Lexicon Pharmaceuticals Inc.

The Woodlands, TX, United States

Lexicon Pharmaceuticals Inc.

The Woodlands, TX, United States

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Patent
Lexicon Pharmaceuticals Inc. | Date: 2016-05-16

Sulfanyl-tetrahydropyran-based compounds, pharmaceutical compositions comprising them, and methods of their use for the treatment of diseases and disorders such as diabetes and obesity are disclosed.


Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R_(1), R_(2 )and R_(3 )are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.


Imidazo[1,2-b]pyridazine-based compounds of the formula: are disclosed, wherein R_(1), R_(2 )and R_(3 )are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.


Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders.


The adaptor associated kinase 1 (AAK1) inhibitor 3-methyloxetan-3-yl-4-(3-(2-methoxypyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate: and pharmaceutically acceptable salts and solid forms thereof are disclosed. Compositions comprising the compound and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by AAK1 activity are also disclosed.


Patent
Lexicon Pharmaceuticals Inc. | Date: 2015-11-17

Inhibitors of sodium glucose cotransporter 1 (SGLT1), compositions comprising them, and methods of their use to treat diseases and disorders such as diabetes are disclosed. Particular compounds are of the formula: the various substituents of which are defined herein.


Imidazo[1,2-b]pyridazine-based compounds of the formula: are disclosed, wherein R_(1), R_(2 )and R_(3 )are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.


The adaptor associated kinase 1 (AAK1) inhibitor 3-methyloxetan-3-yl-4-(3-(2-methoxypyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate: and pharmaceutically acceptable salts and solid forms thereof are disclosed. Compositions comprising the compound and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by AAK1 activity are also disclosed.


Patent
Lexicon Pharmaceuticals Inc. | Date: 2015-10-06

Methods of improving the cardiovascular and/or metabolic health of patients, particularly those suffering from type 2 diabetes, are disclosed, as well as compounds and pharmaceutical compositions useful therein.


Patent
Lexicon Pharmaceuticals Inc. | Date: 2015-11-25

Antibodies that neutralize Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting the bone.

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