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London, United Kingdom

Kitchen D.,Leaders in Oncology Care LOC | Hughes B.,Leaders in Oncology Care LOC | Gill I.,Leaders in Oncology Care LOC | O'Brien M.,Leaders in Oncology Care LOC | And 6 more authors.
British Journal of Cancer | Year: 2012

Background: There are anecdotal data that lower levels of vitamin D may be associated with increased levels of toxicity in individuals receiving chemotherapy; we therefore wished to investigate this further. Methods: From a cohort of over 11 000 individuals, we included those who had vitamin D levels (serum 1,25(OH) 2 D3) measured before and during chemotherapy. They were analysed for side effects correlating Chemotherapy Toxicity Criteria with vitamin D levels, normalising data for general markers of patient health including C-reactive protein and albumin. Results: A total of 241 (2% of the total cohort) individuals entered the toxicity analysis. We found no overall difference in toxicity effects experienced by patients depending on whether they were vitamin D depleted or had sufficient levels (P=0.78). Conclusion: This pilot study suggests routine vitamin D measurement during treatment does not appear to be necessary in the management of chemotherapy-induced toxicity. © 2012 Cancer Research UK All rights reserved. Source

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