LGC Forensics

Abingdon, United Kingdom

LGC Forensics

Abingdon, United Kingdom
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Haas C.,University of Zürich | Hanson E.,University of Central Florida | Anjos M.J.,National Institute of Legal Medicine | Bar W.,University of Zürich | And 31 more authors.
Forensic Science International: Genetics | Year: 2012

A second collaborative exercise on RNA/DNA co-analysis for body fluid identification and STR profiling was organized by the European DNA Profiling Group (EDNAP). Six human blood stains, two blood dilution series (5-0.001 μl blood) and, optionally, bona fide or mock casework samples of human or non-human origin were analyzed by the participating laboratories using a RNA/DNA co-extraction or solely RNA extraction method. Two novel mRNA multiplexes were used for the identification of blood: a highly sensitive duplex (HBA, HBB) and a moderately sensitive pentaplex (ALAS2, CD3G, ANK1, SPTB and PBGD). The laboratories used different chemistries and instrumentation. All of the 18 participating laboratories were able to successfully isolate and detect mRNA in dried blood stains. Thirteen laboratories simultaneously extracted RNA and DNA from individual stains and were able to utilize mRNA profiling to confirm the presence of blood and to obtain autosomal STR profiles from the blood stain donors. The positive identification of blood and good quality DNA profiles were also obtained from old and compromised casework samples. The method proved to be reproducible and sensitive using different analysis strategies. The results of this collaborative exercise involving a RNA/DNA co-extraction strategy support the potential use of an mRNA based system for the identification of blood in forensic casework that is compatible with current DNA analysis methodology. © 2011 Elsevier Ireland Ltd. All rights reserved.


Haas C.,University of Zürich | Hanson E.,University of Central Florida | Anjos M.J.,National Institute of Legal Medicine | Banemann R.,Bundeskriminalamt | And 35 more authors.
Forensic Science International: Genetics | Year: 2013

A third collaborative exercise on RNA/DNA co-analysis for body fluid identification and STR profiling was organized by the European DNA Profiling Group (EDNAP). Twenty saliva and semen stains, four dilution series (10-0.01 μl saliva, 5-0.01 μl semen) and, optionally, bona fide or mock casework samples of human or non-human origin were analyzed by 20 participating laboratories using an RNA extraction or RNA/DNA co-extraction method. Two novel mRNA multiplexes were used: a saliva triplex (HTN3, STATH and MUC7) and a semen pentaplex (PRM1, PRM2, PSA, SEMG1 and TGM4). The laboratories used different chemistries and instrumentation and a majority (16/20) were able to successfully isolate and detect mRNA in dried stains. The simultaneous extraction of RNA and DNA from individual stains not only permitted a confirmation of the presence of saliva/semen (i.e. tissue/fluid source of origin), but allowed an STR profile of the stain donor to be obtained as well. The method proved to be reproducible and sensitive, with as little as 0.05 μl saliva or semen, using different analysis strategies. Additionally, we demonstrated the ability to positively identify the presence of saliva and semen, as well as obtain high quality DNA profiles, from old and compromised casework samples. The results of this collaborative exercise involving an RNA/DNA co-extraction strategy support the potential use of an mRNA based system for the identification of saliva and semen in forensic casework that is compatible with current DNA analysis methodologies. © 2012 Elsevier Ireland Ltd.


News Article | November 29, 2016
Site: www.newsmaker.com.au

Wiseguyreports.Com Adds “Forensic Technologies -Market Demand, Growth, Opportunities and analysis of Top Key Player Forecast to 2021” To Its Research Database This report studies sales (consumption) of Forensic Technologies in Global market, especially in United States, China, Europe, Japan, focuses on top players in these regions/countries, with sales, price, revenue and market share for each player in these regions, covering Market Segment by Regions, this report splits Global into several key Regions, with sales (consumption), revenue, market share and growth rate of Forensic Technologies in these regions, from 2011 to 2021 (forecast), like United States China Europe Japan Split by product Types, with sales, revenue, price and gross margin, market share and growth rate of each type, can be divided into Type I Type II Type III Split by applications, this report focuses on sales, market share and growth rate of Forensic Technologies in each application, can be divided into Application 1 Application 2 Application 3 Global Forensic Technologies Sales Market Report 2016 1 Forensic Technologies Overview 1.1 Product Overview and Scope of Forensic Technologies 1.2 Classification of Forensic Technologies 1.2.1 Type I 1.2.2 Type II 1.2.3 Type III 1.3 Application of Forensic Technologies 1.3.1 Application 1 1.3.2 Application 2 1.3.3 Application 3 1.4 Forensic Technologies Market by Regions 1.4.1 United States Status and Prospect (2011-2021) 1.4.2 China Status and Prospect (2011-2021) 1.4.3 Europe Status and Prospect (2011-2021) 1.4.4 Japan Status and Prospect (2011-2021) 1.5 Global Market Size (Value and Volume) of Forensic Technologies (2011-2021) 1.5.1 Global Forensic Technologies Sales and Growth Rate (2011-2021) 1.5.2 Global Forensic Technologies Revenue and Growth Rate (2011-2021) 7 Global Forensic Technologies Manufacturers Analysis 7.1 Agilent Technologies 7.1.1 Company Basic Information, Manufacturing Base and Competitors 7.1.2 Forensic Technologies Product Type, Application and Specification 7.1.2.1 Type I 7.1.2.2 Type II 7.1.3 Agilent Technologies Forensic Technologies Sales, Revenue, Price and Gross Margin (2011-2016) 7.1.4 Main Business/Business Overview 7.2 Eurofins 7.2.1 Company Basic Information, Manufacturing Base and Competitors 7.2.2 128 Product Type, Application and Specification 7.2.2.1 Type I 7.2.2.2 Type II 7.2.3 Eurofins Forensic Technologies Sales, Revenue, Price and Gross Margin (2011-2016) 7.2.4 Main Business/Business Overview 7.3 LGC Forensics 7.3.1 Company Basic Information, Manufacturing Base and Competitors 7.3.2 145 Product Type, Application and Specification 7.3.2.1 Type I 7.3.2.2 Type II 7.3.3 LGC Forensics Forensic Technologies Sales, Revenue, Price and Gross Margin (2011-2016) 7.3.4 Main Business/Business Overview 7.4 NMS Labs 7.4.1 Company Basic Information, Manufacturing Base and Competitors 7.4.2 Nov Product Type, Application and Specification 7.4.2.1 Type I 7.4.2.2 Type II 7.4.3 NMS Labs Forensic Technologies Sales, Revenue, Price and Gross Margin (2011-2016) 7.4.4 Main Business/Business Overview 7.5 Thermo Fisher Scientific 7.5.1 Company Basic Information, Manufacturing Base and Competitors 7.5.2 Product Type, Application and Specification 7.5.2.1 Type I 7.5.2.2 Type II 7.5.3 Thermo Fisher Scientific Forensic Technologies Sales, Revenue, Price and Gross Margin (2011-2016) 7.5.4 Main Business/Business Overview 7.6 ACR Data Recovery 7.6.1 Company Basic Information, Manufacturing Base and Competitors 7.6.2 Million USD Product Type, Application and Specification 7.6.2.1 Type I 7.6.2.2 Type II 7.6.3 ACR Data Recovery Forensic Technologies Sales, Revenue, Price and Gross Margin (2011-2016) 7.6.4 Main Business/Business Overview 7.7 BAE Systems 7.7.1 Company Basic Information, Manufacturing Base and Competitors 7.7.2 Service Product Type, Application and Specification 7.7.2.1 Type I 7.7.2.2 Type II 7.7.3 BAE Systems Forensic Technologies Sales, Revenue, Price and Gross Margin (2011-2016) 7.7.4 Main Business/Business Overview 7.8 Bio-Rad Laboratories 7.8.1 Company Basic Information, Manufacturing Base and Competitors 7.8.2 Product Type, Application and Specification 7.8.2.1 Type I 7.8.2.2 Type II 7.8.3 Bio-Rad Laboratories Forensic Technologies Sales, Revenue, Price and Gross Margin (2011-2016) 7.8.4 Main Business/Business Overview 7.9 Capsicum Group 7.9.1 Company Basic Information, Manufacturing Base and Competitors 7.9.2 Product Type, Application and Specification 7.9.2.1 Type I 7.9.2.2 Type II 7.9.3 Capsicum Group Forensic Technologies Sales, Revenue, Price and Gross Margin (2011-2016) 7.9.4 Main Business/Business Overview 7.10 Computer Forensics 7.10.1 Company Basic Information, Manufacturing Base and Competitors 7.10.2 Product Type, Application and Specification 7.10.2.1 Type I 7.10.2.2 Type II 7.10.3 Computer Forensics Forensic Technologies Sales, Revenue, Price and Gross Margin (2011-2016) 7.10.4 Main Business/Business Overview 7.11 Creative Forensic Services 7.12 Cyber Agents 7.13 Forensics Consulting Solutions 7.14 Forensic Pathways 7.15 Foster + Freeman 7.16 Global Digital Forensics 7.17 IntegenX 7.18 Leica Geosystems 7.19 MorphoTrust USA 7.20 Neogen 7.21 Orchid Cellmark 7.22 PAPILLON ZAO 7.23 Tri-Tech Forensics


News Article | November 29, 2016
Site: marketersmedia.com

Wiseguyreports.Com Adds “Forensic Technologies -Market Demand, Growth, Opportunities and analysis of Top Key Player Forecast to 2021” To Its Research Database This report studies sales (consumption) of Forensic Technologies in Global market, especially in United States, China, Europe, Japan, focuses on top players in these regions/countries, with sales, price, revenue and market share for each player in these regions, covering Market Segment by Regions, this report splits Global into several key Regions, with sales (consumption), revenue, market share and growth rate of Forensic Technologies in these regions, from 2011 to 2021 (forecast), like United States China Europe Japan Split by product Types, with sales, revenue, price and gross margin, market share and growth rate of each type, can be divided into Type I Type II Type III Split by applications, this report focuses on sales, market share and growth rate of Forensic Technologies in each application, can be divided into Application 1 Application 2 Application 3 Global Forensic Technologies Sales Market Report 2016 1 Forensic Technologies Overview 1.1 Product Overview and Scope of Forensic Technologies 1.2 Classification of Forensic Technologies 1.2.1 Type I 1.2.2 Type II 1.2.3 Type III 1.3 Application of Forensic Technologies 1.3.1 Application 1 1.3.2 Application 2 1.3.3 Application 3 1.4 Forensic Technologies Market by Regions 1.4.1 United States Status and Prospect (2011-2021) 1.4.2 China Status and Prospect (2011-2021) 1.4.3 Europe Status and Prospect (2011-2021) 1.4.4 Japan Status and Prospect (2011-2021) 1.5 Global Market Size (Value and Volume) of Forensic Technologies (2011-2021) 1.5.1 Global Forensic Technologies Sales and Growth Rate (2011-2021) 1.5.2 Global Forensic Technologies Revenue and Growth Rate (2011-2021) 7 Global Forensic Technologies Manufacturers Analysis 7.1 Agilent Technologies 7.1.1 Company Basic Information, Manufacturing Base and Competitors 7.1.2 Forensic Technologies Product Type, Application and Specification 7.1.2.1 Type I 7.1.2.2 Type II 7.1.3 Agilent Technologies Forensic Technologies Sales, Revenue, Price and Gross Margin (2011-2016) 7.1.4 Main Business/Business Overview 7.2 Eurofins 7.2.1 Company Basic Information, Manufacturing Base and Competitors 7.2.2 128 Product Type, Application and Specification 7.2.2.1 Type I 7.2.2.2 Type II 7.2.3 Eurofins Forensic Technologies Sales, Revenue, Price and Gross Margin (2011-2016) 7.2.4 Main Business/Business Overview 7.3 LGC Forensics 7.3.1 Company Basic Information, Manufacturing Base and Competitors 7.3.2 145 Product Type, Application and Specification 7.3.2.1 Type I 7.3.2.2 Type II 7.3.3 LGC Forensics Forensic Technologies Sales, Revenue, Price and Gross Margin (2011-2016) 7.3.4 Main Business/Business Overview 7.4 NMS Labs 7.4.1 Company Basic Information, Manufacturing Base and Competitors 7.4.2 Nov Product Type, Application and Specification 7.4.2.1 Type I 7.4.2.2 Type II 7.4.3 NMS Labs Forensic Technologies Sales, Revenue, Price and Gross Margin (2011-2016) 7.4.4 Main Business/Business Overview 7.5 Thermo Fisher Scientific 7.5.1 Company Basic Information, Manufacturing Base and Competitors 7.5.2 Product Type, Application and Specification 7.5.2.1 Type I 7.5.2.2 Type II 7.5.3 Thermo Fisher Scientific Forensic Technologies Sales, Revenue, Price and Gross Margin (2011-2016) 7.5.4 Main Business/Business Overview 7.6 ACR Data Recovery 7.6.1 Company Basic Information, Manufacturing Base and Competitors 7.6.2 Million USD Product Type, Application and Specification 7.6.2.1 Type I 7.6.2.2 Type II 7.6.3 ACR Data Recovery Forensic Technologies Sales, Revenue, Price and Gross Margin (2011-2016) 7.6.4 Main Business/Business Overview 7.7 BAE Systems 7.7.1 Company Basic Information, Manufacturing Base and Competitors 7.7.2 Service Product Type, Application and Specification 7.7.2.1 Type I 7.7.2.2 Type II 7.7.3 BAE Systems Forensic Technologies Sales, Revenue, Price and Gross Margin (2011-2016) 7.7.4 Main Business/Business Overview 7.8 Bio-Rad Laboratories 7.8.1 Company Basic Information, Manufacturing Base and Competitors 7.8.2 Product Type, Application and Specification 7.8.2.1 Type I 7.8.2.2 Type II 7.8.3 Bio-Rad Laboratories Forensic Technologies Sales, Revenue, Price and Gross Margin (2011-2016) 7.8.4 Main Business/Business Overview 7.9 Capsicum Group 7.9.1 Company Basic Information, Manufacturing Base and Competitors 7.9.2 Product Type, Application and Specification 7.9.2.1 Type I 7.9.2.2 Type II 7.9.3 Capsicum Group Forensic Technologies Sales, Revenue, Price and Gross Margin (2011-2016) 7.9.4 Main Business/Business Overview 7.10 Computer Forensics 7.10.1 Company Basic Information, Manufacturing Base and Competitors 7.10.2 Product Type, Application and Specification 7.10.2.1 Type I 7.10.2.2 Type II 7.10.3 Computer Forensics Forensic Technologies Sales, Revenue, Price and Gross Margin (2011-2016) 7.10.4 Main Business/Business Overview 7.11 Creative Forensic Services 7.12 Cyber Agents 7.13 Forensics Consulting Solutions 7.14 Forensic Pathways 7.15 Foster + Freeman 7.16 Global Digital Forensics 7.17 IntegenX 7.18 Leica Geosystems 7.19 MorphoTrust USA 7.20 Neogen 7.21 Orchid Cellmark 7.22 PAPILLON ZAO 7.23 Tri-Tech Forensics For more information, please visit https://www.wiseguyreports.com/sample-request/770308-global-forensic-technologies-sales-market-report-2016


— DNA forensics is a branch of forensic science that focuses on the use of genetic material in criminal investigation to answer questions pertaining to legal situations, including criminal and civil cases. This report focuses on the DNA Forensic in Global market, especially in North America, Europe and Asia-Pacific, South America, Middle East and Africa. This report categorizes the market based on manufacturers, regions, type and application. For more information or any query mail at sales@wiseguyreports.com Market Segment by Manufacturers, this report covers Roche Thermo Fisher Scientific Illumina Agilent Technologies Laboratory Corporation Promega GE Healthcare QIAGEN LGC Forensics Morpho (Safran) NEC ZyGEM Applied DNA Sciences Inc Market Segment by Regions, regional analysis covers North America (USA, Canada and Mexico) Europe (Germany, France, UK, Russia and Italy) Asia-Pacific (China, Japan, Korea, India and Southeast Asia) South America, Middle East and Africa Market Segment by Applications, can be divided into Law Enforcement Biodefense Healthcare Physical Security There are 13 Chapters to deeply display the global DNA Forensic market. Chapter 2, to analyze the top manufacturers of DNA Forensic, with sales, revenue, and price of DNA Forensic, in 2015 and 2016; Chapter 3, to display the competitive situation among the top manufacturers, with sales, revenue and market share in 2015 and 2016; Chapter 4, to show the global market by regions, with sales, revenue and market share of DNA Forensic, for each region, from 2011 to 2016; 2 Manufacturers Profiles 2.1 Roche 2.1.1 Business Overview 2.1.2 DNA Forensic Type and Applications 2.1.2.1 Type 1 2.1.2.2 Type 2 2.1.3 Roche DNA Forensic Sales, Price, Revenue, Gross Margin and Market Share 2.2 Thermo Fisher Scientific 2.2.1 Business Overview 2.2.2 DNA Forensic Type and Applications 2.2.2.1 Type 1 2.2.2.2 Type 2 2.2.3 Thermo Fisher Scientific DNA Forensic Sales, Price, Revenue, Gross Margin and Market Share 2.3 Illumina 2.3.1 Business Overview 2.3.2 DNA Forensic Type and Applications 2.3.2.1 Type 1 2.3.2.2 Type 2 2.3.3 Illumina DNA Forensic Sales, Price, Revenue, Gross Margin and Market Share 2.4 Agilent Technologies 2.4.1 Business Overview 2.4.2 DNA Forensic Type and Applications 2.4.2.1 Type 1 2.4.2.2 Type 2 2.4.3 Agilent Technologies DNA Forensic Sales, Price, Revenue, Gross Margin and Market Share 2.5 Laboratory Corporation 2.5.1 Business Overview 2.5.2 DNA Forensic Type and Applications 2.5.2.1 Type 1 2.5.2.2 Type 2 2.5.3 Laboratory Corporation DNA Forensic Sales, Price, Revenue, Gross Margin and Market Share 2.6 Promega 2.6.1 Business Overview 2.6.2 DNA Forensic Type and Applications 2.6.2.1 Type 1 2.6.2.2 Type 2 2.6.3 Promega DNA Forensic Sales, Price, Revenue, Gross Margin and Market Share 2.7 GE Healthcare 2.7.1 Business Overview 2.7.2 DNA Forensic Type and Applications 2.7.2.1 Type 1 2.7.2.2 Type 2 2.7.3 GE Healthcare DNA Forensic Sales, Price, Revenue, Gross Margin and Market Share 2.8 QIAGEN 2.8.1 Business Overview 2.8.2 DNA Forensic Type and Applications 2.8.2.1 Type 1 2.8.2.2 Type 2 2.8.3 QIAGEN DNA Forensic Sales, Price, Revenue, Gross Margin and Market Share 2.9 LGC Forensics 2.9.1 Business Overview 2.9.2 DNA Forensic Type and Applications 2.9.2.1 Type 1 2.9.2.2 Type 2 2.9.3 LGC Forensics DNA Forensic Sales, Price, Revenue, Gross Margin and Market Share 2.10 Morpho (Safran) 2.10.1 Business Overview 2.10.2 DNA Forensic Type and Applications 2.10.2.1 Type 1 2.10.2.2 Type 2 2.10.3 Morpho (Safran) DNA Forensic Sales, Price, Revenue, Gross Margin and Market Share 2.11 NEC 2.11.1 Business Overview 2.11.2 DNA Forensic Type and Applications 2.11.2.1 Type 1 2.11.2.2 Type 2 2.11.3 NEC DNA Forensic Sales, Price, Revenue, Gross Margin and Market Share 2.12 ZyGEM 2.12.1 Business Overview 2.12.2 DNA Forensic Type and Applications 2.12.2.1 Type 1 2.12.2.2 Type 2 2.12.3 ZyGEM DNA Forensic Sales, Price, Revenue, Gross Margin and Market Share 2.13 Applied DNA Sciences Inc 2.13.1 Business Overview 2.13.2 DNA Forensic Type and Applications 2.13.2.1 Type 1 2.13.2.2 Type 2 2.13.3 Applied DNA Sciences Inc DNA Forensic Sales, Price, Revenue, Gross Margin and Market Share 3 Global DNA Forensic Market Competition, by Manufacturer 3.1 Global DNA Forensic Sales and Market Share by Manufacturer 3.2 Global DNA Forensic Revenue and Market Share by Manufacturer 3.3 Market Concentration Rate 3.3.1 Top 3 DNA Forensic Manufacturer Market Share 3.3.2 Top 6 DNA Forensic Manufacturer Market Share 3.4 Market Competition Trend For more information or any query mail at sales@wiseguyreports.com ABOUT US: Wise Guy Reports is part of the Wise Guy Consultants Pvt. Ltd. and offers premium progressive statistical surveying, market research reports, analysis & forecast data for industries and governments around the globe. Wise Guy Reports features an exhaustive list of market research reports from hundreds of publishers worldwide. We boast a database spanning virtually every market category and an even more comprehensive collection of market research reports under these categories and sub-categories. For more information, please visit https://www.wiseguyreports.com


Stanworth D.,LGC Forensics | Hunt N.C.A.,Forensic Pathology Services | Flanagan R.J.,King's College
Forensic Science International | Year: 2012

Clozapine is a uniquely effective antipsychotic, but is very toxic in clozapine-naïve subjects. A 34-year-old male patient in a mental health facility, who was not prescribed clozapine, took 350. mg clozapine obtained from another patient at night. He was found dead the next morning. The presence of cardiomegaly related to obesity may have increased the risk of suffering an acute cardiac event after ingestion of clozapine. The medication prescribed to the patient was not thought to have contributed to the fatal outcome. Post mortem femoral blood clozapine and norclozapine concentrations were 0.48 and 0.20. mg/L, respectively. By way of comparison, audit of 104,127 plasma samples (26,796 patients) assayed for therapeutic drug monitoring purposes 1993-2007, showed plasma clozapine 0.35. mg/L or more in 57.5% samples (8.4% 1. mg/L or more). Those involved in the investigation of clozapine-associated deaths need to be aware that that death in an adult may occur after a single 'therapeutic' dose. A diagnosis of fatal clozapine poisoning cannot be made solely on the basis of a post mortem blood clozapine measurement. © 2011 Elsevier Ireland Ltd.


Puch-Solis R.,LGC Forensics | Clayton T.,LGC Forensics
Forensic Science International: Genetics | Year: 2014

The high sensitivity of the technology for producing profiles means that it has become routine to produce profiles from relatively small quantities of DNA. The profiles obtained from low template DNA (LTDNA) are affected by several phenomena which must be taken into consideration when interpreting and evaluating this evidence. Furthermore, many of the same phenomena affect profiles from higher amounts of DNA (e.g. where complex mixtures has been revealed). In this article we present a statistical model, which forms the basis of software DNA LiRa, and that is able to calculate likelihood ratios where one to four donors are postulated and for any number of replicates. The model can take into account dropin and allelic dropout for different contributors, template degradation and uncertain allele designations. In this statistical model unknown parameters are treated following the Empirical Bayesian paradigm. The performance of LiRa is tested using examples and the outputs are compared with those generated using two other statistical software packages likeLTD and LRmix. The concept of ban efficiency is introduced as a measure for assessing model sensitivity. © 2014 Published by Elsevier Ireland Ltd.


Puch-Solis R.,LGC Forensics
Forensic Science International: Genetics | Year: 2014

The technology for producing DNA profiles is very sensitive and is able to produce profiles from process negative controls typically consisting of one or two peaks, a phenomenon known as dropin. There are several types of models that implement likelihood ratios for the statistical evaluation of DNA profiles. One of the types is the family of continuous models because they consider continuous peak height/area measurements from the stain profile. Nowadays, there are several continuous models available. The aim of this article is to expose a statistical model for dropin peak heights supported by data, and illustrate its incorporation into a continuous method. © 2014 Elsevier Ireland Ltd. All rights reserved.


Roth B.L.,University of North Carolina at Chapel Hill | Gibbons S.,University College London | Arunotayanun W.,University College London | Huang X.-P.,University of North Carolina at Chapel Hill | And 3 more authors.
PLoS ONE | Year: 2013

In this paper we determined the pharmacological profiles of novel ketamine and phencyclidine analogues currently used as 'designer drugs' and compared them to the parent substances via the resources of the National Institute of Mental Health Psychoactive Drug Screening Program. The ketamine analogues methoxetamine ((RS)-2-(ethylamino)-2-(3-methoxyphenyl)cyclohexanone) and 3-MeO-PCE (N-ethyl-1-(3-methoxyphenyl)cyclohexanamine) and the 3- and 4-methoxy analogues of phencyclidine, (1-[1-(3-methoxyphenyl)cyclohexyl]piperidine and 1-[1-(4-methoxyphenyl)cyclohexyl]piperidine), were all high affinity ligands for the PCP-site on the glutamate NMDA receptor. In addition methoxetamine and PCP and its analogues displayed appreciable affinities for the serotonin transporter, whilst the PCP analogues exhibited high affinities for sigma receptors. Antagonism of the NMDA receptor is thought to be the key pharmacological feature underlying the actions of dissociative anaesthetics. The novel ketamine and PCP analogues had significant affinities for the NMDA receptor in radioligand binding assays, which may explain their psychotomimetic effects in human users. Additional actions on other targets could be important for delineating side-effects. © 2013 Roth et al.


PubMed | LGC Forensics, Forensic Science Service Ltd, Forensic Science Northern Ireland, SPA Forensic Services and 3 more.
Type: Journal Article | Journal: Science & justice : journal of the Forensic Science Society | Year: 2016

The UK and Ireland Association of Forensic Science Providers (AFSP) Body Fluid Forum (BFF) set out to assist in the interpretation of sexual offence cases where semen is absent on vaginal swabs but female DNA is present on penile swabs or male underwear, and the issue to be addressed is whether or not sexual intercourse occurred. This study aims to investigate the frequency and amount of female DNA transferred to the penis and underwear of males following staged nonintimate social contact with females and to compare the findings with the amount of female DNA transferred to the penis and subsequently to the underwear of a male who had engaged in unprotected sexual intercourse with a female. In this study, no matching female DNA was detected on the inside front of the 44 items of male underwear used in this research following staged contact of a nonintimate nature and subsequent secondary transfer to the penis. After sexual intercourse, full profiles matching the female participant were found on the inside front of the males underwear with maximum peak heights in the range between 1898 and 3157 rfu. It was possible to demonstrate that DNA can occasionally transfer to the waistband and outside front of underwear worn by a male following staged nonintimate social contact. Data obtained in this study suggest that a matching female DNA profile below a peak height of 1000 rfu on the waistband of a males underwear might be explained by nonintimate social contact with secondary transfer of female DNA from the males hands.

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