Leibniz Institute For Naturstoff Forschung Und Infektionsbiologie Hki

Jena, Germany

Leibniz Institute For Naturstoff Forschung Und Infektionsbiologie Hki

Jena, Germany

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Lincke T.,Leibniz Institute For Naturstoff Forschung Und Infektionsbiologie Hki | Behnken S.,Leibniz Institute For Naturstoff Forschung Und Infektionsbiologie Hki | Ishida K.,Leibniz Institute For Naturstoff Forschung Und Infektionsbiologie Hki | Roth M.,Leibniz Institute For Naturstoff Forschung Und Infektionsbiologie Hki | And 2 more authors.
Angewandte Chemie - International Edition | Year: 2010

(Chemical Equation Presented) Choose sulfur in an oxygen-free world: Closthioamide (1) was isolated from the anaerobe Clostridium cellulolyticum (see SEM image) after the induction of its biosynthesis with an aqueous soil extract. An unprecedented type of symmetrical natural product in which all building blocks are connected through thioamide linkages, 1 is active against multiresistant staphylococci. It is the only known secondary metabolite from a strictly anaerobic bacterium. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

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