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Ximenes F.A.,Australian Department of Primary Industries and Fisheries | Grant T.,Level 11
International Journal of Life Cycle Assessment | Year: 2013

Purpose: As the average wood products usage per unit of floor area in Australia has decreased significantly over time, there is potential for increased greenhouse gas (GHG) mitigation benefits through an increased use of wood products in buildings. This study determined the GHG outcomes of the extraction, manufacture, transport, use in construction, maintenance and disposal of wood products and other building materials for two popular house designs in Sydney, Australia. Methods: The life cycle assessment (LCA) was undertaken using the computer model SimaPro 7.1, with the functional unit being the supply of base building elements for domestic houses in Sydney and its subsequent use over a 50-year period. The key data libraries used were the Australian Life Cycle Inventory library, the ecoinvent library (with data adapted to Australian circumstances where appropriate) and data for timber production from an Australian study for a range of Australian forestry production systems and wood products. Two construction variations were assessed: the original intended construction, and a "timber-maximised" alternative. The indicator assessed was global warming, as the focus was on GHG emissions, and the effect of timber production, use and disposal on the fate of carbon. Results and discussion: The timber maximised design resulted in approximately half the GHG emissions associated with the base designs. The sub-floor had the largest greenhouse impact due to the concrete components, followed by the walls due to the usage of bricks. The use of a "timber maximised" design offset between 23 and 25 % of the total operational energy of the houses. Inclusion of carbon storage in landfill made a very significant difference to GHG outcomes, equivalent to 40-60 % of total house GHG emissions. The most beneficial options for disposal from a GHG perspective were landfill and incineration with energy recovery. Conclusions: The study showed that significant GHG emission savings were achieved by optimising the use of wood products for two common house designs in Sydney. The switch of the sub-floor and floor covering components to a "wood" option accounted for most of the GHG savings. Inclusion of end of life parameters significantly impacted on the outcomes of the study. © 2012 Springer-Verlag Berlin Heidelberg.

Research and Markets has announced the addition of the "The Graphene and 2-D Materials Global Opportunity Report" report to their offering. The Graphene and 2D Materials Global Opportunity Report is a comprehensive analysis of the market and commercial opportunitites for these remarkable materials. A growing number of products are integrating graphene and 2-D materials across a range of markets. Two-dimensional (2D) materials are currently one of the most active areas of advanced materials research, and offer a huge opportunity for both fundamental studies and practical applications, including superfast, low-power, flexible and wearable electronics, sensors, photonics and electrochemical energy storage devices that will have an immense impact on our society. Graphene is a ground-breaking 2D material that possesses extraordinary electrical and mechanical properties that promise a new generation of innovative devices. New methods of scalable synthesis of high-quality graphene, clean delamination transfer and device integration have resulted in the commercialization of state-of-the-art electronics devices such as graphene touchscreens in smartphones and flexible RF devices on plastics. The market for graphene continues to expand, with new product launches, multi-million dollar funding for companies and start-ups and new government initiatives worldwide. Beyond graphene, emerging elementary 2D materials such as transition metal dichalcogenides, group V systems including phosphorene, and related isoelectronic structures will potentially allow for flexible electronics and field-effect transistors that exhibit ambipolar transport behaviour with either a direct band-gap or greater gate modulation. Report contents include: - Global production capacities - Current products. - Stage of commercialization for graphene applications by company. - Market drivers, trends and challenges, by target markets. - In-depth market assessment of opportunities for graphene including potential revenues, growth rates, pricing, most likely applications and market challenges. - In-depth company profiles, include products, capacities, and commercial activities. - Predictions for key growth areas and opportunities. Key Topics Covered: 1 Executive Summary 2 Properties Of Nanomaterials 3 Overview Of Graphene 4 Carbon Nanotubes Versus Graphene 5 Other 2-D Materials 6 Graphene Synthesis 7 Graphene Market Structure And Routes To Commercialization 8 Regulations And Standards 9 Patents And Publications 10 Technology Readiness Level 11 Graphene Industry News 2013-2016 12 End User Market Segment Analysis 13 Adhesives 14 Aerospace 15 Automotive 16 Biomedical & Healthcare 17 Coatings 18 Composites 19 Electronics And Photonics 20 Energy Storage, Conversion And Exploration 21 Filtration And Separation 22 Lubricants 23 Sensors 24 Textiles 25 3D Printing 26 Graphene Producers And Product Developers (190 Company Profiles) For more information about this report visit Research and Markets Laura Wood, Senior Manager For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716

Dentice R.,Level 11
Cochrane database of systematic reviews (Online) | Year: 2011

Inhalation of the enzyme dornase alfa reduces sputum viscosity and improves clinical outcomes of people with cystic fibrosis. To determine the effect of timing of dornase alfa inhalation on measures of clinical efficacy in people with cystic fibrosis (in relation to airway clearance techniques or time of day). Relevant randomised and quasi-randomised controlled trials were identified from the Cochrane Cystic Fibrosis Trials Register, Physiotherapy Evidence Database (PEDro), and international CF conference proceedings.Search date: 6 October 2010. Any trial of dornase alfa in people with cystic fibrosis where timing of inhalation was the randomised element in the study with either: inhalation before compared to after airway clearance techniques; or morning compared to evening inhalation. Both authors independently selected trials, assessed risk of bias and extracted data with disagreements resolved by discussion. Relevant data were extracted and, where possible, meta-analysed. We identified 92 trial reports representing 47 studies, of which five studies (providing data on 122 participants) met our inclusion criteria. All five studies used a cross-over design. Intervention periods ranged from two to eight weeks. Four trials compared dornase alfa inhalation before versus after airway clearance techniques. Inhalation after instead of before airway clearance did not significantly change FEV(1). Similarly, FVC and quality of life were not significantly affected; FEF(25) was significantly worse with dornase alfa inhalation after airway clearance, MD -0.17 litres (95% CI -0.28 to -0.05), based on the pooled data from two small studies in children (7 to 19 years) with well-preserved lung function. All other secondary outcomes were statistically non-significant.In one trial, morning versus evening inhalation had no impact on lung function or symptoms. The current evidence derived from a small number of participants does not indicate that inhalation of dornase alfa after airway clearance techniques is more or less effective than the traditional recommendation to inhale nebulised dornase alfa 30 minutes prior to airway clearance techniques, for most outcomes. For children with well-preserved lung function, inhalation before airway clearance may be more beneficial for small airway function than inhalation after. However, this result relied on a measure with high variability and studies with variable follow-up. Apart from this, the timing of dornase alfa inhalation can be largely based on pragmatic reasons or individual preference with respect to the time of airway clearance and time of day. Further research is warranted.

Desborough J.L.,Level 11
Australian Health Review | Year: 2012

Objective. This is a report of a qualitative health research study examining how nurse practitioners construct and implement their roles. Methods. In-depth interviews and a focus group discussion were conducted to obtain narrative data from nurse practitioners from a variety of clinical backgrounds. Data were analysed utilising the principles of grounded theory. Subjects. Seven nurse practitioners participated in face-to-face interviews and six participated in a focus group discussion. Results. The central process of 'developing legitimacy and credibility' is achieved through the processes of: 'developing Clinical Practice Guidelines', 'collaborating with the multidisciplinary team', 'communicating', and 'transitioning to practice'. Conclusion. Policy makers and those responsible for operationalising nurse practitioner roles need to support the central process of developing legitimacy and credibility vital for successful implementation. First, this involves enabling a supportive and informed process of Clinical Practice Guideline development. Second, key inter-disciplinary relationships need to be identified to facilitate collaboration and sources of mentorship for nurse practitioners. Finally, an identified period of transition will facilitate identification, development and implementation of the above processes. © 2012 AHHA.

Huynh H.,Level 11
Biochemical Pharmacology | Year: 2010

With an annual incidence of over 660,000 deaths, hepatocellular carcinoma (HCC) is the third leading cause of cancer death globally. This disease is often diagnosed at an advanced stage, when potentially curative therapies are not feasible. HCC is highly resistant to conventional systemic therapies and prognosis for advanced HCC patients remains poor. Given the clear need, clinical development of novel therapeutic agents in HCC has begun in earnest. Our recent knowledge of the molecular mechanisms responsible of tumor initiation and progression has identified several potential molecular targets in HCC. These targets are the receptor tyrosine kinase-activated pathways, which include the Raf/MEK/ERK, PI-3K/Akt/mTOR, and Jak/Stat. Sorafenib is the multikinase inhibitor that has shown modest survival benefits in advanced HCC in two randomized controlled trials, supporting the use of molecularly targeted therapies in treatment of HCC. A number of strategies including monoclonal antibodies and tyrosine kinase inhibitors such as erlotinib, sunitinib, vandetanib, cediranib, brivanib, foretinib, and dovitinib have been developed and tested in various phases of clinical trials. The successful development of these novel targeted agents in the future will be dependent on the selection of patient populations that are most likely to derive clinical benefit, optimization of the dose used and schedules, and investigation of combined therapies. This review describes evolving molecular targeted agents, their common adverse side effects, and its potential use in management of HCC. © 2010 Elsevier Inc.

Macneill P.U.,Level 11
Medical Humanities | Year: 2011

This paper discusses various justifications for including medical humanities and art in healthcare education. It expresses concern about portrayals of the humanities and art as benign and servile in relation to medicine and the health professions. An alternative is for the humanities to take a more active role within medical education by challenging the assumptions and myths of the predominant biomedical model. Another is to challenge quiescent notions of the arts by examining examples of recent provocative work and, to this end, the paper considers the work of performance artists Stelarc and Orlan who have subjected their bodies to modifications and extensions. Their work challenges, and potentially undermines, conceptions of the body, medicine, and humanity's relationship with technology. Similarly, other artists, working with biological cultures, have raised controversial issues. Recent work of this kind defies easy understanding and resists being pressed into the service of medicine and other health professions for educational purposes by opening up topics for exploration and discussion without providing unitary explanatory frameworks. The paper goes on to discuss the implications for medical education if this is the approach to the arts and humanities in healthcare education. It suggests that there needs to be a shift in the foundational assumptions of medicine if the arts and humanities are to contribute more fully.

Piper A.J.,Level 11
Sleep Medicine Reviews | Year: 2011

Daytime hypercapnia that develops in morbidly obese individuals in the absence of concurrent lung or neuromuscular disease is referred to as the obesity hypoventilation syndrome (OHS). The characteristic polysomnographic (PSG) abnormality is marked sleep hypoxemia. Although the likelihood of hypoventilation increases with increasing body mass index (BMI), it is too simplistic to think of this disorder arising merely from chest wall restriction due to excess weight. Rather, this is a disorder which emerges when the compensatory mechanisms that normally operate to maintain ventilation appropriate for the level of obesity are impaired. OHS develops from a complex interaction between abnormal respiratory function, sleep disordered breathing and diminished respiratory drive. Irrespective of the mechanisms underlying the development of this disorder, early recognition of the problem and institution of effective therapy is important to reduce the significant clinical and societal repercussions of OHS. While therapy directed at improving sleep disordered breathing is effective in reversing daytime respiratory failure, it is not universally successful and information regarding longer term clinical outcomes is limited. Attention to weight reduction strategies are also necessary to reduce comorbid conditions and improve quality of life, but data regarding how successful and sustained this is in obesity hypoventilation are sparse. © 2010 Elsevier Ltd.

Methods and materials as may be utilized to provide consistent contamination testing of surfaces are described. The methods are based upon the designation of particular test zones on surfaces at risk of contamination by infectious agents. The designated test zone(s) can be tested and monitored over time and/or across like materials or devices for contamination. Templates for use in designating consistent test zones on high-touch surfaces are also described.

News Article | August 29, 2013

The Best Way to Start a Business? Start With Nothing

News Article | June 17, 2014

With its 27th annual 100 Best Companies to Work For program, Seattle Business magazine will salute the Washington companies that are setting the standard for leadership, benefits, work environment, training programs and more. Winners will be announced at an awards gala in June 2016 and featured in the July 2016 edition of Seattle Business magazine. Companies on the 100 Best list are chosen based on the responses from employee surveys. In mid-January 2016, companies that have filled out the form below before the January 8 deadline will be sent instructions for administering a simple survey to company employees. *Please note: Companies must have at least 15 full-time Washington state employees to be considered. Check out the event photos and photobooth shots from this year's100 Best Companies to Work For party.

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