Badagry, Nigeria

Lagos State University
Badagry, Nigeria

The Lagos State University - also known as LASU - was established in 1983 by the enabling Law of Lagos State of Nigeria, for the advancement of learning and establishment of academic excellence. The university caters for a population of over 61,000, enrolled in full-time and part-time programmes at the Diploma, Undergraduate and Postgraduate. Lagos State University , located in the city of Ojo, Lagos, Nigeria, is the only state university in the former British colony.The Vice-Chancellor is Professor John Oladapo Obafunwa.Lagos State University offers diploma, degree and post graduate programmes and its MBA programme is reputed to be one of the highly revered in the country. The citadel is also known for various staff union agitations especially the Lecturers' ASUU,non teching staff's SSANU,NASU and others while various unrest has been witnessed with the activities of the students union informally called LASUSU also known as the Lagos State University Student Union.The state university which is known as the best state owned university in Nigeria also boost of a robust academic staff which include highly respected political science scholar-Professor Abubakar Momoh, thespian- Dr. Sola Fosudo, actor-Doyin Hassan amongst others. Wikipedia.

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Despite socio-economic, demographic and epidemiological facts and realities that point to a potential risk for explosion in the prevalence of childhood mental health problems in sub-Saharan Africa, there is still a severe dearth of child and adolescent mental health (CAMH) policy or strategy to respond to the situation in the region. Unfortunately, current attempts at suggesting courses of action in this regard appear to be focused on narrow reactionary approaches. There is a need for theoretical frameworks to capture the full ramification of childhood in sub-Saharan Africa, from which multi-level, context-appropriate and holistic CAMH policy directions can be understood. In this commentary, we propose an amended version of the Bronfenbrenner's ecological model of childhood as such framework that captures proximal, intermediate and distal factors that influence the care environment of children. We then used the insights provided by the model to identify and prioritize intervention points and appropriate intervention strategies in charting a tentative course for CAMH policy development in the region. Though the ecological model provides a distinct perspective to the structure and dynamics of the care environment of children, the proposed framework using the model is still largely theoretical and need to be further integrated into future studies on CAMH policy development in the region. © The Author 2014.

Ethnopharmacological relevance: Amongst the Yoruba tribe (Southwest Nigeria), water decoction of the leaf and seed of Phyllanthus amarus Schum. and Thonn. is reputably used for the local management of diabetes mellitus, obesity and hyperlipidemia. Aim of the study: The present study seeks to evaluate the effectiveness and elucidate mechanism(s) of action of the aqueous leaf and seed extract of Phyllanthus amarus (PAE) in normal and 10% sucrose-induced hyperglycemia and dyslipidemia as an experimental model of insulin resistance diabetes mellitus. Materials and methods: In this study, the repeated oral antihyperglycemic action of 150-600 mg/kg/day of PAE was evaluated in normal and 10% sucrose-induced insulin resistance rats using indicators such as fasting blood glucose (FBG), insulin and insulin resistance indices. The extract's weight losing, antihyperlipidemic and anti-atherogenic effects were also evaluated by measuring the effect of the extract on the body weight, plasma levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c) and atherogenic indices. Results: In normal rats, PAE caused significant (p<0.05, p<0.01 and p<0.001) and dose related decreases in body weight, FBG, TG, TC, LDL-c, and atherogenic indices. Repeated oral treatment with 10% sucrose drink for 30 days was associated with significant (p<0.001) weight gain, hyperglycemia, insulin resistance indices, hyperlipidemia and atherogenic indices. However, pre-treatment with PAE significantly (p<0.05, p<0.01 and p<0.001) and dose-dependently attenuated increase in any of these measured parameters. Conclusions: Overall, results of this study showed PAE to effectively control insulin resistance DM which was mediated via improvement in insulin resistance, thus, validating its ethnomedical use in the local management of DM. © 2012 Elsevier Ireland Ltd.

Popoola A.O.,Lagos State University | Adewuya A.O.,Lagos State University
Psycho-Oncology | Year: 2012

Objective While the physical complications of breast cancer are often recognized and well managed, the psychological sequelae, especially depression are often unrecognized by healthcare providers and therefore under treated. This study aimed to assess the rate and correlate of depressive disorders in breast cancer survivors in Lagos, Nigeria. Methods Patients (n = 124) recruited from a breast cancer outpatient clinic were assessed for the DSM-IV diagnosis of depressive disorders using the Mini International Neuropsychiatric Interview (MINI). The staging of the cancer, length of diagnosis and treatment type were recorded. Also socio-demographic details and their perceived level of social support were obtained. Results Twenty-one (16.9%) were diagnosed as having Major Depressive Disorder, while 29 (23.4%) had Minor depressive disorder making a total of 50 (40.3%) cases with depression. The independent correlates of depression included being not married (odds ratio (OR) 3.09, 95% CI 1.30-7.42), perceived poor social support (OR 5.38, 95% CI 1.88-16.63) and advanced stage of the cancer (OR 3.22, 95% CI 1.32-8.26). Conclusion Our study suggests a high rate of associated depression among patients with breast cancer in our environment. Clinicians should be encouraged and empowered to probe for symptoms of depression in these patient while larger hypothesis-driven studies are needed. Copyright © 2011 John Wiley & Sons, Ltd.

Some physico-chemistry, nutrients and heavy metal content of Badagry Creek, Ologe Lagoon, Agbara and Ojo were compared to ascertain the effects of water hyacinth (Eichhornia crassipes) on these variables of the water bodies. Three of the water bodies (Ologe Lagoon, Agbara and Badagry Creek) have water hyacinth infestation and the control (Ojo) was free from water hyacinth through out the period of the study. This study was carried out between January, 2010 to August, 2010. Eleven physico-chemical parameters, 4 nutrients and 5 heavy metals were measured. The observed values shows that their was significant difference (p<0.05) in the conductivity, total dissolved solid, salinity, dissolved oxygen, Biological Oxygen Demand (BOD) and total hardness among the sampling stations. The highest values in conductivity (9272±994 μS cm -1), salinity (5.00±1.69 ppt), total hardness (1848±396 mg L -1) and Total dissolved solid (5460±841 mg L -1) were recorded in Ojo which has no water hyacinth infestation while the lowest values {conductivity (183±81 μS cm -1), salinity (0.11±0.01 ppt), total hardness (87±8 mg L -1) and total dissolved solid (92±15 mg L -1)} were obtained in Agbara which is one of the sampling stations with water hyacinth infestation. However, BOD was highest in Agbara (97.38±28.60 mg L -1) but lowest in Ojo (35.37±9.67 mg L -1). Sulphate and chloride were significant (p<0.05) among the sampling stations while magnesium was the only significant (p<0.05) heavy metal. Although, water hyacinth may have negative impacts on water quality, its ability to passively absorb heavy metals and nutrients can be put into good use. © 2012 Asian Network for Scientific Information.

Saalu L.C.,Lagos State University
Pakistan Journal of Biological Sciences | Year: 2010

The male factor is considered a major contributory factor to infertility. Apart from the conventional causes for male infertility such as varicocoele, cryptorchidism, infections, obstructive lesions, cystic fibrosis, trauma and tumours, a new and important cause has been identified as being responsible for the so-called idiopathic male infertility: oxidative stress. Oxidative Stress (OS) is a condition that occurs when the production of Reactive Oxygen Species (ROS) overwhelms the antioxidant defense produced against them. In male reproductive pathological conditions, the OS significantly impairs spermatogenesis and sperm function, which may lead to male infertility. Reactive Oxygen Species (ROS) known as free radicals are oxidizing agents generated as a result of metabolism of oxygen and have at least one unpaired electron that make them very reactive species. Spermatozoa generate Reactive Oxygen Species (ROS) in physiological amounts, which play a role in sperm functions during sperm capacitation, Acrosome Reaction (AR) and oocyte fusion, but they need to be controlled and their concentrations maintained at a level that is not deleterious to the cells. Administration of antioxidants in patients with 'male factor' infertility has begun to attract considerable interest. The main difficulty of such an approach is our incomplete understanding of the role of free radicals in normal and abnormal sperm function leading to male infertility. The purpose of the present review is to address the relationship between ROS and idiopathic male factor infertility. © 2010 Asian Network for Scientific Information.

Ibrahim N.A.,Lagos State University | Oludara M.A.,Lagos State University
Breast | Year: 2012

We evaluated the effects of selected socio-demographic factors on late presentation and reasons why our breast cancer patients delay reporting for treatment. All female breast cancer patients referred to one of the general surgery out-patient clinics of Lagos State University Teaching Hospital between January 2009 and December 2010 were interviewed. Relevant socio-demographic and clinical data were obtained and reasons for patient delay documented. Univariate and multivariate logistic regression analyses were conducted to calculate odd ratio for delay. A total of 201 patients were enrolled. Mean duration of symptoms was 12.12 months (SD ± 5.18). Delay for more than 3 months before initial medical consultation was observed in 164 patients (81.6%). Increased risk of late presentation was associated with single women (OR = 2.054), primary level of education (OR = 3.059), negative history of benign breast disease (OR = 1.648) and pre-menopause (OR = 1.861). Ignorance of the nature of illness, belief in spiritual healing, fear of mastectomy and belief in herbal treatment were the leading reasons for delay. Women with higher risk of late presentation should be the target group during interventions aimed at raising breast cancer awareness. Reasons for patient delay should also be addressed. © 2012 Elsevier Ltd.

Ogunleye O.O.,Lagos State University
African journal of medicine and medical sciences | Year: 2012

The clustering of cardiovascular risk factors and diseases has grievous implications on overall morbidity and mortality. There is however relative paucity of this information among the Nigerian population. This study was aimed at defining the prevalence of the clustering of hypertension (HT), diabetes mellitus (DM) and dyslipidemia (DYSL) in a Nigerian teaching hospital outpatient clinics population. A cross sectional study of patients managed at the hypertension and diabetes clinics of the Lagos State University Teaching Hospital, Nigeria between January and December 2008. The baseline demographic characteristics, blood pressures, blood sugars and fasting lipid profiles were obtained retrospectively from hospital records. Using the standard criteria for the diagnosis of HT, DM and DYSL, the prevalence of these conditions and their respective clusters were determined. A total of 506 patients were seen over this period, male; 234 (46.2%), female; 272(53.8%) with mean age of 57.35 (1.28) years. The prevalence of HT, DM and DYSL were 85%, 39.5% and 58.9% respectively. Concurrent HT and DYSL was the most prevalent cluster found in 146 patients (28.9%), followed by the clustering of the three co-morbidities of HT, DM and DYSL in 124 patients (24.5%).Other clusters were DM+HT; 49 (9.7%), DM+DYSL;13 (2.6%). 41.2% of the population had the clustering of at least two co-morbidities and about a quarter had the three conditions coexisting. There is a significant burden of the cardiovascular risk factors occurring in clusters in the Nigerian population studied. This calls for purposeful measures to control these risk factors.

Egunsola O.,University of Nottingham | Oshikoya K.A.,Lagos State University
Malaria Journal | Year: 2013

Background: The purpose of the study was to compare the safety of artemether-lumefantrine (AL) with other artemisinin-based combinations in children. Methods. A search of EMBASE (from 1974 to April 2013), MEDLINE (from 1946 to April 2013) and the Cochrane library of registered controlled trials for randomized controlled trials (RCTs) which compared AL with other artemisinin-based combinations was done. Only studies involving children ≤ 17 years old in which safety of AL was an outcome measure were included. Results: Four thousand, seven hundred and twenty six adverse events (AEs) were recorded in 6,000 patients receiving AL. Common AEs (≥1/100 and <1/10) included: coryza, vomiting, anaemia, diarrhoea, vomiting and abdominal pain; while cough was the only very commonly reported AE (≥1/10). AL-treated children have a higher risk of body weakness (64.9%) than those on artesunate-mefloquine (58.2%) (p = 0.004, RR: 1.12 95% CI: 1.04-1.21). The risk of vomiting was significantly lower in patients on AL (8.8%) than artesunate-amodiaquine (10.6%) (p = 0.002, RR: 0.76, 95% CI: 0.63-0.90). Similarly, children on AL had a lower risk of vomiting (1.2%) than chlorproguanil-dapsone-artesunate (ACD) treated children (5.2%) (p = 0.002, RR: 0.63, 95% CI: 0.47-0.85). The risk of serious adverse events was significantly lower for AL (1.3%) than ACD (5.2%) (p = 0.002, RR: 0.45, 95% CI: 0.27-0.74). Conclusion: Artemether-lumefantrine combination is as safe as ASAQ and DP for use in children. Common adverse events are cough and gastrointestinal symptoms. More studies comparing AL with artesunate-mefloquine and artesunate-azithromycin are needed to determine the comparative safety of these drugs. © 2013 Egunsola and Oshikoya; licensee BioMed Central Ltd.

Ajose F.O.A.,Lagos State University
International Journal of Dermatology | Year: 2012

Background African hair in its natural state poses tenacious grooming challenges; consequently a large portion of the African cosmetic industry is focused on means to relax the tight curls of African hair to make the hair more manageable. In malnourished and hypoproteinemic states, African hair straightens in an uncomplimentary manner. Recently, we observed that in certain diseases African hair changes to a desirable silky wavy texture. Method To identify the diseases that turn African hair silky and their parameters we examined 5612 dermatology patients at a tertiary hospital in Nigeria. We then studied the clinical and basic laboratory parameters of those patients whose diseases were accompanied by the silky hair change. Result Silky hair change similar to the hair of the African neonatal child was observed in five diseases, namely AIDS, rheumatoid arthritis, systemic lupus erythematosus, pulmonary tuberculosis with cachexia, and Behçet's disease. Conclusion Our study identified retrogression of African hair to the neonatal structure in five diseases. Anemia of chronic illness, high erythrocyte sedimentation rate, and mild hypocalcemia were significant laboratory parameters. This is an important observation, which should excite and advance research into the nature and structure of African hair. The causes of structural hair changes should include these five diseases. © 2012 The International Society of Dermatology.

Study was carried out on mudskipper, Periophthalmus papilio in Lagos lagoon, Nigeria to provide information on length-weight relationship and fecundity estimates. Periophthalmus papilio is of an amphibious fish and a member of the family periophthalmidae. A total of 2,167 individual of the specie were caught from the lagoon using non return valve traps. Biometric data such as Total Length (TL) and Body Weight (BW) measurements were recorded in the laboratory. The specimens ranged from 30.0 to 190.0 mmTL and weighed between 0.5 and 65.3 g BW. The mean TL measurements were 76.0566±1.415, 115.953±0.999 and 111.361±0.812 mm and weighing 5.908±0.393, 18.808±0.507 and 16.769±0.367 g for unsex, males and females, respectively. The length weight relationships were: Log W = -4.1053+2.5522 Log TL (n = 185, r = 0.9385) for unsex; Log W = -4.6804+2.8606 Log TL (n = 532, r = 0.9684) for males and Log W = -4.7916+2.915 Log TL (n = 746, r = 0.9784) for females. The growth exponential b values were allometry in this species. The fecundity estimates of the species varied between 508 and 15,700 ripe eggs for fish with size from 91-180 mmTL and 9.1-65.3 gBW. The mean fecundity estimate was 3,482±102 eggs for average fish of 116 mmTL. Positive correlation was exhibited by the fish between its fecundity and body weight (r = 0.4041) and total length (r = 0.3810). The Gonadosomatic Index (GSI) values of the fish varied between 0.01 and 0.48% in males and 0.11-8.40% in females. Higher GSI values indicate a better well being for the fish. © 2011 Academic Journals Inc.

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