Lianshui County Peoples Hospital

Qingshui, China

Lianshui County Peoples Hospital

Qingshui, China
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Ou Q.,Shihezi University | Cheng J.,Shihezi University | Zhang L.,Shihezi University | Wang H.,Shihezi University | And 2 more authors.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine | Year: 2017

Breast cancer is one of the leading malignant tumors that endanger women's health worldwide. Despite the rapid progress on the therapies, including chemotherapy, surgical resection, and other auxiliary methods, there were still numerous people died of breast cancer, which promoted the researchers to concentrate on the prognostic factor of breast cancer. In recent years, an increasing number of studies have been focused on the prognostic value of pretreatment neutrophil-to-lymphocyte ratio in breast cancer. This article is a brief review of the associations between neutrophil-to-lymphocyte ratio and the prognosis of breast cancer patients, which may give a greater insight into the development of breast cancer and enable clinicians to cure it completely.


Pu J.,Lianshui County Peoples Hospital | Xu Y.-Y.,Nanjing Medical University | Dai T.-T.,Nanjing Medical University | Peng J.,Nanjing Medical University
Latin American Journal of Pharmacy | Year: 2017

Esophageal cancer remains to be one of the most severe cancers to threaten the health of humans, and many drugs have been used to treat esophageal cancer. Acetochlor, chloroacetanilide herbicide, is a selective preemergent herbicide exerting efficient controlling ability towards broadleaf weeds and annual grassed in corn fields for approximately 40 years. High possibility exists for the exposure of acetochlor in the patients taking esophageal cancer treatment drugs. Therefore, this study aims to determine the inhibition of drug-metabolizing enzymes (DMEs) involved in the metabolism of esophageal cancer treatment drugs. In vitro recombinant UGTs-catalyzed glucuronidation of 4-methylumbelliferone (4-MU) was selected as the probe reaction to evaluate the inhibition potential of acetochlor on phase II DMEs UDP-glucuronosyltransferases (UGTs). The results showed that 100 μM of acetochlor did not show significant inhibition towards UGT1A1, -1A7, -1A9, -1A10, and -2B17. In the contrast, 100 μM of acetochlor inhibited 32.5% activity of UGT1A3 (p < 0.001) and inhibited 90.4% activity of UGT2B7 (p < 0.001). Interestingly, acetochlor (100 μM) increased 1.8-fold activity of UGT1A8 (p < 0.05). Therefore, should be given much attention to acetochlor-drugs interaction when the exposure of acetochlor occurs in the patients taking drugs mainly undergoing UGT1A3, UGT2B7-catalyzed metabolism. © 2017, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved.


Song W.,Nanjing Medical University | Yan C.-Y.,Lianshui County Peoples Hospital | Zhou Q.-Q.,Huaian Industrial Park Peoples Hospital | Zhen L.-L.,Nanjing Medical University
Biomedicine and Pharmacotherapy | Year: 2017

Breast cancer is reported as the most frequent tumor with limited treatments among the female worldwide. Galangin, a natural active compound 3, 5, 7-trihydroxyflavone, is a type of bioflavonoid isolated from the Alpinia galangal root and suggested to induce apoptosis in various cancers. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an effective anti-tumor agent for human breast cancer. Promoted expression of CHOP, a down-streaming transcription factor for endoplasmic reticulum stress (ER stress), enhanced death factor 4 (DR4) activity and accelerated reactive oxygen species (ROS) as well as cell death. Adenosine monophosphate-activated protein kinase (AMPK) is crucial for various cancers mortality. In the present study, galangin regulated ER stress to augment CHOP and DR4 expression levels, sensitizing TRAIL activity, leading to human breast cancer cell apoptosis through Caspase-3 activation, which was associated with AMPK phosphorylation. In addition, AMPK inhibition and silence reduced anti-cancer activity of galangin and TRAIL in combinational treatment. Hence, our study indicated that galangin could effectively stimulate human breast cancer cells to TRAIL-induced apoptosis through TRAIL/Caspase-3/AMPK signaling pathway. AMPK signaling pathway activation by galangin might be of benefit for promoting the effects of TRAIL-regulated anti-tumor therapeutic strategy. © 2017 Elsevier Masson SAS


Qing Z.S.,Nanjing Medical University | Zhang X.S.,Lianshui County Peoples Hospital | Gao C.C.,Nanjing Medical University | Liu W.D.,Nanjing Medical University | And 3 more authors.
Genetics and Molecular Research | Year: 2015

We explored the protective effect of ischemia preconditioning (IP) on ischemia-reperfusion injury in rat liver transplantation. An orthotopic liver transplantation model was utilized in the study. A total of 54 Sprague-Dawley rats were divided into a control group (group A, no liver transplantation), liver transplantation group (group B, heparin Ringer’s lactate solution was perfused via the portal vein before donor liver collection), and liver transplantation with IP group (group C, IP was performed for different time periods before donor liver collection). Liver function, B-cell lymphoma 2 expression in hepatic cells, cell apoptosis, and cellular ultrastructure changes were detected after surgery. After surgery, serum alanine aminotransferase activity was significantly higher in group B than in group A, while it was not clearly enhanced in group C and decreased progressively with increasing cycles of IP as bile capacity gradually increased. Compared with group B, group C showed alleviated injury of hepatic cells, increased B-cell lymphoma 2 expression, and a lower apoptosis index. IP had a protective effect on ischemia-reperfusion injury in rat liver transplantation, and the mechanism correlated with increased B-cell lymphoma 2 expression in hepatic cells and inhibition of cell apoptosis. © FUNPEC-RP.


Pu J.,Lianshui County Peoples Hospital | Qin S.-S.,Nanjing Medical University | Ding J.-X.,Nanjing Medical University | Zhang Y.,Nanjing Medical University | And 9 more authors.
Journal of Cancer Research and Clinical Oncology | Year: 2013

Background: This study explored whether docetaxel/cisplatin and radiotherapy (TP-R) increases overall survival (OS) and recurrence-free survival (RFS) compared to single-agent cisplatin and radiotherapy (C-R) in patients with high-risk early-stage cervical cancer post surgery. Methods: Patients with clinical stage IB and IIA carcinoma of the cervix, initially treated with radical hysterectomy and pelvic lymphadenectomy, and who had positive pelvic lymph nodes and/or positive margins and/or the diameter of the primary tumor ≥4 cm and/or depth of interstitial infiltration ≥1/2 and/or lymphovascular space invasion were eligible for this study. Patients were randomized to receive C-R or TP-R. Radiotherapy in both groups was external radiation (46-54 Gy) followed by high-dose rate brachytherapy (12-24 Gy). Patients were given cisplatin (40 mg/m2) every week for five cycles (C-R group) or docetaxel (30 mg/m2) and cisplatin (30 mg/m2) every week for five cycles (TP-R group). Results: Between 2003 and 2008, 320 patients were entered onto the study. Final analyses included 285 patients. One hundred and forty patients comprised the C-R group and 145 were in the TP-R group. The 5-year OS were 74.3 % in the C-R group and 82.8 % in the TP-R group. The hazard ratio (HR) for death was 0.65 in the TP-R group (95 % CI: 0.39-1.09, P = 0.098). The RFS were 69.3 % in the C-R group and 79.3 % in the TP-R group, and the HR for recurrence was 0.64 in the TP-R group (95 % CI: 0.40-1.03, P = 0.061). Recurrence rates were similar in both groups (27 in the C-R group and 18 in the TP-R group, P = 0.112). The seriousness of late side effects was similar in the two groups, with a higher rate of reversible hematological effects in the TP-R group. Conclusions: Compared with single-agent cisplatin and radiotherapy, docetaxel/cisplatin in combination with radiotherapy does not increase OS but has the trend of increasing RFS in patients with high-risk early-stage cervical cancer. However, docetaxel/cisplatin in combination with radiotherapy is associated with a higher incidence of side effects, this effect was reversible, and the incidence of late side effects was similar in the two treatment groups. © 2013 Springer-Verlag Berlin Heidelberg.


Chen G.,Lianshui County Peoples Hospital | Peng J.,Nanjing Medical University | Zhu W.,Nanjing Medical University | Tao G.,Nanjing Medical University | And 3 more authors.
Medical Oncology | Year: 2014

microRNA-133a (miR-133a) and miR-133b, located on chromosome 18 in the same bicistronic unit, have been commonly identified as being downregulated in esophageal squamous cell carcinoma (ESCC). The aim of this study was to investigate the correlation of miR-133a/b expression with efficacy of paclitaxel-based chemotherapy and clinical outcome of ESCC patients. miR-133a expression and miR-133b expression were examined in 100 newly diagnosed ESCC patients prior to treatment by quantitative real-time PCR. Then, the patients received four cycles of paclitaxel-based chemotherapy, the short-term treatment efficacy was evaluated, and a 3-year follow-up was performed. Expression levels of miR-133a and miR-133b were both significantly lower in ESCC tissues compared to adjacent noncancerous tissues (both P < 0.001). In addition, combined miR-133a/b downregulation was found to be closely correlated with advanced tumor stage (P = 0.02) and poor differentiation (P = 0.01). Moreover, the response rate of ESCC patients to paclitaxel-based chemotherapy was significantly higher in combined miR-133a/b downregulation group compared with other groups (P = 0.02). Furthermore, univariate and multivariate Cox analyses revealed that tumor stage and combined expression of miR-133a/b were independent prognosis factors in ESCC patients. Our data offer the convincing evidence that combined expression of miR-133a and miR-133b may predict chemosensitivity of patients with ESCC undergoing paclitaxel-based chemotherapy, implying its importance in applying ‘personalized cancer medicine’ in the clinical treatment of ESCC. We also identified combined expression of miR-133a and miR-133b as an effective prognostic marker of this malignancy. © 2014, Springer Science+Business Media New York.


Zhang X.-S.,LianShui County Peoples Hospital | Zhao Z.-Q.,HuaiAn Second Peoples Hospital | Qin Z.-S.,Nanjing Medical University | Wu K.,Nanjing Medical University | And 2 more authors.
European Journal of Drug Metabolism and Pharmacokinetics | Year: 2015

Herb-drug interaction strongly limits the clinical utilization of herbs and drugs. Irinotecan-induced diarrhea is closely related with the UDP-glucuronosyltransferase 1A1-catalyzed glucuronidation of SN-38 which has been widely regarded to be the toxic substance basis of irinotecan. The present study aims to determine the influence of herbal component psoralidin toward the toxicity of irinotecan. In vitro inhibition potential of psoralidin toward the glucuronidation of SN-38 was firstly investigated using human intestinal microsomes incubation system. Dose-dependent inhibition of psoralidin toward SN-38 glucuronidation was observed. Furthermore, Dixon plot showed that the intersection point was located in the second quadrant, indicating the competitive inhibition of psoralidin toward the glucuronidation of SN-38. Through the data fitting using competitive inhibition fitting equation, the inhibition kinetic parameter (K i) was calculated to be 5.8 μM. The translation of these in vitro data into the in vivo situation showed that pre-treatment with psoralidin significantly increased the toxicity of irinotecan, as indicated by the increased body weight loss and more severe colon histology damage. All these data indicated the herb-drug interaction between irinotecan and psoralidin-containing herbs. © 2014 Springer International Publishing Switzerland.


Zuo X.-F.,Lianshui County Peoples Hospital | Li J.-X.,Nanjing Medical University | Zhou W.-D.,Nanjing Medical University
Biomedical Research (India) | Year: 2014

Recent studies have shown that zinc, iron, vitamin A and other nutrients are closely related to the body's resistance to infection. This study was aimed to investigate the nutrient status of Chinese infants with pneumonia and reveal the relationship between nutrients and the outcome of pneumonia. Total 120 infants with pneumonia and 60 healthy infants aged 6 to 36 months were enrolled in this study as diseased and control groups. Serum levels of zinc, calcium, magnesium, iron, vitamin A and vitamin D were measured, and the values were compared between the two groups. We found that the incidences of iron, zinc, and vitamin A deficiency were significantly higher in diseased group than in control group (p<0.05), while the incidences of calcium, magnesium and vitamin D deficiency had no significant differences (p>0.05). Serum levels of zinc, iron, and vitamin A were significantly lower in diseased group than in control group (p<0.05), while those of calcium, magnesium and vitamin D had no significant difference (p>0.05). In conclusion, Zinc, iron, and vitamin A deficiency were observed among Chinese children with pneumonia. Zinc, iron and vitamin A supplementation may be helpful for the prevention and treatment of infant pneumonia.


Chen G.,Lianshui County Peoples Hospital | Peng J.,Lianshui County Peoples Hospital | Zhu W.,Lianshui County Peoples Hospital | Tao G.,Lianshui County Peoples Hospital | And 3 more authors.
Medical oncology (Northwood, London, England) | Year: 2014

microRNA-133a (miR-133a) and miR-133b, located on chromosome 18 in the same bicistronic unit, have been commonly identified as being downregulated in esophageal squamous cell carcinoma (ESCC). The aim of this study was to investigate the correlation of miR-133a/b expression with efficacy of paclitaxel-based chemotherapy and clinical outcome of ESCC patients. miR-133a expression and miR-133b expression were examined in 100 newly diagnosed ESCC patients prior to treatment by quantitative real-time PCR. Then, the patients received four cycles of paclitaxel-based chemotherapy, the short-term treatment efficacy was evaluated, and a 3-year follow-up was performed. Expression levels of miR-133a and miR-133b were both significantly lower in ESCC tissues compared to adjacent noncancerous tissues (both P < 0.001). In addition, combined miR-133a/b downregulation was found to be closely correlated with advanced tumor stage (P = 0.02) and poor differentiation (P = 0.01). Moreover, the response rate of ESCC patients to paclitaxel-based chemotherapy was significantly higher in combined miR-133a/b downregulation group compared with other groups (P = 0.02). Furthermore, univariate and multivariate Cox analyses revealed that tumor stage and combined expression of miR-133a/b were independent prognosis factors in ESCC patients. Our data offer the convincing evidence that combined expression of miR-133a and miR-133b may predict chemosensitivity of patients with ESCC undergoing paclitaxel-based chemotherapy, implying its importance in applying 'personalized cancer medicine' in the clinical treatment of ESCC. We also identified combined expression of miR-133a and miR-133b as an effective prognostic marker of this malignancy.


PubMed | Lianshui County Peoples Hospital
Type: Journal Article | Journal: Medical oncology (Northwood, London, England) | Year: 2014

microRNA-133a (miR-133a) and miR-133b, located on chromosome 18 in the same bicistronic unit, have been commonly identified as being downregulated in esophageal squamous cell carcinoma (ESCC). The aim of this study was to investigate the correlation of miR-133a/b expression with efficacy of paclitaxel-based chemotherapy and clinical outcome of ESCC patients. miR-133a expression and miR-133b expression were examined in 100 newly diagnosed ESCC patients prior to treatment by quantitative real-time PCR. Then, the patients received four cycles of paclitaxel-based chemotherapy, the short-term treatment efficacy was evaluated, and a 3-year follow-up was performed. Expression levels of miR-133a and miR-133b were both significantly lower in ESCC tissues compared to adjacent noncancerous tissues (both P < 0.001). In addition, combined miR-133a/b downregulation was found to be closely correlated with advanced tumor stage (P = 0.02) and poor differentiation (P = 0.01). Moreover, the response rate of ESCC patients to paclitaxel-based chemotherapy was significantly higher in combined miR-133a/b downregulation group compared with other groups (P = 0.02). Furthermore, univariate and multivariate Cox analyses revealed that tumor stage and combined expression of miR-133a/b were independent prognosis factors in ESCC patients. Our data offer the convincing evidence that combined expression of miR-133a and miR-133b may predict chemosensitivity of patients with ESCC undergoing paclitaxel-based chemotherapy, implying its importance in applying personalized cancer medicine in the clinical treatment of ESCC. We also identified combined expression of miR-133a and miR-133b as an effective prognostic marker of this malignancy.

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