laski University Medyczny w Katowicach

Centrum, Poland

laski University Medyczny w Katowicach

Centrum, Poland
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Kazmierski M.,laski University Medyczny w Katowicach | Wojakowski W.,laski University Medyczny w Katowicach | Michalewska-Wludarczyk A.,laski University Medyczny w Katowicach | Podolecka E.,laski University Medyczny w Katowicach | And 3 more authors.
Kardiologia Polska | Year: 2015

Background: Endothelial progenitor cells (EPC) derive from bone marrow and participate in both endothelial regeneration and development of new blood vessels. EPC also play a role in the atherosclerotic process, and their number correlates negatively with the presence of classical risk factors. Aim: To evaluate circulating EPC count and their exercise-induced mobilisation in patients with premature coronary artery disease (CAD). Methods: The study group included 60 patients with stable CAD diagnosed before 45 years of age. The control group consisted of 33 healthy age- and gender-matched volunteers. Venous blood was sampled 3 times in order to assess circulating EPC count immediately before an exercise test (EPC 0) and at 15 min (EPC 15) and 60 min (EPC 60) after the exercise test. Results: Circulating EPC count in the study group at rest and at 15 min after exercise was comparable (2.1 vs. 2.1 cell/μL, p = 0.35) and increased significantly at 60 min after exercise in comparison to resting values (2.1 vs. 3.2 cell/μL, p < 0.00001). In the control group, circulating EPC count increased significantly at 15 min after exercise (2.0 vs. 3.5 cell/μL, p < 0.0001) but later decreased at 60 min after exercise, although it remained greater than at rest (2.7 vs. 2.0 cell/μL, p < 0.0002). Circulating EPC count at rest and at 60 min after exercise was comparable in the two groups (2.1 vs. 2.0 cell/μL, p = 0.96; and 3.2 vs. 2.7 cell/μL, p = 0.13, respectively) but it was significantly lower in the study group compared to the control group at 15 min after exercise (2.1 vs. 3.5 cell/μL, p < 0.00001). Circulating EPC count at rest and at 15 min after exercise did not correlate with the number of stenosed coronary arteries but at 60 min after exercise it was greater in patients with one-vessel disease compared to those with two- or three-vessel disease (4.2 vs. 3.4 cell/μL, p = 0.01; and 4.2 vs. 2.3 cell/μL, p = 0.00003). However, no difference in circulating EPC count was seen at 60 min after exercise between patients with two- or three-vessel disease (3.4 vs. 2.3 cell/μL, p = 0.3). Conclusions: 1. Circulating EPC count at rest is comparable between subjects with premature atherosclerosis and healthy volunteers. 2. A single bout of physical exercise causes a significant increase in circulating EPC count in both groups, but the dynamics of exercise-induced EPC mobilisation is different, with delayed exercise-induced EPC mobilisation in subjects with premature CAD. 3. The extent of atherosclerotic coronary lesions does not influence circulating EPC count at rest. Copyright © Polskie Towarzystwo Kardiologiczne.

cislo P.,Oddzial Kliniczny Psychiatrii | Badura-Brzoza K.,laski University Medyczny w Katowicach | Blachut M.,laski University Medyczny w Katowicach | Gorczyca P.,laski University Medyczny w Katowicach | And 2 more authors.
Psychiatria i Psychologia Kliniczna | Year: 2014

The publication aims to discuss and present the subject of consultation psychiatry. It presents the definition, objectives and tasks, educational activities and history of the concept of consultation psychiatry from antiquity to modern times, with emphasis on the development of this domain in Poland. Literature also presents issues related to consultation psychiatry in different countries, paying special attention to the principles of training and education. The publication presents also the challenges to which consultation psychiatry is exposed. This domain is associated with the progress of medicine, including such specialties as transplantation, oncology, infectious diseases and biomedicine. With advances in medical there will be more psychological and emotional challenges that will create an area for consultation psychiatry. Furthermore, the article discusses the impact of consultation psychiatry on other fields of medicine: notified and performed psychiatric consultations considerably reduce the length of hospitalisation (there is a direct relationship between the time of notification of consultation and the length of hospitalization), they help to reduce the healthcare costs and provide a better access to mental health care, increase the detection of mental diseases, some of which may be life-threatening, and affect the patients' quality of life. The conclusions present five major tasks for consultation psychiatry: diagnostic assessment, identification of barriers to recovery, identification of relapse, brief psychotherapy focused on the problem and pharmacological treatment. © PSYCHIATR. PSYCHOL.KLIN. 2014.

Dlugaszek M.,laski University Medyczny w Katowicach | Krywult A.,laski University Medyczny w Katowicach | Daszyk A.,laski University Medyczny w Katowicach | Dziadzio K.,laski University Medyczny w Katowicach | And 4 more authors.
Diabetologia Kliniczna | Year: 2015

Introduction. The control of diabetes mellitus (DM) has been improved since the insulin pens were introduced into the diabetes treatment. In pen insulin injection site the new cutaneous complication - lipohypertrophy (LHT) was observed. Objectives. The assessment of the occurrences and risk factors of LHT in insulin receive patients. Patients and methods. 130 patients of the Regional Outpatient Diabetes Clinic in Zabrze were included to the study. The demographic, clinical characteristic, insulin therapy technique and knowledge about LHT were noticed in. The inclusion criteria: type 1 and 2 DM, < 2 years insulin therapy, insulin pen usage. LHT was defined as subcutaneous lump in ≤ 1 place in physical examination. Patients were divided into 2 groups according to diameter and thickness of LHT. Results. LHT was observed in 78 (60%) of patients, but 48 (61.5%) patients developed LHT in 1 site, 30 (38.5%) patients developed LHT in < 1 site. 78 (60%) patients could defined LHT, but only 47 (60%) in LHT group. Patients with LHT longer suffer from DM, longer receive insulin and longer use the same needle. They had higher fasting and postprandial glycaemia, higher insulin requirement and more often complain about hypoglycemia. In the multivariate analysis the independent factors for presence of LHT were: needle reuse < 1 day, not changing sites of injection and human insulin usage. Conclusions. LHT is a common cutaneous complication of insulin pen usage. Risk factors obtained in this study are modifiable and they should be taken into account in daily clinical practice. Copyright © 2015 Via Med.

Sobis J.,laski University Medyczny w Katowicach | Kunert L.,laski University Medyczny w Katowicach | Soltysik M.,laski University Medyczny w Katowicach | Piegza M.,laski University Medyczny w Katowicach | And 2 more authors.
Psychiatria | Year: 2015

This article is an overview of epidemiological studies suggesting that deficit in dietary-based omega-3 polyunsaturated fatty acids may make an etiological contribution to mood disorders (major depression, bipolar disorder and seasonal affective disorder). Anthropological and epidemiological data indicate that humans evolved on a shore-based diet with abundant seafood and few calories from seed oils. In contrast, typical Western diets are now nearly devoid of adequate seafood and have excessive linoleic acid. Thus, high dietary intakes of omega-6 fatty acids may cause a shift toward the proinflammatory thereby promoting the pathogenesis of many illnesses such as cardiovascular diseases and depression. Safety profile of EPA/DHA have been shown. Risks of exposure to environmental toxins (mercury, dioxins) from large fish consumption are substantially reduced through purification processes used to concentrate fish oil supplements. In the end, authors suggest further research needs to be done to determine the best recommended doses of supplements of omega-3. Limited clinical data with rapidly growing support of laboratory and epidemiological studies, indicate omega-3 fatty acids as may play a role in the prevention and management of depression. © 2015 Via Medica.

Otreba M.,laski University Medyczny w Katowicach | Buszman E.,laski University Medyczny w Katowicach | Milinski M.,laski University Medyczny w Katowicach | Wrzesniok D.,laski University Medyczny w Katowicach
Postepy Higieny i Medycyny Doswiadczalnej | Year: 2014

Inherited diseases of pigmentation were among the first traits studied in humans because of their easy recognition. This article presents selected hypopigmentary disorders, which can be divided into hypomelanocytoses and hypomelanoses. Hereditary hypomelanoses are caused by abnormal melanin biosynthesis as well as by abnormal transfer of mature melanosomes to melanocyte dendrites and to neighboring cells. These disorders are represented by oculocutaneous albinism, Hermansky-Pudlak syndrome, Chediak-Higashi syndrome, Griscelli syndrome, Menkes syndrome and phenylketonuria, and are caused by different mutations of the following genes: TYR, P, TRP1, MATP, HPS, CHS, MYO5A, RAB27A, MLPH, ATP7A and PAH. Oculocutaneous albinism is caused by a deficiency of melanin pigment in the skin, hair, and eye and results from mutations in the TYR, P, TRP1 and MATP genes involved in the biosynthesis of melanin pigment. Mutations in the HPS, CHS, MYO5A, RAB27A and MLPH genes, which regulate the biogenesis, maturation and transfer of melanosomes to neighboring cells, are responsible for such disorders as Hermansky-Pudlak, Chediak-Higashi and Griscelli syndromes. In turn, mutations of the ATP7A and PAH genes, regulating intracellular copper concentration and activity of phenylalanine hydroxylase, lead to Menkes syndrome and phenylketonuria. Copyright © Postepy Higieny i Medycyny Dos̈wiadczalnej 2015.

Cytological assessment of bone marrow remains one of the most important tests in hematology for many decades. Quite recently, in 2008, International Council for Standardization in Hematology (ICSH) published their recommendations concerning techniques of bone marrow aspiration, smear preparation and microscopic assessment rules. Based on these recommendations, Working Group for Hematology of the College of Laboratory Medicine in Poland proposed national guidelines, taking into account the specificity of Polish health care system. This article contains the rules, which should be followed during bone marrow aspirate examination, with the aim to improve the quality of the analysis. The technique of aspiration was presented in detail. The list of data, which should be transferred together with the sample to the laboratory, the methods of preparing and staining of smears, rules for microscopic assessment and preparing of final report are also included. © 2015 Polskie Towarzystwo Hematologów i Transfuzjologów, Instytut Hematologii i Transfuzjologii.

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