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Košice, Slovakia

Marianna T.,University of P.J. Safarik | Laputkova G.,University of P.J. Safarik | Sabo J.,University of P.J. Safarik | Zivcak J.,Letna
Biomedical Research (India) | Year: 2013

The aim of the study was to evaluate the genotoxic effect of high-frequency electromagnetic field on the human adenocarcinoma cells using HRM analysis. Detecting genetic variations can contribute to the future perspective of anti-tumor strategies combining EMF and anti-cancer drugs. Our data suggest that high-frequency EMF with a frequency of 900 MHz (an input power of 8 W) after 3 h exposure may produce alterations in the melting temperature of DNA of MCF-7 cells from 76.4±0.9°C to 82.6±1.0°C. DNA was extracted from control sample and EMF-exposed MCF-7 cells and MDR1 was sequenced. Comparing the ratio of G+C/A+T on the forward end as well as on the backward end: forward - MCF-7/wt (36.36%/38.67%), MCF-7/EMF (35.30%/39.04%); backward - MCF-7/wt (41.54%/44.62%), MCF-7/EMF (40.13%/44.20%); the decrease of the relative content of G+C/A+T of EMF-exposed MCF-7 cells was observed.

Iveta G.,Letna | Jozef B.,Letna
Applied Mechanics and Materials | Year: 2014

In this paper concepts and behaviour of plasticity, hyperelasticity and hyperplasticity are explained and clarified. Description of hardening models and hyperplastic models is provided too. The theoretical overview presented in this paper covers the crucial prerequisite for creating and applying hyperplastic material models into practice, either for simulation purposes or for real world application. © (2014) Trans Tech Publications, Switzerland.

Repka M.,Institute of Computer Science and Mathematics | Varchola M.,Letna | Drutarovsky M.,Letna
Journal of Electrical Engineering | Year: 2015

In this work, we improved Correlation Power Analysis (CPA) attack against Digital Signature Algorithm (DSA) and its various derivations, such as Elliptic Curve Digital Signature Algorithm (ECDSA). The attack is aimed against integer multiplication with constant secret operand. We demonstrate this improvement on 16-bit integer multiplier in FPGA. The improvement makes it possible to guess more blocks of key, and the improvement also eliminates errors of simulated attacks what is very important when approximating attack success rate and complexity based on simulated attacks. We also discus a possible efficient countermeasure. © 2015 FEI STU.

Ginelliova A.,Letna | Farkas D.,Letna | Farkasova Iannaccone S.,Pavol Jozef Safarik University | Vyhnalkova V.,Letna
Forensic Science, Medicine, and Pathology | Year: 2016

In this paper we report the autopsy findings of a 57 year old woman who died unexpectedly at home. She had been complaining of shortness of breath, episodes of dry coughing, and nausea. Her past medical and social history was unremarkable. She had no previous history of any viral or bacterial disease and no history of oncological disorders. Autopsy revealed multiple grayish-white nodular lesions in the pleura and epicardial fat and areas resembling fibrosis on the cut surface of the anterior and posterior wall of the left ventricle and interventricular septum. Histological examination of the lungs and heart revealed multiple well-formed noncaseating epithelioid cell granulomas with multinucleated giant cells. Death was attributed to myocardial ischemia due to vasculitis of intramural coronary artery branches associated with sarcoidosis. Sarcoidosis is a multisystemic disease of unknown etiology characterized by the formation of noncaseating epithelioid cell granulomas in the affected organs and tissues. The diagnosis of sarcoidosis in this case was established when other causes of granulomatous disease such as tuberculosis, berylliosis, hypersensitivity pneumonitis, and giant cell myocarditis had been reasonably excluded. © 2016 Springer Science+Business Media New York

Ginelliova A.,Letna | Farkas D.,Letna | Farkasova Iannaccone S.,Pavol Jozef Safarik University | Vyhnalkova V.,Letna
Forensic Science, Medicine, and Pathology | Year: 2016

In this paper we report the autopsy findings of a long-term warfarinized 60-year-old man who died unexpectedly 2 days after undergoing laparoscopic transabdominal pre-peritoneal (TAPP) inguinal hernia repair. In his medical records it was stated that the perioperative and postoperative period was uneventful with no sign of bleeding and he was discharged the day after surgery. Autopsy revealed massive bleeding in the pre-peritoneal space at the surgery site and a massive left inguinal canal hematoma spreading through the spermatic cord to the left scrotum. There was no evidence of retroperitoneal bleeding. No sign of traumatic injury to the abdominal wall, major abdominal and pelvic vessels was revealed. The cause of death was hemorrhagic shock. We believe that this is the first documented case of fatal outcome after TAPP inguinal hernia repair in Slovakia. Inguinal hernias account for approximately two-thirds of all abdominal wall hernias. The reported case demonstrates that routine procedures such as TAPP hernia repair can have a fatal outcome, not due to any surgical mishap but because of the altered health status of the patient. © 2016, Springer Science+Business Media New York.

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