Laila Impex Research Center

Vijayawāda, India

Laila Impex Research Center

Vijayawāda, India
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Venkateswarlu S.,Laila Impex Research Center | Murty G.N.,Laila Impex Research Center | Satyanarayana M.,Laila Impex Research Center | Siddaiah V.,Andhra University
Synthetic Communications | Year: 2017

An efficient and green protocol for the synthesis of isoaurones by condensation of benzofuranone with benzaldehydes using polyethylene glycol (PEG) is demonstrated. Excellent yields, no reagents/additional catalysts, E-selectivity, short reaction times, and no work-up/extraction makes an attractive benign procedure. Additionally, 4′,6-dihydroxy-4-methoxyisoaurone isolated from Trichosanthes kirilowii has been synthesized for the first time and confirmed its geometry as E. © 2017 Taylor & Francis


Venkateswarlu S.,Laila Impex Research Center | Murty G.N.,Laila Impex Research Center | Satyanarayana M.,Laila Impex Research Center
Arkivoc | Year: 2017

A simple and green method for the synthesis of aurones by condensation of benzofuranone with aromatic aldehyde in neat water has been developed. The main advantages of this protocol include good yields, absence of catalyst, reagent, organic solvent, work-up and chromatographic purification. 4,5,3',4',5'-Pentamethoxy-6-hydroxyaurone, isolated from Smilax riparia was synthesized for the first time from 3-benzyloxy-4,5-dimethoxybenzaldehyde in five steps. {figure presented}. ©ARKAT USA, Inc.


Venkateswarlu S.,Laila Impex Research Center | Satyanarayana M.,Laila Impex Research Center | Murthy G.N.,Laila Impex Research Center | Siddaiah V.,Andhra University
Tetrahedron Letters | Year: 2012

Cyclisation of 2-(2-aminophenyl)quinazolin-4(3H)-ones on to N 3 and on to N 1 leading to 6-alkyl-(8H)-quinazolino[4,3-b]quinazolin-8- one and 6-alkyl-(13H)-quinazolino[3,4-a]quinazolin-13-one, respectively was described for the first time. The differences in the IR and carbon NMR data of these isomeric fused quinazolinoquinazolinones afford a useful method for distinguishing between the two series. © 2012 Elsevier Ltd. All rights reserved.


Venkateswarlu S.,Laila Impex Research Center | Satyanarayana M.,Laila Impex Research Center | Siddaiah V.,Andhra University
Synthetic Communications | Year: 2013

A new, facile, one-pot synthesis of 8H-quinazolino[4,3-b]quinazolin-8-ones starting from the readily available 2-aminobenzonitriles, dimethylformamide- dimethylacetal, and anthranilic acid/esters in good yields is presented. Copyright © Taylor & Francis Group, LLC.


Venkateswarlu S.,Laila Impex Research Center | Satyanarayana M.,Laila Impex Research Center | Ravikiran P.,Laila Impex Research Center | Siddaiah V.,Andhra University
Journal of Heterocyclic Chemistry | Year: 2013

We report a facile, one-pot, three-component methodology for the synthesis of 8H-quinazolino[4,3-b]quinazolin-8-ones from commercially available 2-aminobenzonitriles, triethyl orthoformate, and anthranilic acids/esters/amides in good yields. © 2013 HeteroCorporation.


Venkateswarlu S.,Laila Impex Research Center | Satyanarayana M.,Laila Impex Research Center | Lakshmikanthan V.,Laila Impex Research Center | Siddaiah V.,Andhra University
Journal of Heterocyclic Chemistry | Year: 2015

13H-quinazolino[3,4-a]quinazolin-13-ones have been synthesized from 2-aminobenzamides in four steps. An acid-catalyzed or base-catalyzed isomerization of 13H-quinazolino[3,4-a]quinazolin-13-ones to 8H-quinazolino[4,3-b]quinazolin-8-ones in excellent yields (90-95%) has been reported. The differences in the infrared and nuclear magnetic resonance (1H & 13C) data of these isomeric fused quinazolinoquinazolinones afford a useful method for distinguishing between the two series. These analogs showed moderate anticancer activity (EGFR-TK inhibition). © 2014 HeteroCorporation.


Saiko P.,Medical University of Vienna | Graser G.,Medical University of Vienna | Giessrigl B.,Medical University of Vienna | Steinmann M.-T.,Medical University of Vienna | And 9 more authors.
Investigational New Drugs | Year: 2013

Digalloylresveratrol (DIG) is a recently synthesized substance aimed to combine the effects of the natural polyphenolic compounds gallic acid and resveratrol, which both are excellent free radical scavengers with anticancer activity. In this study, we investigated the effects of DIG in the human AsPC-1 and BxPC-3 pancreatic adenocarcinoma cell lines. Treatment with DIG dose-dependently attenuated cells in the S phase of the cell cycle and led to a significant depletion of the dATP pool in AsPC-1 cells. The incorporation of 14C-cytidine into nascent DNA of tumor cells was significantly inhibited at all DIG concentrations due to inhibition of ribonucleotide reductase, a key enzyme of DNA synthesis in tumor cells. Furthermore, Erk1/2 became inactivated and moderated p38 phosphorylation reflecting increased replication stress. DIG also activated ATM and Chk2, and induced the phosphorylation and proteasomal degradation of the proto-oncogene Cdc25A, which contributed to cell cycle attenuation. Taken together, DIG is an excellent free radical scavenger, strongly inhibits RR in situ activity, cell cycle progression, and colony formation in AsPC-1 and BxPC-3 cells thus warranting further investigations. © 2013 Springer Science+Business Media New York.


Venkateswarlu S.,Laila Impex Research Center | Satyanarayana M.,Laila Impex Research Center | Srinivas K.,Laila Impex Research Center | Aadisudhakar K.N.V.V.,Laila Impex Research Center
Tetrahedron Letters | Year: 2013

Cyclization of 2-(2-aminophenyl)-2,3-dihydroquinazolin-4(1H)-ones onto N1-nitrogen and onto N3-nitrogen leading to 11b,12-dihydro-(13H)-quinazolino[3,4-a]quinazolin-13-ones and 13,13a-dihydro-(8H)-quinazolino[4,3-b]quinazolin-8-ones, respectively, is described for the first time. An unusual dehydrogenative rearrangement of 11b,12-dihydro-(13H)-quinazolino[3,4-a]quinazolin-13-one to (8H)-quinazolino[4, 3-b]quinazolin-8-one is also described. © 2012 Elsevier Ltd. All rights reserved.


Venkateswarlu S.,Laila Impex Research Center | Satyanarayana M.,Laila Impex Research Center | Ravikiran P.,Laila Impex Research Center | Vijayakumar A.,Laila Impex Research Center
Tetrahedron Letters | Year: 2013

13H-Quinazolino[3,4-a]quinazolin-13-one has been synthesized from 2-aminobenzamide via 11b,12-dihydro-13H-quinazolino[3,4-a]quinazolin-13-one in four steps. However, the spectroscopic data did not match with those of literature data. Thus, the published structure from the reaction of 2-aminobenzonitrile and triethyl orthoformate is not 13H-quinazolino[3,4-a] quinazolin-13-one and has been revised as 8H-quinazolino[4,3-b]quinazolin-8-one. © 2013 Elsevier Ltd. All rights reserved.


Sundararaju D.,Laila Impex Research Center | Krishnaraju A.V.,Laila Impex Research Center | Rao C.V.,Laila Impex Research Center | Trimurtulu G.,Laila Impex Research Center
Asian Journal of Chemistry | Year: 2010

Punica granatum fruit rind extracts were screened for antioxidant activity and brine shrimp lethality assay. All the extracts except hexane extract have shown more potent antioxidant activity compared to BHT, BHA, vitamin C and E. In addition, methanol and aqueous methanol extracts exhibited moderate brine shrimp lethality.

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