Jinhua, China
Jinhua, China

Time filter

Source Type

Ma B.,The Third The Peoples Hospital Of Bengbu | Li M.,Anhui Provincial Hospital | Zhang L.,Lanxi Peoples Hospital | Huang M.,The Third The Peoples Hospital Of Bengbu | And 6 more authors.
Tumor Biology | Year: 2015

The pathogenesis of osteosarcoma involves complex genetic and epigenetic factors. This study was to explore the impact and clinical relevance of long non-coding RNA (lncRNA), Taurine up-regulated gene 1 (TUG1) on patients with osteosarcoma. Seventy-six osteosarcoma tissues and matched adjacent normal tissues were included for analysis. The plasma samples were obtained from 29 patients with osteosarcoma at pre-operation and post-operation, 42 at newly diagnosed, 18 who experienced disease progression or relapse, 45 post-treatment, 36 patients with benign bone tumor, and 20 healthy donors. Quantitative real-time reverse transcript polymerase chain reactions were used to assess the correlation of the expression levels of TUG1 with clinical parameters of osteosarcoma patients. TUG1 was significantly overexpressed in the osteosarcoma tissues compared with matched adjacent normal tissues (P < 0.01) and was closely correlated with tumor size, post-operative chemotherapy, and Enneking surgical stage. Upregulation of TUG1 strongly correlated with poor prognosis and was an independent prognostic indicator for overall survival (HR = 2.78, 95% CI = 1.29–6.00, P = 0.009) and progression-free survival (HR = 1.81, 95% CI = 1.01–3.54, P = 0.037). Our constructed nomogram containing TUG1 had more predictive accuracy than that without TUG1 (c-index 0.807 versus 0.776, respectively). In addition, for plasma samples, TUG1 expression levels were obviously decreased in post-operative patients (mean ΔCT −4.98 ± 0.22) compared with pre-operation patients (mean ΔCT −6.09 ± 0.74), and the changes of TUG1 expression levels were significantly associated with disease status. Receiver operating characteristic (ROC) curve analysis demonstrated that TUG1 could distinguish patients with osteosarcoma from healthy individuals compared with alkaline phosphatase (ALP) (the area under curve 0.849 versus 0.544). TUG1 was overexpressed in patients with osteosarcoma and strongly correlated with disease status. In addition, TUG1 may serve as a molecular indicator in maintaining surveillance and forecasting prognosis. © 2015 International Society of Oncology and BioMarkers (ISOBM)


PubMed | Lanxi Peoples Hospital, Dehua County Hospital, The third the Peoples Hospital of Bengbu, The Second Peoples Hospital of Lianyungang and 4 more.
Type: Journal Article | Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine | Year: 2016

The pathogenesis of osteosarcoma involves complex genetic and epigenetic factors. This study was to explore the impact and clinical relevance of long non-coding RNA (lncRNA), Taurine up-regulated gene 1 (TUG1) on patients with osteosarcoma. Seventy-six osteosarcoma tissues and matched adjacent normal tissues were included for analysis. The plasma samples were obtained from 29 patients with osteosarcoma at pre-operation and post-operation, 42 at newly diagnosed, 18 who experienced disease progression or relapse, 45 post-treatment, 36 patients with benign bone tumor, and 20 healthy donors. Quantitative real-time reverse transcript polymerase chain reactions were used to assess the correlation of the expression levels of TUG1 with clinical parameters of osteosarcoma patients. TUG1 was significantly overexpressed in the osteosarcoma tissues compared with matched adjacent normal tissues (P<0.01) and was closely correlated with tumor size, post-operative chemotherapy, and Enneking surgical stage. Upregulation of TUG1 strongly correlated with poor prognosis and was an independent prognostic indicator for overall survival (HR=2.78, 95% CI=1.29-6.00, P=0.009) and progression-free survival (HR=1.81, 95% CI=1.01-3.54, P=0.037). Our constructed nomogram containing TUG1 had more predictive accuracy than that without TUG1 (c-index 0.807 versus 0.776, respectively). In addition, for plasma samples, TUG1 expression levels were obviously decreased in post-operative patients (mean CT -4.980.22) compared with pre-operation patients (mean CT -6.090.74), and the changes of TUG1 expression levels were significantly associated with disease status. Receiver operating characteristic (ROC) curve analysis demonstrated that TUG1 could distinguish patients with osteosarcoma from healthy individuals compared with alkaline phosphatase (ALP) (the area under curve 0.849 versus 0.544). TUG1 was overexpressed in patients with osteosarcoma and strongly correlated with disease status. In addition, TUG1 may serve as a molecular indicator in maintaining surveillance and forecasting prognosis.


Deng Q.,Nanjing Medical University | He B.,Nanjing Medical University | Liu X.,Nanjing Medical University | Yue J.,Huaian Second Peoples Hospital | And 11 more authors.
Journal of Translational Medicine | Year: 2015

Background: Inflammation plays an integral role in carcinogenesis and tumor progression. Inflammatory response biomarkers have shown to be promising prognostic factors for improving the predictive accuracy in various cancers. The aim of this study is to investigate the prognostic significance of pre-operative neutrophil to lymphocyte ratio (NLR), derived neutrophil to lymphocyte ratio (dNLR), platelet to lymphocyte ratio (PLR) and lymphocyte to monocyte ratio (LMR) in gastric cancer (GC). Methods: 389 patients who had undergone gastrectomy were enrolled from 2007 to 2009 in this study. NLR, dNLR, PLR and LMR were calculated from peripheral blood cell count taken at pre-operation. Receiver operating curve (ROC) was used to determine the optimal cut-off levels for these biomarkers. A predictive model or nomogram was established to predict prognosis for cancer-specific survival (CSS) and disease-free survival (DFS), and the predictive accuracy of the nomogram was determined by concordance index (c-index). Results: The median follow-up period was 24months ranging from 3months to 60months. The optimal cut-off levels were 2.36 for NLR, 1.85 for dNLR, 132 for PLR and 4.95 for LMR by ROC curves analysis. Elevated NLR, dNLR and PLR were significantly associated with worse overall survival (OS), CSS and DFS, however, elevated LMR showed an adverse effect on worse OS, CSS and DFS. Multivariate analysis revealed that elevated dNLR was an independent factor for worse OS, and NLR was superior to dNLR, PLR and LMR in terms of hazard ratio (HR=1.53, 95% CI=1.11-2.11, P=0.010), which was shown to be independent prognostic indicators for both CSS and DFS. Moreover, the nomogram could more accurately predict CSS (c-index: 0.89) and DFS (c-index: 0.84) in surgical GC patients. Conclusions: Pre-operative NLR and dNLR may serve as potential prognostic biomarkers in patients with GC who underwent surgical resection. The proposed nomograms can be used for the prediction of CSS and DFS in patients with GC who have undergone gastrectomy. © 2015 Deng et al.. licensee BioMed Central.


Sun H.,Nanjing Normal University | Hou J.,Mother and Child Health Care Hospital of Qixia District | Hou J.,The North Branch of Nanjing Mother and Child Health Care Hospital | Shi W.,Nanjing Traditional Chinese Medical Hospital | Zhang L.,Lanxi Peoples Hospital
Clinics and Research in Hepatology and Gastroenterology | Year: 2014

Background: Emerging published data on the association between single nucleotide polymorphisms (SNPs) in the estrogen receptor 1 (ESR1) gene and cancer susceptibility are inconsistent. This review and meta-analysis is performed to derive a more precise evaluation of this relationship. Methods: The literature search of PubMed, Embase, Web of Science and CNKI databases was conducted from their inception through June 2014. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association. Results: Twenty-two literatures were enrolled in this meta-analysis. The results indicated that ESR1 rs1801132 (C > G) was associated with cancer risk in Caucasian populations. However, the results of stratified analysis by cancer type and source of controls indicated that no significant association was found. Furthermore, rs2077647 (A > G) was only associated with an increased risk of hepatocellular carcinoma, but was an adverse effect on cancer risk in Caucasian populations. Conclusions: This present meta-analysis indicated that rs1801132 (C > G) and rs2077647 (A > G) may be protective factors in Caucasian populations. Meanwhile, rs2077647 (A > G) may be closely related with hepatocellular carcinoma. © 2014 Elsevier Masson SAS. All rights reserved.


Sun H.,Nanjing Normal University | Hou J.,Mother and Child Health Care Hospital of Qixia District | Shi W.,Nanjing Traditional Chinese Medical Hospital | Zhang L.,Lanxi Peoples Hospital
Clinics and research in hepatology and gastroenterology | Year: 2015

BACKGROUND: Emerging published data on the association between single nucleotide polymorphisms (SNPs) in the estrogen receptor 1 (ESR1) gene and cancer susceptibility are inconsistent. This review and meta-analysis is performed to derive a more precise evaluation of this relationship.METHODS: The literature search of PubMed, Embase, Web of Science and CNKI databases was conducted from their inception through June 2014. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association.RESULTS: Twenty-two literatures were enrolled in this meta-analysis. The results indicated that ESR1 rs1801132 (C>G) was associated with cancer risk in Caucasian populations. However, the results of stratified analysis by cancer type and source of controls indicated that no significant association was found. Furthermore, rs2077647 (A>G) was only associated with an increased risk of hepatocellular carcinoma, but was an adverse effect on cancer risk in Caucasian populations.CONCLUSIONS: This present meta-analysis indicated that rs1801132 (C>G) and rs2077647 (A>G) may be protective factors in Caucasian populations. Meanwhile, rs2077647 (A>G) may be closely related with hepatocellular carcinoma. Copyright © 2014 Elsevier Masson SAS. All rights reserved.


PubMed | Nanjing Medical University, Lanxi Peoples Hospital and Huaian Second Peoples Hospital
Type: | Journal: Journal of translational medicine | Year: 2015

Inflammation plays an integral role in carcinogenesis and tumor progression. Inflammatory response biomarkers have shown to be promising prognostic factors for improving the predictive accuracy in various cancers. The aim of this study is to investigate the prognostic significance of pre-operative neutrophil to lymphocyte ratio (NLR), derived neutrophil to lymphocyte ratio (dNLR), platelet to lymphocyte ratio (PLR) and lymphocyte to monocyte ratio (LMR) in gastric cancer (GC).389 patients who had undergone gastrectomy were enrolled from 2007 to 2009 in this study. NLR, dNLR, PLR and LMR were calculated from peripheral blood cell count taken at pre-operation. Receiver operating curve (ROC) was used to determine the optimal cut-off levels for these biomarkers. A predictive model or nomogram was established to predict prognosis for cancer-specific survival (CSS) and disease-free survival (DFS), and the predictive accuracy of the nomogram was determined by concordance index (c-index).The median follow-up period was 24months ranging from 3months to 60months. The optimal cut-off levels were 2.36 for NLR, 1.85 for dNLR, 132 for PLR and 4.95 for LMR by ROC curves analysis. Elevated NLR, dNLR and PLR were significantly associated with worse overall survival (OS), CSS and DFS, however, elevated LMR showed an adverse effect on worse OS, CSS and DFS. Multivariate analysis revealed that elevated dNLR was an independent factor for worse OS, and NLR was superior to dNLR, PLR and LMR in terms of hazard ratio (HR=1.53, 95% CI=1.11-2.11, P=0.010), which was shown to be independent prognostic indicators for both CSS and DFS. Moreover, the nomogram could more accurately predict CSS (c-index: 0.89) and DFS (c-index: 0.84) in surgical GC patients.Pre-operative NLR and dNLR may serve as potential prognostic biomarkers in patients with GC who underwent surgical resection. The proposed nomograms can be used for the prediction of CSS and DFS in patients with GC who have undergone gastrectomy.


Li H.-C.,Lanxi Peoples Hospital | Wanc W.-P.,Lanxi Peoples Hospital | Li L.,Lanxi Peoples Hospital
Journal of Practical Oncology | Year: 2010

Objective: To evaluate the impact of melatonin (MLT) on the toxicity and side effects after chemotherapy in elderly non-small cell lung cancer (NSCLC) patients. Methods: Ninty-six elderly patients with NSCLC were randomly divided into observation group and control group. The control group received conventional chemotherapy alone,while the observation group received 0.2 mg MLT for oral use in addition to conventional chemotherapy. The complications of various systems were evaluated after chemotherapy. Results: The incidence of complications was not significantly different after the first cycle of chemotherapy. From the second cycle to the fourth cycle, the incidence of toxic side effects of various systems in the observation group significantly decreased compared with the control group. Conclusion: MLT can inhibit the toxicity and side effects of chemotherapeutical drugs in patients with NSCLC.

Loading Lanxi Peoples Hospital collaborators
Loading Lanxi Peoples Hospital collaborators