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Vaish A.K.,University of Lucknow | Consul S.,University of Lucknow | Agrawal A.,University of Lucknow | Chaudhary S.C.,University of Lucknow | And 3 more authors.
Journal of Emergencies, Trauma and Shock | Year: 2013

Here, authors present a review on clinical presentation and management of exposure of phosgene gas after reviewing the literature by searching with keywords phosgene exposure on Google, Cochrane, Embase and PubMed with a background of experience gained from 10 patients who were admitted to our institute after an accidental phosgene exposure in February 2011 nearby a city in India. Phosgene is a highly toxic gas, occupational workers may have accidental exposure. The gas can also be generated inadvertently during fire involving plastics and other chemicals and solvents containing chlorine, which is of concern to emergency responders. Phosgene inhalation may cause initially symptoms of respiratory tract irritation, patients feel fine thereafter, and then die of choking a day later because of build up of fluid in the lungs (delayed onset non-cardiogenic pulmonary edema). Phosgene exposure is associated with significant morbidity and mortality. Patients with a history of exposure should be admitted to the hospital for a minimum of 24 h for observation because of the potential for delayed onset respiratory failure and acute respiratory distress syndrome. Source


Gupta S.P.,Crossing tech | Samanta S.,Birla Institute of Technology | Masand N.,Lala Lajpat Rai Memorial Medical College | Patil V.M.,Bharat Institute of Technology
Medicinal Chemistry Research | Year: 2013

The k nearest neighbor-molecular field analysis (kNN-MFA) is used to study the correlation between the molecular properties and biological activities of the recently reported 2,5-disubstituted imidazo[4,5-c]pyridines as anti-HCV agents. The most predictive kNN-MFA model derived from the superposition of docked conformations, has good cross-validated q 2 (0.96) and satisfied predictive ability $$ r-{\text{pred}}^{2} $$ (0.88). It could rationalize the HCV inhibitory activity profile of many compounds used in the present study as well as the important structural features responsible for activity. Furthermore, the effects of various structural modifications on biological activity are investigated, and biological activities of novel structures are estimated using the developed 3D QSAR model. © 2012 Springer Science+Business Media, LLC. Source


Ameer F.,Lala Lajpat Rai Memorial Medical College | Singh A.,University of Lucknow | Kumar S.,All India Institute of Medical Sciences
Indian Journal of Plastic Surgery | Year: 2013

Background: The harvest of autologous skin graft is considered to be a fundamental skill of the plastic surgeon. The objective of this article is to provide an interesting account of the development of skin grafting instruments as we use them today in various plastic surgical procedures. Materials and Methods: The authors present the chronological evolution and modifications of the skin grafting knife, including those contributions not often cited in the literature, using articles sourced from MEDLINE, ancient manuscripts, original quotes, techniques and illustrations. Results: This article traces the evolution of instrumentation for harvest of skin grafts from free hand techniques to precise modern automated methods. Conclusions: Although skin grafting is one of the basic techniques used in reconstructive surgery yet harvest of a uniform graft of desired thickness poses a challenge. This article is dedicated to innovators who have devoted their lives and work to the advancement of the field of plastic surgery. Source


Mithal C.,Lala Lajpat Rai Memorial Medical College
Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH | Year: 2011

To evaluate the efficacy of lignocaine 2 % jelly as topical anesthesia in pterygium surgery with conjunctival limbal autograft using fibrin glue. A non-randomized interventional study was carried out including twenty-one patients who presented with primary pterygium. Under 2% lignocaine jelly, surgical dissection of the pterygium, scraping of corneal bed with crescent blade, excision of Tenons capsule, harvesting conjunctival limbal autograft superiorly, and securing it with respect to limbus and stromal orientation with fibrin glue were done. Postoperatively, the patients discomfort and pain were evaluated by Wongs pain scoring system. The mean pain score was 0.70 ± 0.97. Only one patient (4.76%) out of the whole series experienced pain who rated more than three on the visual analog scale of 5. Thirteen patients (61.9%) had pain score of zero, that is, no pain. The surgeons evaluation of the technique in terms of surgical ease and complications was favorable. There were no dislodged grafts and no cases required suturing. There were no cases of infection, significant inflammation, epithelial problems and reduction in visual acuity. There was a single case of recurrence (4.76%) five months postoperatively which was managed conservatively. Conclusions: Topical anesthesia with lignocaine 2% jelly using fibrin sealant is safe and effective in pterygium surgery allowing for short operative times. It results in low pain and good aesthetic and functional outcomes. © NEPjOPH. Source


Malhotra M.,Lala Lajpat Rai Memorial Medical College
Journal of Laryngology and Otology | Year: 2010

Objectives: Tympanoplasty continues to pose a challenge in developing countries, where treatment cost and lack of compliance with second stage surgery are often important factors in determining the surgical strategy. This study aimed to determine the effectiveness of the newly developed, umbrella autograft. Materials and methods: In 22 patients suffering chronic suppurative otitis media, in whom the incus and stapes suprastructure were found to be absent during surgery, reconstruction was achieved using cartilage-malleus umbrella graft assembly. Six-month post-operative results were evaluated on the basis of average hearing gain, measured at 0.5, 1, 2 and 3kHz.Results: At six months post-operatively, 77.3 per cent of patients showed hearing improvement. Audiography at this time indicated significant improvement (p<0.001), suggesting that this hearing gain may stand the test of time. Conclusion: Umbrella graft tympanoplasty appears to be a promising technique in terms of cost-effectiveness and the autologous nature of implant materials. © JLO (1984) Limited 2010. Source

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