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Lake Forest, IL, United States

Lake Forest College is a four-year coeducational private liberal arts college in Lake Forest, Illinois, north of Chicago. The College has 1,500 students representing 47 states and 78 countries, and is a member of the Associated Colleges of the Midwest. Lake Forest College competes in the NCAA Division III Midwest Conference. Its current president is Stephen D. Schutt, who joined the College in 2001 after serving as the Vice President and Chief of Staff at the University of Pennsylvania.In addition to academic majors in the humanities and social and natural science, the College offers programs of study in communication, business, Islamic World Studies, finance, neuroscience, digital media design and other contemporary areas. All teaching and advising is carried out by professors. Most of the students live on the wooded 107-acre campus located near Lake Michigan, 30 miles north of Chicago. Wikipedia.

Kelley M.R.,Lake Forest College | Neath I.,Memorial University of Newfoundland | Surprenant A.M.,Memorial University of Newfoundland
Memory and Cognition

There are innumerable demonstrations of serial position functions-with characteristic primacy and recency effects-in episodic tasks, but there are only a handful of such demonstrations in semantic memory tasks, and those demonstrations have used only two types of stimuli. Here, we provide three more examples of serial position functions when recalling from semantic memory. Participants were asked to reconstruct the order of (1) two cartoon theme song lyrics, (2) the seven Harry Potter books, and (3) two sets of movies, and all three demonstrations yielded conventional-looking serial position functions with primacy and recency effects. The data were well-fit by SIMPLE, a local distinctiveness model of memory that was originally designed to account for serial position effects in short- and long-term episodic memory. According to SIMPLE, serial position functions in both episodic and semantic memory tasks arise from the same type of processing: Items that are more separated from their close neighbors in psychological space at the time of recall will be better remembered. We argue that currently available evidence suggests that serial position functions observed when recalling items that are presumably in semantic memory arise because of the same processes as those observed when recalling items that are presumably in episodic memory. © 2012 Psychonomic Society, Inc. Source

Prichard S.J.,University of Washington | Peterson D.L.,U.S. Department of Agriculture | Jacobson K.,Lake Forest College
Canadian Journal of Forest Research

To address hazardous fuel accumulations, many fuel treatments are being implemented in dry forests, but there have been few opportunities to evaluate treatment efficacy in wildfires. We documented the effectiveness of thinning and prescribed burning in the 2006 Tripod Complex fires. Recent fuel treatments burned in the wildfires and offered an opportunity to evaluate if two treatments (thin only and thin and prescribed burn) mitigated fire severity. Fire severity was markedly different between the two treatments. Over 57% of trees survived in thin and prescribed burn (thinRx) units versus 19% in thin only (thin) and 14% in control units. Considering only large-diameter trees (>20 cm diameter at breast height), 73% survived in thinRx units versus 36% and 29% in thin and control units, respectively. Logistic regression modeling demonstrates significant reductions in the log-odds probability of tree death under both treatments with a much greater reduction in thinRx units. Other severity measures, including percent crown scorch and burn severity index, are significantly lower in thinRx units than in thin and control units. This study provides strong quantitative evidence that thinning alone does not reduce wildfire severity but that thinning followed by prescribed burning is effective at mitigating wildfire severity in dry western forests. Source

Havens M.A.,Rosalind Franklin University of Medicine and Science | Reich A.A.,Lake Forest College | Duelli D.M.,Rosalind Franklin University of Medicine and Science | Hastings M.L.,Rosalind Franklin University of Medicine and Science
Nucleic Acids Research

Canonical microRNA biogenesis requires the Microprocessor components, Drosha and DGCR8, to generate precursor-miRNA, and Dicer to form mature miRNA. The Microprocessor is not required for processing of some miRNAs, including mirtrons, in which spliceosome-excised introns are direct Dicer substrates. In this study, we examine the processing of putative human mirtrons and demonstrate that although some are splicing-dependent, as expected, the predicted mirtrons, miR-1225 and miR-1228, are produced in the absence of splicing. Remarkably, knockout cell lines and knockdown experiments demonstrated that biogenesis of these splicing-independent mirtron-like miRNAs, termed 'simtrons', does not require the canonical miRNA biogenesis components, DGCR8, Dicer, Exportin-5 or Argonaute 2. However, simtron biogenesis was reduced by expression of a dominant negative form of Drosha. Simtrons are bound by Drosha and processed in vitro in a Drosha-dependent manner. Both simtrons and mirtrons function in silencing of target transcripts and are found in the RISC complex as demonstrated by their interaction with Argonaute proteins. These findings reveal a non-canonical miRNA biogenesis pathway that can produce functional regulatory RNAs. © 2011 The Author(s). Source

Mirth C.K.,Instituto Gulbenkian Of Ciencia | Shingleton A.W.,Lake Forest College
Communicative and Integrative Biology

Understanding how organisms regulate their body size has interested biologists for decades. Recent work has shown that both insulin/target of rapamycin (TOR) signaling and the steroid hormone ecdysone act to regulate rates of growth and the duration of the growth period in the fruit fly, Drosophila melanogaster. Our recent work has uncovered a third level of interaction, whereby juvenile hormone (JH) regulates levels of both ecdysone and insulin/TOR signaling to control growth rates. These studies highlight a complex network of interactions involved in regulating body and organ size. © 2014 Taylor & Francis Group, LLC. Source

Shingleton A.W.,Lake Forest College
Current Biology

Females of many species adjust their diet to support the energetic requirements of egg production. New research shows how, in flies, females remodel their gut and modify gut physiology too. © 2015 Elsevier Ltd All rights reserved. Source

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