LECO Corporation

Saint Joseph, MI, United States

LECO Corporation

Saint Joseph, MI, United States
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Apparatuses (41, 91, 111, 115, 121, 151) and methods (31) for time-of-flight mass spectrometry providing effective pulsed conversion of continuous ion beams into pulsed ion packets is disclosed. Bunching of energetic continuous ion beams forms ion packets, which are filtered by a subsequent isochronous energy filter (49, 79, 81-84, 110). The bunching method is particularly suitable for ion sources with relatively large spatial emittance, otherwise unable to fir the acceptance of orthogonal accelerators. The method is particularly suitable for multi-reflecting TOF MS, which accommodates small size ion packets and where the duty cycle advantage of orthogonal accelerators is minor.


Implementations of methods and apparatuses are disclosed for decoding multiplexed information in a chromatographic system. Implementations may include the method of pulsing ions from an ion source through an analyzer according to a predetermined multiplexing scheme, each pulse including one or more ions corresponding to a sample, detecting a plurality of ion strikes at a detector, determining a data point for each ion strike, wherein each data point includes an intensity of a detected ion strike and a time of the detected ion strike, maintaining a multiplexed spectrum of the data points, the multiplexed spectrum including the data points, and demultiplexing the time shifted spectrum using the data points of the multiplexed spectrum.


Patent
Leco Corporation | Date: 2016-09-13

An analytical instrument includes a data acquisition system that produces data. The analytical instrument includes a data compression system/process that utilizes a lossless data compression technique that can be implemented using minimal hardware and software resources. The process may be implemented in such a way that it can be split into many parallel operations. The process can be implemented utilizing software and/or processing devices such as Field-Programmable Gate Arrays (FPGAs) or Graphics Processing Units (GPUs).


Patent
Leco Corporation | Date: 2015-03-31

For improving sensitivity, dynamic range, and specificity of GC-MS analysis there are disclosed embodiments of novel apparatuses based on improved characteristics of semi-open source with electron impact ionization, providing much higher brightness compared to known open EI sources. In an implementation, the source becomes compatible with multi-reflecting TOF analyzers for higher resolution analysis for improving detection limit. With improved schemes of spatial and temporal refocusing there are proposed various tandem TOF-TOF spectrometers with PSD, CID, and SID fragmentation and using either singly reflecting TOF or MR-TOF analyzers.


A data acquisition system and method are described that may be used with various spectrometers. The data acquisition system may include an ion detector, an initial processing module, and a spectra processing module. The initial processing module is provided for processing the ion detection signals and for supplying processed signals to the spectra processing module. The spectra processing module generates spectra from the processed signals and supplies the generated spectra to an external processor for post-processing. The spectra processing module may include an ion statistics filter and/or a peak histogram filtering circuit.


Patent
LECO Corporation | Date: 2016-08-23

A multi-reflecting, time-of-flight (MR-TOF) mass spectrometer including two quasi-planar electrostatic ion mirrors extended along drill direction (Z) and formed of parallel electrodes, separated by a field free region. The MR-TOF includes a pulsed ion source to release ion packets at a small angle to X-direction which is orthogonal to the drill direction Z. Ion packets are reflected between ion mirrors and drill along the drift direction. The mirrors are arranged to provide time-of-flight focusing ion packets on the receiver. The MR-TOF mirrors provide spatial focusing M the Y-direction orthogonal to both drift direction Z and on injection direction X. In a preferred embodiment, at least one mirror has a feature providing periodic spatial focusing of ion packets in the drift Z-direction.


Patent
LECO Corporation | Date: 2015-03-31

There is proposed a right angle time-of-flight detector (41, 117, 124, 143, 144, 145) comprising a conductive converter (46) for emitting and accelerating secondary electrons, a magnetic field formed by at least one magnet (47) for deflecting the secondary electrons at a right angle and a sealed photo-multiplier (26). The detector is expected to provide an extended resource and dynamic range and may be fit into tight assemblies, such as MR-TOF MS.


Patent
LECO Corporation | Date: 2016-03-31

An open electrostatic trap mass spectrometer is disclosed for operation with wide and diverging ion packets. Signal on detector is composed of signals corresponding to multiplicity of ion cycles, called multiplets. Using reproducible distribution of relative intensity within multiplets, the signal can be unscrambled for relatively sparse spectra, such as spectra past fragmentation cell of tandem mass spectrometer, past ion mobility and differential ion mobility separators. Various embodiments are provided for particular pulsed ion sources and pulsed converters such as orthogonal accelerators, ion guides, and ion traps. The method and apparatus enhance the duty cycle of pulsed converters, improve space charge tolerance of the open trap analyzer and extends the dynamic range of time-of-flight detectors.


Patent
LECO Corporation | Date: 2016-08-01

A method, apparatus and algorithms are disclosed for operating an open electrostatic trap (E-trap) or a multi-pass TOF mass spectrometer with an extended flight path. A string of start pulses with non equal time intervals is employed for triggering ion packet injection into the analyzer, a long spectrum is acquired to accept ions from the entire string and a true spectrum is reconstructed by eliminating or accounting overlapping signals at the data analysis stage while using logical analysis of peak groups. The method is particularly useful for tandem mass spectrometry wherein spectra are sparse. The method improves the duty cycle, the dynamic range and the space charge throughput of the analyzer and of the detector, so as the response time of the E-trap analyzer. It allows flight extension without degrading E-trap sensitivity.


Patent
LECO Corporation | Date: 2015-06-26

An ion detection system including an ion source and at least one ion detector is disclosed. The ion source includes a source housing, a reactor, first and second ionizers and a sampling channel. The first ionizer is a glow discharge ionizer. The ion detector communicates with the sampling channel. A conditioner, which is sized to remove fast diffusing electrons, connects the first glow discharge ionizer to the reactor. A corresponding method of ionization is also disclosed. The method includes ionizing and conditioning an ionizer gas, receiving the ionizer gas and analyte molecule ions into a reactor, and delivering a flow from the reactor. The conditioning of the ionizer gas removes fast diffusing electrons from the gas flow.

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