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Yuan K.-H.,University of South China | Yuan K.-H.,Laser Plastic and Aesthetic Center | Gao J.-H.,University of South China | Huang Z.,Laser Plastic and Aesthetic Center | Huang Z.,University of Colorado at Denver
Photodiagnosis and Photodynamic Therapy | Year: 2012

Background: Several Chinese studies suggest that Hemoporfin-mediated photodynamic therapy (PDT) is an alternative treatment for port-wine stain (PWS) birthmarks. Objective: To evaluate treatment responses and adverse effects associated with Hemoporfin PDT for the treatment of PWS and their management. Method: The medical records of 700 patients who underwent PDT treatment in our center were retrospectively examined. Treatment-related reactions and adverse effects were reviewed. Result: Different types of PWS lesions and different individuals showed different immediate responses (e.g. swelling, color change, pain). To certain extents these reactions were a useful indicator of the treatment endpoint. Edema and scabbing were the most common post-treatment responses. Short-term (e.g. blister, eczematous dermatitis, cutaneous photosensitivity) and long-term (e.g. pigmentation change, scar formation) adverse effects were generally caused by the phototoxicity associated with the combination of photosensitizer and light exposure. Conclusion: Although PDT is a safe treatment alternative for PWS birthmarks, treatment parameters must be selected for each individual patient and cutaneous changes must be monitored during light irradiation to minimize the risk of adverse effects. Over estimation of required light dosage or failure to recognize cutaneous changes associated with adverse effects can increase the risk of a poor outcome. © 2012 Elsevier B.V. Source


Zhang B.,Laser Plastic and Aesthetic Center | Zhang T.-H.,Southern Medical University | Huang Z.,Fujian Normal University | Huang Z.,University of Colorado at Denver | And 3 more authors.
Photodiagnosis and Photodynamic Therapy | Year: 2014

Background: Vascular-acting photodynamic therapy (PDT) might be an alternative approach for treating port wine stain (PWS) birthmarks, but the usefulness of PDT for pediatric patients has not been fully investigated. Study design: Medical records of pediatric patients (3-10 years old) with red and purple facial PWS were analyzed. Clinical outcomes after one session of PDL (585 nm, 4.8-6.5 J/cm2) and PDT (Hemoporfin - 3.5 mg/kg, copper vapour laser - 120 J/cm2) were compared. Results: The rate of excellent response in PDT group was significantly higher than that in PDL group (25.0% vs 10.9%). For red lesions there was no significant difference in overall response between PDL and PDT group, but for purple lesions the overall response rate of PDT group was significantly higher than that of PDL group (93.0% vs 75.6%). Lesions located at the forehead, cheek and jaw regions showed better responses to PDT. Incidences of pigmentation and scar formation in PDT group were significantly lower than PDL group (8.3% vs 21.1%). Conclusion: This study suggests that PDT is safe and effective for treating facial PWS of childhood patients. © 2014. Source


Gao K.,Southern Medical University | Huang Z.,Laser Plastic and Aesthetic Center | Huang Z.,University of Colorado at Denver | Yuan K.-H.,Laser Plastic and Aesthetic Center | And 2 more authors.
British Journal of Dermatology | Year: 2013

Background Pulsed-dye laser (PDL)-mediated photothermolysis is the current standard treatment for port-wine stain (PWS) birthmarks. Vascular-targeted photodynamic therapy (PDT) might be an alternative for the treatment of PWS. Objectives To compare clinical outcomes of PDT and PDL treatment of PWS. Methods Two adjacent flat areas of PWS lesions were selected from each of 15 patients (two male and 13 female; age 11-36 years) and randomly assigned to either single-session PDL or PDT. PDL was delivered using a 585-nm pulsed laser. PDT was carried out with a combination of haematoporphyrin monomethyl ether (HMME) and a low-power copper vapour laser (510·6 and 578·2 nm). Clinical outcomes were evaluated colorimetrically and visually during follow-up. Results A total of nine red PWS lesions and six purple PWS lesions were treated. For red PWS, colorimetric assessment showed that the blanching rates of PDL and PDT at 2 months ranged from -11% to 24% and 22% to 55%, respectively. For purple PWS, blanching rates of PDL and PDT ranged from 8% to 33% and 30% to 45%, respectively. Overall, there was a significant difference between the blanching effect of single-session PDL treatment and a single-session PDT treatment. Conclusions This side-by-side comparison demonstrates that PDT is at least as effective as PDL and, in some cases, superior. The true value of PDT for the treatment of PWS deserves further investigation. What's already known about this topic? To date, several Chinese studies of photodynamic therapy (PDT) for port-wine stains (PWS) indicate that this therapeutic modality is effective and safe for the treatment of PWS of all colour and in all ages. Our retrospective study suggested that PDT is as effective as pulsed-dye laser (PDL) treatment for pink PWS and more effective than PDL for purple PWS. What does this study add? This is the first side-by-side and quantitative comparison of PDL and PDT. The findings reported here confirm that PDT is at least as effective and safe as PDL, if not superior to, for the treatment of red and purple flat PWS. © 2012 The Authors. BJD © 2012 British Association of Dermatologists. Source


Zhang B.,Laser Plastic and Aesthetic Center | Zhang T.-H.,Southern Medical University | Huang Z.,Fujian Normal University | Huang Z.,University of Colorado at Denver | And 3 more authors.
Photodiagnosis and Photodynamic Therapy | Year: 2014

Vascular-acting photodynamic therapy (PDT) might be an alternative approach for treating port wine stain (PWS) birthmarks, but the usefulness of PDT for pediatric patients has not been fully investigated. Study design: Medical records of pediatric patients (3-10 years old) with red and purple facial PWS were analyzed. Clinical outcomes after one session of PDL (585nm, 4.8-6.5J/cm2) and PDT (Hemoporfin - 3.5mg/kg, copper vapour laser - 120J/cm2) were compared. Results: The rate of excellent response in PDT group was significantly higher than that in PDL group (25.0% vs 10.9%). For red lesions there was no significant difference in overall response between PDL and PDT group, but for purple lesions the overall response rate of PDT group was significantly higher than that of PDL group (93.0% vs 75.6%). Lesions located at the forehead, cheek and jaw regions showed better responses to PDT. Incidences of pigmentation and scar formation in PDT group were significantly lower than PDL group (8.3% vs 21.1%). Conclusion: This study suggests that PDT is safe and effective for treating facial PWS of childhood patients. © 2014. Source

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