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Klagenfurt am Wörthersee, Austria

Wilhelma I.R.,Friedrich - Alexander - University, Erlangen - Nuremberg | Tzabazisa A.,Friedrich - Alexander - University, Erlangen - Nuremberg | Likarb R.,Landeskrankenhaus Klagenfurt | Sittla R.,Friedrich - Alexander - University, Erlangen - Nuremberg | Griessingera N.,Friedrich - Alexander - University, Erlangen - Nuremberg
European Journal of Anaesthesiology | Year: 2010

Background and objective The 5% lidocaine medicated plaster is a topical treatment for peripheral neuropathic pain symptoms (e.g. burning, shooting and stabbing pain) and is registered for the treatment of postherpetic neuralgia. This study examined the efficacy and tolerability of long-term treatment with the 5% lidocaine medicated plaster in patients with localized neuropathic pain conditions. Methods Twenty patients with localized neuropathic pain [postoperative neuropathic pain (n=14); complex regional pain syndrome (n=2); and postherpetic neuralgia (n=4)], who had been successfully treated with 5% lidocaine medicated plaster, were followed up by telephone interview after 3 and 5 years. Questions were related to the efficacy, development of tolerance, tolerability, wear time and comfort of the plaster. Results At 3 years, 10 out of 20 (50%) initial responders were still using the plasters with no decline in analgesic efficacy. After 5 years, eight of the original 20 responders (40%) maintained treatment and continued to experience effective pain relief. The 12 responders who discontinued treatment did so because they no longer required analgesic therapy (n=4); their health insurer refused to fund treatment (n=2); they were lost to follow-up (n=1); or had © 2010 European Society of Anaesthesiology.

Pronai W.,Section of Nephrology | Neyer U.,Feldkirch Academic Teaching Hospital | Neyer U.,Vorarlberg Institute for Vascular Investigation and Treatment VIVIT | Barnas U.,3. Med. Abteilung | And 6 more authors.
Wiener Medizinische Wochenschrift | Year: 2014

ALTERNATE is an international observational study evaluating biweekly darbepoetin alfa (DA) in adult dialysis patients in clinical practice. Austrian ALTERNATE results are presented here (n=505). The follow-up study ALTERNATE follow-up (AFU) followed Austrian ALTERNATE patients for an additional 12 months (n=135). Data were collected 6 months before and 12 months after conversion to biweekly dosing and during 12 months of follow-up. The primary measures were hemoglobin concentration 12 months after conversion and at the end of AFU, respectively. Mean (95% CI) hemoglobin (g/dL) was 11.87 (11.75-11.99) at conversion, 11.71 (11.58-11.83) at month 12, and 11.66 (11.45-11.86) at end of AFU. Geometric mean (95% CI) weekly dose (μg/wk) was 32.97 (30.80-35.30) at conversion, 29.90 (26.71-33.46) 12 months after conversion, and 24.38 (18.40-30.35) at end of AFU. The studies show that hemoglobin and dose could be effectively maintained over an extended period of time after conversion from higher frequency erythropoiesis-stimulating agents to biweekly DA. © 2013 Springer-Verlag.

Kuessel L.,Vienna University Hospital | Grimm C.,Vienna University Hospital | Knofler M.,Vienna University Hospital | Haslinger P.,Vienna University Hospital | And 4 more authors.
Disease Markers | Year: 2013

Oxytocin is crucially involved in the onset and maintenance of labor. We investigated the association between oxytocin receptor gene polymorphisms and preterm birth. The presence of four common oxytocin receptor gene polymorphisms (rs2254298, rs53576, rs2228485 and rs237911) was evaluated in one hundred women with preterm birth and one hundred healthy women using restriction fragment length polymorphism genotyping. No association was found between the presence of any individual oxytocin receptor gene polymorphism and preterm birth. In haplotype analysis, the haplotype combination of rs2254298 A allele, rs2228485 C allele and rs237911 G allele was found to be significantly associated with an increased risk of preterm birth (OR=3.2 [CI 1.04-9.8], p=0.043). In conclusion our findings suggest that a combination of three oxytocin receptor gene polymorphisms is associated with an increased risk for preterm birth. We propose further studies investigating the role of oxytocin receptor gene polymorphisms and preterm birth. © 2013 IOS Press and the authors. All rights reserved.

Remacle M.,University Hospital of Leuven at Mont Godinne | Eckel H.E.,Landeskrankenhaus Klagenfurt
Surgery of Larynx and Trachea | Year: 2010

Written by internationally recognized opinion leaders of the field, this comprehensive textbook covers all the subspecialities of laryngology, from phonosurgery to cancer. Each surgical procedure is explained and well illustrated in a step-by-step manner. Moreover, different surgical methods such as endoscopic versus open surgery and the use of cold instrument versus laser are evaluated so that the reader receives guidance for the use of these complimentary methods. © Springer-Verlag Berlin Heidelberg 2010. All rights are reserved.

Husslein H.,Landeskrankenhaus Klagenfurt | Worda C.,Medical University of Vienna | Leipold H.,Landeskrankenhaus Klagenfurt | Szalay S.,Landeskrankenhaus Klagenfurt
Geburtshilfe und Frauenheilkunde | Year: 2012

Purpose: To evaluate whether ultrasound accuracy of estimated fetal weight (EFW) differs in women with diet controlled gestational diabetes mellitus (GDM) compared to nondiabetic pregnant women. Material and Methods: We included 363 patients, 121 patients with diet controlled GDM and 242 patients with a normal oral glucose tolerance test (oGTT). Each case of diet controlled GDM was matched with 2 unaffected controls. All patients were screened/diagnosed for GDM by means of an oGTT. Both groups received ultrasound examination including fetal biometry, using Hadlocks Formula, within 7 days to delivery. After birth, gestational age, birthweight and Apgar scores were collected from each newborn. Results: There was a good correlation between EFW and birth weight (coefficient = 0.747, p < 0.001 by Pearson correlation, even after adjustment for glucose status). Regression analyses, including noGDM/GDM, maternal age, maternal body mass index, birth weight and time interval between ultrasound and delivery revealed that only fetal birth weight significantly influences weight difference between ultrasound EFW and actual birth weight at term. Conclusion: Our data suggests that ultrasound accuracy of EFW using Hadlocks Formula at term does not differ in women with diet controlled GDM compared to women with normal glucose tolerance.

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