Time filter

Source Type

Masand N.,Lala Lajpat Rai Memorial Medical College | Gupta S.P.,National Institute Of Technical Teachers Training And Research | Khosa R.L.,Bharat Institute of Technology | Patil V.M.,Bharat Institute of Technology
Central Nervous System Agents in Medicinal Chemistry | Year: 2017

Alzheimer’s disease (AD), the most common neurodegenerative disorder and demands to find a way for prevention and delayed onset. The development of therapeutics for AD is based on the amyloid cascade hypothesis (vaccines, β- and γ-Secretase inhibitors), or targeting tau and neurofibrillary tangle formation, neuroinflammation, etc. Cholinesterase, BACE-1, amyloid-β 1-42, γ and β-Secretase, Phosphodiesterase type IV (PDE4) inhibitors are the reported treatment strategies. Among these, the γ- and β-Secretase inhibitors can be clustered in several heterocyclic classes (imidazoles, thiazoles, indoles, benzaldehydes, pyrimidine, etc), with subsequent description of the structure-activity relationships, and extended to the pharmacological profile in order to evaluate their drug-likeness, with special attention to toxicity and bioavailability. This article discusses the approaches proposed by several research groups working on the synthesis of enzyme inhibitors, based on modelling studies and the way these findings were used to obtain new drugs for the treatment of AD. © 2017 Bentham Science Publishers.


PubMed | SGT Dental College Hospital and Research Institute, Lala Lajpat Rai Memorial Medical College, Uttar Pradesh Regional Institute of Medical science and Research and Vardhman Mahavir Medical College and Safdarjung Hospital
Type: | Journal: The open dentistry journal | Year: 2015

Orofacial pain most commonly occurs due to dental causes like caries, gingivitis or periodontitis. Other common causes of orofacial pain are sinusitis, temporomandibular joint(TMJ) dysfunction, otitis externa, tension headache and migraine. In some patients, the etiology of orofacial pain remains undetected despite optimal evaluation. A few patients in the practice of clinical dentistry presents with dental pain without any identifiable dental etiology. Such patients are classified under the category of atypical odontalgia. Atypical odontalgia is reported to be prevalent in 2.1% of the individuals. Atypical orofacial pain and atypical odontalgia can result from the neurological diseases like multiple sclerosis, trigeminal neuralgia and herpes infection. Trigeminal neuralgia has been frequently documented as a cause of atypical orofacial pain and atypical odontalgia. There are a few isolated case reports of acute pontine stroke resulting in atypical orofacial pain and atypical odontalgia. However, pontine stroke as a cause of atypical odontalgia is limited to only a few cases, hence prevalence is not established. This case is one, where a patient presented with acute onset atypical dental pain with no identifiable dental etiology, further diagnosed as an acute pontine infarct on neuroimaging. A 40 years old male presented with acute onset, diffuse teeth pain on right side. Dental examination was normal. Magnetic resonance imaging(MRI) of the brain had an acute infarct in right pons near the trigeminal root entry zone(REZ). Pontine infarct presenting with dental pain as a manifestation of trigeminal neuropathy, has rarely been reported previously. This stresses on the importance of neuroradiology in evaluation of atypical cases of dental pain.


PubMed | Lala Lajpat Rai Memorial Medical College and ITM University
Type: Journal Article | Journal: Indian journal of pharmaceutical sciences | Year: 2014

In an effort to search for more active antiinflammatory agent, a series of pyrazolinylbenzidines and isoxazolylbenzidines was designed, synthesized, and screened for their potential as novel orally inflammation inhibitors. Compounds 4,4-bis-(1-acetyl-5-substitutedaryl-2-pyrazolin-3-yl)benzidines (8-13) and 4,4-bis-(2-substitutedaryl-isoxazolin-4-yl)benzidines (14-19) have been synthesized from 4,4-bis-(substituted benzylidenyl-acetyl)benzidines (2-7). The structures of the products have been delineated by spectral and elemental analysis. Compounds 2-19 evaluated for antiinflammatory activity and acute toxicity and results are reported. The compound 4,4-bis-[1-acetyl-5-(p-methoxyphenyl)-2-pyrazolin-3-yl)benzidine (9) showed more potent and dose-dependent antiinflammatory activity in comparison to reference drug.


PubMed | Sanjay Gandhi Post Graduate Institute of Medical Sciences and Lala Lajpat Rai Memorial Medical College
Type: Journal Article | Journal: Indian journal of endocrinology and metabolism | Year: 2014

Diabetes mellitus is becoming a global health issue with more than 80% diabetics living in developing countries. India accounts for 62.4 million diabetics (2011). Indian Council of Medical Research India Diabetes Study (ICMR-INDIAB) study showed highest weighted prevalence rate in the north India among all studied regions. Diabetes in north India has many peculiarities in all aspects from risk factors to control programmers. North Indians are becoming more prone for diabetes and dyslipidemia because rapid westernization of living style and diet due rapid migration to metropolitan cities for employment. North Indian diabetes is plagued with gender bias against females, poor quality of health services, myths, and lack of disease awareness compounded with small number of prevention and awareness programmers that too are immature to counteract the growing pandemic.


Gupta S.P.,Crossing tech | Samanta S.,Birla Institute of Technology | Masand N.,Lala Lajpat Rai Memorial Medical College | Patil V.M.,Bharat Institute of Technology
Medicinal Chemistry Research | Year: 2013

The k nearest neighbor-molecular field analysis (kNN-MFA) is used to study the correlation between the molecular properties and biological activities of the recently reported 2,5-disubstituted imidazo[4,5-c]pyridines as anti-HCV agents. The most predictive kNN-MFA model derived from the superposition of docked conformations, has good cross-validated q 2 (0.96) and satisfied predictive ability $$ r-{\text{pred}}^{2} $$ (0.88). It could rationalize the HCV inhibitory activity profile of many compounds used in the present study as well as the important structural features responsible for activity. Furthermore, the effects of various structural modifications on biological activity are investigated, and biological activities of novel structures are estimated using the developed 3D QSAR model. © 2012 Springer Science+Business Media, LLC.


Sebastian M.P.,Population Council | Khan M.E.,Population Council | Kumari K.,Lala Lajpat Rai Memorial Medical College | Idnani R.,Lala Lajpat Rai Memorial Medical College
International Perspectives on Sexual and Reproductive Health | Year: 2012

CONTEXT: The Indian family planning program, though successful in increasing contraceptive use among couples who have achieved their desired family size, has not been equally successful in educating couples about the use of contraceptive methods for birth spacing. METHODS: An evaluation was conducted of a behavior change communication intervention integrated into the existing government program to increase knowledge and use of the lactational amenorrhea method and postpartum contraception through counseling by community workers. The intervention, which ran between September 2006 and January 2007, was conducted among 959 pregnant women aged 15-24 who lived in Uttar Pradesh, India. The evaluation used logistic regression analyses to measure differences in knowledge and contraceptive use between baseline and the four- and nine-month postpartum follow-up surveys within and between the intervention and comparison groups. RESULTS: The follow-up data show increases in knowledge of the lactational amenorrhea method and spacing methods and in use of spacing methods. At four months postpartum, women in the intervention group were more likely to know the healthy spacing messages than those in the comparison group (odds ratio, 2.1). At nine months postpartum, women in the intervention group, those with higher knowledge of healthy spacing practices and those with correct knowledge of two or more spacing methods were more likely than others to be using a contraceptive method (1.5-3.5). Use of modern contraceptives for spacing at nine months postpartum was 57% in the intervention group versus 30% in the comparison group. CONCLUSIONS: Targeted behavior change communication using community workers is an effective and feasible strategy for promoting postpartum contraception.


Vaish A.K.,University of Lucknow | Consul S.,University of Lucknow | Agrawal A.,University of Lucknow | Chaudhary S.C.,University of Lucknow | And 3 more authors.
Journal of Emergencies, Trauma and Shock | Year: 2013

Here, authors present a review on clinical presentation and management of exposure of phosgene gas after reviewing the literature by searching with keywords phosgene exposure on Google, Cochrane, Embase and PubMed with a background of experience gained from 10 patients who were admitted to our institute after an accidental phosgene exposure in February 2011 nearby a city in India. Phosgene is a highly toxic gas, occupational workers may have accidental exposure. The gas can also be generated inadvertently during fire involving plastics and other chemicals and solvents containing chlorine, which is of concern to emergency responders. Phosgene inhalation may cause initially symptoms of respiratory tract irritation, patients feel fine thereafter, and then die of choking a day later because of build up of fluid in the lungs (delayed onset non-cardiogenic pulmonary edema). Phosgene exposure is associated with significant morbidity and mortality. Patients with a history of exposure should be admitted to the hospital for a minimum of 24 h for observation because of the potential for delayed onset respiratory failure and acute respiratory distress syndrome.


PubMed | Mayo Institute of Medical science, Lala Lajpat Rai Memorial Medical College and Post Graduate Institute of Medical Education and Research
Type: Journal Article | Journal: Journal of mid-life health | Year: 2015

Sertoli-leydig cell tumors are the uncommon sex-cord stromal tumors of the ovary. We report a case of 42-year-old female with retiform variant of sertoli-leydig cell tumour. She presented with the complaint of mass in abdomen for 7 years. Ultrasound revealed bilateral ovarian mass suggestive of malignancy. Bilateral salpingo-oopherectomy with surgical staging was done. The tumor was diagnosed as stage I retiform variant of sertoli-leydig cell tumor on histopathology and immunohistochemistry.


Mithal C.,Lala Lajpat Rai Memorial Medical College
Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH | Year: 2011

To evaluate the efficacy of lignocaine 2 % jelly as topical anesthesia in pterygium surgery with conjunctival limbal autograft using fibrin glue. A non-randomized interventional study was carried out including twenty-one patients who presented with primary pterygium. Under 2% lignocaine jelly, surgical dissection of the pterygium, scraping of corneal bed with crescent blade, excision of Tenons capsule, harvesting conjunctival limbal autograft superiorly, and securing it with respect to limbus and stromal orientation with fibrin glue were done. Postoperatively, the patients discomfort and pain were evaluated by Wongs pain scoring system. The mean pain score was 0.70 ± 0.97. Only one patient (4.76%) out of the whole series experienced pain who rated more than three on the visual analog scale of 5. Thirteen patients (61.9%) had pain score of zero, that is, no pain. The surgeons evaluation of the technique in terms of surgical ease and complications was favorable. There were no dislodged grafts and no cases required suturing. There were no cases of infection, significant inflammation, epithelial problems and reduction in visual acuity. There was a single case of recurrence (4.76%) five months postoperatively which was managed conservatively. Conclusions: Topical anesthesia with lignocaine 2% jelly using fibrin sealant is safe and effective in pterygium surgery allowing for short operative times. It results in low pain and good aesthetic and functional outcomes. © NEPjOPH.


Malhotra M.,Lala Lajpat Rai Memorial Medical College
Journal of Laryngology and Otology | Year: 2010

Objectives: Tympanoplasty continues to pose a challenge in developing countries, where treatment cost and lack of compliance with second stage surgery are often important factors in determining the surgical strategy. This study aimed to determine the effectiveness of the newly developed, umbrella autograft. Materials and methods: In 22 patients suffering chronic suppurative otitis media, in whom the incus and stapes suprastructure were found to be absent during surgery, reconstruction was achieved using cartilage-malleus umbrella graft assembly. Six-month post-operative results were evaluated on the basis of average hearing gain, measured at 0.5, 1, 2 and 3kHz.Results: At six months post-operatively, 77.3 per cent of patients showed hearing improvement. Audiography at this time indicated significant improvement (p<0.001), suggesting that this hearing gain may stand the test of time. Conclusion: Umbrella graft tympanoplasty appears to be a promising technique in terms of cost-effectiveness and the autologous nature of implant materials. © JLO (1984) Limited 2010.

Loading Lala Lajpat Rai Memorial Medical College collaborators
Loading Lala Lajpat Rai Memorial Medical College collaborators