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Mattoo T.K.,Wayne State University | Carpenter M.A.,University of North Carolina at Chapel Hill | Moxey-Mims M.,U.S. National Institute of Diabetes and Digestive and Kidney Diseases | Chesney R.W.,Le Bonheur Childrens Hospital
Pediatric Nephrology | Year: 2015

Vesicoureteral reflux (VUR) increases the risk of urinary tract infection (UTI) and renal scarring. Many prospective studies have evaluated the role of antimicrobial prophylaxis in the prevention of recurrent UTI and renal scarring in children with VUR. Of these, the RIVUR trial was the largest, randomized, placebo-controlled, double blind, multicenter study, involving 607 children aged 2–72 months with grade I–IV VUR and a first or second symptomatic UTI. The median age of children in the RIVUR trial was 12 months, 92 % were female, 91 % were randomized after a first UTI, 86 % had a febrile index UTI, and 71 (56 %) of 126 toilet-trained children had bladder bowel dysfunction. Trimethoprim/sulfamethoxazole reduced the risk of UTI recurrences by 50 % (hazard ratio 0.50; 95 % confidence interval 0.34–0.74) as compared to placebo. No significant difference was seen in renal scarring between the two groups. However, this does not invalidate the role of prophylaxis in preventing renal scars because RIVUR and other recent prospective studies were not designed to address renal scarring as a primary study endpoint. In view of the RIVUR Trial and other studies that showed similar results, albeit in selected groups of patients, the debate on antimicrobial prophylaxis should shift from “no prophylaxis” to “selective prophylaxis” in children with VUR. © 2015, IPNA. Source


Choudhri X.A.F.,Le Bonheur Childrens Hospital | Choudhri X.A.F.,University of Tennessee Health Science Center | Castillo X.M.,University of North Carolina at Chapel Hill
American Journal of Neuroradiology | Year: 2015

BACKGROUND AND PURPOSE: The growing number of subspecialties within neuroradiology compete for pages in neuroradiology journals. We performed a bibliometric analysis of the American Journal of Neuroradiology to identify the virtual Impact Factor of different journal subsections and article topics. MATERIALS AND METHODS: Original Research and Review Articles published in American Journal of Neuroradiology during 2010-2012 were evaluated. The journal section for each article was recorded, and the number of citations was evaluated by using the Web of Science database. Numbers of citations within the first 2 years after publication were evaluated, normalized to the 2013 journal Impact Factor (for American Journal of Neuroradiology, 3.675), and used to calculate a virtual Impact Factor for different journal subsections. RESULTS: One thousand forty-nine Original Research and Review Articles were published during this time, which obtained an average of 6.59 citations each within their first 2 years after publication; 91.8% of articles obtained at least 1 citation. Expedited Publications had the greatest number of citations, averaging 43.7 citations each (virtual Impact Factor, 24.39), followed by Review Articles averaging 9.39 citations each (virtual Impact Factor 5.23). Virtual Impact Factors for other sections were the following: Interventional, 4.54; Brain, 3.70; Pediatrics, 2.91; Functional, 2.74; Head & Neck, 2.24; and Spine, 1.86. Virtual Impact Factors for article topics were the following: interventional, 4.75; functional/advanced, 3.79; brain, 3.66; pediatrics, 2.99; head and neck, 2.46; and spine, 2.32. CONCLUSIONS: Citation patterns of Original Research and Review Articles in American Journal of Neuroradiology varied widely on the basis of subsections. Understanding the citation patterns of specific topics and subsections of a journal may aid authors and editors in evaluating the appropriate balance among various topics and allow authors to determine whether their articles are being cited at a level expected for similar ones in a journal. Source


Munday R.A.,Le Bonheur Childrens Hospital
Infant, Child, and Adolescent Nutrition | Year: 2015

The importance of providing human milk for the premature infant is well supported in current literature. Neonates born prematurely with congenital anomalies requiring surgery prior to initiation of oral or enteral feeds present an additional challenge to the already complex breastfeeding dyad. As human milk has been proven to be the best source of nutrition for premature infants, the goal of discharging patients home on breastmilk/breastfeeding needs to become a priority. Literature suggests the maternal decision to breastfeed is key in the initiation and duration of a mother’s milk supply. This case report reviews the outcome of maternal decision and lactation support provided to a mother of a premature infant requiring surgical intervention for esophageal atresia with tracheal esophageal fistula within the first few days of life. © 2015, © 2015 The Author(s). Source


Norman J.L.,Le Bonheur Childrens Hospital | Holmes W.L.,Baptist Memorial Hospital | Bell W.A.,Veterans Affairs Medical Center | Finks S.W.,University of Memphis
Journal of Pharmacy Practice | Year: 2013

Angiotensin-converting enzyme inhibitors (ACE-Is) are the primary medication class implicated in drug-associated angioedema. Angioedema is most common early in ACE-I therapy, yet episodes can occur late in therapy and have been reported even as late as 10 years after single treatment initiation. We present a case of a 65-year-old African American woman who experienced 2 episodes of angioedema, with the second being life threatening after receiving several concomitant agents known to cause angioedema, most notably lisinopril for 11 years. © 2012 The Author(s). Source


We evaluate the clinical performance of the Luminex xTAG gastrointestinal (GI) pathogen in vitro diagnostic (IVD) assay in a comparison between clinical and public health laboratories. The site reproducibility study showed 98.7% sensitivity with high positive and negative agreement values (96.2% and 99.8%, respectively), while assay performance against confirmatory methods resulted in 96.4% sensitivity with similar positive and negative agreement values (90.1% and 99.5%, respectively). High-throughput detection of multiple GI pathogens improved turnaround time, consolidated laboratory workflow, and simplified stool culture practices, thus reducing the overall cost and number of specimens processed. Copyright © 2014, American Society for Microbiology. All Rights Reserved. Source

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