Wetzlar, Germany
Wetzlar, Germany

Leica Camera AG , a German optics company, manufactures Leica cameras. The predecessor of the company, formerly known as Ernst Leitz GmbH, is now three companies: Leica Camera AG, Leica Geosystems AG, and Leica Microsystems GmbH, which manufacture cameras, geosurvey equipment, and microscopes, respectively. Leica Microsystems AG owns the Leica brand and licences the sister companies to use it. Wikipedia.


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The invention relates to a method for embedding a tissue sample into an embedding medium. In a first step the tissue sample is held in an intended orientation in a container by means of a holding element that presses the tissue sample against a base of the container. In a further step a liquid embedding medium that has a temperature above 64 degrees Celsius, in particular in the range from 65 degrees Celsius to 67 degrees Celsius, or a temperature of 66 degrees Celsius, is poured into the container, and the base of the container is cooled. In a further step a separating motion is executed by way of which the tissue sample and the holding element move away from each other, those layers of the embedding medium through which the holding element moves during the separating motion having, during the separating motion, temperatures in the range from 54 degrees Celsius to 64 degrees Celsius, in particular of 60 degrees Celsius, and/or those portions of the embedding medium which are directly adjacent to the holding element having, during the separating motion, a temperature in the range from 54 degrees Celsius to 64 degrees Celsius, in particular of 60 degrees Celsius.


The invention relates to an optical sensor element for a measuring machine, comprising a coupling element on the sensor element side for mechanically and optically connecting to a coupling element on the measuring machine side. An optical fiber is arranged in the coupling element on the sensor element side, wherein said optical fiber comprises an optical interface for connecting to an optical machine contact element of the measuring machine, wherein said optical interface is formed by an optical sensor contact element having a self-centering ferrule that encloses the end of the optical fiber. The ferrule is supported in the coupling element on the sensor element side in a floating manner.


Patent
Leica | Date: 2016-09-02

Some embodiments of the invention relate to a surveying pole comprising: at least two pole sections being telescopically insertable into each other so that a height adjustment of the pole is provided, a pointing tip at the lower end of the pole for setting the pole on a terrain point, a position giving means arranged on the pole, a height measuring system for measuring the height of the position giving means relative to the terrain point, wherein the height measuring system comprises a magneto-strictive wire placed inside of the pole, a magnet interacting with the wire, the positioning of the magnet relative to the wire being linked to the height adjustment of the pole, a sensor circuitry for emitting current pulses through the wire, a signal transducer, and a decoder for evaluating the signals and the current pulses, and therewith deriving the height of the position giving means.


Systems and methods for capturing image data using a line scan camera. In an embodiment, a line scan camera captures image data of a sample as a plurality of image stripes. A processor may coarsely align two or more of the plurality of image stripes according to a synchronization process while the line scan camera is capturing at least one of the plurality of image stripes. Subsequently, the processor may also finely align the two or more image stripes using pattern matching.


Calibration device (1) and calibration method for calibration of a laser beam horizontal trueness testing device (50) whereby the calibration device (1) comprises an elongated support body (4) for support of an elongated laser housing (3) with a longitudinal axis (A) and a laser source (2), whereby a laser beam (2) is emittable in direction of the longitudinal axis (A). According to the calibration method, calibration parameters are determined based on at least three impinging positions (P1, P2, P3) of the laser beam (L) of the laser housing (3) for at least two different rotational positions of the laser housing (3) in a first face (F1) and at least one position of the laser housing (3) in a second opposing face (F2).


The invention relates to an Illumination and observation system (1) for a microscope (2), in particular a microscope for performing eye surgery, a microscope and a microscopying method. The Illumination and observation system (1) comprises a first, second, third and fourth observation pupil (4, 5, 8, 9) for the eyes of two observers such as a surgeon and an assistant, a coaxial illumination (6, 10, 11) in the first, third and fourth observation pupil (4, 8, 9) to generate a red reflex (13) in the first, third and fourth observation pupil (4, 8, 9), and a main illumination (7) in the second observation pupil (5). In order to provide a wide illumination of the surroundings, the main illumination has a larger field of illumination than the coaxial illumination (6, 10, 11) in any of the first, third and fourth observation pupil (4, 8, 9). To provide superior observation quality, in particular for the observer using the second observation pupil (5) and further to be able to generate a visible and homogenous red reflex in the second observation pupil (5), it is provided according to the invention that the main illumination overlaps at least 50 % with the second observation pupil (5) to generate a red reflex (13) in the second observation pupil (5). Further improvements relate to align the main illumination (7) within 5 to an optical axis (12) of the second observation pupil (5) and to overlap the coaxial illumination (6, 10, 11) at least 50 % with the respective first, third and fourth observation pupil (4, 8, 9).


The present invention relates to a pivotable optical assembly (1) for a surgical microscope, in particular a zero-degree assistants device (2), the assembly comprising: a microscope body interface (3) for mounting the assembly (1) on a microscope body; an assistants module (5) including an interface (6) for an assistants tube, the assistants module (5) being pivotable about a pivot axis (11) relative to the microscope body (3); and a retaining system (7) that blocks pivoting the assistants module (5) about the pivot axis (11). The present invention furhter relates to a retaining system (7) for such pivotable optical assembly (1) of a surgical microscope. In order to provide a pivotable optical assembly for a surgical microscope and a retaining system therefor, that allows the assistant to change sides quickly, easily and without the requirement of separate equipment, the invention provides a retaining system (7) comprising a retaining element (12) being moveable from a locking position (L) into a release position (R), a biasing member (13) forcing the retaining element (12) into the locking position (L), and a hand-operable control element (14) acting on the retaining element (12) for moving it from the locking position (L) into the release position (R), as well as a pivotable optical assembly (1) comprising said retaining system (7) according to the invention, whose retaining element (12), in its blocking position (L), blocks pivoting the assistants module (5) about the pivot axis (11).


The invention relates to an Illumination and observation system (1), in particular for an ophthalmic microscope. The system comprises a first observation pupil (4) and a second observation pupil (5) for the eyes of an observer such as an assistant. Further, the system comprises a coaxial illumination (6) in the first observation pupil (4) and a main illumination (7), the coaxial illumination (6) being adapted to generate a red reflex (13) in the observed eye in operation and the main illumination having a larger field of illumination than the coaxial illumination (6, 10, 11). In order to facilitate usage of the system (1) and/or the microscope (2) and to create a superior stereoscopic view using the red reflex (13), a control subsystem (21, 27) is provided which is adapted to automatically adjust an intensity of the main illumination (7) depending on a change in an intensity of the coaxial illumination (6).


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-EID | Phase: MSCA-ITN-2016 | Award Amount: 1.53M | Year: 2017

Cardiovascular (CV) disease is a main cause of death worldwide. During adulthood, ischemic heart disease leads to heart failure and perinatally, congenital heart defects are found in over 20% of deaths. Moreover, genetic or epigenetic factors altering development can have an impact much later in life. These facts underscore the need of a better understanding of the genetic and environmental factors that influence CV development. An important way to increase our knowledge is by visualizing cardiac development in vivo. Recent advance in microscopy allows monitoring CV development at a cellular level in organisms such as the zebrafish model. Particularly revolutionary has been the development of light sheet microscopy (LSM). We want to further exploit LSM for in vivo manipulation of cells in the embryonic zebrafish heart and measure with high precision biophysical parameters, by introducing novel features to LSM such as optical tweezers. High throughput cardiac imaging protocols for zebrafish larvae suitable for screenings will be set up. We will develop softwares to enhance resolution of acquisition, large dataset handling and image-processing. The aim is to generate a toolbox to be implemented into existing software packages allowing a complete modeling of zebrafish cardiac morphogenesis. We will adapt LSM for adult zebrafish hearts to study cardiac regeneration and mouse heart development at cellular resolution. Each Early Stage Researchers (ESRs) will develop their own technology to solve a biological problem at the frontier of knowledge. ESRs will receive multidisciplinary (CV development, physics, biocomputing) as well as intersectorial (academic research, SMEs, large companies) training and will achieve unique skills on Microscopy and Image analysis allowing them to interrogate questions on cardiac development and regeneration. Their profile will be at the interface of a bioengineer and a life science researcher filling a currently existing gap on the market.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FOF-01-2016 | Award Amount: 5.95M | Year: 2016

KRAKEN will develop a disruptive hybrid manufacturing concept to equip SME and large industries with affordable All-in-one machine for the customised design, production/reparation and quality control of functional parts (made in aluminium, thermoset or both materials combined from 0,1m till 20m) through subtractive and novel additive technologies in vast working areas without floor space requirements. In KRAKEN project, new additive technologies targeting large areas using aluminium grades as well as thermoset materials will be validated at lab scale (TRL 4) and in relevant environments (TRL 5) and finally integrated and combined (Error! No se encuentra el origen de la referencia.) for the demonstration in industrial relevant environments (TRL 6). KRAKEN will collaborate to the consolidation of the Hybrid Manufacturing value chain by means of a consortium specially selected for linking research results to technological necessities in the fields of software, monitoring, automation, materials, standardization and end-users. KRAKEN machine will be devoted to the production and reparation of functional parts of any size with dimensional tolerances under 0.3 millimetres and surface roughness under Ra 0,1 m aiming to achieve 40% reduction in time and 30 % in cost and 25% increase in productivity. KRAKEN machine will be based on hybrid approach merging MEGAROB subtractive machine (working area 20x6x3 metres) together with high efficient metallic and novel non-metallic AM. After the end of the project, KRAKEN machine will be an affordable solution (1.5M estimated selling price, lower than current equipment and strategies for the production of final parts) for the customised production of large size functional parts; decreasing time (40%) and cost (30%), increasing productivity (at least 25%) and with a 90 % reduction of floor space required because it uses an ceiling installation broadly extended into the whole industry

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