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Boston, MA, United States

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Boston, MA, United States
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"The team at Air Methods has been wonderful to work with for many years. We're thrilled that they have decided to move their company to our Quebec location and truly look forward to working with them in the future," remarked Chairman & CEO of Northstar Commercial Partners, Brian Watson. Air Methods delivers lifesaving care to more than 100,000 patients per year. Often the only choice for saving a life, air medical transport plays an essential role in safety here in Colorado. Many of the organization's team members are U.S. veterans, active duty, or in the reserves. The Air Methods team includes over 4,500 talented members from pilots to clinicians, mechanics, and communications specialists. Air Methods is highly involved in the community, volunteering with Junior Achievement Colorado, training pilots, and operating the organization Flight for Life. Flight for Life is the first hospital-based air ambulance. Their orange helicopters are a familiar sight to Metro Denver and their Flight for Life operates as a community service to the people of Colorado and surrounding regions. Available twenty-four hours a day, Flight For Life Colorado may be requested by any physician, ambulance service, fire department, law enforcement agency, ski patrol, or search and rescue group. A patient's ability to pay is never questioned when urgent transport is needed for their life saving work. "Air Methods chose 5550 S. Quebec for its superior location in the heart of southeast Denver with an easy walk to the Orchard light rail station as well as all the amenities of Landmark Center," said Doug Wulf, Executive Managing Director of Cushman and Wakefield, the broker who represented Northstar on the lease. "In addition, the modern atrium and other options provided by Northstar made this an attractive space for Air Methods to call home," Wulf concluded. There is approximately 100,000 sq. ft. still available for lease at this property for other tenants who wish to join Air Methods. To learn more about Northstar and the assets it owns throughout America, please visit:, and to view the other community empowerment initiatives of Brian Watson its CEO, please visit: To view the original version on PR Newswire, visit:

Sobus J.R.,U.S. Environmental Protection Agency | Pleil J.D.,U.S. Environmental Protection Agency | McClean M.D.,Boston University | Herrick R.F.,Landmark Center | Rappaport S.M.,University of California at Berkeley
Toxicology Letters | Year: 2010

Biomarkers are useful exposure surrogates given their ability to integrate exposures through all routes and to reflect interindividual differences in toxicokinetic processes. Also, biomarker concentrations tend to vary less than corresponding environmental measurements, making them less-biasing surrogates for exposure. In this article, urinary PAH biomarkers (namely, urinary naphthalene [U-Nap]; urinary phenanthrene [U-Phe]; 1-hydroxypyrene [1-OH-Pyr]; and 1-, (2+3)-, 4-, and 9-hydroxyphenanthrene [1-, (2+3)-, 4-, and 9-OH-Phe]) were evaluated as surrogates for exposure to hot asphalt emissions using data from 20 road-paving workers. Linear mixed-effects models were used to estimate the within- and between-person components of variance for each urinary biomarker. The ratio of within- to between-person variance was then used to estimate the biasing effects of each biomarker on a theoretical exposure-response relationship. Mixed models were also used to estimate the amounts of variation in Phe metabolism to individual OH-Phe isomers that could be attributed to Phe exposure (as represented by U-Phe concentrations) and covariates representing time, hydration level, smoking status, age, and body mass index. Results showed that 1-OH-Phe, (2+3)-OH-Phe, and 1-OH-Pyr were the least-biasing surrogates for exposure to hot asphalt emissions, and that effects of hydration level and sample collection time substantially inflated bias estimates for the urinary biomarkers. Mixed-model results for the individual OH-Phe isomers showed that between 63% and 82% of the observed biomarker variance was collectively explained by Phe exposure, the time and day of sample collection, and the hydration level, smoking status, body mass index, and age of each worker. By difference, the model results also showed that, depending on the OH-Phe isomer, a maximum of 6-23% of the total biomarker variance was attributable to differences in unobserved toxicokinetic processes between the workers. Therefore, toxicokinetic processes are probably less influential on urinary biomarker variance than are exposures and observable covariate effects. The methods described in this analysis should be considered for the selection and interpretation of biomarkers as exposure surrogates in future exposure investigations. © 2010.

Dong Z.,Harvard University | Senn D.B.,University of California at San Francisco | Senn D.B.,Landmark Center | Moran R.E.,University of California at Davis | And 2 more authors.
Regulatory Toxicology and Pharmacology | Year: 2013

Low levels of pharmaceutical compounds have been detected in aquatic environments worldwide, but their human and ecological health risks associated with low dose environmental exposure is largely unknown due to the large number of these compounds and a lack of information. Therefore prioritization and ranking methods are needed for screening target compounds for research and risk assessment. Previous efforts to rank pharmaceutical compounds have often focused on occurrence data and have paid less attention to removal mechanisms such as human metabolism. This study proposes a simple prioritization approach based on number of prescriptions and toxicity information, accounting for metabolism and wastewater treatment removal, and can be applied to unmeasured compounds. The approach was performed on the 200 most-prescribed drugs in the US in 2009. Our results showed that under-studied compounds such as levothyroxine and montelukast sodium received the highest scores, suggesting the importance of removal mechanisms in influencing the ranking, and the need for future environmental research to include other less-studied but potentially harmful pharmaceutical compounds. © 2012 .

Ren C.,Landmark Center | Melly S.,Landmark Center | Schwartz J.,Landmark Center
Environmental Health: A Global Access Science Source | Year: 2010

Background. Substantial epidemiological studies demonstrate associations between exposure to ambient ozone and mortality. A few studies simply examine the modification of this ozone effect by individual characteristics and socioeconomic status, but socioeconomic status was usually coded at the city level. Methods. This study used a case-crossover design to examine whether impacts of ozone on mortality were modified by socioeconomic status coded at the tract or characteristics at an individual level in eastern Massachusetts, US for a period May-September, 1995-2002, with a total of 157,197 non-accident deaths aging 35 years or older. We used moving averages of maximal 8-hour concentrations of ozone monitored at 8 stationary stations as personal exposure. Results. A 10 ppb increase in the four-day moving average of maximal 8-hour ozone was associated with 1.68% (95% confidence interval (CI): 0.51%, 2.87%), 1.96% (95% CI: -1.83%, 5.90%), 8.28% (95% CI: 0.66%, 16.48%), 0.44% (95% CI: -1.45%, 2.37%), -0.83% (95% CI: -2.94%, 1.32%), -1.09% (95% CI: -4.27%, 2.19%) and 6.5% (95% CI: 1.74%, 11.49%) changes in all natural deaths, respiratory disorders, diabetes, cardiovascular diseases, heart diseases, acute myocardial infarction and stroke, respectively. We did not find any evidence that the associations were significantly modified by socioeconomic status or individual characteristics although small differences of estimates across subpopulations were demonstrated. Conclusions. Exposure to ozone was associated with specific cause mortality in Eastern Massachusetts during May-September, 1995-2002. There was no evidence that effects of ozone on mortality were significantly modified by socioeconomic status and individual characteristics. © 2010 Ren et al; licensee BioMed Central Ltd.

Baccarelli A.,Landmark Center | Baccarelli A.,Harvard University | Ghosh S.,Harvard University
Current Opinion in Clinical Nutrition and Metabolic Care | Year: 2012

Purpose of review: Epigenetic modifications are heritable alterations of the genome, which can govern gene expression without altering the DNA sequence. The purpose of this review is to render an overview of the possible mechanisms of epigenetic regulation of gene expression in response to environmental pollutants leading to cardiovascular diseases (CVD). Recent findings: An era of cataloging epigenetic marks of the various diseased states has recently commenced, including those within the genes responsible for atherosclerosis, ischemia, hypertension and heart failure. From varied study approaches directed either toward the general understanding of the key pathway regulatory genes, or sampling population cohorts for global and gene-specific changes, it has been possible to identify several epigenetic signatures of environmental exposure relevant to CVD. Signatures of epigenetic dysregulation can be detected in peripheral blood samples, even within a few hours of environmental exposure. However, the field now faces the demand for thorough, systematic, rationalized approaches to establish the relation of exposure-driven epigenetic changes to clinical outcomes, by using sophisticated and reliable research designs and tools. Summary: An understanding of chromatin remodelling in response to environmental stimuli conducive to CVD is emerging, with the promise of novel diagnostic and therapeutic candidates. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Sequist T.D.,Brigham and Women's Hospital | Fitzmaurice G.M.,Brigham and Women's Hospital | Marshall R.,Harvard University | Shaykevich S.,Brigham and Women's Hospital | And 3 more authors.
Annals of Internal Medicine | Year: 2010

Background: Increasing clinician awareness of racial disparities and improving communication may enhance diabetes care among black patients. Objective: To evaluate the effect of cultural competency training and performance feedback for primary care clinicians on diabetes care for black patients. Design: Cluster randomized, controlled trial conducted between June 2007 and May 2008. ( registration number: NCT00436176) Setting: 8 ambulatory health centers in eastern Massachusetts. Participants: 124 primary care clinicians caring for 2699 (36%) black and 4858 (64%) white diabetic patients. Intervention: Intervention clinicians received cultural competency training and monthly race-stratified performance reports that highlighted racial differences in control of hemoglobin A1c (HbA 1c) and low-density lipoprotein (LDL) cholesterol levels and blood pressure. Measurements: Clinician awareness of racial differences in diabetes care and rates of achieving clinical control targets among black patients at 12 months. Results: White and black patients differed significantly in baseline rates of achieving an HbA1c level less than 7% (46% vs. 40%), an LDL cholesterol level less than 2.59 mmol/L (<100 mg/dL) (55% vs. 43%), and blood pressure less than 130/80 mm Hg (32% vs. 24%) (all P < 0.050). At study completion, intervention clinicians were significantly more likely than control clinicians to acknowledge the presence of racial disparities in the 8 health centers as a whole (82% vs. 59%; P = 0.003), within their local health center (70% vs. 51%; P = 0.020), and among their own patients (63% vs. 43%; P = 0.037). Black patients of clinicians in the intervention and control groups did not differ at 12 months in rates of controlling HbA1c level (48% vs. 45%; P = 0.24), LDL cholesterol level (48% vs. 49%; P = 0.40), or blood pressure (23% vs. 25%; P = 0.47). Limitation: 11% of primary care teams did not attend cultural competency training sessions. Conclusion: The combination of cultural competency training and race-stratified performance reports increased clinician awareness of racial disparities in diabetes care but did not improve clinical outcomes among black patients. © 2010 American College of Physicians.

Levy J.I.,Landmark Center | Levy J.I.,Boston University | Hanna S.R.,Landmark Center
Environmental Pollution | Year: 2011

Identification of hot spots for urban fine particulate matter (PM 2.5) concentrations is complicated by the significant contributions from regional atmospheric transport and the dependence of spatial and temporal variability on averaging time. We focus on PM2.5 patterns in New York City, which includes significant local sources, street canyons, and upwind contributions to concentrations. A literature synthesis demonstrates that long-term (e.g., one-year) average PM2.5 concentrations at a small number of widely-distributed monitoring sites would not show substantial variability, whereas short-term (e.g., 1-h) average measurements with high spatial density would show significant variability. Statistical analyses of ambient monitoring data as a function of wind speed and direction reinforce the significance of regional transport but show evidence of local contributions. We conclude that current monitor siting may not adequately capture PM2.5 variability in an urban area, especially in a mega-city, reinforcing the necessity of dispersion modeling and methods for analyzing high-resolution monitoring observations. © 2010 Elsevier Ltd. All rights reserved.

Herrick R.F.,Landmark Center
New solutions : a journal of environmental and occupational health policy : NS | Year: 2010

The issue of polychlorinated biphenyls (PCB) exposures resulting from occupancy of PCB-contaminated buildings is not new, but the contribution of building materials to that contamination is largely unrecognized. A rapidly emerging base of evidence shows that PCBs can be widely found in caulking and paint in masonry buildings constructed or renovated from about 1950 to the late 1970s. These materials can cause extensive PCB contamination of the building interiors and surrounding soil, and people who teach, live, or attend school in these buildings can have elevated serum PCB levels. The potential risk associated with this source of PCB exposure is not known; however, it is worth noting that the specific PCB congeners found at high levels in the building environments, and in biological samples from the occupants, include some that are suspected of being potent neurotoxins. The U. S. Environmental Protection Agency (EPA) is moving to address this issue in schools; however, the costs of remediating contaminated buildings will pose a formidable obstacle to most school districts.

Alexeeff S.E.,Landmark Center | Coull B.A.,Harvard University | Gryparis A.,Harvard University | Suh H.,Landmark Center | And 3 more authors.
Environmental Health Perspectives | Year: 2011

Background: Exposure to traffic-related air pollution (TRAP) contributes to increased cardio-vascular risk. Land-use regression models can improve exposure assessment for TRAP. Objectives: We examined the association between medium-term concentrations of black carbon (BC) estimated by land-use regression and levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1), both markers of inflammatory and endothelial response. Methods: We studied 642 elderly men participating in the Veterans Administration (VA) Normative Aging Study with repeated measurements of sICAM--1 and sVCAM--1 during 1999-2008. Daily estimates of BC exposure at each geocoded participant address were derived using a validated spatio-temporal model and averaged to form 4-, 8-, and 12-week exposures. We used linear mixed models to estimate associations, controlling for confounders. We examined effect modification by statin use, obesity, and diabetes. Results: We found statistically significant positive associations between BC and sICAM--1 for averages of 4, 8, and 12 weeks. An interquartile-range increase in 8-week BC exposure (0.30 μg/m 3) was associated with a 1.58% increase in sICAM--1 (95% confidence interval, 0.18-3.00%). Overall associations between sVCAM--1 and BC exposures were suggestive but not statistically significant. We found a significant interaction with diabetes-where diabetics were more susceptible to the effect of BC-for both sICAM--1 and sVCAM--1. We also observed an interaction with statin use, which was statistically significant for sVCAM--1 and suggestive for sICAM--1. We found no evidence of an interaction with obesity. Conclusion: Our results suggest that medium-term exposure to TRAP may induce an increased inflammatory/endothelial response, especially among diabetics and those not using statins.

Law firm's new space to span 47,000 square feet on top floor of premier downtown building ORLANDO, FL--(Marketwired - February 28, 2017) - Foundry Commercial, the multi-city commercial real estate firm headquartered in Orlando, has successfully completed a 15-year, 47,000-square-foot lease on behalf of law firm Shutts & Bowen at downtown Orlando's Lincoln Plaza building. Recent Foundry recruit and industry veteran Jeff Patterson secured the deal on behalf of the client. Catherine Reeves with Highwoods Properties represented the landlord in the deal. The law firm's decision to relocate its office from the ninth and 10th floors of the Lincoln Plaza building to the entire 9th floor and top (16th) floor stemmed from a desire to create a more efficient, collaborative and attractive workspace to enhance employee productivity, recruitment and retention. To achieve the desired look and feel of the space, Foundry enlisted the help of local interior designer Rob Blakeslee to transform the already visually stunning top floor, which includes features such as a 1,850 square-foot conference/lounge area with a 30-foot-high vaulted ceiling, into Shutts & Bowen's ideal office. Blakeslee's alterations to the space will include significant renovations to the lobby, like a 36 foot by 12 inch fumed oak canopy feature, as well as subtle design touches, such as thin column light fixtures suspended from the vaulted ceiling. "After spending 30 years in Orlando and completing over 500 deals in the region, it is a privilege to continue to be able to assist local businesses like Shutts & Bowen in finding a space that speaks to their organizational goals and company culture," said Patterson, senior vice president at Foundry Commercial. "Since joining the Foundry team, I've been able to maintain the same drive and focus for securing the best deals for my clients that I had while running my own company. I am looking forward to continuing to operate in an environment that encourages associates to remain passionate about every client and every project, every day." "Few brokers can match the time and personal attention that Jeff devotes to his projects," said James Willard, partner at Shutts & Bowen. "He listened and we are thankful to him and the entire Foundry team for securing this lease on our behalf, and for helping us to achieve more than we thought was possible in the deal." Prior to joining Foundry Commercial, Patterson represented prominent tenants such as Federal Express, Compass Research and Ridgeworth Capital and has handled many of Orlando's premier office projects, including: the Landmark Center, Bank of America Center, Citrus Center, and the marketing and development of the $85 million, 31-story One Eleven Project, among many others. Foundry Commercial is a full-service real estate services and investment company with 270 employees and more than 40 million square feet of management and leasing across the Southeast and Texas. Foundry provides corporate services, brokerage, leasing, building management and project management services, and is the largest real estate service provider to religious and not-for-profit organizations in the Country. Foundry also includes a development and investment platform that is fully integrated into its services business, leveraging its local market expertise to control more than $500 million in advantaged investment opportunities in partnership with its clients. Foundry Commercial was founded as CNL Commercial Real Estate in 2007 and launched as Foundry in 2015 through a management-led buyout. For more information, visit

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