating and diarrhea was better than the control group (P values were 0.018, 0.04 and 0.008 after 7 days; P values were 0.018, 0.015 and 0.002 after 14 days); and the cellular immune parameters were better than the control group(△ P = 0.008,▲ P = 0.039, {star, open} P = 0.032); No difference was found in nutrition indicators. To the patients with acute radiation enteritis, microbial immune enteral nutrition could improve the patient's immune status, and the tolerance of enteral nutrition could be better for the bowel function and the patients' rehabilitation. © 2013 Springer Science+Business Media New York.


Shao F.,Liaocheng City Hospital
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery | Year: 2012

To investigate the effects of microbiological and immunological enteral nutrition using composition of probiotics, glutamine, fish oil, and peptisorb on patients with gastrointestinal cancer complicated with diabetes mellitus. From January 2007 to October 2010, 67 patients with gastrointestinal cancer complicated with diabetes mellitus were admitted to the Liaocheng People's Hospital of Shandong Province and were randomized into the treatment group(n=33, enteral nutrition with probiotics, glutamine, and fish oil) and the routine group(n=34, regular enteral nutrition). Fasting blood glucose(FBG), insulin(FINS), number of lymphocytes(including CD3(+)T cell, CD4(+)T cell, CD8(+)T cell, CD4(+)/CD8(+)) and natural killer (NK) cells of the two groups were detected on the day before surgery and postoperative day 3 and 7. Insulin resistance index (InHOMA-IR) was calculated by using the homeostasis model assessment(HOMA). The incidence of nosocomial infections and intestinal function recovery time, and length of hospital stay were collected. On postoperative day 7, FINS[(8.4±3.7) mU/L vs. (13.7±5.4) mU/L, P<0.05] and InHOMA-IR(1.11±0.23 vs. 1.68±0.39, P<0.05) were lower in the treatment group than that in the routine group. The number of CD4(+)[(45.2±5.4)% vs. (38.1±2.9)%, P<0.05], CD4/CD8 (2.05±0.27 vs. 1.58±0.16, P<0.05), and NK cells [(19.5±6.6)% vs. (15.4±5.6)%, P<0.05] were higher in the treatment group. There were no significant differences in nosocomial infection [6.1%(2/33) vs. 17.6%(6/34), P>0.05] and intestinal function recovery time[(69.3±9.5) h vs. (70.1±11.6) h, P>0.05] between the two groups. However, the length of hospital stay [(17±3.8) d vs. (21±4.2) d, P<0.05] was significantly shorter in the treatment group. For patients with gastrointestinal cancer complicated with diabetes mellitus, microbiota enteral nutrition can reduce insulin resistance, improve the immune status, and promote postoperative recovery.


PubMed | Liaocheng City Hospital
Type: Journal Article | Journal: Cell biochemistry and biophysics | Year: 2014

The aim of the study was to investigate the effect of microbial immune enteral nutrition by microecopharmaceutics and deep sea fish oil and glutamine and Peptisorb on the patients with acute radiation enteritis in bowel function and immune status. From June 2010 to January 2013, 46 acute radiation enteritis patients in Liaocheng Peoples Hospital were randomized into the microbial immune enteral nutrition group and the control group: 24 patients in treatment group and 22 patients in control group. The immune microbial nutrition was given to the study group, but not to the control group. The concentration of serum albumin and prealbumin and the number of CD3 (+) T cell, CD4 (+) T cell, CD8 (+) T cell, CD4 (+)/CD8 (+) and natural killer cell of the two groups were detected on the 1, 7 and 14 days after treatment. The arm muscle circumference and triceps skinfold thickness (TSF) were recorded, and the tolerance of the two groups for enteral nutrition and intestinal symptoms was collected and then comparing the two indicators and get results. The tolerance of microbial immune enteral nutrition group about abdominal pain, bloating and diarrhea was better than the control group (P values were 0.018, 0.04 and 0.008 after 7 days; P values were 0.018, 0.015 and 0.002 after 14 days); and the cellular immune parameters were better than the control group(() P = 0.008,([Symbol: see text]) P = 0.039, () P = 0.032); No difference was found in nutrition indicators. To the patients with acute radiation enteritis, microbial immune enteral nutrition could improve the patients immune status, and the tolerance of enteral nutrition could be better for the bowel function and the patients rehabilitation.


PubMed | Liaocheng City Hospital
Type: Journal Article | Journal: European review for medical and pharmacological sciences | Year: 2013

To investigate the effect of microbiological and immunological enteral nutrition (MEIN composed by probiotics, L-Glutamide, deep-sea fish oil and Nutrison Fibre) on intestinal function and immune status in the patients with long-term use of antibiotics.56 severe apoplexy patients with pulmonary infectious complication were randomly divided into two groups: a microbiological and immunological enteral nutrition group (MEIN group, n=28) and an enteral nutrition group (EN group, n=28). MEIN suspension (Live Combined Bifidobacterium, L-Glutamide, deep-sea fish oil and Nutrison Fibre) and ordinary enteral nutrition liquid (Nutrison Fibre) were given to patients of the MEIN group and EN group respectively for at least for 20 days. Then the trophonemata, incidence rates of abdominal pain, abdominal distention and diarrhea, tolerance and immunologic parameters including CD4+, CD8+ T-lymphocyte percentage, CD4+/CD8+ ratio and NK cells in peripheral blood were estimated and compared between the two groups during the period of nutritional support.No statistical difference was observed in trophonemata between the two groups (p > 0.05). The abdominal pain and abdominal distension incidence rates of the patients in MEIN group were significantly lower than those of patients in EN group. (7.2% vs 32.1%, 14.2% vs 39.3%, 0% vs 10.7%) (p < 0.05). There was a significantly better tolerance in MEIN group compared to EN group after treatment (p < 0.05). In addition, the levels of immune parameters of the patients in MEIN group were much higher compared to that of those in EN group on the 20th day after grouping (p < 0.05).Compared with the general formula EN, MEIN is more helpful for the patients with Long-term use of antibiotics in improving intestinal function and cellular immune function.


PubMed | Liaocheng City Hospital
Type: Journal Article | Journal: Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery | Year: 2012

To investigate the effects of microbiological and immunological enteral nutrition using composition of probiotics, glutamine, fish oil, and peptisorb on patients with gastrointestinal cancer complicated with diabetes mellitus.From January 2007 to October 2010, 67 patients with gastrointestinal cancer complicated with diabetes mellitus were admitted to the Liaocheng Peoples Hospital of Shandong Province and were randomized into the treatment group(n=33, enteral nutrition with probiotics, glutamine, and fish oil) and the routine group(n=34, regular enteral nutrition). Fasting blood glucose(FBG), insulin(FINS), number of lymphocytes(including CD3(+)T cell, CD4(+)T cell, CD8(+)T cell, CD4(+)/CD8(+)) and natural killer (NK) cells of the two groups were detected on the day before surgery and postoperative day 3 and 7. Insulin resistance index (InHOMA-IR) was calculated by using the homeostasis model assessment(HOMA). The incidence of nosocomial infections and intestinal function recovery time, and length of hospital stay were collected.On postoperative day 7, FINS[(8.43.7) mU/L vs. (13.75.4) mU/L, P<0.05] and InHOMA-IR(1.110.23 vs. 1.680.39, P<0.05) were lower in the treatment group than that in the routine group. The number of CD4(+)[(45.25.4)% vs. (38.12.9)%, P<0.05], CD4/CD8 (2.050.27 vs. 1.580.16, P<0.05), and NK cells [(19.56.6)% vs. (15.45.6)%, P<0.05] were higher in the treatment group. There were no significant differences in nosocomial infection [6.1%(2/33) vs. 17.6%(6/34), P>0.05] and intestinal function recovery time[(69.39.5) h vs. (70.111.6) h, P>0.05] between the two groups. However, the length of hospital stay [(173.8) d vs. (214.2) d, P<0.05] was significantly shorter in the treatment group.For patients with gastrointestinal cancer complicated with diabetes mellitus, microbiota enteral nutrition can reduce insulin resistance, improve the immune status, and promote postoperative recovery.

Loading Liaocheng City Hospital collaborators
Loading Liaocheng City Hospital collaborators