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Williamson P.,Lensfield Road | Galvan A.,Lensfield Road | Gaunt M.J.,Lensfield Road
Chemical Science | Year: 2017

A cobalt-catalysed C-H carbonylation of aliphatic carboxamide derivatives is described, employing commercially available Co(ii)-salts in the presence of a silver oxidant. This operationally simple process utilises an atmospheric pressure of CO and generates a range of substituted succinimide products bearing diverse functional groups that can be successfully accessed via this methodology. © The Royal Society of Chemistry.


Cope S.M.,Arizona State University | Shinde S.,Arizona State University | Best R.B.,Lensfield Road | Best R.B.,U.S. National Institute of Diabetes and Digestive and Kidney Diseases | And 2 more authors.
Biophysical Journal | Year: 2013

We report for the first time, to our knowledge, that the N-terminal loop (N-loop) of amylin (islet amyloid polypeptide (IAPP) residues 1-8) forms extremely long and stable non-β-sheet fibers in solution under the same conditions in which human amylin (hIAPP) forms amyloid fibers. This observation applies to the cyclic, oxidized form of the N-loop but not to the linear, reduced form, which does not form fibers. Our findings indicate a potential role of direct N-loop-N-loop interactions in hIAPP aggregation, which has not been previously explored, with important implications for the mechanism of hIAPP amyloid fiber formation, the inhibitory action of IAPP variants, and the competition between ordered and disordered aggregation in peptides of the calcitonin peptide family. © 2013 The Authors.


PubMed | Imperial College London, FlexEnable Ltd, Optoelectronics Group, Lensfield Road and King Abdullah University of Science and Technology
Type: | Journal: Nature materials | Year: 2016

Due to their low-temperature processing properties and inherent mechanical flexibility, conjugated polymer field-effect transistors (FETs) are promising candidates for enabling flexible electronic circuits and displays. Much progress has been made on materials performance; however, there remain significant concerns about operational and environmental stability, particularly in the context of applications that require a very high level of threshold voltage stability, such as active-matrix addressing of organic light-emitting diode displays. Here, we investigate the physical mechanisms behind operational and environmental degradation of high-mobility, p-type polymer FETs and demonstrate an effective route to improve device stability. We show that water incorporated in nanometre-sized voids within the polymer microstructure is the key factor in charge trapping and device degradation. By inserting molecular additives that displace water from these voids, it is possible to increase the stability as well as uniformity to a high level sufficient for demanding industrial applications.


Fox J.C.,Lensfield Road | Gilligan R.E.,Lensfield Road | Pitts A.K.,Lensfield Road | Bennett H.R.,Lensfield Road | Gaunt M.J.,Lensfield Road
Chemical Science | Year: 2016

A synthesis of the bioactive indolocarbazole alkaloid K-252c (staurosporinone) via a sequential C-H functionalisation strategy is reported. The route exploits direct functionalisation reactions around a simple arene core and comprises of two highly-selective copper-catalysed C-H arylations, a copper-catalysed C-H amination and a palladium-catalysed C-H carbonylation, which build up the structural complexity of the natural product framework. © The Royal Society of Chemistry 2016.


Less R.J.,Lensfield Road | Allen L.K.,Lensfield Road | Steiner A.,University of Liverpool | Wright D.S.,Lensfield Road
Dalton Transactions | Year: 2015

Reaction of LiAlH4 with 1,2-phenylenediamine (1H4) in THF results in formation of the metallocyclic amido-/imido complex [{Al(1H2)}2{Al(1H)2}2][Li(THF)2]4 (3), while in the presence of various Lewis base ligands 1,8-diaminonaphthalene (2H4) gives the amido-('ate') complexes [Al(2H2)2]-[Li(LL′)]+ [L = THF, L′ = PMDETA (N,N,N′,N′,N′′-pentamethyldiethylenetriamine) (4); L = L′ = TMEDA (N,N,N′,N′-tetramethylethylenediamine) (5)]. The latter complexes provide evidence of intermediates in the proposed reaction pathway for formation of the cyclic framework of the tetraanion [{Al(1H2)}2{Al(1H)2}2]4- of 3. This journal is © The Royal Society of Chemistry 2015.


Bell L.,Cambridge Nanoscience Center | Seshia A.,Cambridge Nanoscience Center | Lando D.,0 Tennis Court Road | Laue E.,0 Tennis Court Road | And 3 more authors.
Sensors and Actuators, B: Chemical | Year: 2014

We describe a microfluidic device designed specifically for the reversible immobilisation of Schizosaccharomyces pombe (Fission Yeast) cells to facilitate live cell super-resolution microscopy. Photo-Activation Localisation Microscopy (PALM) is used to create detailed super-resolution images within living cells with a modal accuracy of >25 nm in the lateral dimensions. The novel flow design captures and holds cells in a well-defined array with minimal effect on the normal growth kinetics. Cells are held over several hours and can continue to grow and divide within the device during fluorescence imaging. © 2013 The Authors. Published by Elsevier B.V. All rights reserved.


Jackson S.E.,Lensfield Road
Topics in Current Chemistry | Year: 2013

Hsp90 is a highly abundant and ubiquitous molecular chaperone which plays an essential role in many cellular processes including cell cycle control, cell survival, hormone and other signalling pathways. It is important for the cell's response to stress and is a key player in maintaining cellular homeostasis. In the last ten years, it has become a major therapeutic target for cancer, and there has also been increasing interest in it as a therapeutic target in neurodegenerative disorders, and in the development of anti-virals and anti-protozoan infections. The focus of this review is the structural and mechanistic studies which have been performed in order to understand how this important chaperone acts on a wide variety of different proteins (its client proteins) and cellular processes. As with many of the other classes of molecular chaperone, Hsp90 has a critical ATPase activity, and ATP binding and hydrolysis known to modulate the conformational dynamics of the protein. It also uses a host of cochaperones which not only regulate the ATPase activity and conformational dynamics but which also mediate interactions with Hsp90 client proteins. The system is also regulated by post-translational modifications including phosphorylation and acetylation. This review discusses all these aspects of Hsp90 structure and function. © Springer-Verlag Berlin Heidelberg 2011.


Abalde-Cela S.,University of Vigo | Auguie B.,University of Vigo | Fischlechner M.,Lensfield Road | Huck W.T.S.,Lensfield Road | And 3 more authors.
Soft Matter | Year: 2011

Microdroplets have been used as reactors for the fabrication of agarose beads with high uniformity in shape and size, and densely loaded with silver ions, which were subsequently reduced into nanoparticles using hydrazine. The resulting nanocomposite beads not only display a high plasmonic activity, but can also trap/concentrate analytes, which can be identified by means of surface-enhanced Raman scattering (SERS) spectroscopy. The size of the beads is such that it allows the detection of a single bead under a conventional optical microscope, which is very useful to reduce the amount of material required for SERS detection. © 2011 The Royal Society of Chemistry.


PubMed | Lensfield Road and University of Cambridge
Type: Journal Article | Journal: Physical chemistry chemical physics : PCCP | Year: 2016

Rechargeable battery systems based on Mg-ion chemistries are generating significant interest as potential alternatives to Li-ion batteries. Despite the wealth of local structural information that could potentially be gained from Nuclear Magnetic Resonance (NMR) experiments of Mg-ion battery materials, systematic


PubMed | Lensfield Road
Type: Journal Article | Journal: Chemical communications (Cambridge, England) | Year: 2016

The presence of 18-crown-6 in the Lewis acid-promoted dehydrocoupling reaction of ammonia borane permits isolation of [(THF)BH2NH3](+) and [BH2(NH3)2](+) cations. [(THF)BH2NH3](+) reacts with Lewis bases to give either boron adducts or by deprotonation at nitrogen to give borazine and ammonia-borane.

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