Warangal, India
Warangal, India

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Kavitha P.,National Institute of Technology Warangal | Rama Chary M.,Lb College | Singavarapu B.V.V.A.,Vimta Labs Ltd. | Laxma Reddy K.,National Institute of Technology Warangal
Journal of Saudi Chemical Society | Year: 2013

In the present study a series of Co(II) complexes of formyl chromone Schiff bases have been synthesized characterized by analytical, molar conductance, IR, electronic, magnetic susceptibility, thermal, fluorescence and powder XRD measurements and screened for various biological activities (antimicrobial, antioxidant, nematicidal, DNA cleavage and cytotoxicity). In all the Co(II) complexes 1:2 metal to ligand molar ratio was obtained from analytical data. The molar conductance data confirm that all complexes are non-electrolytic in nature. Based on the electronic and magnetic data, an octahedral geometry is ascribed for all the Co(II) complexes. Thermal behaviour of the synthesized complexes illustrates the general decomposition patterns of the complexes. The X-ray analysis data show that all the Co(II) complexes have triclinic crystal system with different unit cell parameters. Metal complexes have greater antimicrobial activity than ligands. Antioxidant and nematicidal activities indicate that the ligands exhibit greater activity when compared to their respective Co(II) complexes. All ligands and Co(II) complexes of HL1 and HL2 showed considerable anticancer activity against Raw, MCF-7 and COLO 205 cell lines. All ligands and their Co(II) complexes showed more pronounced DNA cleavage activity in the presence of H2O2. © 2013.

Reddy Ch.V.N.,Lb College | Raju S.,Kakatiya University | Nagi Reddy M.,Kakatiya University | Rajanarendar E.,Kakatiya University
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry | Year: 2010

Synthesis of N-1 (3, 5-dimethyl-4-isoxazolyl)-3-(4-aryl-5-thioxo-4,5- dihydro-1H-1,2,4-triazol-3-yl)-propanamides 7 have been accomplished from 4-amino-3,5-dimethylisoxazole 1 in five steps. The structural elucidation of the synthesized compounds has been performed by IR, 1H NMR and mass spectroscopic data besides elemental analyses.

Swamy S.J.,Kakatiya University | Raveender Reddy S.,Lb College | Dharma Reddy A.,CKM College | Bhaskar K.,Osmania University
Asian Journal of Chemistry | Year: 2011

The substituted 1,8-naphthyridines, 2-hydroxy-1,8-naphthyridine-3- carboxylic acid hydrazide (HNch) and 2-hydroxy-1,8-naphthyridine-3-carboxylic acid o-hydroxybenzylidene hydrazide (HNCHBh) react with Ni(II), Cu(II) and Zn(II) acetate to yield complexes of definite composition. The complexes have been characterized by elemental analysis, thermal, conductance, magnetic studies and IR, electronic, NMR and ESR spectral data. The HNCh and HNCHBh form the complexes of formula [M(HNCh)2] and [M(HNCHBh) (H2O) 2], respectively.

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