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Li X.,Peking Union Medical College | Wei D.,Liangshan Yi Autonomous Prefectural Center for Disease Control and Prevention | He H.,Peking Union Medical College | Zhang J.,Liangshan Yi Autonomous Prefectural Center for Disease Control and Prevention | And 11 more authors.
Asia Pacific Journal of Clinical Nutrition | Year: 2012

The metabolic syndrome is a cluster of abnormalities characterized by obesity, impaired glucose metabolism, hypertension or elevated blood pressure, and dyslipidemia. The aim of this study was to investigate the association of the adiponectin gene (ADIPOQ) +45 T > G polymorphism with the metabolic syndrome among Han Chinese in Sichuan province of China. A case-control design was used including 116 patients with the metabolic syndrome and 108 unrelated controls, matched on age and gender. The ADIPOQ +45G allele (TG+GG) had a significant association with risk of the metabolic syndrome (odds ratio=1.88, 95% confidence interval: 1.03-3.44, p=0.039) adjusted for education, physical activity, family history of related diseases, smoking and drinking, compared with subjects with TT genotype. The association between the ADIPOQ +45 T>G polymorphism and the metabolic syndrome was independent of multiple confounders. Source


Shan G.L.,Chinese Academy of Sciences | Wei D.Y.,Liangshan Yi Autonomous Prefectural Center for Disease Control and Prevention | Wang C.X.,Capital Medical University | Zhang J.H.,Liangshan Yi Autonomous Prefectural Center for Disease Control and Prevention | And 7 more authors.
Biomedical and Environmental Sciences | Year: 2012

Objective: To examine the relationship between overweight or obesity and the risk of the various hypertension hemodynamic subtypes in Yi farmers and migrants. Methods: A cross-sectional study of 2 358 Yi farmers and 1 392 Yi migrants was carried out in the Liangshan Yi autonomous prefecture, Sichuan, China in 2007. Results: The standardized prevalence of overweight in female Yi farmers (6.22) was higher than in males (3.15), whereas in Yi migrants 31.56 of males and 18.78 of females were overweight. The standardized prevalence of obesity was 0 and 0.61 in male and female Yi farmers, compared to 3.91 and 5.57 in male and female Yi migrants, respectively. For both genders the standardized prevalence of ISH, IDH, and SDH was higher in Yi migrants than Yi farmers. Overweight and obese Yi men and women had a higher risk for IDH and SDH (P<0.001) than non-overweight/obese individuals. However, an association of overweight or obesity with ISH was observed only in men. Conclusion: Yi migrants have substantially higher proportion of overweight and obese individuals, as well as individuals affected by ISH, IDH, and SDH, than do Yi farmers. Overweight and obesity are significant risk factors for the development of hypertension in Yi people. © 2012 The Editorial Board of Biomedical and Environmental Sciences. Source


Shan G.,Peking Union Medical College | Wei D.,Liangshan Yi Autonomous Prefectural Center for Disease Control and Prevention | Wang C.,Peking Union Medical College | Zhang J.,Liangshan Yi Autonomous Prefectural Center for Disease Control and Prevention | And 6 more authors.
Biomedical and Environmental Sciences | Year: 2011

To evaluate trends of overweight and obesity prevalence between 1996 and 2007 in Yi farmers and Yi migrants. An Yi migrant study was conducted in Liangshan Yi Autonomous Prefecture, Sichuan Province, China from 1996 to 2007. Data were collected with identical methods, including standardized questionnaire and body measurements. Age- and sex-specific body mass index (BMI) significantly increased from 20.02 in 1996 to 22.36 in 2007, among Yi farmers, which was significantly different from those among Yi migrants (23.67 in 2007 and 20.90 in 1996) (P<0.05). Prevalence of obesity rose from 1.21 in 1996 to 4.55 in 2007 (OR=1.15, P<0.001) in Yi migrants, while that in Yi farmers from none in 1996 to 0.12 in 2007 (P>0.05). Prevalence of overweight rose significantly to 26.24 in 2007 from 17.24 in 1996 (OR=1.06, P<0.001) in Yi migrants, while that in Yi farmers from 1.29 in 1996 to 4.45 in 2007 (OR=1.14, P>0.001). Yi migrants appeared to have a 5.52-fold higher risk on developing overweight and obesity than Yi farmers have. The Yi migrants had a steeper increase of overweight with year and consequently caused more obesity. Change in lifestyle may contribute most likely to higher prevalence of overweight and obesity in Yi migrants. © 2011 The Editorial Board of Biomedical and Environmental Sciences. Source

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