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Suresnes, France

Patent
Les Laboratoires Servier | Date: 2014-03-21

Use of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy}benzamide of formula (I): or an addition salt thereof with a pharmaceutically acceptable acid or base, in the treatment of neuropathic pain and of cognitive disorders, depression and anxiety associated with that pain.


Medicinal products containing the crystalline form I of the compound of formula (I): and/or crystalline form I of the associated free base which are useful in the treatment of disorders of the histaminergic system.


Patent
Les Laboratoires Servier | Date: 2014-03-12

Dividable galenical form for the modified release of active ingredient, wherein the non-subdivided galenical form and a portion of said form obtained by subdivision have identical dissolution profiles.


Compounds of formula (I): wherein X, Y, A Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.


Process for the synthesis of the compound of formula (I): wherein R represents a para-methoxybenzyl (PMB) group or the following group: Application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.

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