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The International Association of HealthCare Professionals is pleased to welcome Dr. Toniya Singh, MD, FACC, Cardiologist to their prestigious organization with her upcoming publication in The Leading Physicians of the World. She is a highly trained and qualified physician with an extensive expertise in all facets of her work. Dr. Singh has been in practice for more than a decade and is currently serving patients within Saint Louis Heart and Vascular in Saint Louis, Missouri. She is also affiliated with Christian Hospital, DePaul Health Center, and the Gateway Regional Medical Center. Dr. Singh’s career in medicine began in 1994 when she graduated with her Medical Degree from Lady Hardinge Medical College at the University of Delhi in New Delhi, India. Upon relocating to the United States, she completed her residency and Cardiology fellowship at St. Louis University Hospital in Missouri, where she served as Chief Resident. Dr. Singh obtained board certification in Internal Medicine, Cardiovascular Diseases, and Adult Echocardiography, and has earned the coveted title of Fellow of the American College of Cardiology. She is a member of the National leadership council for Women in Cardiology. She is a board member of the St Louis Metro American Heart Association. Dr. Singh attributes her success to her hard work and dedication, and when she is not working, she enjoys reading and traveling. Learn more about Dr. Singh here: http://www.slhv.com and by reading her upcoming publication in The Leading Physicians of the World. FindaTopDoc.com is a hub for all things medicine, featuring detailed descriptions of medical professionals across all areas of expertise, and information on thousands of healthcare topics.  Each month, millions of patients use FindaTopDoc to find a doctor nearby and instantly book an appointment online or create a review.  FindaTopDoc.com features each doctor’s full professional biography highlighting their achievements, experience, patient reviews and areas of expertise.  A leading provider of valuable health information that helps empower patient and doctor alike, FindaTopDoc enables readers to live a happier and healthier life.  For more information about FindaTopDoc, visit http://www.findatopdoc.com


ORGAN India, has been strenuously contributing for the cause of organ and body donation --made by the. Trustees of Parashar Foundation Mrs. Kirti Parashar and Ms. Anika Parashar, Chief Executive Officer of ORGAN India Ms. Sunayana Singh, and Special Consultant Ms. Eeda Gujral Chopra were all present to launch the Directory.ORGAN India, has been strenuously contributing for the cause of organ and body donation. An online directory for Body Donation was launched which is now live at www.organindia.org. It will guide the general public exclusively regarding details of medical colleges facilitating voluntary body donation across every State in India.In the past year ORGAN India received a lot of calls on Help lines from all over India from people who wanted to know where they could pledge their bodies for donation after their deaths. ORGAN India decided to create a similar Directory for body Donation to facilitate Body Donation in India. So for the past 6 months, data has been gathered from all States in India where body donation is possible. The Directory is available on the website www.organindia.org and any person in any State in India can go to the Directory, choose the state they want information for, choose the city in that state for which they want the information, and they will get a drop down menu of all Medical Institutions or NGO's  in their chosen city where they can pledge or donate their bodies - along with the names, phone numbers and email id's of the exact people to call. It's extremely simple to operate, it cuts down the time and effort it would take for any individual to get this information from a Medical Institution, and is easily available on the website. With a click of a few buttons, anyone in India will have access to this information, which otherwise is difficult to obtain.It has taken the ORGAN India team months of extremely hard work – lots of phone calls, lots of waiting, lots of explaining – in order to create this directory. We hope that it will go a long way in helping simplifying the noble act of body donation for people across India, leading to many more bodies being available for donation. Please do spread the awareness about this directory in any way that you can so that everyone can know about this service that ORGAN India is providing.The Body Donation Directory was launched by Honorable Union Health Minister Shri JP Nadda in the presence of Director Lady Harding Medical College Dr. Jagdish Chandra, Mr. Alok Kumar, President DadhichiDehDaanSamiti and other dignitaries at the Organ &Whole Body Donation Awareness Campaign 2016-2017 on 12th May 2017 held by Lady Hardinge Medical College and DadhichiDehDaanSamiti.The next of kin of body donors,   registered body donors, and volunteers will were also felicitated as a token of gratitude by the institute. LHMC also released an innovative publication titled 'Tribute to a Silent Teacher – The Human Body' which showcases short stories narrated by undergraduate medical students based on their interactions with Next of Kin of whole body donors associated with the department of Anatomy in the year 2016 – 2017. These are also compiled in the form of short documentaries which will serve to educate and inspire the society at large. This segment designed for students will train them in empathy & compassion as an essence in making of an Ideal Doctor who can provide treatment with kindness. The Module is first of its kind in India which can enhance skills of young doctors.The institute also announced its blog - organandbodydonation.com dedicated to the activities related to organ & tissue donation with the aim to reach out to a larger community through a digital platform.According to, "We were extremely happy to have the Honorable Health Minister launch our body donation Directory. We hope that it will help people across India to be able to donate their bodies with ease. The Parashar Foundation is also extremely thankful to Lady Hardinge Medical College and Dr. Jagdish Chandra for involving us in their wonderful Campaign."


Kakkar A.K.,Safdarjung Hospital | Dahiya N.,Lady Hardinge Medical College
European Journal of Internal Medicine | Year: 2015

Obesity is a growing epidemic and a major contributor to the global burden of disease. Obesity strains the healthcare systems and has profound economic and psychosocial consequences. Historically, pharmacotherapy for obesity has witnessed the rise and fall of several promising drug candidates that had to be eventually withdrawn due to unacceptable safety concerns. Currently four drugs are approved for chronic weight management in obese adults: orlistat, lorcaserin, phentermine/topiramate extended release and naltrexone/bupropion extended release. While lorcaserin and phentermine/topiramate were approved by US Food and Drug Administration (FDA) in 2012, after a gap of 13 years following the licensing of orlistat, naltrexone/bupropion has been recently approved in 2014. This review provides a brief overview of these current therapeutic interventions available for management of obesity along with the evidence of their safety and efficacy. Additionally, several novel monotherapies as well as combination products are undergoing evaluation in various stages of clinical development. These therapies if proven successful will strengthen the existing armamentarium of antiobesity drugs and will be critical to combat the global public health crisis of obesity and its associated co-morbidities. © 2015 European Federation of Internal Medicine. All rights reserved.


Kakkar A.K.,All India Institute of Medical Sciences | Dahiya N.,Lady Hardinge Medical College
Tuberculosis | Year: 2014

Treatment of multidrug-resistant tuberculosis (MDR-TB) is hindered by limited efficacy and significant toxicity of second-line drugs. The need for new therapeutic options is critical to combat the global MDR-TB epidemic. Bedaquiline is a novel oral diarylquinoline approved by Food and Drug administration (FDA) for the treatment of adults with pulmonary MDR-TB on the basis of Phase IIb trial data under the provisions of the accelerated approval regulations for serious or life-threatening conditions. The FDA advisory committee members voted unanimously on efficacy data based on surrogate measures, however they were split on the issues of safety of bedaquiline. Main safety concerns include QT interval prolongation, hepatic related adverse events, and excess mortality in bedaquiline treated patients. While bedaquiline approval is a story of many firsts and certainly a welcome addition to the existing arsenal of anti-TB agents, a cautiously optimistic approach is required to assess the risk benefit profile of the drug. Acceleration of further Phase III trials and clinical studies is imperative, as is timely analysis of emerging data on the real world use of the drug. This mini review outlines the clinical pharmacology of bedaquiline highlighting the potential promises and challenges that implicate the risk benefit profile of drug. © 2014 The Authors. Published by Elsevier Ltd.


Chaudhary B.,Lady Hardinge Medical College
Journal of Indian Academy of Forensic Medicine | Year: 2013

Burn is a major cause of death in all medico-legal cases. Developing countries have a high incidence of burn injuries, creating a formidable public health problem. Our objective of the present study is to measure the magnitude and epidemiology of death due to burns in Central Delhi. A 5 years (from 1st January 2006 to 31st December 2010) autopsies based retrospective study where total 2773 medico-legal autopsies were conducted during this period, out of those 207 (7.46%) were due to burn; 117(56.52%) were males and 90 (43.47%) were females. Maximum 88 (42.51%) of the cases were in the 21-30 years of age group in both gender. The most common manner of the burn was accidental (72.94%), followed by suicidal (17.39%) and homicidal (9.66%). Almost all male deaths were accidental in nature. Smell of kerosene was present in 35 (38.88%) of females bodies. The cause of deaths in 97 (46.85%) was shock followed by 110 (53.14%) septicaemia. The history regarding whether they were killed or ablaze herself was not clear by history records but findings were suggestive of killing of bride in demand of dowry could not be ruled out.


Dwivedi P.,Lady Hardinge Medical College
European review for medical and pharmacological sciences | Year: 2012

STo study the feto-maternal outcome in pregnancy with severe thrombocytopenia. It was an observational study involving 1150 pregnant women with term gestation in labour, who were screened for thrombocytopenia. Ninety-four subjects (8.17%) were found to have thrombocytopenia i.e. platelet count < 1,50,/000/mm3, out of which 47 subjects (group A) had platelet count of less than 50.000/mm3 Simultaneously, 47 term pregnant women (group B) having a normal platelet count i.e. > 1.5 lac/mm3 formed the control group. All the subjects were followed during labour and postpartum period for any feto-maternal outcome. Significant history of bleeding tendencies like prolonged bleeding from wound site, easy bruisability and menorrhagia (p = 0.023) was evident in the study population. Abruptio placentae and early onset pregnancy induced hypertension (PIH) in previous gestations was more commonly found in the study population. Anemia and PIH were significantly more in group A. Incision site oozing during cesarean section was significantly more in group A. Moderate thrombocytopenia was more in neonates of study group (p = 0.014), but without any bleeding complications in neonates. Careful surveillance is required in these high risk patients for earlier detection and treatment of complications so as to decrease the fetomaternal morbidities.


Patra S.K.,Lady Hardinge Medical College | Arora S.,ESI Postgraduate Institute of Medical science
Clinica Chimica Acta | Year: 2012

Background: The cachexia anorexia syndrome is a complex metabolic syndrome associated with cancer and some other palliative conditions characterized by involuntary weight loss involving fat and muscle, weight loss, anorexia, early satiety, fatigue, weakness due to shifts in metabolism caused by tumour by-products and cytokines. Various neuropeptides like Leptin, neuropeptide Y, melanocortin, agouti-related peptides have been known to regulate appetite and body weight. Method: A comprehensive literature search was carried out on the websites of Pubmed Central (http://www.pubmedcentral.nih.gov/), National Library of Medicine (http://www.ncbl.nlm.nih.gov) and various other net resources. Result: Data from observational studies shows that various cytokines (TNF-α, IL-6 and IL-1) are associated with metabolic changes resulting in cachexia in cancer patients. These cytokines may mimic the action of various neuropeptides resulting in anorexia, various metabolic effects resulting from enhanced catabolic state and weight loss. Conclusion: There is a need to understand and explore the role of various neuropeptides and cytokines in the pathophysiology of cancer-anorexia syndrome so that therapeutic measures may be designed for effective palliative care. © 2012 Elsevier B.V.


Jain A.,Lady Hardinge Medical College
Indian Journal of Clinical Biochemistry | Year: 2011

Tuberculosis remains a major public health problem globally, with India being one of the high burden countries. The common causative agent is Mycobacterium tuberculosis but in developing countries M. bovis is reported as a potential human pathogen. Almost 20% of all reported cases of tuberculosis are of extra pulmonary form of disease. Diagnosis of extra pulmonary tuberculosis (EPTB) is not always possible with conventional methods, due to the long time required and the paucibacillary nature of samples; hence the need of rapid molecular methods. A prospective study was conducted on 300 patients of EPTB over a period of 5 years. These patients were suspected cases of tubercular meningitis, tubercular ascites and tubercular lymphadenitis. Samples analyzed were cerebrospinal fluid, ascitic fluid and lymph node fine needle aspirate. A two step PCR targeting hup B gene was used. Clinical response to anti tubercular therapy (ATT) was taken as positive (gold standard). PCR for hup B gene was positive in 147 samples out of 155 ATT responders. Of these 85.71% were infected with M. tuberculosis, 9.52% with M. bovis alone and 4.76% showed co infection with both M.tb and M. bovis. The sensitivity and specificity of PCR was 90.32 and 94.48% respectively. © 2011 Association of Clinical Biochemists of India.


Yadav A.,Lady Hardinge Medical College | Saini V.,Lady Hardinge Medical College | Arora S.,Lady Hardinge Medical College
Clinica Chimica Acta | Year: 2010

Background: Monocyte Chemoattractant Protein (MCP)-1, a potent monocyte attractant, is a member of the CC chemokine subfamily. MCP-1 exerts its effects through binding to G-protein-coupled receptors on the surface of leukocytes targeted for activation and migration. Role of MCP-1 and its receptor CCR2 in monocyte recruitment during infection or under other inflammatory conditions is well known. Method: A comprehensive literature search was conducted from the websites of the National Library of Medicine (http://www.ncbl.nlm.nih.gov) and Pubmed Central, the US National Library of Medicine's digital archive of life sciences literature (http://www.pubmedcentral.nih.gov/). The data was assessed from books and journals that published relevant articles in this field. Result: Recent and ongoing research indicates the role of MCP-1 in various allergic conditions, immunodeficiency diseases, bone remodelling, and permeability of blood - brain barrier, atherosclerosis, nephropathies and tumors. Conclusion: MCP-1 plays an important role in pathogenesis of various disease states and hence MCP-1 inhibition may have beneficial effects in such conditions. © 2010 Elsevier B.V.


Tiwari A.K.,Lady Hardinge Medical College | Lal R.,Lady Hardinge Medical College
International Journal of Surgery | Year: 2014

Background: Diagnosis of skin and soft tissue infections (SSTIs) is difficult as they commonly masquerade as other clinical syndromes. So, the prospective cohort study was carried out to study the clinical profile, evaluate the existing method of severity stratification of SSTIs and identify factors responsible for prolonged stay and poor outcome in patients with SSTIs. Methods: The prospective study was carried out based on clinical profile to evaluate the role of severity stratification of SSTIs in 105 patients attending the surgical outpatient department and surgical emergency. The patients were managed conservatively on oral or intravenous antibiotics and dressing or combined with surgical intervention based on severity stratification. Sometimes radiological investigation helped to know the deep seated abscess and thereby need of early intervention by surgical drainage, fasciotomy and rarely amputation. The data collected, summarised and evaluated using chi-square method. Result: SSTIs has been categorized into mild, moderate and severe form based on clinical and demographic profile of the patient. The study revealed risk factors that were statistically significant to be male patients of lower socioeconomic groups, temperature above 38°C, hypotension, TLC>15000, presence of gangrene, bullae, crepitus, trauma, animal/insect bite, BSA>9% except when involving hand, head & scrotum, loss of sensation, loss of movement/function of affected part and restriction of joint movement (P<0.05). Conclusion: Based on above findings, an algorithm for severity stratification is formulated for reducing the morbidity and mortality of the patients with SSTIs. © 2013 Surgical Associates Ltd.

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