LIA 1066 French Russian Joint Cancer Research Laboratory

France, Russia

LIA 1066 French Russian Joint Cancer Research Laboratory

France, Russia
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Kovina A.P.,Russian Academy of Sciences | Petrova N.V.,Russian Academy of Sciences | Gushchanskaya E.S.,Russian Academy of Sciences | Dolgushin K.V.,Russian Academy of Sciences | And 11 more authors.
Molecular Biology and Evolution | Year: 2017

The genomes are folded in a complex three-dimensional (3D) structure. Some features of this organization are common for all eukaryotes, but little is known about its evolution. Here, we have studied the 3D organization and regulation of zebrafish globin gene domain and compared its organization and regulation with those of other vertebrate species. In birds and mammals, the α- and β-globin genes are segregated into separate clusters located on different chromosomes and organized into chromatin domains of different types, whereas in cold-blooded vertebrates, including Danio rerio, α- and β-globin genes are organized into common clusters. The major globin gene locus of Danio rerio is of particular interest as it is located in a genomic area that is syntenic in vertebrates and is controlled by a conserved enhancer. We have found that the major globin gene locus of Danio rerio is structurally and functionally segregated into two spatially distinct subloci harboring either adult or embryo-larval globin genes. These subloci demonstrate different organization at the level of chromatin domains and different modes of spatial organization, which appears to be due to selective interaction of the upstream enhancer with the sublocus harboring globin genes of the adult type. These data are discussed in terms of evolution of linear and 3D organization of gene clusters in vertebrates. © The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved.


Sklyar I.V.,University Paris - Sud | Sklyar I.V.,Russian Academy of Sciences | Iarovaia O.V.,Russian Academy of Sciences | Lipinski M.,University Paris - Sud | And 2 more authors.
Biopolymers and Cell | Year: 2014

Translocations involving human immunoglobulin heavy chain (IGH) locus are implicated in different leukaemias and lymphomas, including multiple myeloma, mantle cell lymphoma, Burkitt’s lymphoma and diffuse large B cell lymphoma. We have analysed published data and identified eleven breakpoint cluster regions (bcr) related to these cancers within the IgH locus. These ~1 kbp bcrs are specific for one or several types of blood cancer. Our findings could help devise PCR-based assays to detect cancer-related translocations, to identify the mechanisms of translocations and to help in the research of potential translocation partners of the immunoglobulin locus at different stages of B-cell differentiation. © Institute of Molecular Biology and Genetics, NAS of Ukraine, 2014.


Musinova Y.R.,Moscow State University | Sheval E.V.,Moscow State University | Dib C.,LIA 1066 French Russian Joint Cancer Research Laboratory | Dib C.,University Paris - Sud | And 4 more authors.
Cellular and Molecular Life Sciences | Year: 2016

Human immunodeficiency virus-1 (HIV-1) Tat protein is one of the most important regulatory proteins for viral gene expression in the host cell and can modulate different cellular processes. In addition, Tat is secreted by the infected cell and can be internalized by neighboring cells; therefore, it affects both infected and uninfected cells. Tat can modulate cellular processes by interacting with different cellular structures and signaling pathways. In the nucleus, Tat might be localized either in the nucleoplasm or the nucleolus depending on its concentration. Here we review the distinct functions of Tat in the nucleoplasm and the nucleolus in connection with viral infection and HIV-induced oncogenesis. © 2015 Springer Basel.


Razin S.V.,Russian Academy of Sciences | Razin S.V.,Moscow State University | Borunova V.V.,Moscow State University | Iarovaia O.V.,Russian Academy of Sciences | And 2 more authors.
Biochemistry (Moscow) | Year: 2014

Becoming popular at the end of the 20th century, the concept of the nuclear matrix implies the existence of a nuclear skeleton that organizes functional elements in the cell nucleus. This review presents a critical analysis of the results obtained in the study of nuclear matrix in the light of current views on the organization of the cell nucleus. Numerous studies of nuclear matrix have failed to provide evidence of the existence of such a structure. Moreover, the existence of a filamentous structure that supports the nuclear compartmentalization appears to be unnecessary, since this function is performed by the folded genome itself. © 2014 Pleiades Publishing, Ltd.


Razin S.V.,Russian Academy of Sciences | Iarovaia O.V.,Russian Academy of Sciences | Vassetzky Y.S.,LIA 1066 French Russian Joint Cancer Research Laboratory | Vassetzky Y.S.,University Paris - Sud
Chromosoma | Year: 2014

The first papers coining the term "nuclear matrix" were published 40 years ago. Here, we review the data obtained during the nuclear matrix studies and discuss the contribution of this controversial concept to our current understanding of nuclear architecture and three-dimensional organization of genome. © Springer-Verlag 2014.


PubMed | Moscow State University and LIA 1066 French Russian Joint Cancer Research Laboratory
Type: Journal Article | Journal: Cellular and molecular life sciences : CMLS | Year: 2016

Human immunodeficiency virus-1 (HIV-1) Tat protein is one of the most important regulatory proteins for viral gene expression in the host cell and can modulate different cellular processes. In addition, Tat is secreted by the infected cell and can be internalized by neighboring cells; therefore, it affects both infected and uninfected cells. Tat can modulate cellular processes by interacting with different cellular structures and signaling pathways. In the nucleus, Tat might be localized either in the nucleoplasm or the nucleolus depending on its concentration. Here we review the distinct functions of Tat in the nucleoplasm and the nucleolus in connection with viral infection and HIV-induced oncogenesis.

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