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Liaocheng, China

Zhu J.X.,Liaocheng Brain Hospital
Zhonghua zhong liu za zhi [Chinese journal of oncology] | Year: 2010

To evaluate the efficacy and toxicity of combination therapy with surgery and recombinant adenovirus-p53 injection of recurrent malignant gliomas. 38 patients with recurrent malignant gliomas were included in this study. Among them, 18 patients of combined treatment group had Ommaya reservoirs placed into the tumor cavities after the resection of the tumors and received regular recombinant adenovirus-p53 injections after the operation. The other 20 patients received surgery alone. The 6-month and 1-year survival rates after the combination therapy were 66.7% (14/18) and 44.4% (8/18), respectively. The median survival time was 9.7 months. Compared with the surgery-alone group, the combined treatment group achieved significant improvement (P < 0.05). The Karnofsky score was significantly improved at 6 months after the combination therapy compared with that before the treatment (P < 0.05). The recombinant adenovirus-p53 injection is safe and effective in treatment of recurrent malignant gliomas. The combination therapy of surgery and recombinant adenovirus-p53 injection may improve the life quality and the prognosis in patients with recurrent malignant gliomas. Source


Xu Z.,Liaocheng University | Shen A.,Liaocheng Brain Hospital
Proceedings - 9th International Symposium on Distributed Computing and Applications to Business, Engineering and Science, DCABES 2010 | Year: 2010

Fetal macrosomia not only produces a great risk in delivery both to the mother and the fetus, but also has a bad influence to the future of the child. Prediction of fetal macrosomia has an important clinical meaning. In this paper, a new model of estimating fetal macrosomia is proposed. The aim of the model is to predict the fetal macrosomia, not the fetal weight. An artificial neural network is established to estimate the fetal macrosomia, the original data are trained and tested with the Bayesian Regularization method. The model gets an accuracy of 75% with estimating fetal macrosomia. © 2010 IEEE. Source


Wang J.Y.,Liaocheng Brain Hospital
Zhonghua wai ke za zhi [Chinese journal of surgery] | Year: 2011

To evaluate and summarize the possibility and experience of reconstructive vascular operation for kinking of internal carotid artery. Reconstructive vascular operation was performed on 5 patients with symptomatic kinking of internal carotid artery between July 2008 and June 2009. There were 2 male and 3 female patients, age ranged from 53 to 68 years (mean 62 years). Cutting the internal carotid artery at the bifurcation, mobilizing and stretching the internal carotid artery, then anastomosing the internal and common carotid artery. Two of them underwent endarterectomy simultaneously. For the 5 patients, postoperative recovery went smoothly and symptoms were well improved. Except that mild high perfusion syndrome happened in 1 patient, no other obvious complications. Kinking of internal carotid artery had been stretched in the postoperative CT angiography. In the 5-16-month follow-up, no transient ischemic attack or cerebral infarction happened, and no restenosis appeared. Reconstructive vascular operation is an effective surgical approach to kinking and coiling of the internal carotid artery. For some risk exists, all-round evaluation should be performed before operation, and operative indication should be strictly controlled. Source


Zhipeng X.,Liaocheng University | Aifang S.,Liaocheng Brain Hospital
Proceedings - 2011 10th International Symposium on Distributed Computing and Applications to Business, Engineering and Science, DCABES 2011 | Year: 2011

In modeling of fetal macrosomia, some inconsistent data are mixed in samples. Because the procedure of childbearing has been finished, the sample data can not be validated by visiting previous pregnant woman. In order to eliminate the inaccurate samples, a counter propagation neural network is established. Some traditional methods are also used to verify the discarded samples. The new training set shows better classification than original data set. © 2011 IEEE. Source


Zhu J.-X.,Liaocheng Brain Hospital | Li Z.-M.,Liaocheng Brain Hospital | Geng F.-Y.,Liaocheng Brain Hospital | Fu Q.,Liaocheng Brain Hospital | And 4 more authors.
Chinese Journal of Cancer Prevention and Treatment | Year: 2010

OBJECTIVE: To evaluate the efficacy and toxicity of combination therapy with surgery and recombinant human adenovirus-p53 (rAd-p53) for the recurrent malignant gliomas. METHODS: Thirty-eight patients with recurrent malignant gliomas received surgery. Eighteen patients of the combined treatment group(syrgery and rAd-p53)placed Ommaya reserviors into the tumor cavities after the resection of the tumors and received regular rAd-p53 therapy after the operation. Another 20 patients received surgery only. All the patients were followed up for more than one year. RESULTS: The 6-month and 1-year survial rates after the combination therapy were 66.7% (14/18) and 44.4% (8/18) respectively. The median survial time was (42.4±3.1) weeks. Compared with the surgery only group, the combined treatment group achieved significient improvement (P<0.05). Karnofsky scores significantly was improved 6 months after the combination therapy (P<0.05). CONCLUSIONS: rAd-p53 is safe and effective to recurrent malignant gliomas. The combination therapy may improve the life quality and the prognosis of patients with recurrent malignant gliomas. Source

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