Suresnes, France
Suresnes, France

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Association between 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3H-[1,3]-oxazino[6,5-g][1,2,3]benzotriazine-4,9-dione of formula (I): or an addition salt thereof with a pharmaceutically acceptable acid or base, and an acetylcholinesterase inhibitor. Medicinal products containing the same which are useful in treating cognitive disorders associated with cerebral ageing and with neurodegenerative diseases.


Association between 3-[(3-{[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1H-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione of formula (I): or a Z or E isomer thereof and/or an addition salt thereof with a pharmaceutically acceptable acid or base, and a human epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. Medicinal products containing the same which are useful in treating non-small cell lung cancer.


A method of preparing isolated microsomes comprising an irreversibly inhibited cytochrome P450 (CYP450). Isolated microsomes are characterized in that a cytochrome P450 thereof is irreversibly inhibited by a non-reversible inhibitor. The isolated microsomes according to the invention may be used in a method of phenotyping enzymatic reactions of a drug candidate.


Patent
Les Laboratoires Servier | Date: 2015-05-06

Ivabradine hemipamoate of formula (1): and its hydrates. Medicinal products containing the same which are useful in the treatment or prevention of the various clinical situations of myocardial ischaemia such as angina pectoris, myocardial infarction and the associated rhythm disturbances, as well as in the various pathologies involving rhythm disturbances, especially supraventricular rhythm disturbances, and in systolic or diastolic heart failure.


Compounds of formula (I):_(1), R_(2), R_(3), R_(4), R_(5), R_(6), R_(7), R_(12), X, A and n are as defined in the description.


Patent
Les Laboratoires Servier and Vernalis | Date: 2015-07-13

Compounds of formula (I): wherein A_(1), A_(2), R_(a), R_(b), R_(c), R_(d), R_(3), R_(4), R_(5 )and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.


Compounds of formula (I): wherein R_(a), R_(b), R_(c), R_(d), R_(1), R_(2), R_(3), R_(4), R_(5), X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.


Compounds of formula (I): wherein X, Y, A_(1), A_(2), R_(a), R_(b), R_(c), R_(d), R_(3), R_(4, )T and R_(5 )are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.


Use of ivabradine, or 3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-methyl}(methyl)amino]propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one, of its addition salts with a pharmaceutically acceptable acid and of their hydrates, as a diagnostic agent in the method of coronary angiography by multislice computed tomography.


Patent
Les Laboratoires Servier | Date: 2015-04-08

Methods for predicting long-term remission among depressed patients. Biomarkers for the prediction of long-term remission in depression.

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