Liaocheng Brain Hospital

Liaocheng, China

Liaocheng Brain Hospital

Liaocheng, China
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Li Y.-H.,Liaocheng Brain Hospital | Wang F.-Y.,Liaocheng Brain Hospital | Feng C.-Q.,Liaocheng Brain Hospital | Yang X.-F.,Liaocheng Brain Hospital
Pharmacognosy Magazine | Year: 2015

Background: To extract, purify and identify the active constituents in ethanol extract of Radix Salviae Miltiorrhizae, and to analyze the protective effects of tanshinone IIA on cerebral ischemia-reperfusion injury in rats. Materials and Methods: Radix Salviae Miltiorrhizae was extracted by ultrasonic extraction, effective parts were extracted by extraction method, compounds were isolated by preparative TLC and preparative HPLC, and structures of compounds were identified by1 H NMR and13 C NMR; the effects of tanshinone IIA on cerebral ischemia-reperfusion injury in rats were determined by establishing rat model of middle cerebral artery occlusion (MCAO). Results: The experimental data show four compounds were isolated, namely tanshinone IIB, hydroxymethylene tanshinone, salvianolic acid B and 9"'-methyl lithospermate B. Tanshinone IIA could alleviate the symptoms of neurological deficit in rats, the neurological deficit alleviating effect became more obvious with the increase of dose; tanshinone IIA experimental groups could reduce the cerebral infarction size and brain water content in rats, different concentrations of tanshinone IIA could decrease the SOD content and increase the MDA content in the frontal and parietal cortices of ischemic hemisphere in the ischemia reperfusion group, the differences were statistically significant compared with the ischemia reperfusion group. Conclusion: Radix Salviae Miltiorrhizae has the protective effects on cerebral ischemia reperfusion injury in rats.


Zhu J.-X.,Liaocheng Brain Hospital | Li Z.-M.,Liaocheng Brain Hospital | Xiao T.-W.,Liaocheng Peoples Hospital | Chen S.-F.,Liaocheng Peoples Hospital | And 3 more authors.
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2010

BACKGROUND: Previous animal studies demonstrated that bone marrow mesenchymal stem cells could differentiate into nerve cells under a certain condition; however, the clinical application for treating nervous system disease has been less reported. OBJECTIVE: To observe a short-term effect of autologous bone marrow mesenchymal stem cell transplantation on treating cerebral hemorrhage. METHODS: A total of 32 patients with cerebral hemorrhage who were selected from the Department of Neurosurgery, Liaocheng Brain Hospital between November 2007 and January 2009 were considered as a treatment group. According to general data and the amount of hematoma, they were treated by drilling drainage or hematoma evacuation. Drainage tubes were detained into hematoma cavity, and 3.5 mL autologous bone marrow mesenchymal stem cell suspension was injected through drainage tube. A total of 40 additional patients who did not treated with stem cell transplantation were considered as a control group. Neurologic impairment (NIHSS) and activities of daily living (Barthel index) were performed before and 6 months after transplantation; meanwhile, the brain MRI, serum biochemical and tumor marker were evaluated to detect security of stem cell transplantation. RESULTS AND CONCLUSION: The NIHSS score and Barthel index in the treatment group were similar to those in the control group before transplantation. Compared with control group, NIHSS scores were significantly decreased in the treatment group (P < 0.01), but Barthel index was significantly increased 6 months after transplantation (P < 0.01). Compared with before transplantation, NIHSS score were significantly decreased (P < 0.01), but Barthel index was significantly increased in the treatment group 6 months after transplantation (P < 0.01). Two patients in the treatment group had febrile, which was recovered after treatment. The following-up 6 months after transplantation demonstrated that brain MRI and biochemical indicators were normal except an increasing of CA-153 caused by lung cancer in one patient. The autologous bone marrow mesenchymal stem cell transplantation for treatment of cerebral hemorrhage is safe and effective in a short-term period; however the long-term effect still needs to be further studied.


Xu Z.,Liaocheng University | Shen A.,Liaocheng Brain Hospital
Proceedings - 9th International Symposium on Distributed Computing and Applications to Business, Engineering and Science, DCABES 2010 | Year: 2010

Fetal macrosomia not only produces a great risk in delivery both to the mother and the fetus, but also has a bad influence to the future of the child. Prediction of fetal macrosomia has an important clinical meaning. In this paper, a new model of estimating fetal macrosomia is proposed. The aim of the model is to predict the fetal macrosomia, not the fetal weight. An artificial neural network is established to estimate the fetal macrosomia, the original data are trained and tested with the Bayesian Regularization method. The model gets an accuracy of 75% with estimating fetal macrosomia. © 2010 IEEE.


Zhu J.X.,Liaocheng Brain Hospital
Zhonghua zhong liu za zhi [Chinese journal of oncology] | Year: 2010

To evaluate the efficacy and toxicity of combination therapy with surgery and recombinant adenovirus-p53 injection of recurrent malignant gliomas. 38 patients with recurrent malignant gliomas were included in this study. Among them, 18 patients of combined treatment group had Ommaya reservoirs placed into the tumor cavities after the resection of the tumors and received regular recombinant adenovirus-p53 injections after the operation. The other 20 patients received surgery alone. The 6-month and 1-year survival rates after the combination therapy were 66.7% (14/18) and 44.4% (8/18), respectively. The median survival time was 9.7 months. Compared with the surgery-alone group, the combined treatment group achieved significant improvement (P < 0.05). The Karnofsky score was significantly improved at 6 months after the combination therapy compared with that before the treatment (P < 0.05). The recombinant adenovirus-p53 injection is safe and effective in treatment of recurrent malignant gliomas. The combination therapy of surgery and recombinant adenovirus-p53 injection may improve the life quality and the prognosis in patients with recurrent malignant gliomas.


Wang J.Y.,Liaocheng Brain Hospital
Zhonghua wai ke za zhi [Chinese journal of surgery] | Year: 2011

To evaluate and summarize the possibility and experience of reconstructive vascular operation for kinking of internal carotid artery. Reconstructive vascular operation was performed on 5 patients with symptomatic kinking of internal carotid artery between July 2008 and June 2009. There were 2 male and 3 female patients, age ranged from 53 to 68 years (mean 62 years). Cutting the internal carotid artery at the bifurcation, mobilizing and stretching the internal carotid artery, then anastomosing the internal and common carotid artery. Two of them underwent endarterectomy simultaneously. For the 5 patients, postoperative recovery went smoothly and symptoms were well improved. Except that mild high perfusion syndrome happened in 1 patient, no other obvious complications. Kinking of internal carotid artery had been stretched in the postoperative CT angiography. In the 5-16-month follow-up, no transient ischemic attack or cerebral infarction happened, and no restenosis appeared. Reconstructive vascular operation is an effective surgical approach to kinking and coiling of the internal carotid artery. For some risk exists, all-round evaluation should be performed before operation, and operative indication should be strictly controlled.


Zhu J.-X.,Liaocheng Brain Hospital | Li Z.-M.,Liaocheng Brain Hospital | Geng F.-Y.,Liaocheng Brain Hospital | Fu Q.,Liaocheng Brain Hospital | And 4 more authors.
Chinese Journal of Cancer Prevention and Treatment | Year: 2010

OBJECTIVE: To evaluate the efficacy and toxicity of combination therapy with surgery and recombinant human adenovirus-p53 (rAd-p53) for the recurrent malignant gliomas. METHODS: Thirty-eight patients with recurrent malignant gliomas received surgery. Eighteen patients of the combined treatment group(syrgery and rAd-p53)placed Ommaya reserviors into the tumor cavities after the resection of the tumors and received regular rAd-p53 therapy after the operation. Another 20 patients received surgery only. All the patients were followed up for more than one year. RESULTS: The 6-month and 1-year survial rates after the combination therapy were 66.7% (14/18) and 44.4% (8/18) respectively. The median survial time was (42.4±3.1) weeks. Compared with the surgery only group, the combined treatment group achieved significient improvement (P<0.05). Karnofsky scores significantly was improved 6 months after the combination therapy (P<0.05). CONCLUSIONS: rAd-p53 is safe and effective to recurrent malignant gliomas. The combination therapy may improve the life quality and the prognosis of patients with recurrent malignant gliomas.


Zhipeng X.,Liaocheng University | Aifang S.,Liaocheng Brain Hospital
Proceedings - 2011 10th International Symposium on Distributed Computing and Applications to Business, Engineering and Science, DCABES 2011 | Year: 2011

In modeling of fetal macrosomia, some inconsistent data are mixed in samples. Because the procedure of childbearing has been finished, the sample data can not be validated by visiting previous pregnant woman. In order to eliminate the inaccurate samples, a counter propagation neural network is established. Some traditional methods are also used to verify the discarded samples. The new training set shows better classification than original data set. © 2011 IEEE.


Wang C.,Liaocheng Brain Hospital | Liang J.-H.,Liaocheng Brain Hospital | Liu G.-Y.,Liaocheng Brain Hospital | Xu J.-L.,Liaocheng Brain Hospital | Jia A.-H.,Liaocheng Brain Hospital
Journal of Clinical Dermatology | Year: 2011

A case of follicular mucinosis is reported. A 14-year-old boy presented with half a year history of facial pink infiltrated plaque associated with loss of hair. Histopathologic examination showed parakeratosis, acanthosis in the epidermis, there was a mild lymphocytic infiltration in the dermis around and within the affected follicles. Inflammatory lymphocytic infiltrate, admixed with several eosinophils, located around the vessels. Alcian blue stain was positive within the follicular structures. A diagnosis of follicular mucinosis was finally made. He was successfully treated with intralesional compound betamethasone injection.


PubMed | Liaocheng Brain Hospital
Type: Journal Article | Journal: Zhonghua wai ke za zhi [Chinese journal of surgery] | Year: 2011

To evaluate and summarize the possibility and experience of reconstructive vascular operation for kinking of internal carotid artery.Reconstructive vascular operation was performed on 5 patients with symptomatic kinking of internal carotid artery between July 2008 and June 2009. There were 2 male and 3 female patients, age ranged from 53 to 68 years (mean 62 years). Cutting the internal carotid artery at the bifurcation, mobilizing and stretching the internal carotid artery, then anastomosing the internal and common carotid artery. Two of them underwent endarterectomy simultaneously.For the 5 patients, postoperative recovery went smoothly and symptoms were well improved. Except that mild high perfusion syndrome happened in 1 patient, no other obvious complications. Kinking of internal carotid artery had been stretched in the postoperative CT angiography. In the 5-16-month follow-up, no transient ischemic attack or cerebral infarction happened, and no restenosis appeared.Reconstructive vascular operation is an effective surgical approach to kinking and coiling of the internal carotid artery. For some risk exists, all-round evaluation should be performed before operation, and operative indication should be strictly controlled.


PubMed | Liaocheng Brain Hospital
Type: Journal Article | Journal: Pharmacognosy magazine | Year: 2015

To extract, purify and identify the active constituents in ethanol extract of Radix Salviae Miltiorrhizae, and to analyze the protective effects of tanshinone IIA on cerebral ischemia-reperfusion injury in rats.Radix Salviae Miltiorrhizae was extracted by ultrasonic extraction, effective parts were extracted by extraction method, compounds were isolated by preparative TLC and preparative HPLC, and structures of compounds were identified by (1)H NMR and (13)C NMR; the effects of tanshinone IIA on cerebral ischemia-reperfusion injury in rats were determined by establishing rat model of middle cerebral artery occlusion (MCAO).The experimental data show four compounds were isolated, namely tanshinone IIB, hydroxymethylene tanshinone, salvianolic acid B and 9-methyl lithospermate B. Tanshinone IIA could alleviate the symptoms of neurological deficit in rats, the neurological deficit alleviating effect became more obvious with the increase of dose; tanshinone IIA experimental groups could reduce the cerebral infarction size and brain water content in rats, different concentrations of tanshinone IIA could decrease the SOD content and increase the MDA content in the frontal and parietal cortices of ischemic hemisphere in the ischemia reperfusion group, the differences were statistically significant compared with the ischemia reperfusion group.Radix Salviae Miltiorrhizae has the protective effects on cerebral ischemia reperfusion injury in rats.

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