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Laiwu, China

Shen Y.,Southeast University of Bangladesh | Ren M.-L.,Southeast University of Bangladesh | Xu J.,Southeast University of Bangladesh | Xu Q.,Nanjing Southeast University | And 5 more authors.
Gynecologic and Obstetric Investigation

Uterine leiomyoma (UL) is an estrogen-responsive benign tumor in the female reproductive system and the main risk of hysterectomy for women. However, gene polymorphism of estrogen-metabolizing enzymes may lead to the different susceptibility to UL. We detected 10 single mucleotide polymorphisms in three key estrogen metabolite enzymes (COMT, CYP1A1, CYP1B1) in a Chinese Han population consisting of 800 patients and 800 healthy women from five different medical centers. The genetic polymorphism of rs3087869 (IVS1+2329C>T) (OR 3.200, 95% CI 1.614-6.345) and rs4680 (Val158Met) (OR 5.675, 95% CI 2.696-11.942) loci on COMT, rs1048943 (Ile462Val) (OR 4.629, 95% CI 2.216-9.672) and rs4646422 (Gly45Asp) (OR 3.240, 95% CI 1.624-6.461) loci on CYP1A1 and rs1065827 (Ala119Ser) (OR 5.635, 95% CI 2.990-10.619) locus on CYP1B1 were the risk factors to UL development and rs1056836 (Leu432Val) (OR 0.188, 95% CI 0.061-0.575) locus on CYB1B1 may be the protective factor to UL. The results provide a theoretical basis for genetic screening and early intervention to UL-susceptible populations. © 2014 S. Karger AG, Basel. Source

Li M.,Laiwu Peoples Hospital | Liu W.,Laiwu Peoples Hospital
Chinese Journal of Cancer Prevention and Treatment

OBJECTIVE: Evaluation of whole brain radiation therapy and stereotactic synchrotron radiation therapy for the treatment of brain metastases in patients with therapeutic effect. METHODS: A retrospective analysis of 22 patients who had received whole brain radiation therapy and stereotactic radiosurgery for brain metastases reported. The entire brain radiotherapy dosage was the 39.6 Gy/22 times, The single dosage was 1.8 Gy, The three-dimensional direction detection radiotherapy dosage was 15.4 Gy/22 times, The single dosage was 0.7 Gy. RESULTS: Short-term efficacy was listed as follows, 3 cases of CR(13.6%), 8 cases of PR(36.4%), 7 cases of SD(31.8%), 4 cases of PD(18.2%). Totally 22 patients were followed up. The follow-up time was 2-29 months, and the median follow-up time was 12 months (95%CI: 9.27-14.73). The 6-, 12- and 24-months local control rates were 90.9%(20/22), 50.0%(11/22) and 36.4%(8/22), respectively. No severe adverse events and toxicity were observed. Acute radiotherapy adverse reactions mainly related to the central nervous system such as nausea, vomiting, headache and neurological dysfunction caused by brain edema.CONCLUSION: Whole brain irradiation and concurrent stereotactic irradiation can increase the local control rate of brain lesions and improve the quality of life in brain metastasis patients compared with conventional radiation treatment. Source

Qi J.-D.,Laiwu Peoples Hospital | Guo B.-C.,Laiwu Peoples Hospital
Journal of Practical Oncology

Objective: To investigate the effect of local hypeythermia combined with best support treatments(BSC) on cancer cachexia of digestive tract and to offer value clinical data for palliative treatments of patients with advanced malignant tumor.Methods: Fifty-eight patients with cancer cachexia of digestive tract were randomly divided into two groups, the patients in the study group(n=30) were given local hypeythermia plus BSC, and the patients in the control group(n=28) were given BSC alone. The subjective global assessment of nutritional status(SGA) and lab examnations(ALB, pre-ALB and TLC) after 1 month were evaluated.Results: The evaluation of the SGA and ALB, pre-ALB and TLC in both groups had significant difference(P<0.01).Conclusion: Local hypeythermia can change the prognosis and prohibit the progressing of cancer cachexia. Source

Dong Y.,Laiwu Peoples Hospital | Chen G.,Shandong University | Gao M.,Laiwu Peoples Hospital | Tian X.,Jining No. 1 Peoples Hospital

The role of matrix metalloproteinase 14 (MMP14) has been identified to involve tumor progression and prognosis. The purpose of this study is to investigate the role of MMP14 in tumor progression and prognosis of gastric cancer. This study indicated that MMP14 mRNA and protein were overexpressed in gastric cancer tissue (P<. 0.001 and P= 0.037, respectively) and significantly associated with clinical stage (P= 0.005), lymph node metastasis (P= 0.003), and distant metastasis (P= 0.017). Moreover, we found that the overexpression of MMP14 was a significant predictor of poor prognosis for gastric cancer patients (P<. 0.001). Furthermore, we performed a meta-analysis which included 594 cases from 3 studies and showed that MMP14 overexpression was a significantly poor prognostic factor in Chinese patients with gastric cancer and HR (95% CI) was 2.17 (1.64-2.86). In conclusion, MMP14 plays an important role on gastric cancer progression and prognosis and acts as a convictive biomarker for prognostic prediction for Chinese patients with gastric cancer. © 2015 Elsevier B.V. Source

Li X.-M.,Shandong University | Su J.-R.,Shandong University | Yan S.-P.,Shandong University | Cheng Z.-L.,Heze Municipal Hospital | And 2 more authors.
Cancer Biomarkers

AIMS: TIPE2 is a novel inflammation regulator, and the role of TIPE2 in colitis-induced colon cancer is not clear. The aim of this study was to test whether TIPE2 inhibits TLR4 pathway in colon cancer patients and to explore potential mechanism of TIPE2 in colon cancer by caspase-8. METHODS: Expression of TIPE2 and TLR4 in human colon cancer tissues and cell line HT-29 was detected by immunohistochemistry or real-time PCR. TIPE2 mRNA was suppressed by siRNA transfection and the transfection efficiency was proved by fluorescence microscopy and real-time PCR. TLR4 pathway was activated by treating the cells with 1 μg/ml LPS for 4 h. Caspase-8 activities were tested by colorimetric assay in four HT-29 cell groups. RESULTS: TIPE2 was expressed in the cytoplasm of colon cancer tissues and HT-29 cells. TIPE2 expression was more pronounced in colon cancer tissues compared to normal controls and it was related with lymph node metastasis and Dukes stage of colon cancer. TIPE2 expression was positively correlated with that of TLR4 in colon cancer (r=0.7354). TIPE2 expression was knocked down successfully by siRNA transfection. Caspase-8 activity was elevated both in TIPE2 knockdown cells and in TLR4 activated cells compared to wild-type cells (P< 0.05). And the caspase-8 activity was further increased in TIPE2 knockdown cells after TLR4 was activated (P < 0.05). CONCLUSION: TIPE2 can inhibit caspase-8 activity in colon cancer cells. TIPE2 can regulate TLR4 inflammatory effect and inhibit further amplification of cascade reaction via caspase-8, which provides one new therapeutic target for clinical treatment schedule. © 2014 - IOS Press and the authors. All rights reserved. Source

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