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Kitakyūshū, Japan

Oka T.,Kyushu University | Okumi H.,Kinki University | Nishida S.,Red Cross | Ito T.,Labour Welfare Corporation | And 3 more authors.
BioPsychoSocial Medicine | Year: 2014

This article reviews the effectiveness of Kampo (traditional Japanese herbal medicine) in the treatment of functional gastrointestinal disorders, especially functional dyspepsia (FD) and irritable bowel syndrome (IBS). The results of four randomized, controlled trials (RCTs) suggested the usefulness of rikkunshito in relieving the subjective symptoms of patients with FD. Rikkunshito significantly improved not only gastric symptoms, such as epigastiric discomfort, but also extra-gastric symptoms, such as general fatigue, when compared with control drugs. The therapeutic effects of rikkunshito were more evident when it was prescribed to patients with " kyosho", i.e., low energy. Two RCTs suggested the efficacy of keishikashakuyakuto for IBS.Basic research studies have demonstrated that these Kampo medicines have multiple sites of action to improve subjective symptoms. For example, rikkunshito improves gastric motility dysfunction, including impaired adaptive relaxation and delayed gastric emptying, gastric hypersensitivity, and anorexia via facilitation of ghrelin secretion. It also exhibits anti-stress effects, i.e., it attenuates stress-induced exacerbation of gastric sensation and anorexia, as well as the hypothalamic-pituitary-adrenocortical axis and sympathetic activation. Keishikashakuyakuto exhibited not only an antispasmodic effect on intestinal smooth muscle, but also antidepressant-like effects. Case series suggest that other Kampo prescriptions are also effective for FD and IBS. However, further studies are necessary to evaluate their efficacy. © 2014 Oka et al.; licensee BioMed Central Ltd. Source


Iwasawa T.,Kanagawa Cardiovascular and Respiratory Center | Kato S.,Kanagawa Cardiovascular and Respiratory Center | Ogura T.,Kanagawa Cardiovascular and Respiratory Center | Kusakawa Y.,Kanagawa Cardiovascular and Respiratory Center | And 5 more authors.
American Journal of Roentgenology | Year: 2014

OBJECTIVE. We investigated whether the lung volume determined on CT, especially the volume of the normal lung, is correlated with mean pulmonary artery pressure (PAP) in patients with chronic fibrosing idiopathic interstitial pneumonia (IIP). MATERIALS AND METHODS. The subjects were 40 patients with IIP who underwent right heart catheterization (RHC) and chest CT. Thirty-three patients (82.5%) were smokers or former smokers. Using a computer-aided system, the lungs in the 3D CT images were automatically categorized pixel-by-pixel with gaussian histogram-normalized correlations, and the relative volume of each lesion to the CT lung volume was calculated as "normal(%)," "ground-glass opacities(%)," "consolidation(%)," "emphysema(%)," and "fibrosis(%)." The relationship between each "volume(%)" and pulmonary hypertension was evaluated using logistic regression analysis. ROC curves were constructed to assess the predictive value of these CT-based volumes in the identification of pulmonary hypertension. RESULTS. Sixteen patients had pulmonary hypertension at rest (mean PAP > 25 mm Hg on RHC). Emphysema constituted more than 10% of the CT lung volume in 13 patients. On multivariate analysis of each volume(%), normal(%) was significant for detecting pulmonary hypertension (odds ratio, 0.92; 95% CI, 0.86-0.96; p = 0.02). On ROC analysis, the AUC of normal(%) was 0.849 (0.731-0.967). CONCLUSION. The relative CT volume of any single lesion was of limited value in predicting pulmonary hypertension in patients with pulmonary fibrosis and emphysema. In these patients, normal(%), measured by a 3D computer-aided system, was correlated with pulmonary hypertension measured by RHC. © American Roentgen Ray Society. Source


Inoue T.,Labour Welfare Corporation | Inoue T.,Kyushu University | Kobayashi K.,Kyushu University | Katsuragi T.,Labour Welfare Corporation | And 6 more authors.
Diabetology International | Year: 2011

A 75-year-old woman with a history of type 2 diabetes mellitus was admitted to our hospital with symptoms of asthenia. Laboratory results demonstrated a severe inflammatory response, abnormal kidney function, and hyperglycemia. Electrocardiography revealed atrial fibrillation. The patient was treated with antibiotics and insulin injection upon admission, and laboratory data relating to inflammation, kidney, and blood glucose level gradually improved. On the 4th day of hospitalization, chest contrast-enhanced computed tomography showed the existence of masses in both atria and the right pulmonary artery. The differential diagnosis of the left atrial mass included a thrombus and a neoplasm, such as an atrial myxoma. Because surgical removal of the masses, presumed to be thrombi, was declined by the patient, anticoagulation therapy (heparin i. v. followed by warfarin) was initiated. After 12 months of anticoagulation therapy, the masses disappeared completely without systemic embolization. © 2011 The Japan Diabetes Society. Source


Inoue T.,Labour Welfare Corporation | Inoue T.,Kyushu University | Katsuragi T.,Labour Welfare Corporation | Kunimoto M.,Labour Welfare Corporation | And 7 more authors.
Journal of the Japan Diabetes Society | Year: 2010

We report a case of miliary tuberculosis survival with type 2 diabetes mellitus complicated by HPS, DIC, ARDS, and acute renal failure. A 61-year-old man with cold symptoms from January 1, 2009, and a fever of 38 to 39t persisting despite oral antibiotics from January 6 was admitted on January 15 and found in laboratory tests to have abnormal liver function and hyperglycemia. His workup included ultrasound and computed tomography, results of which were normal. No causative pathogens were detected in serological tests or blood, sputum, and urine culture. Intravenous antibiotics administration was initiated, but his condition deteriorated with disseminated intravascular coagulation (DIC), acute respiratory distress syndrome (ARDS), and acute renal failure. He developed pancytopenia and increased serum ferritin. Hemophagocytic syndrome (HPS) was diagnosed in bone marrow biopsy findings on January 21. His fever decreased after steroid treatment started, but biliary enzymes continued elevated. Miliary tuberculosis was diagnosed with liver biopsy findings on January 27. After antituberculous therapy was started, his clinical situation gradually improved. Source

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