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Penmatsa C.,Lenora Institute of Dental science | Jampanapalli S.R.,JKK Nataraja Dental College and Hospital | Bezawada S.,College of St. Joseph | Birapu U.K.C.,SVS Institute of Dental science
Journal of Clinical and Diagnostic Research

Zinsser-Cole-Engmann syndrome also called Dyskeratosis Congenita (DKC) is a rare genodermatosis first described by Zinsser in 1906. Mutations in DKC1 gene is responsible for DKC. It is usually inherited as an X-linked recessive trait, resulting in a striking male predilection. It is characterized by a triad of reticular skin pigmentation, nail dystrophy and mucosal leukoplakia. Complications include predisposition to malignancy and bone marrow failure. Here, we report a case of DKC in a 9-year-old boy with classic triad of signs. Special investigations like endoscopy, barium swallow and bone-marrow aspiration study confirmed the diagnosis. There is no effective treatment for DKC. Some preventive measures can be adopted and the only long term cure for the haematological abnormalities is allogenic haemopoietic stem cell transplantation. © 2016, Journal of Clinical and Diagnostic Research. All rights reserved. Source

Rao K.V.S.E.,Lenora Institute of Dental science | Chitturi R.T.,Sibar Institute of Dental science | Kattappagari K.K.,Sibar Institute of Dental science | Kantheti L.P.C.,Sibar Institute of Dental science | And 2 more authors.
Indian Journal of Sexually Transmitted Diseases

Background: Human immunodeficiency virus (HIV) infection remains a global health problem, although the development of highly active antiretroviral therapy (HAART) has significantly modified the course of HIV disease into a manageable disease with improved quality-of-life mainly in the developed countries. Very few studies are available regarding effect of HAART on oral lesions in developing countries like India. Aims and Objectives: The aim was to document and compare oral lesions in HIV-seropositive patients before and after HAART. Materials and Methods: Oral manifestations were recorded in 320 HIV seropositive patients attending to the Voluntary Counseling and Confidential Testing Centre at the Government General Hospital, Guntur, before and after treating with HAART and the results were statistically analyzed using Student's t-test and Chi-square test. Results: Oral Candidiasis was significantly reduced in patients under HAART after 3 months. Furthermore, there was decreased incidence of periodontal diseases, but increased hyperpigmentation in patients undergoing HAART. Conclusion: The oral manifestations of HIV infection have changed due to the advent of HAART. Many opportunistic infections have resolved as a result of an improved immune system. Though the risk of hyperpigmentation in those with HAART has increased the prevalence of oral candidiasis and periodontal diseases were less in patients who had access to HAART. Source

Subbarao V.V.,Lenora Institute of Dental science | Regalla R.R.,Rajiv Gandhi Institute of Medical science | Santi V.,Drs Sudha and Nageswara Rao Siddhartha Institute of Dental science | Kattimani V.S.,Sibar Institute of Dental science
The journal of contemporary dental practice

BACKGROUND: Orthodontists have several methods to detect inter arch-tooth size discrepancies in patients presenting for orthodontic treatment. Many methods such as Pont's analysis, Nance and Carey's analysis, Peck and Peck ratio, Bolton's analysis are commonly used methods. A thorough search of literature reveals a paucity of reliable data on the mesiodistal dimensions of the crowns of the permanent dentition of Indian population. Without information about the size of individual tooth and groups of teeth for Indian population, it is difficult for the clinician to make an adequate diagnosis and treatment plan and to carry out a plan of therapy.AIM: To determine the size of individual permanent tooth and the sex differences, with tooth size ratios according to Bolton's formula and to evaluate the reliability of Bolton's norms (Anterior/ Posterior) in Indian population.MATERIALS AND METHODS: One hundred and twenty cases in which an excellent occlusion was naturally existent with the mean age of 22 years (18-27 years) were selected in the study. The casts were prepared after taking alginate impression of maxillary and mandibular arches and pouring them immediately with dental stone. A sliding Digital Vernier calliper used to measure the teeth. The ratios of the mean of mesiodistal dimensions of types of teeth were computed.RESULTS: The mean overall ratio for the Indian population is found to be 92.11 with a standard deviation of 2.12. The values ranged from 86.50-97.13 and the median is 92.16. The mean anterior ratio for the Indian population is found to be 78.14 with a standard deviation of 2.59.CONCLUSION: Bolton's original data does not represent Indian population. In our study greater size variability was found in maxillary teeth as compared with mandibular teeth except mandibular first molar. Our study indicated that population-specific standards are necessary for clinical assessments. Significant differences were shown for the overall ratio and anterior ratio for both sexes as compared to Bolton's ratio. Source

Maloth U.K.,Kamineni Institute of Dental science | Dorankula Y.P.R.,Kamineni Institute of Dental science | Pasupula A.P.,Mallareddy Dental College For Womens | Thokala M.R.,Lenora Institute of Dental science | And 2 more authors.
Journal of Clinical and Diagnostic Research

Background: Langerhans cells (LCs) are immunocompetent cells resident within oral mucosa which, together with intraepithelial lymphocytes, play a role in mucosal defence. LCs play a role in the pathogenesis of Oral lichen planus (OLP), a chronic mucocutaneous disorder thought to result from cell-mediated immune damage. In oral squamous cell carcinoma (OSCC), LCs are thought to present tumour antigens to the lymphocytes. Aim: To assess and compare LCs immuno-histochemically in normal mucosa, oral lichen planus and oral squamous cell carcinoma using anti S100 antibody and to know whether LCs play any role in local immune response to these diseases. Materials and Methods: The study was carried out in 65 cases (study group), 30 oral lichen planus and 35 oral squamous cell carcinoma (15 well differentiated, 14 moderately differentiated and 6 poorly differentiated), that were randomly selected from the archives of department of oral pathology and along with control group consisting of 30 normal healthy mucosa. The tissue sections were stained immunohisto-chemically by using anti S100 antibody in each group for detection of LCs. Results: There was significant change in mean value of number of LCs in the study groups i.e. OLP and OSCC when compared to that of control group. The results of our study also revealed that there was decrease in the mean value of langerhans cells as the tumour progressed from well differentiated squamous cell carcinoma to poorly differentiated LCs carcinoma. Conclusion: A better understanding and clarity of LCs is pivotal for designing novel or improved therapeutic approaches that will allow proper functioning of LC’s in patients with OLP and OSCC, thus significantly reducing the morbidity of OLP and OSCC patients. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved. Source

Gupta N.,Institute of Dental Education and Advanced Studies | Reddy U.N.,G Pulla Reddy Dental College and Hospital | Leela Vasundhar P.,Sri Sai Dental College and Research Institute | Sita Ramarao K.,Lenora Institute of Dental science | And 2 more authors.
Journal of Contemporary Dental Practice

Patients frequently report sensitivity of prepared abutment teeth during the temporization period and after the final cementation of full coverage restoration. Purpose of this clinical investigation was to evaluate the effectiveness of desensitizing agents in reducing the pre- and postcementation sensitivity for full coverage restorations and to compare the relative efficacy of three in office applied desensitizing agents in relieving the postcementation sensitivity with the use of glass ionomer luting cement. Materials and methods: This study consisted of 30 patients requiring either full coverage restoration or 3 unit fixed partial denture. Total of 40 restorations (n = 40) were made and were randomly assigned into four groups comprising 10 restoration (n = 10) in each group. Group C control where no desensitizer application was done, group BB applied with BisBlock dentin desensitizer (Bisco Inc.), group ST applied with Systemp desensitizer (Ivoclar Vivadent), group GC applied with GC Tooth Mousse desensitizer (GC Asia). Desensitizer application was done immediately after the tooth preparation. Sensitivity of the tested abutment was determined by the patient response to cold, hot and bite stimuli and were recorded on visual analog scale (VAS). Sensitivity level scores was evaluated at 4 time intervals, i.e. 1 week after desensitizer application at baseline precementation appointment and others at 5 minutes, 1 day and 1 week postcementation appointment. VAS score data was statistically analyzed using one-way ANOVA followed by post hoc Tukey's test. Results: BisBlock and GC Tooth Mousse desensitizer resulted in statistically significant (p < 0.01) reduction in postcementation sensitivity of glass ionomer cement in comparison to Systemp desensitizer at 5 minutes, 1 week postcementation time interval with no statistical difference was seen between all desensitizer groups at 1 day postcementation. Application of BisBlock and GC Tooth Mousse desensitizer resulted in highly significant (p < 0.01) reduction in sensitivity level at the end of 1 week. Clinical significance: Desensitizer's application on the prepared abutment teeth is considerably effective in relieving both pre- and postcementation sensitivity for full coverage restoration over the short duration of time. Immediate reduction in postoperative sensitivity relatively in a short time period may be beneficial in terms of patient's comfort. Nonetheless, multicenter long-term clinical trials should be conducted to confirm the results. Conclusion: Efficacy of BisBlock and GC Tooth Mousse desensitizer was more in relieving the postcementation sensitivity of glass ionomer cement at various time intervals in comparison to Systemp desensitizer. In conclusion, application of desensitizers was beneficial to reduce the pre- and postcementation abutment sensitivity. Source

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