Quebec, Canada
Quebec, Canada

Laval University is the oldest centre of education in Canada , and was the first institution in North America to offer higher education in French. Its main campus is located on the outskirts of the historic city in Quebec City, the capital of the Province of Quebec. The university is ranked among the top ten Canadian universities in terms of research funding. Wikipedia.

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A method for preparing polymers by direct heteroarylation or arylation polycondensation is described herein. The method includes preparing a reaction mixture including at least a monomer to be polymerized, a catalyst and a ligand; heating the reaction mixture; and, optionally, end-capping the reaction mixture.

Gm Global Technology Operations Llc and Laval University | Date: 2016-07-26

An extended-reach assist device for an assembly task includes a base mechanism and a compliant end-effector. The articulated base mechanism provides one or more passive degrees of freedom. The end-effector is connected to the base mechanism, and has one or more active or passive degrees of freedom collectively configured to react to contact forces with the assist device when completing the dexterous assembly task. A weight of the end-effector is supported by the base mechanism. The end-effector may be optionally configured as a passive device configured to produce a remote center of compliance or as a robot mechanism. A mechanism may actively or passively augment a force applied by the operator. A sensor may detect a signature indicative of successful task completion, e.g., an acoustic, visual, or audio sensor.

Laval University | Date: 2014-06-05

A fiber-optic thermometer probe has an optical fiber with a sensing portion, namely a region of reduced cladding thickness coated with a temperature-dependent refractive index material to provide variations in propagated light power upon changes in temperature in a vicinity of the sensing portion. A reflective interface optically coupled to a core of the optical fiber reflects light propagated therein. The sensing portion can be the tip and prepared by etching using a dipping process.

A composition of purified and biologically active p-coumaroyl hexose and/or polyphenols is provided by separation from strawberrys pulp by a method of extraction and purification using a hydrophobic adsorbent using GRAS solvent. Also provided is the use of the composition.

The present invention relates to the use of leukotriene B_(4 )to enhance the response of Toll-like receptor (TLR), RIG-I-like receptor (RLR), and NOD-like receptor (NLR) when stimulated simultaneously with respective proper ligands. The use in combination of LTB_(4 )with those ligands is useful to potentiate immune response for the treatment of autoimmune diseases, immunosuppressive diseases, as well as immunological disorders.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: BG-09-2016 | Award Amount: 15.49M | Year: 2016

The overall objective of INTAROS is to develop an integrated Arctic Observation System (iAOS) by extending, improving and unifying existing systems in the different regions of the Arctic. INTAROS will have a strong multidisciplinary focus, with tools for integration of data from atmosphere, ocean, cryosphere and terrestrial sciences, provided by institutions in Europe, North America and Asia. Satellite earth observation data plays an increasingly important role in such observing systems, because the amount of EO data for observing the global climate and environment grows year by year. In situ observing systems are much more limited due to logistical constraints and cost limitations. The sparseness of in situ data is therefore the largest gap in the overall observing system. INTAROS will assess strengths and weaknesses of existing observing systems and contribute with innovative solutions to fill some of the critical gaps in the in situ observing network. INTAROS will develop a platform, iAOS, to search for and access data from distributed databases. The evolution into a sustainable Arctic observing system requires coordination, mobilization and cooperation between the existing European and international infrastructures (in-situ and remote including space-based), the modeling communities and relevant stakeholder groups. INTAROS will include development of community-based observing systems, where local knowledge is merged with scientific data. An integrated Arctic Observation System will enable better-informed decisions and better-documented processes within key sectors (e.g. local communities, shipping, tourism, fisheries), in order to strengthen the societal and economic role of the Arctic region and support the EU strategy for the Arctic and related maritime and environmental policies.

Vinh-Thang H.,Laval University | Kaliaguine S.,Laval University
Chemical Reviews | Year: 2013

Researchers share their views on the latest scientific and technological advances in the development of theoretical models focused on the prediction of the gas separation performance of mixed-matrix membranes (MMM). An overview of the latest MMMs using various kinds of fillers is introduced for better understanding. The status, applicability, and future theoretical research for estimating the gas separation performance of MMMs are highlighted and validated. The mixed-matrix membranes (MMMs) where inorganic fillers in solid, liquid, or solid and liquid forms are dispersed in a polymer matrix, have been identified to provide a solution to the upper-bound trade-off limit of the polymeric membranes while addressing the brittleness obstacle of the inorganic membranes. MMMs are also expected to combine the potential advantages in separation performances of inorganic and polymer membranes.

Rodes-Cabau J.,Laval University
Nature Reviews Cardiology | Year: 2012

The first human transcatheter aortic valve implantation (TAVI) in 2002, and several subsequent single-center series, showed the feasibility of this new approach for the treatment of patients with severe aortic stenosis who were considered to be at very high or prohibitive surgical risk. More-recent multicenter registries have confirmed the safety and efficacy of this procedure, despite a very-high-risk patient profile. Moreover, the randomized, controlled PARTNER trial has confirmed both the superiority of TAVI over medical treatment in patients not considered to be candidates for standard surgical aortic valve replacement and the noninferiority of TAVI compared with surgical aortic valve replacement in high-risk patients. The hemodynamics of transcatheter valves are usually excellent, although residual paravalvular aortic regurgitation (usually trivial or mild) is frequent. Stroke, major vascular complications, and conduction disturbances leading to permanent pacemaker implantation remain among the most-concerning periprocedural complications of TAVI. Nevertheless, promising preliminary data exist for long-term outcomes following TAVI, 'valve-in-valve' TAVI for surgical prosthesis dysfunction, and for the treatment of lower-risk patients. Improvements in transcatheter valve technology, optimization of procedural and midterm results, and confirmation of long-term durability of transcatheter valve prostheses will determine the expansion of TAVI towards the treatment of a broader spectrum of patients. © 2011 Macmillan Publishers Limited. All rights reserved.

Mercier L.G.,Laval University | Leclerc M.,Laval University
Accounts of Chemical Research | Year: 2013

The coupling of aryl halides with catalytically activated aryl C-H bondsprovides a desirable and atom-economical alternative to standard cross-coupling reactions for the construction of new C-C bonds. The reaction, termed direct (hetero)arylation, is believed to follow a base-assisted, concerted metalation-deprotonation (CMD) pathway. During this process, carboxylate or carbonate anions coordinate to the metal center, typically palladium, in situ and assist in the deprotonation transition state. Researchers have employed this methodology with numerous arenes and heteroarenes, including substituted benzenes, perfluorinated benzenes, and thiophenes. Thiophene substrates have demonstrated high reactivity toward C-H bond activation when appropriately substituted with electron-rich and/or electron-deficient groups. Because of the pervasive use of thiophenes in materials for organic electronics, researchers have used this chemistry to modularly prepare conjugated small molecules and, more recently, conjugated polymers. Although optimization of reaction conditions such as solvent system, phosphine ligand, carboxylate additives, temperature, and time is necessary for efficient C-H bond reactivity of each monomer, direct (hetero)arylation polymerization (DHAP) can afford high yielding polymeric materials with elevated molecular weights. The properties of these materials often rival those of polymers prepared by traditional methods. Moreover, DHAP provides a facile means for the synthesis of polymers that were previously inaccessible or difficult to prepare due to the instability of organometallic monomers. The major downfall of direct (hetero)arylation, however, is the lack of C-H bond selectivity, particularly for thiophene substrates, which can result in cross-linked material during polymerization reactions. Further fine-tuning of reaction conditions such as temperature and reaction time may suppress these unwanted side reactions. Alternatively, new monomers can be designed where other reactive bonds are blocked, either sterically or by substitution with unreactive alkyl or halogen groups. In this Account, we illustrate these methods and present examples of DHAP reactions that involve the preparation of common homopolymers used in organic electronics (P3HT, PEDOT, PProDOT), copolymers formed by activation of electron-rich (bithiophene, fused bithiophenes) and electron-deficient monomers (TPD, 1,2,4,5-tetrafluorobenzene, 2,2′-bithiazole). Our group is optimizing these reactions and developing ways to make DHAP a common atom-economical synthetic tool for polymer chemists. © 2013 American Chemical Society.

Beaulieu J.-M.,Laval University
Journal of Psychiatry and Neuroscience | Year: 2012

Mental illnesses, such as bipolar disorder, attention-deficit/hyperactivity disorder, depression and schizophrenia are a major public health concern worldwide. Several pharmacologic agents acting on monoamine neurotransmission are used for the management of these disorders. However, there is still little understanding of the ultimate molecular mechanisms responsible for the therapeutic effects of these drugs or their relations with disease etiology. Here I provide an overview of recent advances on the involvement of the signalling molec ules Akt and glycogen synthase kinase-3 (GSK3) in the regulation of behaviour by the monoamine neurotransmitters dopamine (DA) and serotonin (5-HT). I examine the possible participation of these signalling molecules to the effects of antidepressants, lithium and anti psychotics, as well as their possible contribution to mental disorders. Regulation of Akt and GSK3 may constitute an important signalling hub in the subcellular integration of 5-HT and DA neurotransmission. It may also provide a link between the action of these neurotransmitters and gene products, like disrupted in schizophrenia 1 (DISC1) and neuregulin (NRG), that are associated with increased risk for mental disorders. However, changes in Akt and GSK3 signalling are not restricted to a single disorder, and their contribution to specific behavioural symptoms or therapeutic effects may be modulated by broader changes in biologic contexts or signalling landscapes. Under standing these interactions may provide a better understanding of mental illnesses, leading to better efficacy of new therapeutic approaches. © 2012 Canadian Medical Association.

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