Lepu Medical Technology Beijing Co.

Beijing, China

Lepu Medical Technology Beijing Co.

Beijing, China
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Fu X.,Beijing University of Chemical Technology | He H.,Beijing University of Chemical Technology | Wang W.,Beijing University of Chemical Technology | Wang W.,Lepu Medical Technology Beijing Co.
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2017

The forming of balloons used in medical treatment is a kind of “black box art”. When a new balloon is being developed, the process parameters and tube dimension are usually determined by a method of trial and error. This method is inefficient in current rapid development of computer technology. Numerical simulation is expected to replace the experiments and experience to guide the development of the new products. In this study, the moulding of the balloon was simulated by a finite element method and the results obtained from the simulation agreed with that of the experiments under the same actual process parameters. Therefore the numerical simulation used is feasible for the process of balloons forming. The effect of process parameters on the wall thickness of balloon was analyzed based on orthogonal design method. The results showed that the effect of first stretch rate on the wall thickness of the balloon was the most significant compared with other process parameters. A regression model of the relationship between wall thickness and the process parameters was established, which could be used to guide the selection of production process parameters. © Springer International Publishing AG 2017.


Chang H.-B.,Navy General Hospital of PLA | Pan T.-F.,Lepu Medical Technology Beijing Co. | Lu W.-S.,Navy General Hospital of PLA | Wang P.,Navy General Hospital of PLA | And 2 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2014

BACKGROUND: Dural repair materials in current application mainly include autologous tissue repair material, allograft material, heterogeneous biological material and synthetic material, most of which are imported products with expensive price. OBJECTIVE: To evaluate safety and efficacy of a new biological type dura mater patch made in China based on animal experiments. METHODS: Bilateral dura mater defect models were established in 24 healthy domestic dogs: on the left side of the implant model, a new type biological dura patch was transplanted as experimental group; on the right side, another brand artificial dura patch that was on sale was transplanted as control group. After 1, 3, 6 and 12 months of implantation, we compared degradation, angiogenesis, growth and surrounding tissue reaction of dural substitutes of the experimental group and control group by hematoxylin-eosin staining, detected residual dose of epoxy-cross-linked agent in dogs' blood and cerebrospinal fluid by fluorescence spectrophotometry. RESULTS AND CONCLUSION: During 1-12 months of implantation, all dogs grew well and no infection or motor disorder was observed. Pathological examination showed that dura substitutes of the experimental group and control group had good biocompatibility, no or slightly inflammatory response. After 6 months of implantation, the surface of the new biological dural substitute (experimental group) was degraded and became a transit-state biomaterial with surrounding tissue, but the control group materials showed no degradation. After 12 months of implantation, the dura patch in the experimental group degraded nearly 50%, which appeared with neovascularization; while, the dura patch in the control group degraded 30%, and neovascularization was observed in only a small amount of samples. Epoxy compounds of cross-linked agent were not detected in dogs' blood and cerebrospinal fluid after 1, 3, 7 and 14 postoperative days. These findings show that this new type of biological dural substitute is a safe and effective dural repair material.


PubMed | Lepu Medical Technology Beijing Co., The General Hospital of the Peoples Liberation Army, Zhengzhou University and Peking University
Type: Journal Article | Journal: Acta Cardiologica Sinica | Year: 2016

In-stent restenosis following the insertion of conventional drug-eluting stent has become an extremely serious problem due to coating techniques, with polymer matrices used to bind biological ingredients to the stent surface. However, several studies have indicated that new pro-healing technique could prevent stent thrombosis that can be caused by conventional drug-eluting stents.A novel method of attaching anti-CD34 antibodies directly on the porous surface of a 316L stainless steel bare metal stent was developed in this study, which achieved both high stability of attached anti-CD34 antibodies on the metal stent surface and high antibody activity for stem cell capture.The in vitro and in vivo experimental results indicated that the new stent with directly coupled anti-CD34 antibodies can efficiently enhance stent endothelialization.This study indicates that we have developed a unique method of attaching anti-CD34 antibodies directly on the porous surface of a 316L stainless steel bare metal stent, which provides a novel polymer-free approach for developing pro-healing stents.


Yu Z.-J.,China Pharmaceutical University | Chen Y.-Q.,Lepu Medical Technology Beijing Co. | Yang X.-D.,China Pharmaceutical University
Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica | Year: 2013

Stainless steel (AISI 316L) is commonly used as a material in medical devices. Modification of the metal surface with bioactive molecules and/or nanoparticles to develop next-generation smart biomaterial, e.g., cardiovascular stents, has recently attracted great attention. The present work investigated adsorption of antibodies and enzymes on micro/nanoporous 316L stainless steel compared with that on smooth and gold-coated stainless steel surfaces. The experimental results showed that the micro/nanoporous stainless steel surface produced by electrochemical erosion can adsorb a large amount of proteins (antibodies or horse radish peroxidase (HRP)), with comparable or better results than the sputtered-gold surface. Washes with surfactants (e.g., 10% bull serum albumin (BSA) or 0.2% Tween 20 solution) did not remove the enzymes/antibodies. In contrast, pretreatment of the metal plates with 5% Tween 20 halved antibody adsorption but did not affect adsorption of HRP. The wettability of the porous metal surface coated with proteins depended on the protein species and amount of protein adsorbed. The protein-coated porous surface was hydrophilic (water contact angle&<50°), which should make it biocompatible. The proteins on the micro/nanoporous stainless steel surface retained their high biological activity; in particular, micro/nanoporous stainless steel stents modified with an anti-CD34 antibody using the present method can effectively and selectively developing novel polymer-free, smart, economic applications. © Editorial office of Acta Physico·Chimica Sinica.


Patent
Lepu Medical Technology Beijing Co. | Date: 2013-05-22

An inflation-deflation device for tourniquet comprising: a barrel (11) and a plunger (12) fitting tightly within the barrel (11). A connecting rod (13) is fixed at one end of the plunger (12). The barrel (11) is fixedly connected at its bottom to a short tube (10). The short tube (10) is connected to the interior space of the barrel (11). The connecting rod (13) having a cruciform cross-section structure, a baffle (16) is perpendicularly fixed to the two sides opposite each other from the central axis of the structure. Connected on the barrel (11) is a clasp (15), the clasp (15) is fixedly connected to the barrel (11) and extends into the interior surface of the barrel (11). The inflation-deflation device has a distinctively designed inflation hole connection tip, to prevent confusion with a standard Luer connection of an ordinary liquid syringe, and also has a distinctively designed deflation limit, to control effectively the volume of gas discharged in a single deflation, and to prevent mishandling.


Patent
Lepu Medical Technology Beijing Co. | Date: 2011-07-14

An inflation-deflation device for tourniquet comprising: a barrel (11) and a plunger (12) fitting tightly within the barrel (11). A connecting rod (13) is fixed at one end of the plunger (12). The barrel (11) is fixedly connected at its bottom to a short tube (10). The short tube (10) is connected to the interior space of the barrel (11). The connecting rod (13) having a cruciform cross-section structure, a baffle (16) is perpendicularly fixed to the two sides opposite each other from the central axis of the structure. Connected on the barrel (11) is a clasp (15), the clasp (15) is fixedly connected to the barrel (11) and extends into the interior surface of the barrel (11). The inflation-deflation device has a distinctively designed inflation hole connection tip, to prevent confusion with a standard Luer connection of an ordinary liquid syringe, and also has a distinctively designed deflation limit, to control effectively the volume of gas discharged in a single deflation, and to prevent mishandling.


Patent
Lepu Medical Technology Beijing Co. | Date: 2016-05-11

An ultrasonic ablation catheter comprises a catheter body (1), an ultrasonic treatment energy converter set (2), an ultrasonic imaging energy converter set (3), a control handle (4) and an energy converter interface (5). The catheter body (1) is of a cylindrical structure; the ultrasonic treatment energy converter set (2) is disposed on the lateral surface of the far end of the catheter body (1), is of a sheet shape or an unclosed ring shape and can emit line-shaped or subrounded ultrasonic beams. The crossing distance between every two adjacent ultrasonic treatment energy converters (21) is more than or equal to 1 cm. Each ultrasonic imaging energy converter (31) is positioned between every two adjacent ultrasonic treatment energy converters (21). The control handle (4) is disposed at the near end of the catheter body (1). The energy converter interface (5) comprises a first interface (51) and a second interface (52). After sympathetic nerve fibers are ablated by the ablation catheter, the nerve fibers can be cut into sections which are not continuous mutually and are completely separated in the middle; moreover, the coverage distance between the ultrasonic treatment energy converters (21) is long (more than or equal to 1 cm), so that mutual chemotaxis and self repair of the completely separated nerve fibers are avoided and stability of an effect of removing the sympathetic nerve fibers is improved.


Patent
Lepu Medical Technology Beijing Co. | Date: 2014-04-30

A medical closure system comprises a closure stent (100) and a delivery device (200); the closure stent (100) comprises a stent outer layer (1), a film (3) disposed on the stent outer layer (1), and a mandrel (8) passing through the stent outer layer (1); the distal end of the mandrel (8) is fixedly connected to the distal end of the stent outer layer (1); the closure stent (100) is made of a degradable polymer; the delivery device (200) comprises an external push tube (11) and an internal push rod (10) installed in the external push tube (11); the external push tube (11) and the internal push rod (10) are movable relative to each other in an axial direction; the external push tube (11) is movably connected to the proximal end of the stent outer layer (1); and the internal push rod (10) is movably connected to the proximal end of the mandrel (8). The medical closure system can automatically degrade after being implanted into a human body, thus eliminating the hidden risk of a side effect caused by residue of the closure stem left in the human body.


Patent
Lepu Medical Technology Beijing CO. | Date: 2010-03-17

A method for fixing antibody on the surface of a medical instrument, mainly includes: 1) pre-treating the instrument surface; 2) preparing holes: preparing multicrystal phase structure which has holes of the same size in the surface of the instrument by chemical corrosion, electrochemical corrosion, anodic oxidation, micro-arc oxidation, or micro-arc nitridation; 3) post-treating the instrument surface; 4) fixing the antibody: immersing the bare metal scaffold which has holes in its surface into a buffer solution containing antibody, adjusting the pH value of the antibody buffer solution, fixing the antibody on the surface of the instrument by the attraction between positive and negative charge and hole effect; and 5) confirming the effectiveness of the fixed antibody by artificial simulation hemodynamics and detecting method of antibody activity in the scaffold surface. The method can promote the degree to which the antibody is firmly fixed on the surface of the instrument, and keep high activity of the antibody on the surface of medical instrument.


Wu X.,Chongqing University | Wang G.,Chongqing University | Tang C.,Chongqing University | Zhang D.,Chongqing University | And 4 more authors.
Journal of Biomedical Materials Research - Part A | Year: 2011

This study is designed to make a novel cell seeding stent and to evaluate reendothelialization and anti-restenosis after the stent implantation. In comparison with cell seeding stents utilized in previous studies, Mesenchymal stem cells (MSCs) have advantages on promoting of issue repair. Thus it was employed to improve the reendothelialization effects of endovascular stent in present work. MSCs were isolated by density gradient centrifugation and determined as CD29+CD44+CD34- cells by immunofluorescence and immunocytochemistry; gluten and polylysine coated stents were prepared by ultrasonic atomization spray, and MSCs seeded stents were made through rotation culture according to the optimized conditions that were determined in previous studies. The results from animal experiments, in which male New Zealand white rabbits were used, show that the reendothelialization of MSCs coated stents can be completed within one month; in comparison with 316L stainless steel stents (316L SS stents) and gluten and polylysine coated stents, the intimal hyperplasia and in-stent restenosis are significantly inhibited by MSCs coated stents. Endovascular stent seeded with MSCs promotes reendothelialization and inhibits the intimal hyperplasia and in-stent restenosis compared with the 316L SS stents and the gluten and polylysine coated stents. Copyright © 2011 Wiley Periodicals, Inc.

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