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Jbail, Lebanon

The Lebanese American University is a secular, private and independent American university and research institution located in Lebanon. The university is chartered by the Board of Regents of the University of the State of New York and is accredited by the Commission on Institutions of Higher Education of the New England Association of Schools and Colleges . It is composed of two campuses, one in Beirut and the other in Byblos, and offers programs leading to degrees in Arts, Business, Engineering, Nursing, science, Pharmacy, and Medicine.LAU is governed by a Board of Trustees that oversees the primary functions of leadership, stewardship and audit. A Board of International Advisors provides counsel on university policies and other matters to the Board of Trustees, president, and senior management. Wikipedia.

Tokajian S.,Lebanese American University
Clinical Microbiology and Infection | Year: 2014

Staphylococcus aureus is a bacterial pathogen that is distributed worldwide and represents an increasing problem, both in hospitals and in the community. Global transmission of methicillin-resistant S. aureus (MRSA) has been the subject of many studies. Determining the incidence of colonization with community-acquired MRSA in hospitalized patients and outpatients has been the aim of several studies conducted in the Middle East (western Asia). The local epidemiology within countries in this region is changing, owing to the introduction of new strains with the intercontinental exchange of several clones. Sequence type 80-MRSA-IV is one common clone detected in different countries within the region showing country-based differences, and hence more likely to form clonal lineages. MRSA is endemic in this region, and the burden and the difficulty in detecting imported strains are increasing. This is also increasing the risk of domestic and global transmission. To counter the threat associated with the high incidence of MRSA carriage and infections, systematic surveillance of both hospital and community isolates is required, along with appropriate measures designed to limit their spread. Additionally, antibiotic stewardship is needed to contain the further development of the observed resistance and to help in preserving antibiotics as precious therapeutic resources. It is critical for countries in this region to establish both national and international initiatives to develop better measurements designed to limit and control the spread of infections. Finally, more sequence-based studies are needed to better understand the pathogenicity and epidemiology of these important pathogens. Clinical Microbiology and Infection © 2014 European Society of Clinical Microbiology and Infectious Diseases.

Arnaout J.-P.,Lebanese American University
Journal of Intelligent Manufacturing | Year: 2013

This paper addresses the Euclidean location-allocation problem with an unknown number of facilities, and an objective of minimizing the fixed and transportation costs. This is a NP-hard problem and in this paper, a three-stage ant colony optimization (ACO) algorithm is introduced and its performance is evaluated by comparing its solutions to the solutions of genetic algorithms (GA). The results show that ACO outperformed GA and reached better solutions in a faster computational time. Furthermore, ACO was tested on the relaxed version of the problem where the number of facilities is known, and compared to existing methods in the literature. The results again confirmed the superiority of the proposed algorithm. © 2011 Springer Science+Business Media, LLC.

El-Sibai M.,Lebanese American University
BMC complementary and alternative medicine | Year: 2014

BACKGROUND: Daucus carota L.ssp.carota (wild carrot), an herb used in folk medicine worldwide, was recently demonstrated to exhibit anticancer activity. In this study we examined the anticancer effect of Daucus carota oil extract (DCOE) fractions on the human breast adenocarcinoma cell lines MDA-MB-231 and MCF-7 and clarified the mechanism of action.METHODS AND RESULTS: Using the WST assay, the pentane fraction (F1) and 1:1 pentane:diethyl ether fraction (F2) were shown to possess the highest cytotoxicity against both cell lines. Flow cytometric analysis revealed that both fractions induced the accumulation of cells in the sub-G1 phase, increase in apoptotic cell death and chromatin condensation. The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. Furthermore, treatment of MDA-MB-231 cells with either fraction significantly reduced the level of phosphorylated Erk but did not show any effect on phosphorylated Akt. The combined treatment with a potent PI3K inhibitor (wortmannin) and F1 or F2 fraction had a synergistic inhibitory effect on cell survival which shows that these two drugs work on different pathways.CONCLUSIONS: These results suggest that the pentane-based fractions of DCOE possess potential anti-cancer activity that is mainly mediated through the Erk pathway.

Khabbaz M.J.,Concordia University at Montreal | Assi C.M.,Concordia University at Montreal | Fawaz W.F.,Lebanese American University
IEEE Communications Surveys and Tutorials | Year: 2012

Nowadays, wireless networks are witnessing several deployments in various extreme environments where they suffer from different levels of link disruptions depending on the severity of the operating conditions. In all cases, their operation requirements are differently altered and their performance is negatively affected rendering them heterogeneous by nature. In the open literature, these networks are known as Intermittently Connected Networks (ICNs). The existing Internet protocols fail to operate properly in the context of ICNs, thus raising a variety of new challenging problems that are attracting the attention of the networking research community. Delay-/Disruption-Tolerant Networking emerged as a highly active area of research where networking experts compete in addressing the various ICN problems. Over time, unicast routing, one of the architectural key components common to all ICNs, became an almost independent field of research in which significant efforts continue to be invested. In contrast, network architectural designs, scheduling and forwarding issues dating from the early days of Inter-Planetary Networks (IPNs) have received relatively little attention and accumulate numerous pending challenges. Moreover, the gap caused by the lack of accurate ICN mathematical models is still large irrespective of some of the appreciated seminal works in this direction. This paper sheds the light over the latest advancements in each of the above-mentioned research sectors and highlight pending open issues in each of them. © 1998-2012 IEEE.

Abou-Rjeily C.,Lebanese American University
Journal of Lightwave Technology | Year: 2013

In this paper, we evaluate the performance of a selective-relaying (SR) protocol that is suitable for cooperative free-space optical (FSO) communications with any number of relays. The SR strategy is based on transmitting all information symbols either along the direct link between the source and the destination or along one of the indirect links via the relays. We derive closed-form expressions of upper-bounds on the average error probability that can be achieved over Rayleigh and lognormal fading channels. We also provide an asymptotic analysis for quantifying the diversity gain and reduction in fading variance that can be realized by the cooperative scheme. The performance analysis shows the superiority of the SR scheme over the strategy that corresponds to activating all available links. © 1983-2012 IEEE.

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