Les Laboratoires Servier

Suresnes, France

Les Laboratoires Servier

Suresnes, France
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Compounds of formula (I): wherein R_(1), R_(2), R_(3), R_(4), R_(5), R_(6), R_(7), R_(12), X, A and n are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.


Patent
Les Laboratoires Servier and Vernalis | Date: 2017-01-30

Compounds of formula (I): wherein A_(1), A_(2), R_(a), R_(b), R_(c), R_(d), R_(3), R_(4), R_(5 )and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.


Compounds of formula (I): wherein R_(a), R_(b), R_(c), R_(d), R_(1), R_(2), R_(3), R_(4), R_(5), X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.


Combination between 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8- dihydro-3H-[l,3] oxazino[6,5-g][l,2,3]benzotriazine-4,9-dione of formula (I) or an addition salt thereof with a pharmaceutically acceptable acid or base, and an acetylcholinesterase inhibitor.


Compounds of formula (I): wherein X, Y, A_(1), A_(2), R_(a), R_(b), R_(c), R_(d), R_(3), R_(4), T and R_(5 )are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.


The invention relates to novel isoquinoline derivatives of formula (I), to the synthesis thereof, and to the use of same in the prevention and/or treatment of pathologies resulting from the activation of the RhoA/ROCK pathway and the phosphorylation of the light chain of myosin. X represents a group -C(=0)-, -CH(OH)- or -CH2-, and the other substituents represent various groups such as those defined in claim 1.


A method of preparing isolated microsomes comprising an irreversibly inhibited cytochrome P450 (CYP450). Isolated microsomes are characterized in that a cytochrome P450 thereof is irreversibly inhibited by a non-reversible inhibitor. The isolated microsomes according to the invention may be used in a method of phenotyping enzymatic reactions of a drug candidate.


Association between 3-[(3-{[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1H-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione of formula (I): or a Z or E isomer thereof and/or an addition salt thereof with a pharmaceutically acceptable acid or base, and a human epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. Medicinal products containing the same which are useful in treating non-small cell lung cancer.


Patent
Les Laboratoires Servier and French National Center for Scientific Research | Date: 2017-03-06

The present disclosure is directed to progastrin monoclonal antibodies, fragments thereof, compositions comprising progastrin monoclonal antibodies, and methods of making and using progastrin monoclonal antibodies and compositions thereof. The present disclosure is directed to methods of treating colorectal cancer with progastrin monoclonal antibodies and compositions comprising progastrin monoclonal antibodies or fragments thereof. The present disclosure is further directed to methods comprising detection of progastrin, including methods of diagnosing colorectal cancer and methods of monitoring efficacy of anti-cancer therapy in subjects suffering from colorectal cancer.


Use of ivabradine, or 3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-methyl}(methyl)amino]propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one, of its addition salts with a pharmaceutically acceptable acid and of their hydrates, as a diagnostic agent in the method of coronary angiography by multislice computed tomography.

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