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Francois S.,Laval University | Sarra-Bournet C.,Laval University | Jaffre A.,Laval University | Chakfe N.,Les Hopitaux Universitaires Of Strasbourg | And 2 more authors.
Journal of Biomedical Materials Research - Part B Applied Biomaterials | Year: 2010

It was previously showed that PLLA nanofiber mesh promoted good endothelial cell proliferation. A new technique was developed to produce nanofibers by air jet spinning inside the tubular shape of vascular prostheses and to characterize this nanofiber mesh. Polymer macromolecule stability was assessed by gel permeation chromatography. Thermal analyses were conducted with differential scanning calorimetry and dynamic mechanical analysis on PLLA nanofibers obtained with 4% and 7% solutions (w/v) in chloroform. Polyethylene terephthalate (PET) was also treated with atmospheric pressure dielectric barrier discharge under air or nitrogen atmosphere to optimize PLLA nanofiber adherence, assessed by peel tests. Air spinning induced a reduction of number-average molecular weight (Mn) for the 7% PLLA solution but not for the 4% solution. The nanofibers were more crystalline and less sensible to viscoelastic relaxation as a function of aging in the 4% solution than in the 7% solution. Discharge treatment of the PET promoted identical surface modification on PET film and PET textile surfaces. Moreover, the best PLLA nanofibers adhesion results were obtained under nitrogen atmosphere. This study demonstrates that it is possible to coat the internal side of tubular vascular prostheses with PLLA nanofibers, and provides a better understanding of the air spinning process as well as optimizing nanofibers adhesion. © 2010 Wiley Periodicals, Inc. Source

Khoffi F.,CNRS Textile Mechanics and Physics Laboratory | Khoffi F.,Institute dAnatomie Pathologique | Dieval F.,CNRS Textile Mechanics and Physics Laboratory | Dieval F.,Institute dAnatomie Pathologique | And 4 more authors.
Physics Procedia | Year: 2011

The objective of this study is to develop a technique for measuring the compliance of the textile vascular prostheses without membrane. The principle of this test is to investigate the dimensional changes of prostheses, using imaging techniques, submitted to internal pressure. The internal compliance is broken into three categories: the radial compliance, the longitudinal compliance and the volumetric compliance. The results have shown a significant difference in compliance between the polyethylene terephthalate (PET) vascular grafts and the healthy host arteries. © 2011 Published by Elsevier B.V. Source

Bogni S.,University of Bern | Ortner M.-A.,University of Bern | Vajtai I.,University of Bern | Jost C.,University of Bern | And 3 more authors.
Gastrointestinal Endoscopy | Year: 2012

Background: Complete closure of gastrotomy is the linchpin of safe natural orifice transgastric endoscopic surgery. Objective: To evaluate feasibility and efficacy of a new method of gastrotomy closure by using a sutureless laser tissue-soldering (LTS) technique in an ex vivo porcine stomach. Design: In vitro experiment. Setting: Experimental laboratory. Interventions: Histological analysis and internal and external liquid pressure with and without hydrochloric acid exposure were determined comparing gastrotomy closure with LTS and with hand-sewn surgical sutures. Main Outcome Measurements: Comparison of LTS and hand-sewn surgical gastrotomy closure. The primary outcome parameter was the internal leak pressure. Secondary parameters were the difference between internal and external leak pressures, the impact of an acid environment on the device, histological changes, and feasibility of endoscopic placement. Results: The internal liquid leak pressure after LTS was almost twice as high as after hand-sewn surgical closure (416 ± 53 mm Hg vs 229 ± 99 mm Hg; P = .01). The internal leak pressure (416 ± 53 mm Hg) after LTS was higher than the external leak pressure (154 ± 46 mm Hg; P < .0001). An acidic environment did not affect leak pressure after LTS. Endoscopic LTS closure was feasible in all experiments. Histopathology revealed only slight alterations beneath the soldering plug. Limitations: In vitro experiments. Conclusions: Leak pressure after LTS closure of gastrotomy is higher than after hand-sewn surgical closure. LTS is a promising technique for closure of gastrotomies and iatrogenic perforations. Further experiments, in particular survival studies, are mandatory. © 2012 American Society for Gastrointestinal Endoscopy. Source

Duclos M.,Service de Medecine du Sport et des Explorations Fonctionnelles | Duclos M.,University of Auvergne | Duche P.,University Blaise Pascal | Guezennec C.-Y.,Center National du Rugby | And 4 more authors.
Science and Sports | Year: 2010

Objectives: Physical activity is recommended at every stage of the care of obesity in adults and in children, with a high level of scientific evidences. The objective of this review is to propose practical answers to key-questions of physicians faced to prescription of regular physical activity in obese subjects. Methodology: Five " question-reply" were developed: (1) what are the costs of obesity? Of sedentary lifestyle? Of strategies to promote physical activity in obese subjects? (2) What are the benefits of regular physical activity in obese subjects? (3) What type of activity should be prescribed and/or avoided? (4) Is there contra-indications to physical activity in obese subjects? (5) How measuring habitual physical activity in obese subjects? Results and conclusion: This review leads to a consensus statement of the French Society for Sports Medicine and proposes a " check list" that may help the physician to prescribe physical activity in obese subjects. © 2010 Elsevier Masson SAS. Source

Reix N.,Les Hopitaux Universitaires Of Strasbourg | Reix N.,University of Strasbourg | Agin A.,Les Hopitaux Universitaires Of Strasbourg | Agin A.,University of Strasbourg | And 28 more authors.
Annales de Biologie Clinique | Year: 2015

We report in this publication the use of two educational tools, a questionnaire of satisfaction and a training book, to improve the training of students during their internship in clinical laboratory at the "Pôle de biologie des Hôpitaux universitaires de Strasbourg" in France. First, the ongoing training was assessed by the interns with a questionnaire measuring satisfaction. The analysis of this questionnaire identified four key points to improve: 1) define the teaching objectives, 2) organize the training with a schedule, 3) revise certain teaching methods and 4) ensure better integration of the students in the team of medical biologists. After this assessment, we implemented a training book to answer these four points. Indeed, the training book presents the objectives, the schedule of training, and how to validate the educational objectives. A new assessment was performed again using the same methodology. Results showed an improvement in student satisfaction from 74 to 88%. The questionnaire of satisfaction and the training book are presented in this article. The aim of the assessment of training combined with the training book is to incite the actors of the training (students and teachers) to continually improve the training. The objectives of the Pôle de Biologie are to obtain an 80% satisfaction rate during the 6 months trainings and to reduce or eliminate dissatisfaction, and finally to ensure the validation by students of 80 to 100% of their predetermined objectives. © 2015, John Libbey Eurotext. All rights reserved. Source

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