Legal Medicine Research Center

Tehrān, Iran

Legal Medicine Research Center

Tehrān, Iran
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Moaddeli A.,University of Yazd | Moaddeli A.,Legal Medicine Research Center | Abdollahi-Alibeik M.,University of Yazd
Journal of Porous Materials | Year: 2017

The condensation of aldehydes or ketones with amines and alkynes in the presence of pyridine-2-carboimine copper(I) complex immobilized on Fe3O4@MCM-41 nanoparticles as a novel catalyst was described, which provides an efficient and practical route to synthesize propargylamine derivatives in the mild conditions. The prepared catalyst was characterized by XRD, SEM, EDX, TEM, VSM, UV–Vis, BET and FTIR techniques. The results have been shown a unique activity for the catalyst in the reaction even at room temperature. The nano-sized magnetic catalyst was recovered by simple separation with an external magnet and favorable reusability was observed after several cycles for recovered catalyst in the model reaction. © 2017 Springer Science+Business Media New York

Tehrani H.,Islamic Azad University at Tehran | Halvaie Z.,Islamic Azad University at Tehran | Shadnia S.,Shahid Beheshti University of Medical Sciences | Soltaninejad K.,Legal Medicine Research Center | Abdollahi M.,Tehran University of Medical Sciences
Clinical Toxicology | Year: 2013

Objective. Aluminum phosphide is used as a fumigant. It produces phosphine gas (PH3). PH3 is a mitochondrial poison which inhibits cytochrome c oxidase, it leads to generation of reactive oxygen species; so one of the most important suggested mechanisms for its toxicity is induction of oxidative stress. In this regard, it could be proposed that a drug like N-acetylcysteine (NAC) as an antioxidant would improve the tolerance of aluminum phosphide-intoxicated cases. The objective of this study was to evaluate the protective effects of NAC on acute aluminum phosphide poisoning. Methods. This was a prospective, randomized, controlled open-label trial. All patients received the same supportive treatments. NAC treatment group also received NAC. The blood thiobarbituric acid reactive substances as a marker of lipid peroxidation and total antioxidant capacity of plasma were analyzed. Results. Mean ingested dose of aluminum phosphide in NAC treatment and control groups was 4.8 ± 0.9 g vs. 5.4 ± 3.3 g, respectively (p = 0.41). Significant increase in plasma malonyldialdehyde level in control group was observed (139 ± 28.2 vs. 149.6 ± 35.2 μmol/L, p = 0.02). NAC infusion in NAC treatment group significantly decreased malondialdehyde level (195.7 ± 67.4 vs. 174.6 ± 48.9 μmol/L, p = 0.03), duration of hospitalization (2.7 ± 1.8 days vs. 8.5 ± 8.2 days, p = 0.02), rate of intubation and ventilation (45.4% vs. 73.3%, p = 0.04). Mortality rate in NAC treatment and control groups were 36% and 60%, respectively with odds ratio 2.6 (0.7-10.1, 95% CI). Conclusion. NAC may have a therapeutic effect in acute aluminum phosphide poisoning. Copyright © 2013 Informa Healthcare USA, Inc.

Shadnia S.,Shahid Beheshti University of Medical Sciences | Rahimi M.,Shahid Beheshti University of Medical Sciences | Hassanian-Moghaddam H.,Shahid Beheshti University of Medical Sciences | Soltaninejad K.,Legal Medicine Research Center | Noroozi A.,Tehran University of Medical Sciences
Clinical Toxicology | Year: 2013

Context. Due to an increase in the number of methadone maintenance clinics in the past decade in Iran, acute methadone overdose has become one of the common poisonings in our society. Objective. To compare the characteristics of methadone poisoning between syrup and tablet formulation as well as to discuss the relative advantages and disadvantages of poisoning from the perspective of toxicity. Material and methods. In a retrospective cross-sectional study from 2000 to 2010, sampled data of all hospitalized methadone-overdosed patients were collected through chart review of hospital records. Concurrently, the total number of methadone sales was gathered. Results. A total of 1426 patients with methadone poisoning had been hospitalized, including 1072 cases who consumed syrup or tablet solely. Mean ± SD milligram ingested dose of syrup and tablet were 153 ± 339 and 88 ± 274, respectively (p < 0.001). The mean time elapsed since ingestion was 9 ± 9 and 7 ± 7 h, respectively. Most of the accidental poisoning cases occurred as a result of syrup formulation, particularly by children under 12 years old after being mistaken for cough mixture or water. Conversely, exposure to methadone tablets was more common in patients with suicidal intent. There was no statistically significant difference between the rates of intubation and death between the two groups. Discussion. Higher doses of methadone in the syrup form appear to exert a similar severity of poisoning and outcomes compared to lesser doses of that in the tablet form. Similarities in outcomes, despite differences in exposure history, may reflect relatively prompt transfer to hospital and adequate provision of clinical care, including supportive care and naloxone. Conclusion. In order to reduce the rate of poisoning, we recommend the use of child-resistant containers for dispensing syrup, reduction in methadone concentration, adding a coloring agent, special flavor, and education of patients on the safe storage of methadone in their home in order to reduce the occurrence of accidental poisonings. © 2013 Informa Healthcare USA, Inc.

Shadnia S.,Loghman Hakim Hospital | Shadnia S.,Shahid Beheshti University of Medical Sciences | Mehrpour O.,Birjand University | Soltaninejad K.,Legal Medicine Research Center
Indian Journal of Medical Sciences | Year: 2010

Background : Aluminum phosphide (AlP) is used as a fumigant. It produces phosphine gas, which is a mitochondrial poison. Unfortunately, there is no known antidote for AlP intoxication, and also, there are few data about its prognostic factors. AIMS: The aim of this study was to determine the impact of the Simplified Acute Physiology Score II (SAPSII) in the prediction of outcome in patients with acute AlP poisoning requiring admission to the Intensive Care Unit (ICU). Materials and Methods : This was a prospective study in patients with acute AlP poisoning, admitted to the ICU over a period of 12 months. The demographic data were collected and SAPSII was recorded. The patients were divided into survival and non-survival groups due to outcome. Statistical Analysis : The data were expressed as mean ±SD for continuous or discrete variables and as frequency and percentage for categorical variables. The results were compared between the two groups using SPSS software. Results : During the study period, 39 subjects were admitted to the ICU with acute AlP poisoning. All 39 patients required endotracheal intubation and mechanical ventilation in addition to gastric decontamination with sodium bicarbonate, permanganate potassium, and activated charcoal, therapy with MgSO 4 and calcium gluconate and adequate hydration. Among these patients, 26 (66.7%) died. SAPSII was significantly higher in the non-survival group than in the survival group (11.88 4.22 vs. 4.31 ±2.06, respectively) (P< 0.001). Conclusion : SAPSII calculated within the first 24 hours was recognized as a good prognostic indicator among patients with acute AlP poisoning requiring ICU admission.

Soltaninejad K.,Legal Medicine Research Center | Beyranvand M.-R.,Shahid Beheshti University of Medical Sciences | Momenzadeh S.-A.,Shahid Beheshti University of Medical Sciences | Shadnia S.,Shahid Beheshti University of Medical Sciences
Journal of Forensic and Legal Medicine | Year: 2012

Aluminium phosphide (AlP) poisoning has a high mortality due to cardiovascular involvement. In this study, we evaluated the frequency of cardiac manifestations and electrocardiographic (ECG) findings in 20 patients with acute AlP poisoning, who were admitted to the intensive care unit (ICU) in Tehran, Iran, over a period of 6 months (between October 2008 and April 2009). The sex, age, cause and manner of ingestion, number of ingested AlP tablets, cardiac and ECG manifestations, creatine phosphokinase (CPK), CPK-myocardial band (CPK-mb) and troponin-T (TnT) were extracted from the patients' files. All data were analysed with Statistical Package for the Social Sciences (SPSS) software. The majority (60%) of patients were male. The mean age was 27 ± 8.7 years. The mortality rate was 40%. In all of the patients, the cause of poisoning was intentional suicide and ingestion was the route of exposure. The mean number of ingested AlP tablets per patient was 2.2 ± 1.1. The average time interval between admission and cardiovascular manifestations or ECG findings was 168.8 ± 116.2 min. The range of systolic (SBP) and diastolic blood pressure was 60-130 mmHg and 40-70 mmHg, respectively. Dysrhythmia was observed in nine (45%) cases. Elevation of the ST segment was seen in nine cases (45%). Seven patients (35%) had prolonged QTc intervals. Bundle branch block (BBB) was observed in four (20%) patients. In nine (45%) patients, the serum cardiac TnT qualitative assay was positive. There were no significant differences between normal and abnormal ECG groups according to sex, age, number and manner of ingested AlP tablets and SBP. There was a significant correlation between cardiac manifestations and ECG findings and TnT-positive results with mortality in acute AlP poisoning. © 2012 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

Hedjazi A.,Legal Medicine Research Center | Nikbakht A.,Legal Medicine Research Center | Hosseini M.,Legal Medicine Research Center | Hoseinzadeh A.,Legal Medicine Research Center | Hosseini S.M.V.,Hormozgan University of Medical Sciences
Legal Medicine | Year: 2013

Allele frequency data at 15 short tandem repeat loci, D8S1179, D21S11, D7S820, CSF1PO, D3S1358, THO1, D13S317, D16S539, D2S1338, D19S433, VWA, TPOX, D18S51, D5S818 and FGA have been determined for unrelated individuals in a population sample of Iranian Fars individuals. With exception of the D13S317 (P-value = 0.0458) and TPOX (P-value = 0.0477), no deviation from HWE were found in the study population using the exact test. The most discriminating loci were FGA (PD = 0.965) and D2S1338 (PD = 0.964). These data can be used for estimating the frequency of short tandem repeat profiles in a population of Fars province individuals. © 2013 Elsevier Ireland Ltd.

Kalhor M.,Tehran University of Medical Sciences | Gharehdaghi J.,Tehran University of Medical Sciences | Gharehdaghi J.,Legal Medicine Research Center | Schoeniger R.,Tehran University of Medical Sciences | And 2 more authors.
Bone and Joint Journal | Year: 2015

The modified Smith-Petersen and Kocher-Langenbeck approaches were used to expose the lateral cutaneous nerve of the thigh and the femoral, obturator and sciatic nerves in order to study the risk of injury to these structures during the dissection, osteotomy, and acetabular reorientation stages of a Bernese peri-acetabular osteotomy. Injury of the lateral cutaneous nerve of thigh was less likely to occur if an osteotomy of the anterior superior iliac spine had been carried out before exposing the hip. The obturator nerve was likely to be injured during unprotected osteotomy of the pubis if the far cortex was penetrated by > 5 mm. This could be avoided by inclining the osteotome 45° medially and performing the osteotomy at least 2 cm medial to the iliopectineal eminence. The sciatic nerve could be injured during the first and last stages of the osteotomy if the osteotome perforated the lateral cortex of ischium and the ilio-ischial junction by > 10 mm. The femoral nerve could be stretched or entrapped during osteotomy of the pubis if there was significant rotational or linear displacement of the acetabulum. Anterior or medial displacement of < 2 cm and lateral tilt (retroversion) of < 30° were safe margins. The combination of retroversion and anterior displacement could increase tension on the nerve. Strict observation of anatomical details, proper handling of the osteotomes and careful manipulation of the acetabular fragment reduce the neurological complications of Bernese peri-acetabular osteotomy. © 2015 The British Editorial Society of Bone & Joint Surgery.

Kalhor M.,Tehran University of Medical Sciences | Horowitz K.,Texas Childrens Hospital | Gharehdaghi J.,Legal Medicine Research Center | Beck M.,University of Bern | Ganz R.,University of Bern
HIP International | Year: 2012

The purpose of this cadaveric study was to clearly define the blood supply to the femoral head to help further reduce the incidence of iatrogenic avascular necrosis (AVN). Thirty-five hips of twenty-eight fresh cadavers were injected with colored silicone. Anterior and posterior dissection was performed to assess the vessels contributing to femoral head vascularity. The medial femoral circumflex artery (MFCA) was found to be the main blood supply to the hip in twenty-nine specimens; the inferior gluteal artery (IGA) was found to be the main blood supply in six. The MFCA consistently provided at least one smaller-calibre inferomedial retinacular artery. The foveal artery provided no significant vascular contribution in any specimen. The quantity and calibre of superior retinacular vessels demonstrated their dominance in head vascularity, although inferior retinacular arteries were consistently present. To reduce the risk of iatrogenic AVN, branches of both the IGA and MFCA traversing the interval between the quadratus femoris and piriformis muscles must be protected during surgery. Since all intracapsular vessels penetrated the capsule near its distal attachment, distal capsulotomy carries a significantly higher risk of AVN than proximal capsulotomy, particularly posterolaterally and inferomedially. © 2012 Wichtig Editore.

Bahador A.,Tehran University of Medical Sciences | Raoofian R.,Legal Medicine Research Center | Raoofian R.,Islamic Azad University at Mashhad | Pourakbari B.,Tehran University of Medical Sciences | And 3 more authors.
Frontiers in Microbiology | Year: 2015

Carbapenem-resistant Acinetobacter baumannii (CR-AB) causes serious nosocomial infections, especially in ICU wards of hospitals, worldwide. Expression of blaOXA genes is the chief mechanism of conferring carbapenem resistance among CR-AB. Although some blaOXA genes have been studied among CR-AB isolates from Iran, their blaOXA-23-like genes have not been investigated. We used a multiplex-PCR to detect Ambler class A, B, and D carbapenemases of 85 isolates, and determined that 34 harbored blaOXA-23-like genes. Amplified fragment length polymorphism (AFLP) genotyping, followed by DNA sequencing of blaOXA-23-like amplicons of CR-AB from each AFLP group was used to characterize their blaOXA-23-like genes. We also assessed the antimicrobial susceptibility pattern of CR-AB isolates, and tested whether they harbored insertion sequences ISAba1 and ISAba4. Sequence comparison with reference strain A. baumannii (NCTC12156) revealed five types of mutations in blaOXA-23-like genes; including one novel variant and four mutants that were already reported from China and the USA. All of the blaOXA-23-like genes mutations were associated with increased minimum inhibitory concentrations (MICs) against imipenem. ISAba1 and ISAba4 sequences were detected upstream of blaOXA-23 genes in 19 and 7% of isolates, respectively. The isolation of CR-AB with new blaOXA-23 mutations including some that have been reported from the USA and China highlights CR-AB pervasive distribution, which underscores the importance of concerted national and global efforts to control the spread of CR-AB isolates worldwide. © 2015 Bahador, Raoofian, Pourakbari, Taheri, Hashemizadeh and Hashemi.

Kalhor M.,Tehran University of Medical Sciences | Horowitz K.,Baylor College of Medicine | Beck M.,University of Bern | Nazparvar B.,Legal Medicine Research Center | Ganz R.,University of Bern
Journal of Bone and Joint Surgery - Series A | Year: 2010

Background: The acetabular labrum plays an important role in hip joint stability and protection of the articular cartilage of the hip. Despite this, few investigators have evaluated its microscopic vasculature and, to our knowledge, none has assessed its macroscopic blood supply. The purposes of this study were to identify the origin and course of the vascular supply to the acetabular labrum to determine if this blood supply is affected by a labral tear. Methods: Colored silicone was injected into the vascular tree proximal to thirty-five hips in twenty-eight fresh cadavers. Twenty-four hours after injection, anatomic dissection was performed and the vessels supplying the labrum were followed from their origin to their final distribution. Additionally, labral segments of fifteen randomly selected hips were resected to assess the acetabular rim's vascular contribution, and fifteen hips were dislocated for complete intra-articular inspection of the labrum. Results: Radial branches of a previously described periacetabular periosteal vascular ring were identified as the source of labral blood supply in all thirty-five hips. These branches coursed toward the hip joint on the periosteal surface, penetrated the joint capsule near its innominate insertion, and continued within a loose connective-tissue layer on the capsular surface of the labrum. No contribution from the hip capsule, synovial lining, or osseous acetabular rim could be demonstrated. An intact vascular supply was identified in all seven hips with a labral tear. Conclusions: The acetabular labrum receives its blood supply from radial branches of a periacetabular periosteal vascular ring that traverses the osseolabral junction on its capsular side and continues toward the labrum's free edge. The hip capsule, the synovial lining, and the osseous acetabular rim do not appear to provide substantial contributions to the labral blood supply. Clinical Relevance: The blood supply to the acetabular labrum probably remains intact in the majority of hips with labral tears, which are typically partial-thickness tears on the articular side. An improved understanding of labral vasculature may have implications for the surgical treatment of labral tears and associated osseous abnormalities. Copyright © 2010 by The Journal of Bone and Joint Surgery, Incorporated.

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