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Xie C.,Leshan Teachers College | Liu K.,Leshan Peoples Hospital | Xiao L.,Leshan Teachers College | Tang R.,Leshan Peoples Hospital
Orthopedics | Year: 2012

The purpose of this study was to determine whether the use of computer-assisted surgery can improve the clinical results in total knee arthroplasty (TKA) compared with conventional methods of TKA. A literature search of PubMed (1966 to August 2011), CENTRAL (Cochrane Controlled Trials Register; issue 3, 2011), and EMBASE (1984 to August 2011) was conducted. Randomized, controlled trials detecting the clinical outcomes of TKA with or without the use of computer-assisted surgery were identified. A meta-analysis of these clinical trials was then performed. Twenty-one articles were included in the meta-analysis. The results confirmed that operative time was significantly increased with the use of computer-assisted TKA (mean standard difference, 14.68; 95% confidence interval [CI], 11.74 to 17.62; P<.00001], whereas no significant difference existed between the 2 groups regarding the total operative blood loss (mean standard difference, -54.38; 95% CI, -119.76 to 11.00; P=.10). As for other clinical outcomes, including the Knee Society Score (mean standard difference, 4.47; 95% CI, -1.05 to 9.99; P=.36) and range of motion (mean standard difference, 1.38; 95% CI, -1.43 to 4.18; P=.34), the use of computer-assisted TKA did not help to improve function recovery post-operatively.

Chang S.,South China Agricultural University | Li K.-S.,South China Agricultural University | Hu J.-P.,Leshan Teachers College | Jiao X.,Taiyuan University of Technology | Tian X.-H.,South China Agricultural University
Soft Matter | Year: 2011

The major facilitator superfamily (MFS) is an important and widespread family of secondary membrane transporters. Recently, an outward-open structure of MFS, the fucose/H+ symporter FucP was determined by X-ray crystallography. In this article, the outward-open form of FucP is analyzed by elastic network models. It is found that the periplasmic half region has remarkable fluctuation, and the closure of the periplasmic half is the most dominant conformational change for outward-open conformation of FucP. To ascertain the process of transport, an adaptive anisotropic network model is applied to explore the allosteric transitions of FucP. In particular, our simulation not only yields the intermediate states similar to that seen in the EmrD crystal structure, but also exhibits the whole transport process of FucP. On the basis of the coarse-grained analyses, we propose a new working model of how FucP mediates the symport of l-fucose and a proton. The allosteric and transport knowledge of FucP revealed in this work can provide some insights into the mechanism studies of MFS and other transport proteins. © 2011 The Royal Society of Chemistry.

Chang S.,South China Agricultural University | Hu J.-P.,Leshan Teachers College | Lin P.-Y.,South China Agricultural University | Jiao X.,Taiyuan University of Technology | Tian X.-H.,South China Agricultural University
Molecular BioSystems | Year: 2010

The l-arginine (Arg)/agmatine (Agm) antiporter AdiC is a vital transport protein of the arginine-dependent extreme acid resistance system of enteric bacteria. Recently, both substrate-free and Arg-bound structures of AdiC were determined by X-ray crystallography. In this article, the two different proteins were investigated with three simple models. Gaussian network model provided the information of conformational changes. It is found that Arg binding induces structural rearrangement in the extracellular domain, and transmembrane helix 6 (TM6) has the most pronounced trend of conformational changes. The moving directions of fluctuation regions were further ascertained by using anisotropy elastic network model and cross-correlation analysis. Interestingly, the two substrate-binding sites hypothesis of AdiC was confirmed directly by molecular docking. Furthermore, the binding preferences of these two sites were explained from the aspects of electrostatic complementarity and geometric matching. These simple coarse-grained analyses can be used as a general and quick method for the mechanism studies of transport proteins. © 2010 The Royal Society of Chemistry.

Hu J.,Leshan Teachers College | Wang C.,Beijing University of Technology
Chinese Journal of Chemistry | Year: 2010

The biological function of HIV-1 integrase (IN) is to integrate viral DNA into the host cell chromosome, and the specific binding of IN with viral DNA is a precondition for IN to function correctly. Beforehand, the binding mode of IN dimer (IN 2) with the 27 bp segment of viral DNA before 3' processing (3'-P) was obtained via a molecular docking method. Based on the binding mode, the aim of this article was to explore the changes of motive mode and correlative motion for the IN 2 and DNA systems after their binding through dynamical cross-correlation map (DCCM) and principal component analysis (PCA). Finally, solvent effect during the association was analyzed briefly. The results show that there is a significantly increased positive correlation in the interface region between IN 2 and viral DNA, and some obvious motive mode changes of the two systems (IN 2 and DNA) were also observed after their binding. It was found that water molecules played an important role in the recognition between IN 2 and viral DNA through analyzing the water-mediated hydrogen bonds. © 2010 SIOC, CAS, Shanghai, & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chen Y.,Hefei University of Technology | Xiang C.-B.,Hefei University of Technology | Ye X.,Leshan Teachers College
Plant Physiology Communications | Year: 2010

Resurrection is a specialized adaptation of organisms to drastic dehydration. In plant kingdom, this phenomenon is widespread among mosses and ferns. Some higher plants have also developed this remarkable trait. Resurrection plants are able to recover from a state of more than 95% body water loss upon watering. This amazing capability allows these plants to survive under extreme drought environment. Resurrection plants are very attractive to plant biologists. However, the underlying molecular mechanisms are not well understood. Recent studies showed that some low-molecular-weight metabolites including sugars, amino acids, lipids and some proteins such as LEA accumulated to very high levels during dehydration and went back to normal during recovery. Those highly accumulated metabolites and proteins likely play important roles in protecting membranes and macromolecules. The dehydration signaling and gene regulation of resurrection plants are thought to be similar to other higher plants perhaps with special modifications. As the development of 'omics' technologies, it is possible to investigate the molecular mechanisms of resurrection at the whole genome level. A better understanding of the underlying mechanisms may help us to better improve crops and vegetables.

Hu L.,Leshan Teachers College
Proceedings of 2011 International Conference on Electronic and Mechanical Engineering and Information Technology, EMEIT 2011 | Year: 2011

The purpose of this paper is to propose a new algorithm which is based on combining the linear model and the method about smooth exponential. It is used to simulate the AR model of the Single sliding window sequence of observations and gets the average value of the square of slide window observed values' residual noise and achieve the previous statistics on the latter statistic forecast with exponential smoothing method so as to decide whether the network traffic is normal or not. This algorithm is more efficiently comparing with GLR method and more reliable comparing with smooth exponential method, and has been proved is effectively in the detection for network traffic anomalies. © 2011 IEEE.

Guo J.,Chinese Academy of Sciences | Guo J.,Leshan Teachers College | Yang Y.,Chinese Academy of Sciences | Wang G.,Chinese Academy of Sciences | And 2 more authors.
Physiologia Plantarum | Year: 2010

Abies fabri (Mast.) Craib. (A. fabri) is an endemic and dominant species in typical subalpine dark coniferous forests distributed in mountainous regions of Western Sichuan, China. We investigated the ecophysiological responses of A. fabri seedlings to short-term experimental drought, nitrogen supply and their interaction. Drought stress was created by excluding natural precipitation with automatically controlled plastic roof that covered the seedlings. Nitrogen fertilization was applied weekly by spraying over seedlings ammonium nitrate solution (50 kg N ha-1 year-1) during the growing season of 2009. The results showed that drought stress decreased leaf relative water content (RWC), whereas it caused marked increases in root mass ratio (RMR) and root/shoot mass ratio by 6.19 and 10.39%, respectively, as compared with the control. Drought stress increased malondialdehyde (MDA) content, electrolyte leakage, proline content, soluble sugars content and the activities of antioxidant enzymes, whereas nitrogen supply decreased MDA content, but enhanced activities of some antioxidant enzymes [especially peroxidase (POD)]. In the drought stressed plots, nitrogen supply increased RWC and decreased the content of MDA. The combination of drought stress and nitrogen supply also decreased the activities of antioxidant enzymes. These results indicated that the negative effects of drought stress on A. fabri seedlings might be alleviated by nitrogen supply. Copyright © Physiologia Plantarum 2010.

Wu S.-L.,Leshan Teachers College | Liu F.,Leshan Teachers College
Acta Crystallographica Section E: Structure Reports Online | Year: 2012

The title compound [systematic name: (1,3,6,8β,13β,14,16β)- 20-ethyl-8-ethoxy-3,13-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl) aconitan-14-yl 4-methoxybenzoate], C35H51NO10, was isolated from roots of Aconitum carmichaeli Debx., which is a typical C 19-diterpenoid alkaloid. The molecule has an aconitane carbon skeleton with four six-membered rings and two five-membered rings. The six-membered rings adopt chair conformations or boat conformations, while the five-membered rings have envelope conformations. Intramolecular O - H⋯O and O - H⋯N hydrogen bonds help to stabilize the molecular structure. Weak intermolecular C - H⋯O interactions occur in the crystal structure. © 2012 International Union of Crystallography.

Zhang J.,Leshan Teachers College
Communications in Computer and Information Science | Year: 2011

This paper explains a small power photovoltaic control system based on PLD. And a new way is applied to trace the maximum power point based on the improved accelerating simplex method. The system perfects the management and protection for the charge and discharge of storage battery also for the load and solar power supply. It's very important part that the techniques of maximum power point tracking and islanding protecting, but also the technique for inverter to connected with grid are discussed at emphasis. This system scheme can be made use of in several photovoltaic products and obtain the satisfied result. © 2011 Springer-Verlag Berlin Heidelberg.

Li X.-M.,Leshan Teachers College
Defect and Diffusion Forum | Year: 2010

The local distortion of the impurity Ni+ center in magnesium oxide is theoretically studied by analyzing its electron paramagnetic resonance g factor from the formula of a 3d9 ion under octahedra with tetragonal elongation deformation. The defect center is suggested to exhibit the relative elongation along the four-fold axis by about 0.05 Ä of the Jahn-Teller nature. The observed isotropic g factor (≈ 2.2391) is attributable to the dynamical average of the anisotropic g values under tetragonal elongation due to the dynamical Jahn-Teller effect. © (2010) Trans Tech Publications.

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