Wetzlar, Germany
Wetzlar, Germany

Leica Camera AG , a German optics company, manufactures Leica cameras. The predecessor of the company, formerly known as Ernst Leitz GmbH, is now three companies: Leica Camera AG, Leica Geosystems AG, and Leica Microsystems GmbH, which manufacture cameras, geosurvey equipment, and microscopes, respectively. Leica Microsystems AG owns the Leica brand and licences the sister companies to use it. Wikipedia.


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Patent
Leica | Date: 2017-01-25

The invention relates to a surgical-microscope stand (100), comprising a first slide (16) arranged on a first support arm (14), which first slide can be driven by a first drive unit, and a second slide (18) arranged on a second support arm (22), which second slide can be driven by a second drive unit. The surgical-microscope stand (100) also comprises an operating region (34), within which at least one operating unit for manually controlling the first and second drive units is provided.


Patent
Leica | Date: 2017-02-06

Embodiments may include methods and systems for obtaining location information regarding an object. In one example, a laser pulse may be generated. The laser pulse may be divided into a plurality of laser pulse signals. Each of the laser pulse signals may be provided to a corresponding delay path, each delay path having a different length. An output of each delay path may be directed to the object. A plurality of reflected time-separated laser pulse signals from the object may be detected. The plurality of time-separated laser pulse signals may be combined to provide a recombined laser pulse signal. The recombined laser pulse signal may be resolved to generate object location information regarding the object.


Patent
Leica and Embl European Molecular Biology Laboratory | Date: 2017-02-07

A method for scanning a sample using an electrically or electronically controllable microscope includes performing a continuous scanning of the sample so as to repeatedly generate a plurality of images of the sample, each of the plurality of images corresponding to a different time, the microscope being controlled via a control computer during the scanning. The plurality of images are analyzed using at least one second computer connected via a network, wherein the at least one second computer is configured to classify each of the plurality of images as one of interesting and non-interesting while the continuous scanning of the sample with the microscope continues. The continuous scanning of the sample is automatically influenced based on the classifying of the images performed by the at least one second computer.


Method for creating a spatial model of a target object (3) with a hand-held distance measuring device (1), the device comprising a laser distance meter, a camera, a computing unit and a data storage device, the method comprising measuring with the laser distance meter one or more distances (50, 51, 52) to the target object from different positions, storing the measured distances in the data storage device, capturing with the camera a plurality of images (60, 61, 62) of the target object, wherein each of the measured distances is associated with one of the captured images, determining with the computing unit relative camera poses (70, 71, 72) for the plurality of images, and calculating with the computing unit based on the plurality of images and on the determined relative camera poses a three-dimensional geometry of the target object, characterized in that after the three-dimensional geometry has been calculated, the method further comprises retrieving at least one of the measured distances from the data storage device, and adding a scale to the three-dimensional geometry to obtain the spatial model of the target object, wherein the scale is calculated based on the at least one retrieved distance.


Patent
Leica | Date: 2017-06-21

The invention relates to a surveying pole (1) comprising at least two pole sections (11,11) being telescopically insertable into each other so that a height adjustment of the pole (1) is provided, a pointing tip (13) at the lower end of the pole (1) for setting the pole (1) on a terrain point (4), a receptacle (20) at an upper end of the pole for mounting a position giving means (5,6), a height measuring system for indicating the distance of the position giving means (5,6) relative to the terrain point (4), wherein the height measuring system comprises an electronic distance measuring unit (18), in the following called EDM unit, and a target (19), the EDM unit and the target being placed inside of the pole in such a way that the EDM unit being adapted to emit a light beam towards the target and to detect the light backscattered by the target, the light beam following a path inside of the pole, the EDM unit and the target further being mounted to the at least two pole sections so that a correlation between the height adjustment of the pole and the separation of the EDM unit and the target is provided, and an evaluation unit for deriving the height of the position giving means based on the detected light of the EDM unit.


The invention relates to a loading station (100, 200) for transferring a frozen sample for electron microscopy, comprising a chamber (104, 204), which is open in the upward direction and which can be at least partially filled with a coolant, wherein the chamber (104, 204) has, in a side wall thereof, at least two connections (101a, 102a, 103a) for different sample transfer devices (101, 102, 103), wherein the connections (101a, 102a, 103a) allow a frozen sample to be inserted into the chamber (104, 204) by means of a selected sample transfer device and allow a frozen sample to be removed from the chamber by means of a different sample transfer device, and wherein a receptacle (108, 208) for at least two differently designed sample holders (109, 110) is arranged in the chamber (104, 204), wherein the at least two sample holders (109, 110) can be detachably fastened to at least one of the sample transfer devices (101) in order to insert the frozen sample into the chamber (104, 204) and to remove the frozen sample from the chamber (104, 204).


The invention relates to a method for microscopically examining a sample (5). The method includes the steps: bringing the sample (5) into contact with an optically transparent medium (12) which has a higher refraction index than the sample (5), generating an illumination light beam (13), and guiding the illumination light beam (13) through an illumination lens (1) which focuses the illumination light beam. Subsequently, the deflecting of the illumination light beam (13) is carried out in the direction of the sample (5) to be examined using a deflection means arranged on a detection lens (2), in such a way that the illumination light beam hits an interface (10) between the optically transparent medium (12) and the sample (5) and is there completely reflected for evanescent illumination of the sample (5). Finally, detection is carried out of the fluorescent light emitted by the sample (5) and passing through the detection lens (2).


The invention relates to a microscope (21, 40, 60) having at least one correction unit (10), arranged in a beam path, for correcting a variable spherical aberration. The correction unit (10) comprises at least one optical correction element (12) that is moveably arranged along the optical axis (O) in a convergent or divergent region (14) of the beam path. The optical correction element (12) has a correction surface (18), the part of which that is passed through by the convergent or divergent region (14) of the beam path forming a correctionally effective surface section (20), the radial expansion of which can be altered across the optical axis (O) by moving the correction element (12) along the optical axis (O).


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-EID | Phase: MSCA-ITN-2016 | Award Amount: 1.53M | Year: 2017

Cardiovascular (CV) disease is a main cause of death worldwide. During adulthood, ischemic heart disease leads to heart failure and perinatally, congenital heart defects are found in over 20% of deaths. Moreover, genetic or epigenetic factors altering development can have an impact much later in life. These facts underscore the need of a better understanding of the genetic and environmental factors that influence CV development. An important way to increase our knowledge is by visualizing cardiac development in vivo. Recent advance in microscopy allows monitoring CV development at a cellular level in organisms such as the zebrafish model. Particularly revolutionary has been the development of light sheet microscopy (LSM). We want to further exploit LSM for in vivo manipulation of cells in the embryonic zebrafish heart and measure with high precision biophysical parameters, by introducing novel features to LSM such as optical tweezers. High throughput cardiac imaging protocols for zebrafish larvae suitable for screenings will be set up. We will develop softwares to enhance resolution of acquisition, large dataset handling and image-processing. The aim is to generate a toolbox to be implemented into existing software packages allowing a complete modeling of zebrafish cardiac morphogenesis. We will adapt LSM for adult zebrafish hearts to study cardiac regeneration and mouse heart development at cellular resolution. Each Early Stage Researchers (ESRs) will develop their own technology to solve a biological problem at the frontier of knowledge. ESRs will receive multidisciplinary (CV development, physics, biocomputing) as well as intersectorial (academic research, SMEs, large companies) training and will achieve unique skills on Microscopy and Image analysis allowing them to interrogate questions on cardiac development and regeneration. Their profile will be at the interface of a bioengineer and a life science researcher filling a currently existing gap on the market.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FOF-01-2016 | Award Amount: 5.95M | Year: 2016

KRAKEN will develop a disruptive hybrid manufacturing concept to equip SME and large industries with affordable All-in-one machine for the customised design, production/reparation and quality control of functional parts (made in aluminium, thermoset or both materials combined from 0,1m till 20m) through subtractive and novel additive technologies in vast working areas without floor space requirements. In KRAKEN project, new additive technologies targeting large areas using aluminium grades as well as thermoset materials will be validated at lab scale (TRL 4) and in relevant environments (TRL 5) and finally integrated and combined (Error! No se encuentra el origen de la referencia.) for the demonstration in industrial relevant environments (TRL 6). KRAKEN will collaborate to the consolidation of the Hybrid Manufacturing value chain by means of a consortium specially selected for linking research results to technological necessities in the fields of software, monitoring, automation, materials, standardization and end-users. KRAKEN machine will be devoted to the production and reparation of functional parts of any size with dimensional tolerances under 0.3 millimetres and surface roughness under Ra 0,1 m aiming to achieve 40% reduction in time and 30 % in cost and 25% increase in productivity. KRAKEN machine will be based on hybrid approach merging MEGAROB subtractive machine (working area 20x6x3 metres) together with high efficient metallic and novel non-metallic AM. After the end of the project, KRAKEN machine will be an affordable solution (1.5M estimated selling price, lower than current equipment and strategies for the production of final parts) for the customised production of large size functional parts; decreasing time (40%) and cost (30%), increasing productivity (at least 25%) and with a 90 % reduction of floor space required because it uses an ceiling installation broadly extended into the whole industry

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