LG Household and Health Care Co.

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South Korea

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Park S.-K.,LG Household and Health Care Co. | Park S.-K.,Chungbuk National University | Jung I.-C.,Daejeon University | Lee W.K.,LG Household and Health Care Co. | And 8 more authors.
Journal of Medicinal Food | Year: 2011

A combination of green tea extract and l-theanine (LGNC-07) has been reported to have beneficial effects on cognition in animal studies. In this randomized, double-blind, placebo-controlled study, the effect of LGNC-07 on memory and attention in subjects with mild cognitive impairment (MCI) was investigated. Ninety-one MCI subjects whose Mini Mental State Examination-K (MMSE-K) scores were between 21 and 26 and who were in either stage 2 or 3 on the Global Deterioration Scale were enrolled in this study. The treatment group (13 men, 32 women; 57.58±9.45 years) took 1,680mg of LGNC-07, and the placebo group (12 men, 34 women; 56.28±9.92 years) received an equivalent amount of maltodextrin and lactose for 16 weeks. Neuropsychological tests (Rey-Kim memory test and Stroop color-word test) and electroencephalography were conducted to evaluate the effect of LGNC-07 on memory and attention. Further analyses were stratified by baseline severity to evaluate treatment response on the degree of impairment (MMSE-K 21-23 and 24-26). LGNC-07 led to improvements in memory by marginally increasing delayed recognition in the Rey-Kim memory test (P=.0572). Stratified analyses showed that LGNC-07 improved memory and selective attention by significantly increasing the Rey-Kim memory quotient and word reading in the subjects with MMSE-K scores of 21-23 (LGNC-07, n=11; placebo, n=9). Electroencephalograms were recorded in 24 randomly selected subjects hourly for 3 hours in eye-open, eye-closed, and reading states after a single dose of LGNC-07 (LGNC-07, n=12; placebo, n=12). Brain theta waves, an indicator of cognitive alertness, were increased significantly in the temporal, frontal, parietal, and occipital areas after 3 hours in the eye-open and reading states. Therefore, this study suggests that LGNC-07 has potential as an intervention for cognitive improvement. © Copyright 2011, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition.


Ryu J.H.,Dermaopro Ltd | Seo Y.K.,Dermaopro Ltd | Boo Y.C.,Kyungpook National University | Chang M.Y.,LG Household and Health Care Co. | And 2 more authors.
International Journal of Cosmetic Science | Year: 2014

Synopsis Objective Skin texture is a fine structure of skin surface where the hill and furrow were crossed to form a star shape. This study was performed to establish a quantitative evaluation method of skin texture affected by skin ageing using replica images of the cheek. Methods After producing replicas of the left cheek areas of 80 female subjects, representative replica images were chosen to establish six-level facial skin texture index. Using this new index, skin texture of different-aged subjects was visually assessed by multiple examiners. The number of star configurations was also analysed using the same replica images. Other factors contributing to skin texture, such as skin elasticity, roughness, dermal density, moisture and gloss, were also analysed. Results The concordance between skin texture scores evaluated by three researchers was high (0.896), and there was a high correlation between skin texture score and age (r = 0.642). The number of star configurations showed high correlations with skin texture scores (r = 0.753) and with age (r = 0.776). Skin texture scores were highly correlated with skin roughness and dermal density, but not with moisture, gloss and elasticity. Conclusion This study suggests that visual grading of skin texture score based on new facial skin texture index and quantification of star configurations will be useful in evaluating skin ageing. © 2014 Society of Cosmetic Scientists and the Société Française de Cosmétologie.


Lee S.J.,Korea Research Institute of Chemical Technology | Jung T.-H.,Korea Research Institute of Chemical Technology | Kim H.,LG Household and Healthcare Ltd. | Jeong D.,Korea Research Institute of Chemical Technology | And 5 more authors.
Archives of Pharmacal Research | Year: 2014

The interaction of stem cell factor (SCF) with its cognate receptor c-Kit is closely associated with the survival and maturation of melanocytes. To investigate novel depigmentation agents, we screened 2,000 plant extracts for c-Kit inhibitors to identify active small molecules by using time-resolved fluorescence enzyme assays. For the active extracts identified as inhibitors of c-Kit enzyme, we evaluated the effects of the active extracts and isolated flavonoids on c-Kit phosphorylation in MO7e/melanocytes. Anti-melanogenic activity was also examined in melanocytes and melanoderm model. The flavonoids such as diosmetin, apigenin, acacetin and luteolin isolated from Chrysanthemum morifolium were found to be active in inhibiting c-Kit both at enzyme and cellular levels. In addition, these flavonoids attenuated SCF-induced proliferation of human primary melanocytes without toxicity and suppressed ultraviolet (UV) B irradiation-mediated melanin synthesis significantly. Among the active flavonoids, diosmetin was found to inhibit SCF-induced melanogenesis in a human melanoderm model. These results strongly suggest that C. morifolium extract and diosmetin have potential to suppress SCF-/UVB-induced melanogenesis, and could be developed as anti-pigmentation agents. © 2013 The Author(s).


Hong L.-Y.,Chungnam National University | Ryu S.-H.,LG Household and Health Care Ltd. | Kim D.-P.,Chungnam National University
Journal of Nanoscience and Nanotechnology | Year: 2010

The microcellular SiCN ceramics with high porosity and high surface area were fabricated from polysilazane as a viscous SiCN ceramic precursor and expandable microspheres as a self-sacrificial template. The fabrication steps were composed of (1) forming of expandable microsphere compact, (2) infiltrating polysilazane into the compact, (3) foaming and curing, (4) pyrolysis in N 2 gas. The microcellular structures and properties of the obtained ceramic products depended on the foaming and curing conditions as well as the pyrolysis temperature. When foamed and cured at 120 °C for 30 min, then pyrolyzed at 1000 °C in N 2, the microcellular product exhibited the largest cell size 9.3 μm with the lowest cell densities 2.2 × 108 cells/cm 2, 93% of porosity and surface area of 356 m 2/g. Furthermore, the higher temperature pyrolysis at 1300 °C induced significant change in the microcellular morphology by reducing the cell size with thicker wall and the cell density. Finally, it demonstrated an efficient way of manufacturing highly porous microcellular ceramics with no etching process using a polyvinylsilazane and expandable microspheres for catalytic supporting application. Copyright © 2010 American Scientific Publishers.


Kang N.-H.,Chungbuk National University | Lee W.K.,LG Household and Health Care Ltd. | Yi B.-R.,Chungbuk National University | Lee H.-R.,Chungbuk National University | And 4 more authors.
Molecular Medicine Reports | Year: 2013

Protamine from salmon spermaries is a novel dietary protein. Chitooligosaccharide (COS) is an oligosac-charide derived from chitin or chitosan, a long-chain polymer, by chemical or enzymatic hydrolysis. These two compounds are known to enhance lipid metabolism by interrupting the digestion and absorption of fat in the body. Cardiovascular disease (CVD) refers to any type of specific disease that affects the heart and circulatory system. Dyslipidemia, a condition involving high levels of low-density lipoprotein (LDL) cholesterol and low levels of high-density lipoprotein (HDL) cholesterol, is generally known to be a primary cause of CVD development. The risk of CVD is usually associated with the atherogenic index (AI) and cardiac risk factor (CRF). The CVD risk is also closely associated with serum levels of total cholesterol (T-CHO), LDL cholesterol and HDL cholesterol. In the present study, we evaluated alterations in serum lipid contents following the administration of protamine, COS and mixtures of these two compounds to male Sprague-Dawley (SD) rats, and their ability to reduce CVD risk. Based on the results of a serum lipid assay, protamine, COS and their mixtures were found to significantly reduce AI, CRF and CVD risk by decreasing serum levels of TG, T-CHO and LDL cholesterol and increasing serum HDL cholesterol levels. By contrast, TG and T-CHO concentrations in feces were markedly increased. Accumulation of lipids in the liver tissues of the SD rats fed high-fat diets was also inhibited by the intake of protamine and COS. Our findings suggest that protamine, COS and combinations of the two compounds may be used as a dietary therapy for preventing CVD due to their suppressive effects on hyperlipidemia and hypercholesterolemia. © 2013 Spandidos Publications Ltd.


Jung J.,Korea University | Jung J.,LG Household and Health Care Ltd. | Kim C.,Korea University
Journal of the Korean Physical Society | Year: 2013

In this study, we performed experimental studies on the formation of stripe patterns in a granular mixture under horizontal vibration. The granular mixture was prepared by mixing brass and glass beads of 1 mm in diameter in the ratio of 1:2 by volume and immersing them in a liquid. The mixture becomes separated into glass-only and brass-only bands of random sizes. The number of bands is an increasing function of Γ × √Re only (Γ: acceleration relative to gravity; Re: Reynolds number based on the particle diameter). As the mechanism of stripe formation, the formation of clusters in the mixture due to local fluctuations and strong hydrodynamic interactions between particles is proposed. The initial-condition dependency also supports the cluster formation mechanism rather than the Kelvin-Helmholtz-like hydrodynamic instability. © 2013 The Korean Physical Society.


Kim M.-S.,LG Household and Healthcare Ltd. | Song H.J.,LG Household and Healthcare Ltd. | Lee S.H.,LG Household and Healthcare Ltd. | Lee C.K.,LG Household and Healthcare Ltd.
Journal of Cosmetic Dermatology | Year: 2014

Background: Dermal fibroblast is a primary cell type responsible for synthesis and remodeling of extracellular matrix in human skin. Type I collagen and hyaluronan are main components that have roles in skin fibrosis, wound healing, tissue remodeling as well as skin aging. Several studies have reported cytokine-dependent changes in collagen expression or hyaluronan production; however, the cytokines' effect was controversial in human dermal fibroblasts. Aims: To clarify the role of various growth factors, cytokines or chemokines on the production of interstitial type I collagen and hyaluronan in dermal fibroblasts. Methods: We confirmed the presence of various corresponding receptors and assessed the effects of 33 human recombinants on the production of type I collagen and hyaluronan using the assay system in dermal fibroblasts. Results: Platelet-derived growth factor (PDGF)-AA, PDGF-BB, epidermal growth factor (EGF), transforming growth factor (TGF)-β1, MCP-1, IP-10, interleukin (IL)-1α, IL-1β, and IL-15 were effective on both type I collagen and hyaluronan production, as compared with no stimulated control. On the other hand, IL-10 and IFN- α caused a significant decrease in type I collagen production, and IL-8 and GM-CSF caused a decrease in hyaluronan production compared with no cytokine-treated control. Interestingly, some chemokines, such as MCP-1 (CCL2), RANTES (CCL5), eotaxin-2 (CCL24), IP-10 (CXCL10), or fractalkine (CX3CL1) significantly induced the type I collagen or hyaluronan production. Conclusions: Various growth factors and cytokines on the regulation of type I collagen and hyaluronan in human dermal skin probably function as key factors in skin remodeling and skin aging. Our profile may help to apply to cosmeceutical area maintaining as young skin through the increase in extracellular matrix. © 2014 Wiley Periodicals, Inc.


Jeong E.T.,LG Household and Healthcare Ltd. | Jin M.H.,LG Household and Healthcare Ltd. | Kim M.-S.,LG Household and Healthcare Ltd. | Chang Y.H.,LG Household and Healthcare Ltd. | Park S.G.,LG Household and Healthcare Ltd.
Archives of Pharmacal Research | Year: 2010

Piceid (5,4′-dihydroxystilbene-3-O-β-D-glucopyranoside) is one of the stilbenes found in Polygonum cuspidatum. Previous studies have shown that this compound has little effect on tyrosinase inhibition when compared with other stilbenes in a cell-free tyrosinase assay. Furthermore, its role for melanogenesis in melanocytes is relatively unknown. In melanocytes, piceid inhibits tyrosinase activity and melanin production in a concentration-dependent manner. To explore the action of piceid on melanogenesis, we studied its effect on several key cellular enzymes and a transcriptional factor known to be involved in melanogenesis, including: tyrosinase, tyrosinase-related protein 1, tyrosinase-related protein 2, and microphthalmia-associated transcription factor. Interestingly, the effects of piceid on hypopigmentation and inhibition of tyrosinase activity were better than those of arbutin, which is well known to inhibit melanin formation in melanocytes. In addition, piceid suppressed the mRNA and protein expression of the aforementioned enzymes and transcriptional factor in a concentration-dependent manner. In this regards, our results showed that piceid represents a safe and new candidate for a skin-lightening agent. © 2010 The Pharmaceutical Society of Korea and Springer Netherlands.


Yogiara,Yonsei University | Yogiara,Atma Jaya Catholic University of Indonesia | Hwang S.J.,LG Household and Healthcare Ltd | Park S.,LG Household and Healthcare Ltd | And 2 more authors.
Letters in Applied Microbiology | Year: 2015

Preservative agents determining the shelf life of cosmetic products must have effective antimicrobial activity while meeting safety requirements for topical use. In this study, we determined the antimicrobial activity of 1,2-hexanediol against several Gram-positive and Gram-negative bacteria. Antimicrobial susceptibility tests have shown that 1,2-hexanediol exhibits broad-spectrum activity against Gram-positive and Gram-negative bacteria with MICs of 0·5-2% (v/v). The bactericidal concentration of 1,2-hexanediol was ranging from 1 to 2 × MIC as demonstrated by time-kill curve assay. A membrane depolarization assay showed that 1,2-hexanediol disrupted the cytoplasmic membrane potential. A checkerboard assay indicated that the effective concentration of 1,2-hexanediol was reduced up to 0·25-0·5 × MIC when combined with macelignan and octyl gallate against Gram-positive bacteria. However, this combination was not effective against Gram-negative bacteria. A turbidity reduction assay demonstrated that the combination of a high concentration of 1,2-hexanediol with food-grade antimicrobial compounds could trigger lytic activity towards Bacillus cereus cells. The remaining cell turbidity was 24·6 and 22·2% when 2% of 1,2-hexanediol was combined with 8 mg l-1 octyl gallate or with 32 mg l-1 macelignan respectively. This study showed that food-grade antimicrobial compounds may be used in combination with 1,2-hexanediol to increase its efficacy as a preservative agent in cosmetics. Significance and Impact of the Study: The antimicrobial activity of 1,2-hexanediol against Gram-positive and Gram-negative bacteria was potentiated with food-grade antimicrobials including xanthorrhizol, macelignan, panduratin A and octyl gallate, which have already been reported to display anti-inflammatory and other beneficial activities related to cosmetics. Therefore, the combination of 1,2-hexanediol and these food-grade antimicrobial agents would have benefits not only for increasing the antimicrobial activity but also in cosmetics use. Significance and Impact of the Study: The antimicrobial activity of 1,2-hexanediol against Gram-positive and Gram-negative bacteria was potentiated with food-grade antimicrobials including xanthorrhizol, macelignan, panduratin A and octyl gallate, which have already been reported to display anti-inflammatory and other beneficial activities related to cosmetics. Therefore, the combination of 1,2-hexanediol and these food-grade antimicrobial agents would have benefits not only for increasing the antimicrobial activity but also in cosmetics use. © 2015 The Society for Applied Microbiology.


PubMed | LG Household and Health Care Co.
Type: Journal Article | Journal: Journal of medicinal food | Year: 2011

A combination of green tea extract and l-theanine (LGNC-07) has been reported to have beneficial effects on cognition in animal studies. In this randomized, double-blind, placebo-controlled study, the effect of LGNC-07 on memory and attention in subjects with mild cognitive impairment (MCI) was investigated. Ninety-one MCI subjects whose Mini Mental State Examination-K (MMSE-K) scores were between 21 and 26 and who were in either stage 2 or 3 on the Global Deterioration Scale were enrolled in this study. The treatment group (13 men, 32 women; 57.589.45 years) took 1,680mg of LGNC-07, and the placebo group (12 men, 34 women; 56.289.92 years) received an equivalent amount of maltodextrin and lactose for 16 weeks. Neuropsychological tests (Rey-Kim memory test and Stroop color-word test) and electroencephalography were conducted to evaluate the effect of LGNC-07 on memory and attention. Further analyses were stratified by baseline severity to evaluate treatment response on the degree of impairment (MMSE-K 21-23 and 24-26). LGNC-07 led to improvements in memory by marginally increasing delayed recognition in the Rey-Kim memory test (P=.0572). Stratified analyses showed that LGNC-07 improved memory and selective attention by significantly increasing the Rey-Kim memory quotient and word reading in the subjects with MMSE-K scores of 21-23 (LGNC-07, n=11; placebo, n=9). Electroencephalograms were recorded in 24 randomly selected subjects hourly for 3 hours in eye-open, eye-closed, and reading states after a single dose of LGNC-07 (LGNC-07, n=12; placebo, n=12). Brain theta waves, an indicator of cognitive alertness, were increased significantly in the temporal, frontal, parietal, and occipital areas after 3 hours in the eye-open and reading states. Therefore, this study suggests that LGNC-07 has potential as an intervention for cognitive improvement.

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