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Washington Court House, OH, United States

Lake Erie College is a private liberal arts college founded in 1856 that is located in Painesville, Ohio, approximately 30 miles east of Cleveland. As of the 2012-2013 academic year, the enrollment was approximately 1200 undergraduates and graduate students.Lake Erie is best known for its equine studies program, which attracts students from across the country, and around the world, and is the most popular major at the college. The George M. Humphrey Equestrian Center is located 5 miles to the south of the main campus, in Concord Township. In 2011, the Lake Erie College IDA team won champion honors at the 9th annual IDA National Championship held at the Canterbury Equestrian Show Place in Newberry, Florida.Prior to 1986, it was one of three remaining women's colleges in Ohio, along with Ursuline College and Notre Dame College, the latter of which is also now co-educational. Wikipedia.

Kulesza R.J.,Lake Erie College | Grothe B.,Ludwig Maximilians University of Munich
Frontiers in Neuroanatomy | Year: 2015

The medial nucleus of the trapezoid body (MNTB) is a collection of brainstem neurons that function within the ascending auditory pathway. MNTB neurons are associated with a number of anatomical and physiological specializations which make these cells especially well-equipped to provide extremely fast and precise glycinergic inhibition to its target neurons in the superior olivary complex and ventral nucleus of the lateral lemniscus. The inhibitory influence of MNTB neurons plays essentials roles in the localization of sound sources and encoding temporal features of complex sounds. The morphology, afferent and efferent connections and physiological response properties of MNTB neurons have been well-characterized in a number of laboratory rodents and some carnivores. Furthermore, the MNTB has been positively identified in all mammals examined, ranging from opossum and mice to chimpanzees. From the early 1970s through 2009, a number of studies denied the existence of the MNTB in humans and consequentially, the existence of this nucleus in the human brain has been debated for nearly 50 years. The absence of the MNTB from the human brain would negate current principles of sound localization and would require a number of novel adaptations, entirely unique to humans. However, a number of recent studies of human post-mortem tissue have provided evidence supporting the existence of the MNTB in humans. It therefore seems timely to review the structure and function of the MNTB, critically review the literature which led to the denial of the human MNTB and then review recent investigations supporting the existence of the MNTB in the human brain. © 2015 Kulesza and Grothe. Source

Ortoski R.A.,Lake Erie College
The Journal of the American Osteopathic Association | Year: 2011

The association between human papillomavirus (HPV) and anal cancer and the similarities between the "transitional zones" within the cervix and anus have raised questions regarding the medical biology of anal cancer. In recent years, increased rates of HPV infection and anal cancer among men have encouraged the medical community to search for causes and ways to identify the less insidious precursor, anal intraepithelial neoplasia. The "alphabet soup" terminology describing anal cytologic findings obtained by Papanicolaou (Pap) tests and the anal histologic findings obtained from biopsy specimens need to be better understood as distinct entities. Risk factors for the development of anal cancer have been identified and should be discussed with patients--especially those infected with human immunodeficiency virus--who have a much higher than normal risk of anal cancer. The anal Pap test has been used by the Northwest Pennsylvania Rural AIDS Alliance to detect potential precursors to cancer and degrees of anal dyplasia in patients with HIV infection. The Alliance has been instrumental in creating guidelines for anal Pap testing and encouraging other medical professionals and clinics to do the same, and these guidelines are provided herein. Source

Human topoisomerase I (Top1) relaxes supercoiled DNA during cell division. Camptothecin stabilizes Top1/dsDNA covalent complexes which ultimately results in cell death, and this makes Top1 an anti-cancer target. There are two current models for how camptothecin and derivatives bind to Top1/dsDNA covalent complexes (Staker, et al., 2002, Proc Natl Acad Sci USA 99: 15387-15392; and Laco, et al., 2004, Bioorg Med Chem 12: 5225-5235). The interaction energies between bound camptothecin, and derivatives, and Top1/dsDNA in the two models were calculated. The published structure-activity-relationships for camptothecin and derivatives correlated with the interaction energies for camptothecin and derivatives in the Laco et al. model, however, this was not the case for several camptothecin derivatives in the Stacker et al. model. By defining the binding orientation of camptothecin and derivatives in the Top1/dsDNA active-site these results allow for the rational design of potentially more efficacious camptothecin derivatives. © 2011 Gary S. Laco. Source

Malerich S.,Lake Erie College | Berson D.,Cornell University
Dermatologic Clinics | Year: 2014

The aging process is unavoidable and often augmented by extrinsic forces, such as ultraviolet radiation. The increasing middle-aged population is leading to the production of many new cosmetic products promising improvement of the various signs of aging, termed cosmeceuticals. Within this booming industry, several different types exist. This article focuses on updates in those involving peptides, growth factors, cytokines, and stem cells. © 2014 Elsevier Inc. Source

Caldwell J.D.,Lake Erie College | Jirikowski G.F.,Friedrich - Schiller University of Jena
Steroids | Year: 2014

Contrary to the long-held postulate of steroid-hormone binding globulin action, these protein carriers of steroids are major players in steroid actions in the body. This manuscript will focus on our work with sex hormone binding globulin (SHBG) and corticosteroid binding globulin (CBG) and demonstrate how they are actively involved in the uptake, intracellular transport, and possibly release of steroids from cells. This manuscript will also discuss our own findings that the steroid estradiol is taken up into the cell, as demonstrated by uptake of fluorescence labeled estradiol into Chinese hamster ovary (CHO) cells, and into the cytoplasm where it may have multiple actions that do not seem to involve the cell nucleus. This manuscript will focus mainly on events in two compartments of the cell, the plasma membrane and the cytoplasm. © 2013 Elsevier Inc. All rights reserved. Source

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