Lead Discovery and Rapid Structure Elucidation Group

St. Louis, MO, United States

Lead Discovery and Rapid Structure Elucidation Group

St. Louis, MO, United States

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Starks C.M.,Lead Discovery and Rapid Structure Elucidation Group | Norman V.L.,Lead Discovery and Rapid Structure Elucidation Group | Williams R.B.,Lead Discovery and Rapid Structure Elucidation Group | Goering M.G.,Lead Discovery and Rapid Structure Elucidation Group | And 3 more authors.
Natural Product Communications | Year: 2014

One new and seven known diterpenes were identified from an antibacterial chromatographic fraction of Taxodium ascendens. Of these, demethylcryptojaponol (2), 6-hydroxysalvinolone (3), hydroxyferruginol (4), and hinokiol (5) demonstrated potent activity against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). These compounds represent a class of synthetically accessible compounds that could be further developed for treatment of drug-resistant bacterial infections.

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